Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | HEATR5A (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HEATR5A mRNA | CTD | PMID:22079256 | (-)-epigallocatechin 3-gallate | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | epigallocatechin gallate results in decreased expression of HEATR5A protein | CTD | PMID:31195006 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of HEATR5A mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of HEATR5A mRNA] | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HEATR5A mRNA | CTD | PMID:19465110 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Heatr5a (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HEATR5A mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of HEATR5A mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Heatr5a (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of HEATR5A mRNA | CTD | PMID:22298810 | 2-hydroxypropanoic acid | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of HEATR5A mRNA | CTD | PMID:30851411 | 2-palmitoylglycerol | increases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of HEATR5A mRNA | CTD | PMID:37199045 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of HEATR5A protein | CTD | PMID:31675489 | acrolein | multiple interactions | ISO | HEATR5A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of HEATR5A mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | aflatoxin B1 | increases methylation | ISO | HEATR5A (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of HEATR5A intron | CTD | PMID:30157460 | alpha-pinene | multiple interactions | ISO | HEATR5A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of HEATR5A mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of HEATR5A mRNA | CTD | PMID:32699268 | atrazine | affects methylation | ISO | Heatr5a (Rattus norvegicus) | 6480464 | Atrazine affects the methylation of HEATR5A gene | CTD | PMID:35440735 | benzo[a]pyrene | increases expression | EXP | | 6480464 | Benzo(a)pyrene results in increased expression of HEATR5A mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases methylation | ISO | HEATR5A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of HEATR5A exon | CTD | PMID:27901495 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzo[a]pyrene diol epoxide I | increases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:26238291 | bis(2-ethylhexyl) phthalate | increases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of HEATR5A mRNA | CTD | PMID:31163220 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of HEATR5A mRNA | CTD | PMID:26063408 | bisphenol A | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of HEATR5A protein | CTD | PMID:31675489 | bisphenol A | affects expression | ISO | Heatr5a (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of HEATR5A mRNA | CTD | PMID:25181051 and PMID:30816183 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of HEATR5A mRNA | CTD | PMID:37019170 | copper atom | multiple interactions | ISO | HEATR5A (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of HEATR5A mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | HEATR5A (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of HEATR5A mRNA | CTD | PMID:20971185 | Cuprizon | increases expression | ISO | Heatr5a (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of HEATR5A mRNA | CTD | PMID:26577399 | decabromodiphenyl ether | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | decabromobiphenyl ether results in decreased expression of HEATR5A protein | CTD | PMID:31675489 | doxorubicin | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of HEATR5A mRNA | CTD | PMID:29803840 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of HEATR5A mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | EXP | | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of HEATR5A mRNA] | CTD | PMID:22206623 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of HEATR5A mRNA | CTD | PMID:25629700 | FR900359 | decreases phosphorylation | ISO | HEATR5A (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of HEATR5A protein | CTD | PMID:37730182 | genistein | increases expression | EXP | | 6480464 | Genistein results in increased expression of HEATR5A mRNA | CTD | PMID:32186404 | gentamycin | increases expression | ISO | Heatr5a (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of HEATR5A mRNA | CTD | PMID:33387578 | leflunomide | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | leflunomide results in decreased expression of HEATR5A mRNA | CTD | PMID:28988120 | oxaliplatin | multiple interactions | ISO | Heatr5a (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of HEATR5A mRNA | CTD | PMID:25729387 | ozone | multiple interactions | ISO | HEATR5A (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of HEATR5A mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | paracetamol | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of HEATR5A mRNA | CTD | PMID:21420995 | potassium chromate | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of HEATR5A mRNA | CTD | PMID:22079256 | potassium chromate | multiple interactions | ISO | HEATR5A (Homo sapiens) | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HEATR5A mRNA | CTD | PMID:22079256 | rac-lactic acid | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of HEATR5A mRNA | CTD | PMID:30851411 | resveratrol | multiple interactions | ISO | HEATR5A (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of HEATR5A mRNA | CTD | PMID:23557933 | silicon dioxide | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of HEATR5A mRNA | CTD | PMID:25895662 | sodium arsenite | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of HEATR5A mRNA | CTD | PMID:28595984 and PMID:34032870 | testosterone | decreases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | Testosterone results in decreased expression of HEATR5A mRNA | CTD | PMID:33359661 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of HEATR5A mRNA | CTD | PMID:31919559 | thioacetamide | increases expression | ISO | Heatr5a (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of HEATR5A mRNA | CTD | PMID:23411599 and PMID:34492290 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of HEATR5A mRNA | CTD | PMID:23557971 | topotecan | decreases expression | ISO | Heatr5a (Rattus norvegicus) | 6480464 | Topotecan results in decreased expression of HEATR5A mRNA | CTD | PMID:25729387 | topotecan | multiple interactions | ISO | Heatr5a (Rattus norvegicus) | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of HEATR5A mRNA | CTD | PMID:25729387 | triptonide | decreases expression | EXP | | 6480464 | triptonide results in decreased expression of HEATR5A mRNA | CTD | PMID:33045310 | valproic acid | increases expression | ISO | HEATR5A (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of HEATR5A mRNA | CTD | PMID:23179753 more ... | |