Emx1 (empty spiracles homeobox 1) - Rat Genome Database
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Gene: Emx1 (empty spiracles homeobox 1) Mus musculus
Analyze
Symbol: Emx1
Name: empty spiracles homeobox 1
RGD ID: 1557750
MGI Page MGI
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including in utero embryonic development; nervous system development; and neuroepithelial cell differentiation. Localizes to nucleus. Is expressed in several structures, including branchial pouch; genitourinary system; nervous system; sensory organ; and surface ectoderm. Orthologous to human EMX1 (empty spiracles homeobox 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ethanol; valproic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: empty spiracles homolog 1; empty spiracles-like protein 1; homeobox protein EMX1; MGC129284; MGC129285
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,164,913 - 85,181,445 (+)NCBIGRCm39mm39
GRCm38685,187,931 - 85,204,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,187,438 - 85,204,462 (+)EnsemblGRCm38mm10GRCm38
MGSCv37685,137,925 - 85,154,457 (+)NCBIGRCm37mm9NCBIm37
MGSCv36685,153,589 - 85,170,016 (+)NCBImm8
Celera687,159,523 - 87,176,441 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal action potential  (IAGP)
abnormal afterhyperpolarization  (IAGP)
abnormal Ammon gyrus morphology  (IAGP)
abnormal anterior commissure morphology  (IAGP)
abnormal anterior corticospinal tract morphology  (IAGP)
abnormal axon guidance  (IAGP)
abnormal axon morphology  (IAGP)
abnormal barrel cortex morphology  (IAGP)
abnormal basement membrane morphology  (IAGP)
abnormal behavior  (IAGP)
abnormal blood vessel physiology  (IAGP)
abnormal bone structure  (IEA)
abnormal brain commissure morphology  (IAGP)
abnormal brain ependyma motile cilium morphology  (IAGP)
abnormal brain internal capsule morphology  (IAGP)
abnormal brain morphology  (IAGP)
abnormal brain vasculature morphology  (IAGP)
abnormal brain ventricle morphology  (IAGP)
abnormal brain wave pattern  (IAGP)
abnormal Cajal-Retzius cell morphology  (IAGP)
abnormal cell cycle  (IAGP)
abnormal cell cycle checkpoint function  (IAGP)
abnormal cell physiology  (IAGP)
abnormal cerebellar cortex morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal cerebral cortex pyramidal cell morphology  (IAGP)
abnormal corpus callosum morphology  (IAGP)
abnormal cortical marginal zone morphology  (IAGP)
abnormal cortical plate morphology  (IAGP)
abnormal cortical ventricular zone morphology  (IAGP)
abnormal corticospinal tract morphology  (IAGP)
abnormal dendrite morphology  (IAGP)
abnormal dendritic spine morphology  (IAGP)
abnormal dentate gyrus morphology  (IAGP)
abnormal depression-related behavior  (IAGP)
abnormal DNA methylation  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic/fetal subventricular zone morphology  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal gait  (IAGP)
abnormal glutamate-mediated receptor currents  (IAGP)
abnormal Golgi trans cisterna morphology  (IAGP)
abnormal hearing physiology  (IAGP)
abnormal heart morphology  (IEA)
abnormal hippocampal mossy fiber morphology  (IAGP)
abnormal hippocampus CA1 region morphology  (IAGP)
abnormal hippocampus CA3 region morphology  (IAGP)
abnormal hippocampus development  (IAGP)
abnormal hippocampus layer morphology  (IAGP)
abnormal hippocampus morphology  (IAGP)
abnormal hippocampus neuron morphology  (IAGP)
abnormal hippocampus pyramidal cell layer  (IAGP)
abnormal hippocampus pyramidal cell morphology  (IAGP)
abnormal hippocampus region morphology  (IAGP)
abnormal hippocampus stratum oriens morphology  (IAGP)
abnormal lateral ganglionic eminence morphology  (IAGP)
abnormal lateral ventricle morphology  (IAGP)
abnormal locomotor activation  (IAGP)
abnormal long term depression  (IAGP)
abnormal lysosome physiology  (IAGP)
