Tle6 (transducin-like enhancer of split 6) - Rat Genome Database

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Gene: Tle6 (transducin-like enhancer of split 6) Mus musculus
Analyze
Symbol: Tle6
Name: transducin-like enhancer of split 6
RGD ID: 1557715
MGI Page MGI
Description: Predicted to enable transcription corepressor activity. Involved in several processes, including cytoskeleton organization; positive regulation of embryonic development; and spermatogonial cell division. Acts upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Located in cell cortex and nucleus. Part of subcortical maternal complex. Is expressed in brain; early conceptus; foregut-midgut junction; and genitourinary system. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1810057E06Rik; Grg; Grg6; Groucho-related protein 6; transducin-like enhancer of split 6, homolog of Drosophila E(spl); transducin-like enhancer protein 6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm5190   Gm9136  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,426,738 - 81,437,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,426,738 - 81,436,907 (-)EnsemblGRCm39 Ensembl
GRCm381081,590,904 - 81,601,185 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,590,904 - 81,601,073 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,053,650 - 81,063,645 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,994,034 - 81,004,029 (-)NCBIMGSCv36mm8
Celera1082,614,086 - 82,624,081 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11486032   PMID:12477932   PMID:14610273   PMID:16141072   PMID:16141073   PMID:16314515   PMID:16602821  
PMID:18287559   PMID:18551179   PMID:18554416   PMID:18778483   PMID:18799693   PMID:18804437   PMID:19376971   PMID:20059953   PMID:20211142   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:23990468   PMID:24501176   PMID:24952961   PMID:25208553   PMID:28317850   PMID:28992324   PMID:31330130   PMID:31575650   PMID:32823735   PMID:35623357   PMID:37493331   PMID:37922900  
PMID:38060382  


Genomics

Comparative Map Data
Tle6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,426,738 - 81,437,021 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,426,738 - 81,436,907 (-)EnsemblGRCm39 Ensembl
GRCm381081,590,904 - 81,601,185 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,590,904 - 81,601,073 (-)EnsemblGRCm38mm10GRCm38
MGSCv371081,053,650 - 81,063,645 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,994,034 - 81,004,029 (-)NCBIMGSCv36mm8
Celera1082,614,086 - 82,624,081 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
TLE6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,977,401 - 2,995,179 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,977,538 - 2,995,179 (+)EnsemblGRCh38hg38GRCh38
GRCh37192,977,562 - 2,995,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36192,928,562 - 2,946,176 (+)NCBINCBI36Build 36hg18NCBI36
Build 34192,928,561 - 2,946,176NCBI
Celera192,911,604 - 2,929,249 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef192,745,089 - 2,762,613 (+)NCBIHuRef
CHM1_1192,977,119 - 2,995,109 (+)NCBICHM1_1
T2T-CHM13v2.0192,950,897 - 2,968,675 (+)NCBIT2T-CHM13v2.0
Tle6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,757,846 - 8,769,405 (+)NCBIGRCr8
mRatBN7.278,107,050 - 8,118,639 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,107,207 - 8,118,639 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0710,964,136 - 10,988,127 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl710,962,330 - 10,988,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,133,166 - 11,155,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,582,621 - 9,591,827 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera76,299,927 - 6,309,683 (+)NCBICelera
Cytogenetic Map7q11NCBI
Tle6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554955,367,237 - 5,369,601 (-)NCBIChiLan1.0ChiLan1.0
TLE6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,382,145 - 7,390,510 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,606,334 - 6,624,408 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,003,011 - 2,020,577 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,953,184 - 2,978,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,953,184 - 2,978,179 (+)Ensemblpanpan1.1panPan2
TLE6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,159,045 - 56,169,740 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,956,718 - 55,967,584 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,891,741 - 56,902,431 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12055,946,809 - 55,957,461 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,430,998 - 56,441,644 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,629,592 - 56,640,312 (-)NCBIUU_Cfam_GSD_1.0
