Trim62 (tripartite motif-containing 62) - Rat Genome Database

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Gene: Trim62 (tripartite motif-containing 62) Mus musculus
Analyze
Symbol: Trim62
Name: tripartite motif-containing 62
RGD ID: 1557724
MGI Page MGI
Description: Predicted to have identical protein binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in negative regulation of epithelial to mesenchymal transition. Predicted to localize to cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; maxillary process; sensory organ; and submandibular gland primordium. Orthologous to human TRIM62 (tripartite motif containing 62); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6330414G21Rik; AI450348; Dea; Dear1; E3 ubiquitin-protein ligase TRIM62; RING-type E3 ubiquitin transferase TRIM62; tripartite motif-containing protein 62
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394128,777,837 - 128,805,119 (+)NCBIGRCm39mm39
GRCm39 Ensembl4128,777,373 - 128,805,121 (+)Ensembl
GRCm384128,884,044 - 128,911,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4128,883,580 - 128,911,328 (+)EnsemblGRCm38mm10GRCm38
MGSCv374128,561,384 - 128,588,570 (+)NCBIGRCm37mm9NCBIm37
MGSCv364128,386,444 - 128,413,630 (+)NCBImm8
Celera4127,221,836 - 127,249,023 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18287559   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:22988430   PMID:23838884   PMID:24890125   PMID:26238476   PMID:26488816   PMID:30208054   PMID:32325033   PMID:32703402  


Genomics

Comparative Map Data
Trim62
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394128,777,837 - 128,805,119 (+)NCBIGRCm39mm39
GRCm39 Ensembl4128,777,373 - 128,805,121 (+)Ensembl
GRCm384128,884,044 - 128,911,326 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4128,883,580 - 128,911,328 (+)EnsemblGRCm38mm10GRCm38
MGSCv374128,561,384 - 128,588,570 (+)NCBIGRCm37mm9NCBIm37
MGSCv364128,386,444 - 128,413,630 (+)NCBImm8
Celera4127,221,836 - 127,249,023 (+)NCBICelera
Cytogenetic Map4D2.2NCBI
TRIM62
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl133,145,399 - 33,182,059 (-)EnsemblGRCh38hg38GRCh38
GRCh38133,145,399 - 33,184,774 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37133,611,000 - 33,647,644 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36133,383,591 - 33,419,854 (-)NCBINCBI36hg18NCBI36
Build 34133,280,096 - 33,316,360NCBI
Celera131,881,193 - 31,917,797 (-)NCBI
Cytogenetic Map1p35.1NCBI
HuRef131,726,962 - 31,763,317 (-)NCBIHuRef
CHM1_1133,726,505 - 33,763,168 (-)NCBICHM1_1
Trim62
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.25141,230,830 - 141,260,629 (+)NCBI
Rnor_6.0 Ensembl5147,069,616 - 147,095,242 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.05147,068,725 - 147,099,024 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05150,799,760 - 150,830,499 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera5139,714,974 - 139,746,021 (+)NCBICelera
Cytogenetic Map5q36NCBI
Trim62
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545211,347,741 - 11,378,040 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545211,348,001 - 11,377,413 (-)NCBIChiLan1.0ChiLan1.0
TRIM62
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1133,614,555 - 33,650,859 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl133,614,555 - 33,650,859 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0132,429,824 - 32,467,185 (-)NCBIMhudiblu_PPA_v0panPan3
TRIM62
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1268,247,138 - 68,265,530 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl268,247,139 - 68,264,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha264,814,365 - 64,845,785 (+)NCBI
ROS_Cfam_1.0268,798,384 - 68,829,793 (+)NCBI
UMICH_Zoey_3.1265,611,056 - 65,642,474 (+)NCBI
UNSW_CanFamBas_1.0266,633,570 - 66,665,005 (+)NCBI
UU_Cfam_GSD_1.0267,625,508 - 67,656,947 (+)NCBI
Trim62
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505850,174,190 - 50,204,740 (-)NCBI
SpeTri2.0NW_00493647415,998,996 - 16,029,555 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM62
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl689,406,478 - 89,442,746 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1689,406,470 - 89,442,794 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2683,434,103 - 83,470,360 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TRIM62
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12099,697,568 - 99,731,660 (+)NCBI
Vero_WHO_p1.0NW_02366603316,958,127 - 16,993,441 (-)NCBI
Trim62
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476416,200,539 - 16,230,713 (-)NCBI

