Arl8b (ADP-ribosylation factor-like 8B) - Rat Genome Database

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Gene: Arl8b (ADP-ribosylation factor-like 8B) Mus musculus
Analyze
Symbol: Arl8b
Name: ADP-ribosylation factor-like 8B
RGD ID: 1557811
MGI Page MGI
Description: Predicted to enable guanyl ribonucleotide binding activity and tubulin binding activity. Involved in several processes, including antigen processing and presentation of polysaccharide antigen via MHC class II; late endosome to lysosome transport; and viral exocytosis. Acts upstream of or within endosomal transport. Located in axon; lysosome; and synapse. Is expressed in several structures, including alimentary system; central nervous system; limb; sensory organ; and skin. Orthologous to human ARL8B (ADP ribosylation factor like GTPase 8B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610313E07Rik; 3100002J04Rik; ADP-ribosylation factor-like 10C; ADP-ribosylation factor-like protein 10C; ADP-ribosylation factor-like protein 8B; Arl; Arl10c; gie1; novel small G protein indispensable for equal chromosome segregation 1; small G protein indispensable for equal chromosome segregation 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,760,020 - 108,800,684 (+)NCBIGRCm39mm39
GRCm39 Ensembl6108,760,060 - 108,802,239 (+)Ensembl
GRCm386108,783,059 - 108,823,723 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,783,099 - 108,825,278 (+)EnsemblGRCm38mm10GRCm38
MGSCv376108,733,053 - 108,773,717 (+)NCBIGRCm37mm9NCBIm37
MGSCv366108,748,887 - 108,789,496 (+)NCBImm8
Celera6110,581,538 - 110,625,807 (+)NCBICelera
Cytogenetic Map6E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:15331635   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:16861820   PMID:21267068   PMID:21873635   PMID:22909026   PMID:24457600   PMID:24841562   PMID:25637027   PMID:27626380   PMID:28378742   PMID:28827407  
PMID:29150602   PMID:30174114   PMID:30550785   PMID:30753473   PMID:31038803   PMID:32325033   PMID:33157038  