Tle6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,116,827 - 216,126,808 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365881,708,013 - 1,717,956 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLE6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1275,537,641 - 75,550,676 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2276,058,662 - 76,063,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLE6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.162,750,838 - 2,768,451 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl62,751,525 - 2,768,269 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660815,817,283 - 5,834,667 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tle6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,149,869 - 6,157,875 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tle6
213 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2108
Count of miRNA genes:607
Interacting mature miRNAs:736
Transcripts:ENSMUST00000072020, ENSMUST00000124724, ENSMUST00000127546, ENSMUST00000128278, ENSMUST00000129282, ENSMUST00000131530, ENSMUST00000134457, ENSMUST00000135008, ENSMUST00000137631, ENSMUST00000142948, ENSMUST00000146239, ENSMUST00000149721, ENSMUST00000151858, ENSMUST00000153379
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069735830130430862Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073506901107507047Mouse
4142107Obrq12_mobesity resistance QTL 12 (mouse)Not determined7398721682491121Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1073987216125515907Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1073987216125515907Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075338568109338767Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75338568109338767Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075338568109338767Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078381268112381268Mouse

Markers in Region
Tle6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371081,056,938 - 81,057,105UniSTSGRCm37
Celera1082,617,374 - 82,617,541UniSTS
Cytogenetic Map10C1UniSTS
cM Map10 UniSTS
Tle6  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381081,594,193 - 81,594,360UniSTSGRCm38
MGSCv371081,056,938 - 81,057,105UniSTSGRCm37
Celera1082,617,374 - 82,617,541UniSTS
Cytogenetic Map10C1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001346695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001359135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006513088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017313766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036155513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC153919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF145957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK007880 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC048832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY236020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466553 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000072020   ⟹   ENSMUSP00000071905
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,426,739 - 81,436,734 (-)Ensembl
GRCm38.p6 Ensembl1081,590,905 - 81,600,900 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,430,073 - 81,431,642 (-)Ensembl
GRCm38.p6 Ensembl1081,594,239 - 81,595,808 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127546   ⟹   ENSMUSP00000114738
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,431,830 - 81,436,907 (-)Ensembl
GRCm38.p6 Ensembl1081,595,996 - 81,601,073 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128278
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,426,738 - 81,433,424 (-)Ensembl
GRCm38.p6 Ensembl1081,590,904 - 81,597,590 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129282
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,426,739 - 81,428,549 (-)Ensembl
GRCm38.p6 Ensembl1081,590,905 - 81,592,715 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131530
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,431,043 - 81,433,172 (-)Ensembl
GRCm38.p6 Ensembl1081,595,209 - 81,597,338 (-)Ensembl
RefSeq Acc Id: ENSMUST00000134457
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,429,753 - 81,431,078 (-)Ensembl
GRCm38.p6 Ensembl1081,593,919 - 81,595,244 (-)Ensembl
RefSeq Acc Id: ENSMUST00000135008
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,431,787 - 81,433,201 (-)Ensembl
GRCm38.p6 Ensembl1081,595,953 - 81,597,367 (-)Ensembl
RefSeq Acc Id: ENSMUST00000137631
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,426,741 - 81,433,179 (-)Ensembl
GRCm38.p6 Ensembl1081,590,907 - 81,597,345 (-)Ensembl
RefSeq Acc Id: ENSMUST00000142948   ⟹   ENSMUSP00000117287
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,426,738 - 81,436,709 (-)Ensembl
GRCm38.p6 Ensembl1081,590,904 - 81,600,875 (-)Ensembl
RefSeq Acc Id: ENSMUST00000146239
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,426,967 - 81,428,652 (-)Ensembl
GRCm38.p6 Ensembl1081,591,133 - 81,592,818 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149721
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,431,063 - 81,433,165 (-)Ensembl