abnormal medium spiny neuron morphology  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal mitotic spindle morphology  (IAGP)
abnormal mitral cell morphology  (IAGP)
abnormal motor coordination/balance  (IAGP)
abnormal myelination  (IAGP)
abnormal neocortex morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal nervous system tract morphology  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal neurohypophysis morphology  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuron number  (IAGP)
abnormal neuron specification  (IAGP)
abnormal neuronal migration  (IAGP)
abnormal neuronal precursor cell migration  (IAGP)
abnormal neuronal precursor cell number  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal neuronal stem cell morphology  (IAGP)
abnormal neuronal stem cell physiology  (IAGP)
abnormal nursing  (IAGP)
abnormal object recognition memory  (IAGP)
abnormal olfactory bulb development  (IAGP)
abnormal olfactory bulb layer morphology  (IAGP)
abnormal olfactory bulb morphology  (IAGP)
abnormal olfactory cortex morphology  (IAGP)
abnormal pallium development  (IAGP)
abnormal pituitary diverticulum morphology  (IAGP)
abnormal pituitary gland development  (IAGP)
abnormal pituitary gland morphology  (IAGP)
abnormal pituitary infundibular stalk morphology  (IAGP)
abnormal placing response  (IAGP)
abnormal postnatal growth  (IAGP)
abnormal primary motor cortex morphology  (IAGP)
abnormal primary somatosensory cortex morphology  (IAGP)
abnormal pyramidal neuron dendrite morphology  (IAGP)
abnormal radial glial cell apoptosis  (IAGP)
abnormal radial glial cell morphology  (IAGP)
abnormal sleep behavior  (IAGP)
abnormal somatosensory cortex morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spatial reference memory  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal stratification in cerebral cortex  (IAGP)
abnormal suckling behavior  (IAGP)
abnormal susceptibility to Riboviria infection  (IAGP)
abnormal synaptic bouton morphology  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal telencephalon morphology  (IAGP)
abnormal visual cortex morphology  (IAGP)
absent barrels in primary somatosensory cortex  (IAGP)
absent Cajal-Retzius cell  (IAGP)
absent choroid plexus  (IAGP)
absent corpus callosum  (IAGP)
absent dentate gyrus  (IAGP)
absent hippocampal commissure  (IAGP)
absent hippocampal fimbria  (IAGP)
absent hippocampus  (IAGP)
absent hippocampus CA1 region  (IAGP)
absent hippocampus CA2 region  (IAGP)
absent hippocampus CA3 region  (IAGP)
absent pituitary intermediate lobe  (IAGP)
absent telencephalon  (IAGP)
astrocytosis  (IAGP)
behavioral despair  (IAGP)
circling  (IAGP)
convulsive seizures  (IAGP)
decreased anterior commissure size  (IAGP)
decreased anxiety-related response  (IAGP)
decreased aspartic acid level  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased brain size  (IAGP)
decreased brain weight  (IEA)
decreased cell proliferation  (IAGP)
decreased cerebral cortex cell number  (IAGP)
decreased corpus callosum size  (IAGP)
decreased dentate gyrus size  (IAGP)
decreased exploration in new environment  (IAGP)
decreased food intake  (IAGP)
decreased forebrain size  (IAGP)
decreased gamma-aminobutyric acid level  (IAGP)
decreased glutamic acid level  (IAGP)
decreased glutamine level  (IAGP)
decreased grip strength  (IAGP)
decreased hippocampal commissure size  (IAGP)
decreased neocortex size  (IAGP)
decreased neuron number  (IAGP)
decreased neuronal precursor cell number  (IAGP)
decreased neuronal precursor proliferation  (IAGP)
decreased neurotransmitter release  (IAGP)
decreased paired-pulse facilitation  (IAGP)
decreased radial glial cell number  (IAGP)
decreased striatum size  (IAGP)
decreased survivor rate  (IAGP)
decreased synaptic glutamate release  (IAGP)
decreased total body fat amount  (IEA)
decreased vertical activity  (IAGP)
delayed eyelid opening  (IAGP)
dilated lateral ventricles  (IAGP)
disheveled coat  (IAGP)
