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Gene: Mthfs (5, 10-methenyltetrahydrofolate synthetase) Mus musculus
Symbol: Mthfs
Name: 5, 10-methenyltetrahydrofolate synthetase
Description: Predicted to have 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Localizes to the mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to several human genes including ST20-MTHFS (ST20-MTHFS readthrough); PARTICIPATES IN folate metabolic pathway; hereditary folate malabsorption pathway; methotrexate pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110034I12Rik; 2310020H23Rik; 5,10-methenyl-tetrahydrofolate synthetase; 5-formyltetrahydrofolate cyclo-ligase; AI119695; methenyl-THF synthetase
Homo sapiens (human) : MTHFS (methenyltetrahydrofolate synthetase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mthfs (methenyltetrahydrofolate synthetase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mthfs (methenyltetrahydrofolate synthetase)
Canis lupus familiaris (dog) : MTHFS (methenyltetrahydrofolate synthetase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mthfs (methenyltetrahydrofolate synthetase)
Sus scrofa (pig) : LOC102167410 (5-formyltetrahydrofolate cyclo-ligase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38989,211,190 - 89,240,225 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37989,106,028 - 89,135,063 (+)NCBIGRCm37mm9NCBIm37
MGSCv36989,009,083 - 89,038,118 (+)NCBImm8
Celera988,839,126 - 88,843,217 (+)NCBICelera
Celera987,292,813 - 87,293,205 (+)NCBICelera
Cytogenetic Map9 E3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mthfs
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557764
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.