GRCm38.p6 Ensembl1081,595,229 - 81,597,331 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151858   ⟹   ENSMUSP00000119945
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,431,827 - 81,436,691 (-)Ensembl
GRCm38.p6 Ensembl1081,595,993 - 81,600,857 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153379
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1081,426,739 - 81,431,249 (-)Ensembl
GRCm38.p6 Ensembl1081,590,905 - 81,595,415 (-)Ensembl
RefSeq Acc Id: NM_001346695   ⟹   NP_001333624
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,436,734 (-)NCBI
GRCm381081,590,904 - 81,600,900 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001359134   ⟹   NP_001346063
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,424 (-)NCBI
GRCm381081,590,904 - 81,597,590 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001359135   ⟹   NP_001346064
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,201 (-)NCBI
GRCm381081,590,904 - 81,597,367 (-)NCBI
Sequence:
RefSeq Acc Id: NM_053254   ⟹   NP_444484
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,739 - 81,436,734 (-)NCBI
GRCm381081,590,905 - 81,600,900 (-)NCBI
MGSCv371081,053,650 - 81,063,645 (-)RGD
Celera1082,614,086 - 82,624,081 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006513081   ⟹   XP_006513144
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,436,741 (-)NCBI
GRCm381081,590,904 - 81,600,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513083   ⟹   XP_006513146
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,437,021 (-)NCBI
GRCm381081,590,904 - 81,601,185 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513085   ⟹   XP_006513148
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,436,741 (-)NCBI
GRCm381081,590,904 - 81,600,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006513088   ⟹   XP_006513151
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,446 (-)NCBI
GRCm381081,590,904 - 81,597,606 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017313766   ⟹   XP_017169255
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,436,739 (-)NCBI
GRCm381081,590,904 - 81,600,907 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244827   ⟹   XP_030100687
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,285 (-)NCBI
GRCm381081,590,904 - 81,597,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244828   ⟹   XP_030100688
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,265 (-)NCBI
GRCm381081,590,904 - 81,597,373 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155506   ⟹   XP_036011399
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,437,013 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155507   ⟹   XP_036011400
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,437,015 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155508   ⟹   XP_036011401
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,446 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155509   ⟹   XP_036011402
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,446 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155510   ⟹   XP_036011403
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,262 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155511   ⟹   XP_036011404
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,451 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155512   ⟹   XP_036011405
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036155513   ⟹   XP_036011406
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391081,426,738 - 81,433,450 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001333624 (Get FASTA)   NCBI Sequence Viewer  
  NP_001346063 (Get FASTA)   NCBI Sequence Viewer  
  NP_001346064 (Get FASTA)   NCBI Sequence Viewer  
  NP_444484 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513144 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513146 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513148 (Get FASTA)   NCBI Sequence Viewer  
  XP_006513151 (Get FASTA)   NCBI Sequence Viewer  
  XP_017169255 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100687 (Get FASTA)   NCBI Sequence Viewer  
  XP_030100688 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011399 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011400 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011401 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011402 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011403 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011404 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011405 (Get FASTA)   NCBI Sequence Viewer  
  XP_036011406 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD37693 (Get FASTA)   NCBI Sequence Viewer  
  AAH48832 (Get FASTA)   NCBI Sequence Viewer  
  BAE22649 (Get FASTA)   NCBI Sequence Viewer  
  EDL31391 (Get FASTA)   NCBI Sequence Viewer  
  EDL31392 (Get FASTA)   NCBI Sequence Viewer  
  EDL31393 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000071905
  ENSMUSP00000071905.3