ectopic cortical neuron  (IAGP)
ectopic hippocampus pyramidal cells  (IAGP)
ectopic neuron  (IAGP)
enlarged brain ventricles  (IAGP)
enlarged heart  (IEA)
enlarged lateral ventricles  (IAGP)
environmentally induced seizures  (IAGP)
female infertility  (IAGP)
gliosis  (IAGP)
hippocampal neuron degeneration  (IAGP)
hippocampus hypoplasia  (IAGP)
hippocampus pyramidal cell degeneration  (IAGP)
hydrocephaly  (IAGP)
hyperactivity  (IAGP)
hypoactivity  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired cued conditioning behavior  (IAGP)
impaired neuron differentiation  (IAGP)
impaired spatial learning  (IAGP)
increased aggression  (IAGP)
increased anxiety-related response  (IAGP)
increased bone mineral content  (IEA)
increased brain apoptosis  (IAGP)
increased brain size  (IAGP)
increased Cajal-Retzius cell number  (IAGP)
increased cell death  (IAGP)
increased exploration in new environment  (IAGP)
increased forebrain apoptosis  (IAGP)
increased hemangioma incidence  (IAGP)
increased lean body mass  (IEA)
increased mitotic index  (IAGP)
increased neocortex size  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuron number  (IAGP)
increased neuronal precursor cell number  (IAGP)
increased neuronal precursor proliferation  (IAGP)
increased radial glial cell number  (IAGP)
increased somatotroph cell number  (IAGP)
increased stereotypic behavior  (IAGP)
increased subiculum size  (IAGP)
increased susceptibility to induction of seizure by inducing agent  (IAGP)
increased susceptibility to pharmacologically induced seizures  (IAGP)
increased thermal nociceptive threshold  (IAGP)
jerky movement  (IAGP)
jumpy  (IAGP)
limb grasping  (IAGP)
loss of cortex neurons  (IAGP)
loss of hippocampal neurons  (IAGP)
male infertility  (IAGP)
microcephaly  (IAGP)
microgliosis  (IAGP)
neurodegeneration  (IAGP)
neuron degeneration  (IAGP)
no abnormal phenotype detected  (IAGP)
obese  (IAGP)
pituitary gland hypoplasia  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
premature neuronal precursor differentiation  (IAGP)
prenatal growth retardation  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
radial glial endfoot detachment  (IAGP)
reduced fertility  (IAGP)
reduced long term depression  (IAGP)
reduced long term potentiation  (IAGP)
reduced NMDA receptor mediated synaptic activity in barrel cortex  (IAGP)
seizures  (IAGP)
short mandible  (IAGP)
slow postnatal weight gain  (IAGP)
small brain ventricles  (IAGP)
small hippocampus  (IAGP)
small thalamus  (IAGP)
social withdrawal  (IAGP)
sporadic seizures  (IAGP)
stereotypic behavior  (IAGP)
telencephalon hypoplasia  (IAGP)
thickened cerebral cortex  (IAGP)
thin cerebral cortex  (IAGP)
thin cortical plate  (IAGP)
tonic-clonic seizures  (IAGP)
whorled hair  (IAGP)
References

Additional References at PubMed
PMID:642215   PMID:1352754   PMID:1353864   PMID:1353865   PMID:7605629   PMID:7669695   PMID:7806216   PMID:7901323   PMID:7915635   PMID:7959790   PMID:8743751   PMID:8754282  
PMID:8812118   PMID:8837770   PMID:8843394   PMID:8889548   PMID:9006071   PMID:9078438   PMID:9098922   PMID:9169087   PMID:9367432   PMID:9570774   PMID:9636075   PMID:9831645  
PMID:10342446   PMID:10349636   PMID:10409502   PMID:10594069   PMID:10601036   PMID:10625551   PMID:10640277   PMID:10648716   PMID:10729342   PMID:10772936   PMID:10841580   PMID:10873661  
PMID:10906711   PMID:10906797   PMID:10963597   PMID:11003836   PMID:11018158   PMID:11027526   PMID:11042159   PMID:11050125   PMID:11074448   PMID:11076861   PMID:11124115   PMID:11217851  
PMID:11239428   PMID:11493561   PMID:11739261   PMID:11782416   PMID:12020859   PMID:12091317   PMID:12118260   PMID:12151506   PMID:12196586   PMID:12354394   PMID:12417641   PMID:12466851  
PMID:12477932   PMID:12498788   PMID:12561075   PMID:12727448   PMID:12756176   PMID:12764040   PMID:12878679   PMID:12890780   PMID:12921747   PMID:12925582   PMID:14521993   PMID:14642275  