Position Markers
AI450348  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384128,910,861 - 128,911,123UniSTSGRCm38
MGSCv374128,588,105 - 128,588,367UniSTSGRCm37
Celera4127,248,558 - 127,248,820UniSTS
Cytogenetic Map4D2.2UniSTS
Whitehead/MRC_RH41678.55UniSTS
D5Rat238  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm384128,887,332 - 128,887,500UniSTSGRCm38
MGSCv374128,564,576 - 128,564,744UniSTSGRCm37
Celera4127,225,033 - 127,225,201UniSTS
Cytogenetic Map4D2.2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156183778Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000129100000Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138615442Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000129100000Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155600000Mouse
25314312Syncl2_msynaptonemal complex length 2 (mouse)465800000146500000Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468100000130500000Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468100000150800000Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469200000131000000Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined89063832140740892Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined89063832140740892Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined89063832140740892Mouse
1357529Lvrq8_mliver weight QTL 8 (mouse)Not determined489063832140740892Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)489063832140740892Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined489063832151570093Mouse
13208562Wght7_mweight 7 (mouse)491000000148000000Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined495069342150592401Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100214774134215009Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100214774134215009Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101300000135300000Mouse
15039377Bw45_mbody weight QTL 45 (mouse)4105812001139812001Mouse
15039378Adip30_madiposity 30 (mouse)4105812001139812001Mouse
15039382Ltgq7_mliver triglyceride QTL 7 (mouse)4105812001139812001Mouse
12910794Pwbwq8_mpost-weaning body weight QTL 8 (mouse)4105978113141706527Mouse
12910797Pwgrq4_mpre-weaning growth rate QTL 4 (mouse)4105978113141706527Mouse
12910808Pwbwq9_mpost-weaning body weight QTL 9 (mouse)4105978113141706527Mouse
12910813Pwbwq4_mpre-weaning body weight QTL 4 (mouse)4105978113141706527Mouse
1357800Tgq3_mtriglyceride QTL 3 (mouse)Not determined4107161300141161387Mouse
1300663Start2_mstartle response 2 (mouse)Not determined4107371164141371360Mouse
1300809Ccrs2_mcorpus callosum hemisphere surface size 2 (mouse)Not determined4107371164141371360Mouse
1300781Lith8_mlithogenic gene 8 (mouse)Not determined4107371164141371360Mouse
1301382Arvm2_mautoimmune renal vasculitis 2 (mouse)Not determined4107897771141897963Mouse
10755520Rbc1_mred blood cell count 1 (mouse)4108583899142583899Mouse
10755522Hgb1_mhemoglobin 1 (mouse)4108583899142583899Mouse
10755521Hct1_mhematocrit 1 (mouse)4108583899142583899Mouse
10412072Ssen1_msuseptibility to Sendai virus 1 (mouse)Not determined4109800935133427471Mouse
1300839Dyscalc2_mdystrophic cardiac calcinosis 2 (mouse)Not determined4111115258145115487Mouse
1300743Skull6_mskull morphology 6 (mouse)Not determined4111115258145115487Mouse
15039385Mvlq3_mmacrovesicular liver lesion QTL 3 (mouse)4112288593146288593Mouse
4141001Tgq17_mtriglyceride QTL 17 (mouse)Not determined112629696146629696Mouse
10047132Albq19_malbuminuria QTL 19 (mouse)Not determined4112930596146930596Mouse
1300655Nidds_mnon-insulin-dependent diabetes mellitus in SJL (mouse)Not determined4115173580129572122Mouse
4142493Femwf13_mfemur work to failure 13 (mouse)Not determined116427367150427471Mouse
1302078Sluc21_msusceptibility to lung cancer 21 (mouse)Not determined4117673830151673964Mouse
14746982Manh56_mmandible shape 56 (mouse)4118088606152088606Mouse
1301964Bw8q2_mbody weight at 8 weeks QTL 2 (mouse)Not determined4120137122154137225Mouse
1302102Bis1_mbeta-carboline-induced seizures 1 (mouse)Not determined4120137122154137225Mouse
13503348Bntq18_mbone traits QTL 18 (mouse)4120890537154890684Mouse
10412210Cypr6_mcytokine production 6 (mouse)Not determined4120890537154890684Mouse
1300803Sluc6_msusceptibility to lung cancer 6 (mouse)Not determined4120946694154946840Mouse
4141180Ssic1_msusceptibility to small intestinal cancer 1 (mouse)Not determined120946694154946840Mouse
4142061Chlq16_mcirculating hormone level QTL 16 (mouse)Not determined4121615338155615442Mouse
1301452Elsgp1_melevated serum gp70 1 (mouse)Not determined4121615338155615442Mouse
10043985Stheal12_msoft tissue heal 12 (mouse)Not determined4121615338155615442Mouse
27226757Femd1_mfemur midshaft diameter 1, 5 week (mouse)4124100000144600000Mouse
4141065Shali2_msurvival time to hyperoxic acute lung injury 2 (mouse)Not determined124161300141845481Mouse
1300917Gasa1_mgastritis type A susceptibility locus 1 (mouse)Not determined4124161300142711450Mouse
1302149Tlsr2_mthymic lymphoma suppressor region 2 (mouse)Not determined4124371164142504390Mouse
1301525Lmb1_mlupus in MRL and B6 F2 cross (mouse)Not determined4124371164150592401Mouse
10755531Lymph3_mlymphocyte differential 3 (mouse)4124826172156508116Mouse
1301982Pltiq1_mphospholipid transfer protein inducibility QTL 1 (mouse)Not determined4124893970156508116Mouse
1300858Tafat_mtally ho associated mesenteric fat pad weight (mouse)Not determined4124893970156508116Mouse
4142139Adip12_madiposity 12 (mouse)Not determined4124893970156508116Mouse
1300933Cdcs9_mcytokine deficiency colitis susceptibility 9 (mouse)Not determined4125504302156508116Mouse
10045620Heal22_mwound healing/regeneration 22 (mouse)Not determined4125504302156508116Mouse
1300621Tpnr1_mthermal pain response 1 (mouse)Not determined4125504302156508116Mouse
11533916Mts1_mmammary tumor susceptibility 1 (mouse)4125562755156508116Mouse
4142481Gct1_mgranulosa cell tumorigenesis 1 (mouse)Not determined4128057656156508116Mouse
10043996Gct5_mgranulosa cell tumorigenesis 5 (mouse)Not determined4128057656156508116Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1423
Count of miRNA genes:685
Interacting mature miRNAs:862
Transcripts:ENSMUST00000035667, ENSMUST00000147852
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035667   ⟹   ENSMUSP00000039121
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4128,883,588 - 128,911,328 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147852   ⟹   ENSMUSP00000123646
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl4128,883,580 - 128,903,565 (+)Ensembl
RefSeq Acc Id: NM_001370756   ⟹   NP_001357685
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394128,777,837 - 128,805,119 (+)NCBI
GRCm384128,884,044 - 128,911,326 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001370757   ⟹   NP_001357686
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394128,777,837 - 128,805,119 (+)NCBI
GRCm384128,884,044 - 128,911,326 (+)NCBI
Sequence:
RefSeq Acc Id: NM_178110   ⟹   NP_835211
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394128,777,837 - 128,805,119 (+)NCBI
GRCm384128,884,044 - 128,911,326 (+)NCBI
MGSCv374128,561,384 - 128,588,570 (+)RGD
Celera4127,221,836 - 127,249,023 (+)RGD
cM Map4 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001357685 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357686 (Get FASTA)   NCBI Sequence Viewer  
  NP_835211 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH49095 (Get FASTA)   NCBI Sequence Viewer  
  EDL30224 (Get FASTA)   NCBI Sequence Viewer  
  Q80V85 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_835211   ⟸   NM_178110
- Peptide Label: isoform 2
- UniProtKB: Q80V85 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001357685   ⟸   NM_001370756
- Peptide Label: isoform 1
RefSeq Acc Id: NP_001357686   ⟸   NM_001370757
- Peptide Label: isoform 3
RefSeq Acc Id: ENSMUSP00000123646   ⟸   ENSMUST00000147852
RefSeq Acc Id: ENSMUSP00000039121   ⟸   ENSMUST00000035667
Protein Domains
B box-type   B30.2/SPRY   RING-type