  ENSMUSP00000114738.2
  ENSMUSP00000117287
  ENSMUSP00000117287.2
  ENSMUSP00000119945.2
GenBank Protein Q9WVB3 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_444484   ⟸   NM_053254
- Peptide Label: isoform 1
- UniProtKB: Q9WVB3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006513146   ⟸   XM_006513083
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006513148   ⟸   XM_006513085
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006513144   ⟸   XM_006513081
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006513151   ⟸   XM_006513088
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017169255   ⟸   XM_017313766
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: NP_001333624   ⟸   NM_001346695
- Peptide Label: isoform 2
- UniProtKB: D3Z5E1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001346063   ⟸   NM_001359134
- Peptide Label: isoform 3
- UniProtKB: Q80XH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_030100688   ⟸   XM_030244828
- Peptide Label: isoform X7
RefSeq Acc Id: XP_030100687   ⟸   XM_030244827
- Peptide Label: isoform X6
RefSeq Acc Id: NP_001346064   ⟸   NM_001359135
- Peptide Label: isoform 3
- UniProtKB: Q80XH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000071905   ⟸   ENSMUST00000072020
RefSeq Acc Id: ENSMUSP00000114738   ⟸   ENSMUST00000127546
RefSeq Acc Id: ENSMUSP00000119945   ⟸   ENSMUST00000151858
RefSeq Acc Id: ENSMUSP00000117287   ⟸   ENSMUST00000142948
RefSeq Acc Id: XP_036011400   ⟸   XM_036155507
- Peptide Label: isoform X4
- UniProtKB: D3Z5E1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011399   ⟸   XM_036155506
- Peptide Label: isoform X3
- UniProtKB: Q9WVB3 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_036011405   ⟸   XM_036155512
- Peptide Label: isoform X8
RefSeq Acc Id: XP_036011404   ⟸   XM_036155511
- Peptide Label: isoform X9
- UniProtKB: Q80XH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036011406   ⟸   XM_036155513
- Peptide Label: isoform X8
RefSeq Acc Id: XP_036011401   ⟸   XM_036155508
- Peptide Label: isoform X6
RefSeq Acc Id: XP_036011402   ⟸   XM_036155509
- Peptide Label: isoform X7
RefSeq Acc Id: XP_036011403   ⟸   XM_036155510
- Peptide Label: isoform X8

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVB3-F1-model_v2 AlphaFold Q9WVB3 1-581 view protein structure

Promoters
RGD ID:6820020
Promoter ID:MM_KWN:5028
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   Brain
Transcripts:OTTMUST00000068894,   OTTMUST00000068900
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361081,055,181 - 81,055,812 (-)MPROMDB
RGD ID:6820024
Promoter ID:MM_KWN:5030
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000068888,   OTTMUST00000068893,   OTTMUST00000068896,   OTTMUST00000068897,   UC007GIT.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361081,059,916 - 81,060,416 (-)MPROMDB
RGD ID:6820023
Promoter ID:MM_KWN:5031
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Kidney,   Liver,   Lung
Transcripts:NM_053254,   OTTMUST00000068891,   OTTMUST00000068892,   UC007GIV.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361081,063,696 - 81,064,196 (-)MPROMDB
RGD ID:8672832
Promoter ID:EPDNEW_M14447
Type:multiple initiation site
Name:Tle6_1
Description:Mus musculus transducin-like enhancer of split 6 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14448  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381081,597,345 - 81,597,405EPDNEW
RGD ID:8672834
Promoter ID:EPDNEW_M14448
Type:single initiation site
Name:Tle6_2
Description:Mus musculus transducin-like enhancer of split 6 , transcriptvariant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14447  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381081,600,874 - 81,600,934EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2149593 AgrOrtholog
Ensembl Genes ENSMUSG00000034758 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000072020 ENTREZGENE
  ENSMUST00000072020.9 UniProtKB/Swiss-Prot
  ENSMUST00000127546.2 UniProtKB/TrEMBL
  ENSMUST00000128278 ENTREZGENE
  ENSMUST00000137631 ENTREZGENE
  ENSMUST00000142948 ENTREZGENE
  ENSMUST00000142948.8 UniProtKB/TrEMBL
  ENSMUST00000151858.8 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Groucho_enhance UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:114606 UniProtKB/Swiss-Prot
MGD MGI:2149593 ENTREZGENE
NCBI Gene 114606 ENTREZGENE
PANTHER PTHR10814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSDUCIN-LIKE ENHANCER PROTEIN 6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tle6 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3YV26_MOUSE UniProtKB/TrEMBL
  D3Z5E1 ENTREZGENE, UniProtKB/TrEMBL
  D6RI70_MOUSE UniProtKB/TrEMBL
  Q3UXB4_MOUSE UniProtKB/TrEMBL
  Q80XH3 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVB3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-14 Tle6  transducin-like enhancer of split 6    transducin-like enhancer of split 6, homolog of Drosophila E(spl)  Symbol and/or name change 5135510 APPROVED