Genomics

Comparative Map Data
Arl8b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,760,020 - 108,800,684 (+)NCBIGRCm39mm39
GRCm39 Ensembl6108,760,060 - 108,802,239 (+)Ensembl
GRCm386108,783,059 - 108,823,723 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,783,099 - 108,825,278 (+)EnsemblGRCm38mm10GRCm38
MGSCv376108,733,053 - 108,773,717 (+)NCBIGRCm37mm9NCBIm37
MGSCv366108,748,887 - 108,789,496 (+)NCBImm8
Celera6110,581,538 - 110,625,807 (+)NCBICelera
Cytogenetic Map6E2NCBI
ARL8B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3835,122,292 - 5,180,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl35,122,249 - 5,180,911 (+)EnsemblGRCh38hg38GRCh38
GRCh3735,163,977 - 5,222,596 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3635,138,930 - 5,197,601 (+)NCBINCBI36hg18NCBI36
Build 3435,138,929 - 5,197,599NCBI
Celera35,101,851 - 5,160,484 (+)NCBI
Cytogenetic Map3p26.1NCBI
HuRef35,096,488 - 5,155,029 (+)NCBIHuRef
CHM1_135,114,266 - 5,172,980 (+)NCBICHM1_1
T2T-CHM13v2.035,116,223 - 5,174,843 (+)NCBI
Arl8b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24141,748,634 - 141,792,605 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl4141,748,587 - 141,792,596 (+)Ensembl
Rnor_6.04140,837,745 - 140,881,866 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4140,837,745 - 140,881,865 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04217,450,494 - 217,494,707 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44144,299,366 - 144,344,431 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4130,399,834 - 130,444,983 (+)NCBICelera
Cytogenetic Map4q41NCBI
Arl8b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554218,231,582 - 8,276,907 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554218,231,337 - 8,276,907 (-)NCBIChiLan1.0ChiLan1.0
ARL8B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.135,169,950 - 5,225,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl35,169,950 - 5,225,543 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v035,069,592 - 5,127,301 (+)NCBIMhudiblu_PPA_v0panPan3
ARL8B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12012,479,680 - 12,525,330 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2012,481,860 - 12,525,499 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2012,454,038 - 12,499,863 (-)NCBI
ROS_Cfam_1.02012,523,061 - 12,568,915 (-)NCBI
ROS_Cfam_1.0 Ensembl2012,523,082 - 12,568,816 (-)Ensembl
UMICH_Zoey_3.12012,228,473 - 12,274,183 (-)NCBI
UNSW_CanFamBas_1.02012,569,937 - 12,615,505 (-)NCBI
UU_Cfam_GSD_1.02012,556,036 - 12,601,620 (-)NCBI
Arl8b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494211,475,542 - 11,519,807 (+)NCBI
SpeTri2.0NW_0049365774,430,939 - 4,475,186 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARL8B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1361,640,659 - 61,720,719 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11361,640,619 - 61,696,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21367,874,603 - 67,921,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21368,038,504 - 68,047,742 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARL8B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12241,192,458 - 41,247,048 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2241,192,484 - 41,244,822 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041125,375,218 - 125,430,540 (-)NCBIVero_WHO_p1.0
Arl8b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477315,785,339 - 15,832,668 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462477315,785,883 - 15,833,832 (+)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645290993128811995Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46912919136400690Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648696934125336963Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648696934148351498Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648703490125333748Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652138693116132228Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673476983134676963Mouse
12792979Fbmd2_mfemoral bone mineral density 2, females only (mouse)675026989115026943Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675584287109584431Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675693484109693678Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676440930110441074Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678606487121092347Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683690851146954059Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684099474118099474Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686783787113521563Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687480321121480516Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined688982366122982564Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690772571124772807Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92584287111981699Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692584287146330736Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined694981612128981699Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696324286130324483Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696324286130324483Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96632912146535124Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96632912146535124Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696632912146535124Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698219814132219938Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698483798145881170Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698694477132694676Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698908709132916997Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699132089133132228Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103754405136400690Mouse
12910776Hcga4b_mhome cage activity 4b (mouse)6104480321110937026Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104480321127019938Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104480321136400690Mouse
1357793Pnhdlc1_mplasma non-HDL cholesterol 1 (mouse)Not determined6105541783114345810Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined105982366120894102Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:554
Count of miRNA genes:416
Interacting mature miRNAs:456
Transcripts:ENSMUST00000032196
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_026011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB185206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC132443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK009279 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK012024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK205370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY261755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032196   ⟹   ENSMUSP00000032196
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6108,760,060 - 108,802,239 (+)Ensembl
GRCm38.p6 Ensembl6108,783,099 - 108,825,278 (+)Ensembl
RefSeq Acc Id: ENSMUST00000204483   ⟹   ENSMUSP00000145035
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl6108,771,858 - 108,798,734 (+)Ensembl
GRCm38.p6 Ensembl6108,794,897 - 108,821,773 (+)Ensembl
RefSeq Acc Id: NM_026011   ⟹   NP_080287
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396108,760,020 - 108,800,684 (+)NCBI
GRCm386108,783,059 - 108,823,723 (+)ENTREZGENE
MGSCv376108,733,053 - 108,773,717 (+)RGD
Celera6110,581,538 - 110,625,807 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_080287   ⟸   NM_026011
- UniProtKB: Q9CQW2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000032196   ⟸   ENSMUST00000032196
RefSeq Acc Id: ENSMUSP00000145035   ⟸   ENSMUST00000204483

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CQW2-F1-model_v2 AlphaFold Q9CQW2 1-186 view protein structure

Promoters
RGD ID:6838950
Promoter ID:MM_KWN:47108
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026011
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366108,732,921 - 108,733,421 (+)MPROMDB
RGD ID:6890588
Promoter ID:EPDNEW_M8745
Type:initiation region
Name:Arl8b_1
Description:Mus musculus ADP-ribosylation factor-like 8B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386108,783,094 - 108,783,154EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914416 AgrOrtholog
Ensembl Genes ENSMUSG00000030105 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032196 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145035 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032196 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000204483 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Arl8a/8b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_ARF/SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67166 UniProtKB/Swiss-Prot
MGD MGI:1914416 ENTREZGENE
NCBI Gene 67166 ENTREZGENE
Pfam Arf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Arl8b PhenoGen
PRINTS SAR1GTPBP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARF UniProtKB/Swiss-Prot
SMART SAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SVB8_MOUSE UniProtKB/TrEMBL
  ARL8B_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q9DAB3_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TXD7 UniProtKB/Swiss-Prot
  Q3U769 UniProtKB/Swiss-Prot
  Q3UBB1 UniProtKB/Swiss-Prot
  Q3UJU2 UniProtKB/Swiss-Prot