PMID:14687546   PMID:15048810   PMID:15084466   PMID:15115821   PMID:15147765   PMID:15219872   PMID:15238450   PMID:15469968   PMID:15489334   PMID:15509747   PMID:15618518   PMID:15632069  
PMID:15708565   PMID:15736266   PMID:15738064   PMID:15803506   PMID:15858069   PMID:15878992   PMID:15882643   PMID:15902206   PMID:15917450   PMID:16049178   PMID:16141072   PMID:16141073  
PMID:16197942   PMID:16284245   PMID:16286922   PMID:16410414   PMID:16436615   PMID:16602821   PMID:16793035   PMID:16815331   PMID:16873667   PMID:16892058   PMID:17030986   PMID:17065460  
PMID:17150988   PMID:17299771   PMID:17329367   PMID:17409249   PMID:17426285   PMID:17482548   PMID:17490651   PMID:17507397   PMID:17589506   PMID:17596436   PMID:17644613   PMID:17694053  
PMID:17822844   PMID:17828260   PMID:17901218   PMID:17928435   PMID:17928865   PMID:17942732   PMID:17956903   PMID:17959802   PMID:17959817   PMID:17972876   PMID:18032654   PMID:18094027  
PMID:18172552   PMID:18202285   PMID:18423864   PMID:18462697   PMID:18487195   PMID:18501628   PMID:18524897   PMID:18579678   PMID:18599790   PMID:18614579   PMID:18625319   PMID:18702697  
PMID:18753373   PMID:18760695   PMID:18840685   PMID:18997113   PMID:19030180   PMID:19036983   PMID:19050759   PMID:19103804   PMID:19149881   PMID:19226509   PMID:19240213   PMID:19329571  
PMID:19332109   PMID:19357712   PMID:19386638   PMID:19403657   PMID:19453629   PMID:19474326   PMID:19527706   PMID:19542358   PMID:19571125   PMID:19661288   PMID:19666831   PMID:19709628  
PMID:19709629   PMID:19749747   PMID:19804761   PMID:19806666   PMID:19820705   PMID:19837136   PMID:19838179   PMID:19859539   PMID:19961580   PMID:20016109   PMID:20023653   PMID:20059953  
PMID:20080609   PMID:20089898   PMID:20103535   PMID:20163789   PMID:20211142   PMID:20335472   PMID:20345913   PMID:20346763   PMID:20399730   PMID:20445055   PMID:20473291   PMID:20579975  
PMID:20601948   PMID:20653027   PMID:20667915   PMID:20668538   PMID:20713502   PMID:20798045   PMID:20835249   PMID:20887964   PMID:20980600   PMID:21092859   PMID:21159961   PMID:21185282  
PMID:21210220   PMID:21219481   PMID:21267068   PMID:21312341   PMID:21321212   PMID:21418559   PMID:21436036   PMID:21452199   PMID:21490227   PMID:21561989   PMID:21677750   PMID:21745337  
PMID:21766338   PMID:21779533   PMID:21864586   PMID:21873635   PMID:21907282   PMID:21925158   PMID:21965613   PMID:21970971   PMID:21976438   PMID:21976507   PMID:21976703   PMID:21991391  
PMID:22028625   PMID:22031906   PMID:22034427   PMID:22056141   PMID:22101327   PMID:22123939   PMID:22213801   PMID:22228756   PMID:22235033   PMID:22266795   PMID:22284184   PMID:22308344  
PMID:22343123   PMID:22378886   PMID:22405202   PMID:22412988   PMID:22445340   PMID:22446880   PMID:22479201   PMID:22522401   PMID:22542181   PMID:22546691   PMID:22553025   PMID:22588081  
PMID:22632977   PMID:22658827   PMID:22674026   PMID:22678282   PMID:22705452   PMID:22723706   PMID:22726441   PMID:22820053   PMID:22844492   PMID:22858543   PMID:22874921   PMID:22903314  
PMID:22997174   PMID:23049074   PMID:23129644   PMID:23136427   PMID:23178126   PMID:23196213   PMID:23259054   PMID:23292680   PMID:23293287   PMID:23307637   PMID:23307639   PMID:23341629  
PMID:23349620   PMID:23359422   PMID:23395374   PMID:23396189   PMID:23512182   PMID:23535656   PMID:23575831   PMID:23623502   PMID:23643363   PMID:23643936   PMID:23658188   PMID:23680462  
PMID:23696555   PMID:23744948   PMID:23765158   PMID:23791179   PMID:23818142   PMID:23830831   PMID:23831966   PMID:23861879   PMID:23863479   PMID:23872636   PMID:23894587   PMID:23895693  
PMID:23897647   PMID:23922229   PMID:23928811   PMID:23968833   PMID:23992846   PMID:24009395   PMID:24014668   PMID:24036464   PMID:24048849   PMID:24056077   PMID:24097044   PMID:24109434  
