Med26 (mediator complex subunit 26) - Rat Genome Database
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Gene: Med26 (mediator complex subunit 26) Mus musculus
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Symbol: Med26
Name: mediator complex subunit 26
RGD ID: 1557558
MGI Page MGI
Description: Predicted to have transcription coregulator activity. Predicted to be involved in positive regulation of gene expression and regulation of transcription by RNA polymerase II. Localizes to mediator complex. Is expressed in central nervous system; limb; and retina. Orthologous to human MED26 (mediator complex subunit 26); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730493L18Rik; AI414941; AW495270; cofactor required for Sp1 transcriptional activation subunit 7; cofactor required for Sp1 transcriptional activation, subunit 7, 70kDa; Cr; CRSP complex subunit 7; Crsp7; mediator of RNA polymerase II transcription subunit 26
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,248,402 - 73,302,154 (-)NCBIGRCm39mm39
GRCm38872,494,555 - 72,548,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,494,561 - 72,548,270 (-)EnsemblGRCm38mm10GRCm38
MGSCv37875,018,457 - 75,072,209 (-)NCBIGRCm37mm9NCBIm37
MGSCv36875,423,550 - 75,477,259 (-)NCBImm8
Celera876,839,095 - 76,894,758 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11591653   PMID:12477932   PMID:12520002   PMID:12904583   PMID:14610273   PMID:14681479   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:18799693   PMID:19362612   PMID:20059953   PMID:20362541   PMID:20508642   PMID:21267068   PMID:21873635   PMID:25575120   PMID:32325033  


Genomics

Comparative Map Data
Med26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39873,248,402 - 73,302,154 (-)NCBIGRCm39mm39
GRCm38872,494,555 - 72,548,310 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl872,494,561 - 72,548,270 (-)EnsemblGRCm38mm10GRCm38
MGSCv37875,018,457 - 75,072,209 (-)NCBIGRCm37mm9NCBIm37
MGSCv36875,423,550 - 75,477,259 (-)NCBImm8
Celera876,839,095 - 76,894,758 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
MED26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1916,574,907 - 16,629,062 (-)EnsemblGRCh38hg38GRCh38
GRCh381916,574,919 - 16,628,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371916,685,718 - 16,739,015 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361916,546,718 - 16,600,015 (-)NCBINCBI36hg18NCBI36
Build 341916,547,837 - 16,599,754NCBI
Celera1916,587,557 - 16,640,853 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1916,254,284 - 16,307,727 (-)NCBIHuRef
CHM1_11916,685,204 - 16,738,514 (-)NCBICHM1_1
Med26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,001,061 - 19,050,874 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,001,061 - 19,050,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01618,863,765 - 18,913,816 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41617,716,525 - 17,767,690 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11617,716,790 - 17,766,106 (+)NCBI
Celera1617,565,596 - 17,569,307 (+)NCBICelera
Cytogenetic Map16p14NCBI
Med26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555241,166,582 - 1,201,902 (+)NCBIChiLan1.0ChiLan1.0
MED26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,043,523 - 17,060,213 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01916,065,074 - 16,118,385 (-)NCBIMhudiblu_PPA_v0panPan3
MED26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,923,034 - 45,977,118 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Med26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365964,008,155 - 4,061,277 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1260,984,233 - 61,035,661 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2260,571,076 - 60,622,193 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED26
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,082,453 - 15,136,412 (-)NCBI
Med26
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908870,181 - 912,685 (+)NCBI

Position Markers
AW495270  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,495,100 - 72,495,245UniSTSGRCm38
MGSCv37875,018,999 - 75,019,144UniSTSGRCm37
Celera876,839,637 - 76,839,782UniSTS
Cytogenetic Map8B3.3UniSTS
AI414941  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38872,494,883 - 72,494,988UniSTSGRCm38
MGSCv37875,018,782 - 75,018,887UniSTSGRCm37
Celera876,839,420 - 76,839,525UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8772.55UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:238
Interacting mature miRNAs:251
Transcripts:ENSMUST00000058534
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000058534   ⟹   ENSMUSP00000058697
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl872,494,561 - 72,548,270 (-)Ensembl
RefSeq Acc Id: NM_027485   ⟹   NP_081761
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39873,248,402 - 73,302,154 (-)NCBI
GRCm38872,494,558 - 72,548,310 (-)NCBI
MGSCv37875,018,457 - 75,072,209 (-)RGD
Celera876,839,095 - 76,894,758 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_081761   ⟸   NM_027485
- UniProtKB: Q7TN02 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000058697   ⟸   ENSMUST00000058534
Protein Domains
TFIIS N-terminal

Promoters
RGD ID:8667481
Promoter ID:EPDNEW_M11772
Type:initiation region
Name:Med26_1
Description:Mus musculus mediator complex subunit 26 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38872,548,247 - 72,548,307EPDNEW
RGD ID:6843229
Promoter ID:MM_KWN:54875
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:AK054489_1700085D22RIK,   NM_027485,   XM_001478638_GM3847
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36875,072,076 - 75,072,842 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917875 AgrOrtholog
Ensembl Genes ENSMUSG00000045248 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000058697 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000058534 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.930.10 UniProtKB/Swiss-Prot
InterPro MED26 UniProtKB/Swiss-Prot
  Med26_C UniProtKB/Swiss-Prot
  Med26_Mid UniProtKB/Swiss-Prot
  TFIIS/CRSP70_N_sub UniProtKB/Swiss-Prot
  TFIIS/LEDGF_dom_sf UniProtKB/Swiss-Prot
  TFIIS_N UniProtKB/Swiss-Prot
KEGG Report mmu:70625 UniProtKB/Swiss-Prot
MGD MGI:1917875 ENTREZGENE
NCBI Gene 70625 ENTREZGENE
PANTHER PTHR15201 UniProtKB/Swiss-Prot
Pfam Med26 UniProtKB/Swiss-Prot
  Med26_C UniProtKB/Swiss-Prot
  Med26_M UniProtKB/Swiss-Prot
PhenoGen Med26 PhenoGen
PROSITE TFIIS_N UniProtKB/Swiss-Prot
SMART TFS2N UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47676 UniProtKB/Swiss-Prot
UniGene Mm.235885 ENTREZGENE
  Mm.440960 ENTREZGENE
UniProt MED26_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8BUP9 UniProtKB/Swiss-Prot
  Q8R1G7 UniProtKB/Swiss-Prot
  Q9CS67 UniProtKB/Swiss-Prot