Asxl1 (ASXL transcriptional regulator 1) - Rat Genome Database

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Gene: Asxl1 (ASXL transcriptional regulator 1) Mus musculus
Analyze
Symbol: Asxl1
Name: ASXL transcriptional regulator 1
RGD ID: 1557697
MGI Page MGI
Description: Enables nuclear retinoic acid receptor binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator activity. Involved in several processes, including kidney development; negative regulation of fat cell differentiation; and regulation of signal transduction. Acts upstream of or within several processes, including heart morphogenesis; hematopoietic or lymphoid organ development; and lung saccule development. Located in nucleus. Is expressed in several structures, including limb bud; lung; nervous system; paraxial mesenchyme; and salivary gland. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: additional sex combs like 1; additional sex combs-like protein 1; DKFZp434N0535; mKIAA0978; polycomb group protein ASXL1; putative Polycomb group protein ASXL1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392153,187,750 - 153,245,927 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2153,187,749 - 153,245,927 (+)EnsemblGRCm39 Ensembl
GRCm382153,345,830 - 153,404,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,345,829 - 153,404,007 (+)EnsemblGRCm38mm10GRCm38
MGSCv372153,171,875 - 153,229,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362153,037,493 - 153,095,448 (+)NCBIMGSCv36mm8
MGSCv362154,151,679 - 154,209,986 (+)NCBIMGSCv36mm8
Celera2159,188,615 - 159,246,403 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal blood cell morphology/development  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal common myeloid progenitor cell morphology  (IAGP)
abnormal coping response  (IEA)
abnormal cornea morphology  (IEA)
abnormal craniofacial morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal hematopoietic stem cell morphology  (IAGP)
abnormal hematopoietic stem cell physiology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal immune system cell morphology  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal leukocyte morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal lymphopoiesis  (IAGP)
abnormal megakaryocyte morphology  (IAGP)
abnormal myelopoiesis  (IAGP)
abnormal neutrophil morphology  (IAGP)
abnormal neutrophil physiology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spleen white pulp morphology  (IAGP)
abnormal thymus morphology  (IAGP)
anemia  (IAGP)
anophthalmia  (IAGP)
cleft palate  (IAGP)
corneal opacity  (IEA)
decreased B cell number  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased CD4-positive, alpha-beta T cell number  (IAGP)
decreased circulating free fatty acids level  (IEA)
decreased circulating glucose level  (IEA)
decreased circulating triglyceride level  (IEA)
decreased erythroid progenitor cell number  (IAGP)
decreased hematopoietic stem cell number  (IAGP)
decreased hemoglobin content  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased lumbar vertebrae number  (IEA)
decreased lymphocyte cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased mean corpuscular hemoglobin  (IEA)
decreased monocyte cell number  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased pre-B cell number  (IAGP)
decreased spleen red pulp amount  (IAGP)
decreased spleen weight  (IAGP)
decreased splenocyte number  (IAGP)
decreased T cell number  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
eye opacity  (IAGP)
impaired hematopoiesis  (IAGP)
increased apoptosis  (IAGP)
increased blood uric acid level  (IEA)
increased bone marrow cell number  (IAGP)
increased cell proliferation  (IAGP)
increased circulating alkaline phosphatase level  (IEA)
increased circulating iron level  (IEA)
increased double-negative T cell number  (IAGP)
increased erythroid progenitor cell number  (IAGP)
increased hematopoietic stem cell number  (IAGP)
increased leukemia incidence  (IAGP)
increased leukocyte cell number  (IAGP)
increased malignant tumor incidence  (IAGP)
increased mean corpuscular hemoglobin concentration  (IEA)
increased monocyte cell number  (IAGP)
increased nucleated erythrocyte cell number  (IAGP)
increased number of Howell-Jolly bodies  (IAGP)
increased opacity of vitreous body  (IAGP)
increased sacral vertebrae number  (IEA)
increased sarcoma incidence  (IAGP)
increased single-positive T cell number  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
lethality, complete penetrance  (IAGP)
mandible hypoplasia  (IAGP)
microphthalmia  (IAGP)
myeloid hyperplasia  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
polychromatophilia  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
small spleen  (IAGP)
spleen atrophy  (IAGP)
spleen hyperplasia  (IAGP)
thrombocytopenia  (IAGP)
vertebral fusion  (IEA)
vertebral transformation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations. Chou WC, etal., Blood. 2010 Nov 18;116(20):4086-94. doi: 10.1182/blood-2010-05-283291. Epub 2010 Aug 6.
2. ASXL1 but not TET2 mutations adversely impact overall survival of patients suffering systemic mastocytosis with associated clonal hematologic non-mast-cell diseases. Damaj G, etal., PLoS One. 2014 Jan 21;9(1):e85362. doi: 10.1371/journal.pone.0085362. eCollection 2014.
3. ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia. Gelsi-Boyer V, etal., Br J Haematol. 2010 Nov;151(4):365-75. doi: 10.1111/j.1365-2141.2010.08381.x. Epub 2010 Sep 29.
4. Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. Inoue D, etal., J Clin Invest. 2013 Nov;123(11):4627-40.
5. Loss of ASXL1 expression is associated with lymph node metastasis in colorectal cancer. Lee JH, etal., Indian J Pathol Microbiol. 2020 Apr-Jun;63(2):221-225. doi: 10.4103/IJPM.IJPM_822_19.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, etal., DNA Res 2003 Feb 28;10(1):35-48.
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Disruption of the ASXL1 gene is frequent in primary, post-essential thrombocytosis and post-polycythemia vera myelofibrosis, but not essential thrombocytosis or polycythemia vera: analysis of molecular genetics and clinical phenotypes. Stein BL, etal., Haematologica. 2011 Oct;96(10):1462-9. doi: 10.3324/haematol.2011.045591. Epub 2011 Jun 28.
14. Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes. Thol F, etal., J Clin Oncol. 2011 Jun 20;29(18):2499-506. doi: 10.1200/JCO.2010.33.4938. Epub 2011 May 16.
15. Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms. Traina F, etal., Leukemia. 2014 Jan;28(1):78-87. doi: 10.1038/leu.2013.269. Epub 2013 Sep 18.
16. Mutations and prognosis in primary myelofibrosis. Vannucchi AM, etal., Leukemia. 2013 Sep;27(9):1861-9. doi: 10.1038/leu.2013.119. Epub 2013 Apr 26.
17. TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes. Wang J, etal., Leuk Res. 2013 Mar;37(3):305-11. doi: 10.1016/j.leukres.2012.10.004. Epub 2012 Oct 23.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14681479   PMID:15033168   PMID:16141072  
PMID:16141073   PMID:16412590   PMID:16606617   PMID:16869965   PMID:17967808   PMID:18799693   PMID:19833123   PMID:19861679   PMID:21047783   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:22542624   PMID:22876197   PMID:22878500   PMID:23870131   PMID:24218140   PMID:24255920   PMID:24860998   PMID:25859222   PMID:26095772   PMID:26385183   PMID:26398943   PMID:27237378  
PMID:27480124   PMID:28116354   PMID:28516957   PMID:28697759   PMID:28701722   PMID:29113963   PMID:29643185   PMID:29743720   PMID:29967380   PMID:30013160   PMID:30226831   PMID:30266822  
PMID:30389914   PMID:30545639   PMID:30651633   PMID:30973865   PMID:32325033   PMID:32381577   PMID:33758188   PMID:34103328   PMID:34170818   PMID:34321999   PMID:34433054   PMID:34699595  
PMID:35133065   PMID:36005555   PMID:36068610   PMID:36526735  


Genomics

Comparative Map Data
Asxl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392153,187,750 - 153,245,927 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2153,187,749 - 153,245,927 (+)EnsemblGRCm39 Ensembl
GRCm382153,345,830 - 153,404,007 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,345,829 - 153,404,007 (+)EnsemblGRCm38mm10GRCm38
MGSCv372153,171,875 - 153,229,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362153,037,493 - 153,095,448 (+)NCBIMGSCv36mm8
MGSCv362154,151,679 - 154,209,986 (+)NCBIMGSCv36mm8
Celera2159,188,615 - 159,246,403 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
ASXL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382032,358,331 - 32,439,319 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2032,358,330 - 32,439,319 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,946,134 - 31,027,122 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,409,814 - 30,490,783 (+)NCBINCBI36Build 36hg18NCBI36
Build 342030,409,820 - 30,490,783NCBI
Celera2027,702,183 - 27,783,146 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,742,560 - 27,816,603 (+)NCBIHuRef
CHM1_12030,850,605 - 30,932,052 (+)NCBICHM1_1
T2T-CHM13v2.02034,083,215 - 34,164,178 (+)NCBIT2T-CHM13v2.0
Asxl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83162,273,828 - 162,341,742 (+)NCBIGRCr8
mRatBN7.23141,814,012 - 141,881,526 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,813,433 - 141,881,538 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.03148,832,231 - 148,902,356 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,837,814 - 148,900,452 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,202,740 - 155,267,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,703,295 - 143,767,523 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3140,560,551 - 140,627,551 (+)NCBICelera
Cytogenetic Map3q41NCBI
Asxl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542228,664,282 - 28,721,896 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542228,662,392 - 28,721,896 (-)NCBIChiLan1.0ChiLan1.0
ASXL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22138,038,565 - 38,130,871 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12038,043,027 - 38,123,069 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02028,647,004 - 28,727,865 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,773,836 - 29,852,433 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,774,582 - 29,850,453 (+)Ensemblpanpan1.1panPan2