PMID:24165879   PMID:24174665   PMID:24201284   PMID:24262147   PMID:24360544   PMID:24367105   PMID:24431991   PMID:24448406   PMID:24453338   PMID:24523563   PMID:24595293   PMID:24609464  
PMID:24614806   PMID:24623763   PMID:24719100   PMID:24719109   PMID:24744380   PMID:24771530   PMID:24771701   PMID:24777420   PMID:24781987   PMID:24784230   PMID:24799694   PMID:24813889  
PMID:24855953   PMID:24857653   PMID:24930700   PMID:24937429   PMID:24945774   PMID:24949968   PMID:24952961   PMID:25002511   PMID:25003601   PMID:25009276   PMID:25037921   PMID:25071457  
PMID:25085976   PMID:25088366   PMID:25100583   PMID:25100586   PMID:25131210   PMID:25143599   PMID:25155958   PMID:25157170   PMID:25159148   PMID:25161316   PMID:25182747   PMID:25231486  
PMID:25234641   PMID:25275521   PMID:25277454   PMID:25282615   PMID:25303526   PMID:25336744   PMID:25467984   PMID:25471559   PMID:25476605   PMID:25561230   PMID:25568313   PMID:25571974  
PMID:25644422   PMID:25664912   PMID:25684539   PMID:25698938   PMID:25727174   PMID:25741722   PMID:25742799   PMID:25744204   PMID:25757017   PMID:25759645   PMID:25762686   PMID:25763846  
PMID:25766255   PMID:25792481   PMID:25913859   PMID:25913861   PMID:25922524   PMID:25948253   PMID:25963901   PMID:25976033   PMID:25988834   PMID:25996136   PMID:26023682   PMID:26079333  
PMID:26106292   PMID:26125563   PMID:26177896   PMID:26180201   PMID:26182416   PMID:26195764   PMID:26203155   PMID:26220974   PMID:26235615   PMID:26245956   PMID:26290337   PMID:26291160  
PMID:26319231   PMID:26324926   PMID:26371510   PMID:26383973   PMID:26387942   PMID:26414615   PMID:26446225   PMID:26464960   PMID:26499080   PMID:26509897   PMID:26517967   PMID:26534986  
PMID:26621269   PMID:26656997   PMID:26671461   PMID:26705332   PMID:26728565   PMID:26733533   PMID:26748089   PMID:26776514   PMID:26795843   PMID:26802325   PMID:26813976   PMID:26814051  
PMID:26848828   PMID:26856890   PMID:26901526   PMID:26915960   PMID:26958833   PMID:26985044   PMID:27001694   PMID:27030755   PMID:27100196   PMID:27111087   PMID:27117402   PMID:27117416  
PMID:27133954   PMID:27170123   PMID:27181636   PMID:27194399   PMID:27238024   PMID:27269285   PMID:27293187   PMID:27300105   PMID:27307230   PMID:27321927   PMID:27334849   PMID:27345935  
PMID:27383233   PMID:27385014   PMID:27390776   PMID:27445711   PMID:27530555   PMID:27545744   PMID:27618312   PMID:27626380   PMID:27640726   PMID:27641496   PMID:27664421   PMID:27673329  
PMID:27686624   PMID:27693255   PMID:27707798   PMID:27732850   PMID:27779093   PMID:27798843   PMID:27845329   PMID:27871306   PMID:27889578   PMID:27926877   PMID:27939640   PMID:28009277  
PMID:28031177   PMID:28041852   PMID:28041880   PMID:28041940   PMID:28052921   PMID:28053041   PMID:28059700   PMID:28076783   PMID:28119463   PMID:28123024   PMID:28160463   PMID:28213441  
PMID:28224988   PMID:28232627   PMID:28238546   PMID:28264913   PMID:28288114   PMID:28291836   PMID:28297673   PMID:28297715   PMID:28334242   PMID:28341853   PMID:28346453   PMID:28346493  
PMID:28426966   PMID:28472654   PMID:28472660   PMID:28475893   PMID:28498492   PMID:28534484   PMID:28592694   PMID:28728023   PMID:28747385   PMID:28751609   PMID:28765330   PMID:28768199  
PMID:28779130   PMID:28794407   PMID:28817801   PMID:28858618   PMID:28917843   PMID:28932809   PMID:28942925   PMID:28947178   PMID:28970783   PMID:28978667   PMID:28981898   PMID:29016848  
PMID:29024662   PMID:29024667   PMID:29025924   PMID:29033205   PMID:29040524   PMID:29043563   PMID:29104535   PMID:29138280   PMID:29146941   PMID:29158580   PMID:29184199   PMID:29214672  
PMID:29224725   PMID:29263200   PMID:29281825   PMID:29293918   PMID:29311744   PMID:29335427   PMID:29360985   PMID:29466446   PMID:29615610   PMID:29628187   PMID:29656873   PMID:29662492  
