Cfp (complement factor properdin) - Rat Genome Database

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Gene: Cfp (complement factor properdin) Mus musculus
Analyze
Symbol: Cfp
Name: complement factor properdin
RGD ID: 1557720
MGI Page MGI
Description: Involved in complement activation, alternative pathway. Located in extracellular space and secretory granule. Is expressed in embryo; liver left lobe; and liver right lobe. Human ortholog(s) of this gene implicated in X-linked properdin deficiency. Orthologous to human CFP (complement factor properdin).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BCFG; complement factor P; Pf; Pfc; properdin; properdin factor, complement
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,791,693 - 20,797,794 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,791,693 - 20,797,794 (-)EnsemblGRCm39 Ensembl
GRCm38X20,925,454 - 20,931,555 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,925,454 - 20,931,555 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X20,502,661 - 20,508,650 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,082,494 - 20,088,465 (-)NCBIMGSCv36mm8
CeleraX19,059,397 - 19,065,386 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (EXP)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bisphenol A  (EXP,ISO)
carbon nanotube  (EXP)
cerium trichloride  (EXP)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
D-glucose  (EXP)
endosulfan  (ISO)
flutamide  (ISO)
fucoxanthin  (EXP)
fulvestrant  (ISO)
fumonisin B1  (EXP)
glucose  (EXP)
lead diacetate  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
niclosamide  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
pirinixic acid  (EXP)
poly(I:C)  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (EXP)
Soman  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thimerosal  (EXP)
titanium dioxide  (EXP)
trichloroethene  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
versicolorin A  (ISO)
vinclozolin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs. Goundis D and Reid KB, Nature 1988 Sep 1;335(6185):82-5.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Circulating immune complexes and complement levels in hemophilic children. Verroust F, etal., J Clin Lab Immunol. 1981 Sep;6(2):127-30.
Additional References at PubMed
PMID:1916808   PMID:2272504   PMID:6352806   PMID:8468042   PMID:8530041   PMID:8835523   PMID:10036977   PMID:10349636   PMID:10920247   PMID:11042159   PMID:11076861   PMID:11217851  
PMID:12466851   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:17916747   PMID:18292556   PMID:18453618   PMID:20226532   PMID:20637190   PMID:20941861   PMID:21267068  
PMID:21677750   PMID:22308431   PMID:22368277   PMID:22387270   PMID:22830570   PMID:23184055   PMID:23204401   PMID:23427256   PMID:23901101   PMID:24667818   PMID:24706855   PMID:24728387  
PMID:25725105   PMID:26116506   PMID:27235854   PMID:27295359   PMID:28052346   PMID:28250926   PMID:29531168   PMID:29858280   PMID:29895552   PMID:29898960   PMID:30025090   PMID:32325033  
PMID:32867176   PMID:34552582   PMID:37207230   PMID:37951917  


Genomics

Comparative Map Data
Cfp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,791,693 - 20,797,794 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,791,693 - 20,797,794 (-)EnsemblGRCm39 Ensembl
GRCm38X20,925,454 - 20,931,555 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,925,454 - 20,931,555 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X20,502,661 - 20,508,650 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,082,494 - 20,088,465 (-)NCBIMGSCv36mm8
CeleraX19,059,397 - 19,065,386 (-)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.44NCBI
CFP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,623,282 - 47,630,305 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,623,172 - 47,630,305 (-)EnsemblGRCh38hg38GRCh38
GRCh37X47,482,681 - 47,489,704 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,368,569 - 47,374,648 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X47,239,878 - 47,245,958NCBI
CeleraX51,678,874 - 51,684,967 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX45,196,561 - 45,202,654 (-)NCBIHuRef
CHM1_1X47,514,712 - 47,520,808 (-)NCBICHM1_1
T2T-CHM13v2.0X47,033,182 - 47,040,206 (-)NCBIT2T-CHM13v2.0
Cfp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,715,551 - 3,721,113 (+)NCBIGRCr8
mRatBN7.2X1,162,014 - 1,167,576 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,161,979 - 1,167,573 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,190,089 - 1,195,651 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,665,782 - 4,671,345 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X987,013 - 992,576 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,311,121 - 1,316,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,311,121 - 1,316,682 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,126,142 - 2,131,704 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,584,709 - 12,590,271 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX1,730,903 - 1,736,462 (+)NCBICelera
Cytogenetic MapXq11NCBI
Cfp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516449,993 - 456,492 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955516449,993 - 455,897 (+)NCBIChiLan1.0ChiLan1.0
CFP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,250,665 - 49,259,498 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,254,037 - 49,265,230 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,060,106 - 40,066,720 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,956,191 - 47,961,965 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,956,191 - 47,961,965 (-)Ensemblpanpan1.1panPan2
CFP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,245,868 - 41,252,194 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,245,905 - 41,251,623 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,620,466 - 15,626,213 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,379,663 - 41,385,406 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,379,658 - 41,385,368 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,367,204 - 41,372,947 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,355,500 - 41,361,239 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,448,168 - 41,453,913 (-)NCBIUU_Cfam_GSD_1.0
Cfp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,550,861 - 33,558,058 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,391,535 - 13,397,440 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,391,613 - 13,398,723 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,143,697 - 42,152,868 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,145,754 - 42,152,879 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,326,173 - 47,335,086 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103231897
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,801,388 - 44,807,177 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,801,354 - 44,807,402 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366686812,398 - 18,196 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cfp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978184,286 - 190,970 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978180,352 - 194,467 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cfp
162 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:264
Count of miRNA genes:184
Interacting mature miRNAs:201
Transcripts:ENSMUST00000001156, ENSMUST00000122862
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
13208553Wght11_mweight 11 (mouse)X1186623959045360Mouse
13208557Lgth13_mbody length 13 (mouse)X1186623959045360Mouse
1558721Bw1_mbody weight QTL 1 (mouse)Not determinedX2060678347179225Mouse
1301551Spha1_msperm head anomaly 1 (mouse)Not determinedX1026622539921652Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse

Markers in Region
AW822254  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA3UniSTS
cM MapX6.2UniSTS
Whitehead/MRC_RHX360.84UniSTS
Cfp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA3UniSTS
cM MapX16.44UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000001156   ⟹   ENSMUSP00000001156
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,791,693 - 20,797,794 (-)Ensembl
GRCm38.p6 EnsemblX20,925,454 - 20,931,555 (-)Ensembl
RefSeq Acc Id: ENSMUST00000122862
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX20,791,890 - 20,793,853 (-)Ensembl
GRCm38.p6 EnsemblX20,925,651 - 20,927,614 (-)Ensembl
RefSeq Acc Id: NM_008823   ⟹   NP_032849
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X20,791,693 - 20,797,794 (-)NCBI
GRCm38X20,925,454 - 20,931,555 (-)NCBI
MGSCv37X20,502,661 - 20,508,650 (-)RGD
CeleraX19,059,397 - 19,065,386 (-)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032849   ⟸   NM_008823
- Peptide Label: precursor
- UniProtKB: Q3TB98 (UniProtKB/Swiss-Prot),   Q3U779 (UniProtKB/Swiss-Prot),   P11680 (UniProtKB/Swiss-Prot),   A2AE15 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000001156   ⟸   ENSMUST00000001156
Protein Domains
TSP type-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11680-F1-model_v2 AlphaFold P11680 1-464 view protein structure

Promoters
RGD ID:6845557
Promoter ID:MM_KWN:59760
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000051734
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,504,571 - 20,505,447 (-)MPROMDB
RGD ID:6845380
Promoter ID:MM_KWN:59761
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B6,   Spleen
Transcripts:AK005351_1500032P08RIK,   OTTMUST00000041609
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X20,508,301 - 20,509,237 (-)MPROMDB
RGD ID:13680206
Promoter ID:EPDNEW_M24252
Type:initiation region
Name:Cfp_1
Description:Mus musculus complement factor properdin , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X20,931,507 - 20,931,567EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97545 AgrOrtholog
Ensembl Genes ENSMUSG00000001128 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001156 ENTREZGENE
  ENSMUST00000001156.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.20.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CFP_TSR-0 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18636 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:97545 ENTREZGENE
NCBI Gene 18636 ENTREZGENE
PANTHER PROPERDIN UniProtKB/Swiss-Prot
  PROPERDIN UniProtKB/Swiss-Prot
  PROPERDIN UniProtKB/TrEMBL
  PROPERDIN UniProtKB/TrEMBL
Pfam TSP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cfp PhenoGen
PRINTS TSP1REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TSP1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF82895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2AE15 ENTREZGENE, UniProtKB/TrEMBL
  P11680 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TB98 ENTREZGENE
  Q3U779 ENTREZGENE
UniProt Secondary Q3TB98 UniProtKB/Swiss-Prot
  Q3U779 UniProtKB/Swiss-Prot