ASXL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,725,126 - 21,804,745 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,661,059 - 21,802,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,372,658 - 21,451,415 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02422,413,734 - 22,492,956 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2422,414,540 - 22,493,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,690,505 - 21,768,566 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,797,741 - 21,876,696 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,228,633 - 22,307,459 (+)NCBIUU_Cfam_GSD_1.0
Asxl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,792,007 - 170,865,824 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648519,227,400 - 19,298,912 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648519,218,494 - 19,297,188 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASXL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,985,535 - 36,067,119 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,985,978 - 36,067,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,908,208 - 40,984,182 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ASXL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,735,449 - 36,810,447 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,735,830 - 36,812,387 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,099,728 - 90,176,128 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asxl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741188,745 - 250,142 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741188,985 - 258,065 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Asxl1
1299 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:996
Count of miRNA genes:549
Interacting mature miRNAs:686
Transcripts:ENSMUST00000109790, ENSMUST00000123215, ENSMUST00000138571, ENSMUST00000144722
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse
1301961Bts1_mbladder tumor susceptibility 1 (mouse)Not determined2132024159166024330Mouse
11049567Lmr28f_mleishmaniasis resistance 28f (mouse)2133144911167145058Mouse
11049566Lmr28e_mleishmaniasis resistance 28e (mouse)2133144911167145058Mouse
11341717Rvfs1_mRift Valley fever susceptibility 1 (mouse)2135432544173449616Mouse
4141703Chlq13_mcirculating hormone level QTL 13 (mouse)Not determined2135699221169699361Mouse
1301907Rends_mrenal disease susceptibility (mouse)Not determined2135699221169699361Mouse
10043956Gnf5_mgrowth and fatness 5 (mouse)Not determined2135699221169699361Mouse
10054066Bwq9_mbody weight QTL 9 (mouse)Not determined2135699221169699361Mouse
1300846Pbwg11_mpostnatal body weight growth 11 (mouse)Not determined2138966600172966729Mouse
11353826Bdln10_mbody length 10 (mouse)2140441482174441482Mouse
12801461Intim1_mintima modifier 1 (mouse)2142428347176428450Mouse
12801456Intmrm1_mintima/media ratio modifier 1 (mouse)2142428347176428450Mouse
1301783Bhr1_mbronchial hyperresponsiveness 1 (mouse)Not determined2142593476178442452Mouse
4141033Wg2d_mweight gain in high growth mice 2d (mouse)Not determined143773445160303008Mouse
1357484Bsbob_mBSB obesity (mouse)Not determined2143773445165665019Mouse
1558939Gnf1_mgrowth and fatness 1 (mouse)Not determined2143773445169117924Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
1302013Tbbmd3_mtotal body bone mineral density 3 (mouse)Not determined2145196949179197085Mouse
1300806Aod4_mautoimmune ovarian dysgenesis 4 (mouse)Not determined2145228719179228841Mouse
1301865Hdlq19_mHDL QTL 19 (mouse)Not determined2145518775179518926Mouse
13504830Bacsq1_mbaculum shape QTL 1 (mouse)2145716184161016184Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1357862Epfq1_mepididymal fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1357772Scfq1_msubcutaneous fat pad weight QTL 1 (mouse)Not determined2151640941162737074Mouse
1558842Tailq2_mtail length QTL 2 (mouse)Not determined2151640941162737074Mouse
10412080Hylaq2_mHyperlocomotor activity related QTL 2 (mouse)Not determined2151640941164119146Mouse
12910520Scgq3_mspontaneous crescentic glomerulonephritis QTL 3 (mouse)2151709273174389124Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
13825247Agoc2_magouti coat color QTL 2 (mouse)2151841920159841920Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1558852Gnf2_mgrowth and fatness 2 (mouse)Not determined2152699221162197085Mouse
1558867Gnf3_mgrowth and fatness 3 (mouse)Not determined2152699221169117924Mouse

Markers in Region
D2Mit195  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382153,390,705 - 153,390,842UniSTSGRCm38
MGSCv372153,216,441 - 153,216,578UniSTSGRCm37
Celera2159,233,205 - 159,233,350UniSTS
Cytogenetic Map2H1UniSTS
cM Map286.0UniSTS
Whitehead Genetic272.1UniSTS
UniSTS:234559  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382153,400,151 - 153,400,505UniSTSGRCm38
MGSCv372153,225,887 - 153,226,241UniSTSGRCm37
Celera2159,242,548 - 159,242,902UniSTS
Cytogenetic Map2H1UniSTS
UniSTS:234563  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382153,401,470 - 153,401,698UniSTSGRCm38
MGSCv372153,227,206 - 153,227,434UniSTSGRCm37
Celera2159,243,867 - 159,244,095UniSTS
Cytogenetic Map2H1UniSTS
RH64149  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382153,397,513 - 153,397,608UniSTSGRCm38