PMID:29681532   PMID:29713079   PMID:29720086   PMID:29739868   PMID:29747665   PMID:29760646   PMID:29779941   PMID:29809135   PMID:29891551   PMID:29897332   PMID:29899142   PMID:29937280  
PMID:29969655   PMID:30053506   PMID:30056076   PMID:30093551   PMID:30093555   PMID:30143575   PMID:30175250   PMID:30224746   PMID:30233336   PMID:30260951   PMID:30270041   PMID:30305734  
PMID:30322923   PMID:30329130   PMID:30382937   PMID:30392800   PMID:30455454   PMID:30468146   PMID:30523785   PMID:30529950   PMID:30559150   PMID:30578296   PMID:30597194   PMID:30601941  
PMID:30626697   PMID:30659230   PMID:30661931   PMID:30668728   PMID:30705426   PMID:30709655   PMID:30787442   PMID:30789343   PMID:30809123   PMID:30824354   PMID:30873428   PMID:30883329  
PMID:30910807   PMID:30962870   PMID:30985297   PMID:31015467   PMID:31027966   PMID:31028115   PMID:31038456   PMID:31042712   PMID:31048552   PMID:31071314   PMID:31073041   PMID:31080058  
PMID:31097699   PMID:31099752   PMID:31108505   PMID:31112699   PMID:31118206   PMID:31125447   PMID:31130380   PMID:31197172   PMID:31213987   PMID:31296412   PMID:31310785   PMID:31318893  
PMID:31357244   PMID:31371378   PMID:31395862   PMID:31415124   PMID:31454079   PMID:31455734   PMID:31501572   PMID:31548370   PMID:31551604   PMID:31557161   PMID:31585079   PMID:31606247  
PMID:31649512   PMID:31655624   PMID:31666685   PMID:31666704   PMID:31680852   PMID:31715135   PMID:31722597   PMID:31736463   PMID:31736707   PMID:31749685   PMID:31780329   PMID:31794431  
PMID:31796586   PMID:31813652   PMID:31844315   PMID:31875542   PMID:31907211   PMID:31909712   PMID:31924768   PMID:31945419   PMID:31949109   PMID:31962128   PMID:32001437   PMID:32009901  
PMID:32027825   PMID:32041791   PMID:32049024   PMID:32071228   PMID:32142410   PMID:32160554   PMID:32167467   PMID:32186707   PMID:32202496   PMID:32203496   PMID:32222555   PMID:32280987  
PMID:32286224   PMID:32291328   PMID:32418612   PMID:32471877   PMID:32562661   PMID:32579270   PMID:32737167   PMID:32780108   PMID:32840212   PMID:32851975   PMID:32873638   PMID:32994168  
PMID:33060174   PMID:33086056   PMID:33140451   PMID:33177537   PMID:33177719   PMID:33200984   PMID:33443207  


Genomics

Comparative Map Data
Emx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39685,164,913 - 85,181,445 (+)NCBIGRCm39mm39
GRCm38685,187,931 - 85,204,463 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl685,187,438 - 85,204,462 (+)EnsemblGRCm38mm10GRCm38
MGSCv37685,137,925 - 85,154,457 (+)NCBIGRCm37mm9NCBIm37
MGSCv36685,153,589 - 85,170,016 (+)NCBImm8
Celera687,159,523 - 87,176,441 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map637.21NCBI
EMX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl272,916,260 - 72,936,071 (+)EnsemblGRCh38hg38GRCh38
GRCh38272,910,949 - 72,936,691 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37273,144,648 - 73,162,020 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh37273,144,604 - 73,162,020 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36272,998,112 - 73,015,528 (+)NCBINCBI36hg18NCBI36
Build 34273,056,258 - 73,073,131NCBI
Celera272,995,445 - 73,012,863 (+)NCBI
Cytogenetic Map2p13.2NCBI
HuRef272,880,195 - 72,897,613 (+)NCBIHuRef
CHM1_1273,074,790 - 73,092,204 (+)NCBICHM1_1
Emx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24117,725,148 - 117,741,616 (+)NCBI
Rnor_6.0 Ensembl4116,968,000 - 116,985,551 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04116,967,646 - 116,984,136 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04181,547,418 - 181,563,890 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44119,420,621 - 119,436,740 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4106,708,318 - 106,724,802 (+)NCBICelera
Cytogenetic Map4q34NCBI
Emx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542412,664,104 - 12,683,023 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542412,666,280 - 12,683,023 (-)NCBIChiLan1.0ChiLan1.0
