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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Tgif2 | Mouse | 1,2-dichloroethane | decreases expression | EXP | | 6480464 | ethylene dichloride results in decreased expression of TGIF2 mRNA | CTD | PMID:28960355 | Tgif2 | Mouse | 1,2-dimethylhydrazine | increases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of TGIF2 mRNA | CTD | PMID:22206623 | Tgif2 | Mouse | 17alpha-ethynylestradiol | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGIF2 mRNA | CTD | PMID:17942748 | Tgif2 | Mouse | 17beta-estradiol | increases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Estradiol results in increased expression of TGIF2 mRNA | CTD | PMID:23019147 | Tgif2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of TGIF2 mRNA | CTD | PMID:21570461 and PMID:24058054 | Tgif2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TGIF2 mRNA | CTD | PMID:33387578 | Tgif2 | Mouse | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TGIF2 mRNA and Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to TGIF2 promoter] | CTD | PMID:17942748 and PMID:19654925 | Tgif2 | Mouse | 3,4-methylenedioxymethamphetamine | decreases expression | EXP | | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of TGIF2 mRNA | CTD | PMID:20188158 | Tgif2 | Mouse | 6-propyl-2-thiouracil | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Propylthiouracil results in increased expression of TGIF2 mRNA | CTD | PMID:24780913 and PMID:30047161 | Tgif2 | Mouse | acrylamide | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Acrylamide results in increased expression of TGIF2 mRNA | CTD | PMID:28959563 | Tgif2 | Mouse | Aflatoxin B2 alpha | decreases methylation | ISO | TGIF2 (Homo sapiens) | 6480464 | aflatoxin B2 results in decreased methylation of TGIF2 promoter | CTD | PMID:30157460 | Tgif2 | Mouse | all-trans-retinoic acid | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of TGIF2 mRNA | CTD | PMID:33167477 | Tgif2 | Mouse | alpha-Zearalanol | multiple interactions | ISO | Tgif2 (Rattus norvegicus) | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of TGIF2 mRNA | CTD | PMID:35163327 | Tgif2 | Mouse | amitrole | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Amitrole results in increased expression of TGIF2 mRNA | CTD | PMID:30047161 | Tgif2 | Mouse | arsenite(3-) | increases methylation | ISO | TGIF2 (Homo sapiens) | 6480464 | arsenite results in increased methylation of TGIF2 promoter | CTD | PMID:23974009 | Tgif2 | Mouse | benzo[a]pyrene | multiple interactions | EXP | | 6480464 | Benzo(a)pyrene affects the reaction [AHR protein binds to TGIF2 promoter] | CTD | PMID:19654925 | Tgif2 | Mouse | benzo[a]pyrene | affects methylation | ISO | TGIF2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TGIF2 promoter | CTD | PMID:27901495 | Tgif2 | Mouse | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of TGIF2 mRNA | CTD | PMID:21569818 | Tgif2 | Mouse | beta-lapachone | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | beta-lapachone results in decreased expression of TGIF2 mRNA | CTD | PMID:38218311 | Tgif2 | Mouse | bisphenol A | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of TGIF2 mRNA | CTD | PMID:30816183 and PMID:34947998 | Tgif2 | Mouse | bleomycin A2 | increases expression | EXP | | 6480464 | Bleomycin results in increased expression of TGIF2 mRNA | CTD | PMID:36087614 | Tgif2 | Mouse | cadmium dichloride | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of TGIF2 mRNA | CTD | PMID:38568856 | Tgif2 | Mouse | caffeine | affects phosphorylation | ISO | TGIF2 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of TGIF2 protein | CTD | PMID:35688186 | Tgif2 | Mouse | cannabidiol | multiple interactions | EXP | | 6480464 | [lipopolysaccharide and E coli O55-B5 co-treated with Cannabidiol] results in decreased expression of TGIF2 mRNA | CTD | PMID:30742662 | Tgif2 | Mouse | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of TGIF2 mRNA | CTD | PMID:37019170 | Tgif2 | Mouse | choline | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGIF2 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGIF2 gene | CTD | PMID:20938992 | Tgif2 | Mouse | copper atom | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TGIF2 mRNA | CTD | PMID:20971185 | Tgif2 | Mouse | copper(0) | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of TGIF2 mRNA | CTD | PMID:20971185 | Tgif2 | Mouse | copper(II) sulfate | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of TGIF2 mRNA | CTD | PMID:19549813 | Tgif2 | Mouse | coumestrol | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 more ... | CTD | PMID:19167446 | Tgif2 | Mouse | coumestrol | increases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of TGIF2 mRNA | CTD | PMID:19167446 | Tgif2 | Mouse | Cuprizon | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Cuprizone results in increased expression of TGIF2 mRNA | CTD | PMID:26577399 | Tgif2 | Mouse | cyclosporin A | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of TGIF2 mRNA | CTD | PMID:25562108 | Tgif2 | Mouse | DDE | increases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Dichlorodiphenyl Dichloroethylene results in increased expression of TGIF2 mRNA | CTD | PMID:38568856 | Tgif2 | Mouse | diazinon | increases methylation | ISO | TGIF2 (Homo sapiens) | 6480464 | Diazinon results in increased methylation of TGIF2 gene | CTD | PMID:22964155 | Tgif2 | Mouse | Dibutyl phosphate | affects expression | ISO | TGIF2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of TGIF2 mRNA | CTD | PMID:37042841 | Tgif2 | Mouse | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of TGIF2 mRNA | CTD | PMID:17361019 | Tgif2 | Mouse | dicrotophos | increases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | dicrotophos results in increased expression of TGIF2 mRNA | CTD | PMID:28302478 | Tgif2 | Mouse | dorsomorphin | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF2 mRNA | CTD | PMID:27188386 | Tgif2 | Mouse | endosulfan | decreases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Endosulfan results in decreased expression of TGIF2 mRNA | CTD | PMID:29391264 | Tgif2 | Mouse | Enterolactone | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of TGIF2 mRNA | CTD | PMID:19167446 | Tgif2 | Mouse | etoposide | decreases expression | EXP | | 6480464 | Etoposide results in decreased expression of TGIF2 mRNA | CTD | PMID:25270620 | Tgif2 | Mouse | folic acid | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGIF2 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGIF2 gene | CTD | PMID:20938992 | Tgif2 | Mouse | gentamycin | affects expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Gentamicins affects the expression of TGIF2 mRNA | CTD | PMID:33387578 | Tgif2 | Mouse | glyphosate | increases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Glyphosate results in increased expression of TGIF2 mRNA | CTD | PMID:31295307 | Tgif2 | Mouse | hydralazine | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of TGIF2 mRNA | CTD | PMID:17183730 | Tgif2 | Mouse | L-methionine | multiple interactions | EXP | | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TGIF2 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TGIF2 gene | CTD | PMID:20938992 | Tgif2 | Mouse | lidocaine | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Lidocaine results in increased expression of TGIF2 mRNA | CTD | PMID:35283115 | Tgif2 | Mouse | methimazole | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Methimazole results in increased expression of TGIF2 mRNA | CTD | PMID:30047161 | Tgif2 | Mouse | methotrexate | affects expression | EXP | | 6480464 | Methotrexate affects the expression of TGIF2 mRNA | CTD | PMID:18502557 | Tgif2 | Mouse | methyl methanesulfonate | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in decreased expression of TGIF2 mRNA | CTD | PMID:23649840 | Tgif2 | Mouse | paracetamol | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of TGIF2 mRNA | CTD | PMID:22230336 | Tgif2 | Mouse | paracetamol | decreases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Acetaminophen results in decreased expression of TGIF2 mRNA | CTD | PMID:33387578 | Tgif2 | Mouse | perfluorononanoic acid | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in decreased expression of TGIF2 mRNA | CTD | PMID:25812627 | Tgif2 | Mouse | perfluorooctane-1-sulfonic acid | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in decreased expression of TGIF2 mRNA | CTD | PMID:25812627 | Tgif2 | Mouse | perfluorooctanoic acid | multiple interactions | ISO | Tgif2 (Rattus norvegicus) | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of TGIF2 mRNA | CTD | PMID:35163327 | Tgif2 | Mouse | perfluorooctanoic acid | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | perfluorooctanoic acid results in decreased expression of TGIF2 mRNA | CTD | PMID:25812627 | Tgif2 | Mouse | phenylmercury acetate | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of TGIF2 mRNA | CTD | PMID:26272509 | Tgif2 | Mouse | phenylmercury acetate | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF2 mRNA | CTD | PMID:27188386 | Tgif2 | Mouse | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of TGIF2 mRNA | CTD | PMID:23811191 | Tgif2 | Mouse | quercetin | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of TGIF2 mRNA | CTD | PMID:21632981 | Tgif2 | Mouse | quercitrin | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | quercitrin results in decreased expression of TGIF2 mRNA | CTD | PMID:25193878 | Tgif2 | Mouse | resveratrol | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [Coumestrol co-treated with Resveratrol] results in increased expression of TGIF2 mRNA and [Plant Extracts co-treated with Resveratrol] results in decreased expression of TGIF2 mRNA | CTD | PMID:19167446 and PMID:23557933 | Tgif2 | Mouse | rimonabant | multiple interactions | EXP | | 6480464 | Rimonabant inhibits the reaction [Dietary Fats results in decreased expression of TGIF2 mRNA] | CTD | PMID:19030233 | Tgif2 | Mouse | SB 431542 | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TGIF2 mRNA | CTD | PMID:27188386 | Tgif2 | Mouse | sodium arsenite | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of TGIF2 mRNA | CTD | PMID:38568856 | Tgif2 | Mouse | sulfadimethoxine | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Sulfadimethoxine results in increased expression of TGIF2 mRNA | CTD | PMID:30047161 | Tgif2 | Mouse | temozolomide | increases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of TGIF2 mRNA | CTD | PMID:31758290 | Tgif2 | Mouse | thioacetamide | increases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of TGIF2 mRNA | CTD | PMID:34492290 | Tgif2 | Mouse | thiram | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Thiram results in decreased expression of TGIF2 mRNA | CTD | PMID:38568856 | Tgif2 | Mouse | titanium dioxide | decreases methylation | EXP | | 6480464 | titanium dioxide results in decreased methylation of TGIF2 gene | CTD | PMID:35295148 | Tgif2 | Mouse | titanium dioxide | increases methylation | EXP | | 6480464 | titanium dioxide results in increased methylation of TGIF2 promoter | CTD | PMID:35295148 | Tgif2 | Mouse | trichloroethene | decreases expression | ISO | Tgif2 (Rattus norvegicus) | 6480464 | Trichloroethylene results in decreased expression of TGIF2 mRNA | CTD | PMID:33387578 | Tgif2 | Mouse | trichostatin A | affects expression | ISO | TGIF2 (Homo sapiens) | 6480464 | trichostatin A affects the expression of TGIF2 mRNA | CTD | PMID:28542535 | Tgif2 | Mouse | tungsten | increases expression | EXP | | 6480464 | Tungsten results in increased expression of TGIF2 mRNA | CTD | PMID:30912803 | Tgif2 | Mouse | uranium atom | affects expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Uranium affects the expression of TGIF2 mRNA | CTD | PMID:15672453 | Tgif2 | Mouse | urethane | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Urethane results in decreased expression of TGIF2 mRNA | CTD | PMID:28818685 | Tgif2 | Mouse | valproic acid | multiple interactions | ISO | TGIF2 (Homo sapiens) | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of TGIF2 mRNA | CTD | PMID:17183730 | Tgif2 | Mouse | valproic acid | affects expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of TGIF2 mRNA | CTD | PMID:25979313 | Tgif2 | Mouse | valproic acid | decreases expression | ISO | TGIF2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of TGIF2 mRNA | CTD | PMID:23179753 more ... | |