MGSCv372153,223,249 - 153,223,344UniSTSGRCm37
Celera2159,239,919 - 159,240,014UniSTS
Cytogenetic Map2H1UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000109790   ⟹   ENSMUSP00000105413
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2153,187,765 - 153,245,927 (+)Ensembl
GRCm38.p6 Ensembl2153,345,845 - 153,404,007 (+)Ensembl
RefSeq Acc Id: ENSMUST00000123215
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2153,189,595 - 153,199,098 (+)Ensembl
GRCm38.p6 Ensembl2153,347,675 - 153,357,178 (+)Ensembl
RefSeq Acc Id: ENSMUST00000138571
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2153,234,780 - 153,238,757 (+)Ensembl
GRCm38.p6 Ensembl2153,392,860 - 153,396,837 (+)Ensembl
RefSeq Acc Id: ENSMUST00000144722
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2153,189,723 - 153,233,514 (+)Ensembl
GRCm38.p6 Ensembl2153,347,803 - 153,391,594 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227428   ⟹   ENSMUSP00000154224
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2153,187,749 - 153,245,927 (+)Ensembl
GRCm38.p6 Ensembl2153,345,829 - 153,404,007 (+)Ensembl
RefSeq Acc Id: NM_001039939   ⟹   NP_001035028
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392153,187,750 - 153,245,927 (+)NCBI
GRCm382153,345,830 - 153,404,007 (+)NCBI
MGSCv372153,171,875 - 153,229,743 (+)RGD
Celera2159,188,615 - 159,246,403 (+)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006499330   ⟹   XP_006499393
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392153,223,029 - 153,245,927 (+)NCBI
GRCm382153,381,107 - 153,403,684 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161492   ⟹   XP_036017385
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392153,188,231 - 153,245,927 (+)NCBI
Sequence:
RefSeq Acc Id: XR_374455
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392153,188,230 - 153,233,536 (+)NCBI
GRCm382153,346,139 - 153,391,616 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001035028   ⟸   NM_001039939
- UniProtKB: P59598 (UniProtKB/Swiss-Prot),   Q24JP2 (UniProtKB/TrEMBL),   A0A2I3BQW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006499393   ⟸   XM_006499330
- Peptide Label: isoform X2
- UniProtKB: A0A2I3BQW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000154224   ⟸   ENSMUST00000227428
RefSeq Acc Id: ENSMUSP00000105413   ⟸   ENSMUST00000109790
RefSeq Acc Id: XP_036017385   ⟸   XM_036161492
- Peptide Label: isoform X1
- UniProtKB: A0A2I3BQW0 (UniProtKB/TrEMBL)
Protein Domains
DEUBAD   HTH HARE-type   Protein ASX-like PHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P59598-F1-model_v2 AlphaFold P59598 1-1514 view protein structure

Promoters
RGD ID:6830841
Promoter ID:MM_KWN:32424
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000109790,   NM_001039939
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362153,171,086 - 153,171,917 (+)MPROMDB
RGD ID:6830840
Promoter ID:MM_KWN:32425
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Kidney,   MEF_B4
Transcripts:OTTMUST00000040688,   OTTMUST00000040689
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362153,172,466 - 153,173,242 (+)MPROMDB
RGD ID:6830842
Promoter ID:MM_KWN:32426
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver
Transcripts:OTTMUST00000040690
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362153,217,661 - 153,218,932 (+)MPROMDB
RGD ID:6879262
Promoter ID:EPDNEW_M3082
Type:initiation region
Name:Asxl1_1
Description:Mus musculus additional sex combs like 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382153,346,132 - 153,346,192EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2684063 AgrOrtholog
Ensembl Genes ENSMUSG00000042548 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000109790 ENTREZGENE
  ENSMUST00000109790.2 UniProtKB/Swiss-Prot
  ENSMUST00000227428.2 UniProtKB/TrEMBL
InterPro ASX-like_PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASX/ASX-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASXH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEUBAD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HB1/Asxl_HTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:228790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2684063 ENTREZGENE
NCBI Gene 228790 ENTREZGENE
PANTHER PTHR13578 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13578:SF19 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ASXH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HARE-HTH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PHD_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Asxl1 PhenoGen
PROSITE DEUBAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HTH_HARE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BQW0 ENTREZGENE, UniProtKB/TrEMBL
  ASXL1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q24JP2 ENTREZGENE, UniProtKB/TrEMBL
  Q3V0J6_MOUSE UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-11-03 Asxl1  ASXL transcriptional regulator 1  Asxl1  additional sex combs like 1  Symbol and/or name change 5135510 APPROVED
2012-07-05 Asxl1  additional sex combs like 1  Asxl1  additional sex combs like 1 (Drosophila)  Symbol and/or name change 5135510 APPROVED