EMX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A74,462,012 - 74,482,159 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02A72,969,693 - 73,030,427 (+)NCBIMhudiblu_PPA_v0panPan3
EMX1
(Canis lupus familiaris - dog)
No map positions available.
Emx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649116,745,310 - 16,762,422 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EMX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl369,831,459 - 69,859,731 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1369,842,061 - 69,863,940 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2373,041,590 - 73,061,316 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EMX1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11434,232,425 - 34,250,807 (-)NCBI
ChlSab1.1 Ensembl1434,232,819 - 34,249,253 (-)Ensembl
Emx1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624762685,331 - 702,040 (-)NCBI

Position Markers
Emx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37685,144,034 - 85,144,215UniSTSGRCm37
Celera687,165,631 - 87,165,812UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.5UniSTS
cM Map635.5UniSTS
Emx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38685,194,040 - 85,194,221UniSTSGRCm38
MGSCv37685,144,034 - 85,144,215UniSTSGRCm37
Celera687,165,631 - 87,165,812UniSTS
Cytogenetic Map6C3UniSTS
cM Map635.5UniSTS
Emx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS
cM Map635.5UniSTS
Emx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:443
Count of miRNA genes:308
Interacting mature miRNAs:350
Transcripts:ENSMUST00000045942, ENSMUST00000173919
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000045942   ⟹   ENSMUSP00000046026
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,187,438 - 85,204,358 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173919
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl685,193,519 - 85,204,462 (+)Ensembl
RefSeq Acc Id: NM_010131   ⟹   NP_034261
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39685,164,913 - 85,181,445 (+)NCBI
GRCm38685,187,931 - 85,204,463 (+)ENTREZGENE
MGSCv37685,137,925 - 85,154,457 (+)RGD
Celera687,159,523 - 87,176,441 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_034261 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA48752 (Get FASTA)   NCBI Sequence Viewer  
  EDK99122 (Get FASTA)   NCBI Sequence Viewer  
  Q04742 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_034261   ⟸   NM_010131
- UniProtKB: Q04742 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000046026   ⟸   ENSMUST00000045942

Promoters
RGD ID:6839228
Promoter ID:MM_KWN:46671
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:NM_010131
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,137,481 - 85,137,981 (+)MPROMDB
RGD ID:6847991
Promoter ID:MM_ACW:41791
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:EMX1.BSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36685,143,876 - 85,144,376 (+)MPROMDB
RGD ID:6890216
Promoter ID:EPDNEW_M8559
Type:single initiation site
Name:Emx1_1
Description:Mus musculus empty spiracles homeobox 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38685,187,995 - 85,188,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95387 AgrOrtholog
Ensembl Genes ENSMUSG00000033726 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000046026 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000045942 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
KEGG Report mmu:13796 UniProtKB/Swiss-Prot
MGD MGI:95387 ENTREZGENE
NCBI Gene 13796 ENTREZGENE
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Emx1 PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniProt EMX1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3SXG0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-31 Emx1  empty spiracles homeobox 1  Emx1  empty spiracles homolog 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED