Tssk6 (testis-specific serine kinase 6) - Rat Genome Database
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Gene: Tssk6 (testis-specific serine kinase 6) Mus musculus
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Symbol: Tssk6
Name: testis-specific serine kinase 6
RGD ID: 1557737
MGI Page MGI
Description: Exhibits magnesium ion binding activity and protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and sperm chromatin condensation. Predicted to localize to cytoplasm and nucleus. Orthologous to human TSSK6 (testis specific serine kinase 6); INTERACTS WITH 1,2-dimethylhydrazine; 4,4'-diaminodiphenylmethane; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: serine/threonine protein kinase SSTK; serine/threonine-protein kinase SSTK; small serine/threonine kinase; Ss; Sstk; testis-specific kinase 6; testis-specific serine/threonine-protein kinase 6; TSK-6; TSSK-6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,354,834 - 70,356,168 (+)NCBIGRCm39mm39
GRCm38869,902,184 - 69,903,518 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,902,184 - 69,903,518 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,426,114 - 72,427,417 (+)NCBIGRCm37mm9NCBIm37
MGSCv36872,831,204 - 72,832,507 (+)NCBImm8
Celera872,462,020 - 72,463,323 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
nucleus  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:15489334   PMID:15870294   PMID:16141072   PMID:16141073   PMID:19596796   PMID:20729278   PMID:20829357  
PMID:21873635   PMID:23599433   PMID:28389581  


Genomics

Comparative Map Data
Tssk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,354,834 - 70,356,168 (+)NCBIGRCm39mm39
GRCm38869,902,184 - 69,903,518 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl869,902,184 - 69,903,518 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,426,114 - 72,427,417 (+)NCBIGRCm37mm9NCBIm37
MGSCv36872,831,204 - 72,832,507 (+)NCBImm8
Celera872,462,020 - 72,463,323 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
TSSK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1919,512,418 - 19,515,548 (-)EnsemblGRCh38hg38GRCh38
GRCh381919,514,219 - 19,515,548 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371919,625,028 - 19,626,469 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361919,486,028 - 19,487,469 (-)NCBINCBI36hg18NCBI36
Celera1919,529,087 - 19,530,528 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1919,187,321 - 19,188,762 (-)NCBIHuRef
CHM1_11919,625,724 - 19,627,165 (-)NCBICHM1_1
Tssk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01621,272,282 - 21,274,756 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1621,273,387 - 21,274,688 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01621,189,471 - 21,190,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41620,009,499 - 20,010,800 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1619,713,817 - 19,715,118 (-)NCBICelera
Cytogenetic Map16p14NCBI
Tssk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555242,433,955 - 2,434,776 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555242,433,855 - 2,434,864 (+)NCBIChiLan1.0ChiLan1.0
TSSK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11919,948,494 - 19,951,687 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1919,950,614 - 19,951,435 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01918,952,643 - 18,954,101 (-)NCBIMhudiblu_PPA_v0panPan3
TSSK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2043,730,907 - 43,731,728 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12043,730,769 - 43,732,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tssk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365961,953,797 - 1,955,753 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TSSK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,411,122 - 58,411,943 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,411,122 - 58,411,943 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,286,057 - 58,286,878 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TSSK6
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1617,974,174 - 17,975,996 (-)NCBI
Tssk6
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249082,310,456 - 2,311,803 (-)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:165
Interacting mature miRNAs:186
Transcripts:ENSMUST00000050373
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000050373   ⟹   ENSMUSP00000062783
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl869,902,184 - 69,903,518 (+)Ensembl
RefSeq Acc Id: NM_032004   ⟹   NP_114393
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,354,834 - 70,356,168 (+)NCBI
GRCm38869,902,184 - 69,903,518 (+)NCBI
MGSCv37872,426,114 - 72,427,417 (+)RGD
Celera872,462,020 - 72,463,323 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_114393 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK48828 (Get FASTA)   NCBI Sequence Viewer  
  BAC36437 (Get FASTA)   NCBI Sequence Viewer  
  EDL28768 (Get FASTA)   NCBI Sequence Viewer  
  Q925K9 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_114393   ⟸   NM_032004
- UniProtKB: Q925K9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000062783   ⟸   ENSMUST00000050373
Protein Domains
Protein kinase

Promoters
RGD ID:8667253
Promoter ID:EPDNEW_M11658
Type:multiple initiation site
Name:Tssk6_1
Description:Mus musculus testis-specific serine kinase 6 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38869,902,184 - 69,902,244EPDNEW
RGD ID:6843847
Promoter ID:MM_KWN:54650
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_032004
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36872,426,919 - 72,427,419 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2148775 AgrOrtholog
Ensembl Genes ENSMUSG00000047654 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000062783 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000050373 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  TSSK6_STKc UniProtKB/Swiss-Prot
KEGG Report mmu:83984 UniProtKB/Swiss-Prot
MGD MGI:2148775 ENTREZGENE
NCBI Gene 83984 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Tssk6 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniGene Mm.432504 ENTREZGENE
UniProt Q925K9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5RL09 UniProtKB/Swiss-Prot
  Q8C625 UniProtKB/Swiss-Prot