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Gene: Mthfs (5, 10-methenyltetrahydrofolate synthetase) Mus musculus
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Symbol: Mthfs
Name: 5, 10-methenyltetrahydrofolate synthetase
Description: Predicted to have 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Localizes to the mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to several human genes including ST20-MTHFS (ST20-MTHFS readthrough); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110034I12Rik; 2310020H23Rik; 5,10-methenyl-tetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase; AI119695; methenyl-THF synthetase
Orthologs:
Homo sapiens (human) : MTHFS (methenyltetrahydrofolate synthetase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mthfs (methenyltetrahydrofolate synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mthfs (methenyltetrahydrofolate synthetase)
Canis lupus familiaris (dog) : MTHFS (methenyltetrahydrofolate synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mthfs (methenyltetrahydrofolate synthetase)
Sus scrofa (pig) : LOC102167410 (5-formyltetrahydrofolate cyclo-ligase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38989,211,190 - 89,240,225 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37989,106,028 - 89,135,063 (+)NCBIGRCm37mm9NCBIm37
MGSCv36989,009,083 - 89,038,118 (+)NCBImm8
Celera988,839,126 - 88,843,217 (+)NCBICelera
Celera987,292,813 - 87,293,205 (+)NCBICelera
Cytogenetic Map9 E3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mthfs
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557764
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.