Promoters
RGD ID:6836566
Promoter ID:MM_KWN:39747
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Lung
Transcripts:OTTMUST00000021854,   OTTMUST00000021855
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364128,560,851 - 128,561,722 (+)MPROMDB
RGD ID:6884722
Promoter ID:EPDNEW_M5812
Type:initiation region
Name:Trim62_1
Description:Mus musculus tripartite motif-containing 62 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384128,884,148 - 128,884,208EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914775 AgrOrtholog
Ensembl Genes ENSMUSG00000041000 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000039121 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000123646 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035667 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000147852 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot
  B30.2/SPRY_sf UniProtKB/Swiss-Prot
  Butyrophylin_SPRY UniProtKB/Swiss-Prot
  ConA-like_dom_sf UniProtKB/Swiss-Prot
  PRY UniProtKB/Swiss-Prot
  PRY/SPRY_TRIM62 UniProtKB/Swiss-Prot
  SPRY_dom UniProtKB/Swiss-Prot
  Znf_B-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:67525 UniProtKB/Swiss-Prot
MGD MGI:1914775 ENTREZGENE
NCBI Gene 67525 ENTREZGENE
Pfam PRY UniProtKB/Swiss-Prot
  SPRY UniProtKB/Swiss-Prot
  zf-B_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Trim62 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/Swiss-Prot
PROSITE B302_SPRY UniProtKB/Swiss-Prot
  ZF_BBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PRY UniProtKB/Swiss-Prot
  RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
UniProt D6RJM1_MOUSE UniProtKB/TrEMBL
  Q80V85 ENTREZGENE, UniProtKB/Swiss-Prot