Lats1 (large tumor suppressor) - Rat Genome Database
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Gene: Lats1 (large tumor suppressor) Mus musculus
Analyze
Symbol: Lats1
Name: large tumor suppressor
RGD ID: 1557546
MGI Page MGI
Description: Predicted to have several functions, including ATP binding activity; estrogen receptor binding activity; and magnesium ion binding activity. Involved in several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Predicted to localize to spindle pole. Is expressed in acoustic ganglion; early conceptus; embryo; endolymphatic appendage; and otocyst. Orthologous to human LATS1 (large tumor suppressor kinase 1); INTERACTS WITH 1,2-dimethylhydrazine; 3,4-methylenedioxymethamphetamine; arsane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW208599; expressed sequence AW208599; large tumor suppressor homolog 1; large tumor supressor, homolog 1; serine/threonine-protein kinase LATS1; WARTS protein kinase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,556,964 - 7,592,225 (+)NCBIGRCm39mm39
GRCm38107,681,200 - 7,716,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,681,214 - 7,716,460 (+)EnsemblGRCm38mm10GRCm38
MGSCv37107,401,007 - 7,436,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv36107,371,399 - 7,403,706 (+)NCBImm8
Celera107,558,767 - 7,594,190 (+)NCBICelera
Cytogenetic Map10A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)
spindle pole  (IBA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal bile duct epithelium morphology  (IAGP)
abnormal cell physiology  (IAGP)
abnormal centrosome morphology  (IAGP)
abnormal female reproductive system morphology  (IAGP)
abnormal fertility/fecundity  (IAGP)
abnormal mammary gland development  (IAGP)
abnormal mitosis  (IAGP)
abnormal mitotic spindle morphology  (IAGP)
abnormal ovarian follicle morphology  (IAGP)
abnormal tumor morphology  (IAGP)
absent corpus luteum  (IAGP)
absent estrous cycle  (IAGP)
absent nipple  (IAGP)
adenohypophysis hyperplasia  (IAGP)
decreased body weight  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased circulating aspartate transaminase level  (IEA)
decreased circulating growth hormone level  (IAGP)
decreased circulating luteinizing hormone level  (IAGP)
decreased circulating prolactin level  (IAGP)
decreased grip strength  (IEA)
decreased lean body mass  (IEA)
decreased mature ovarian follicle number  (IAGP)
enlarged liver  (IAGP)
female infertility  (IAGP)
hypoactivity  (IEA)
impaired ovarian folliculogenesis  (IAGP)
increased blood urea nitrogen level  (IEA)
increased fibroblast proliferation  (IAGP)
increased grip strength  (IEA)
increased leukocyte cell number  (IEA)
increased liver weight  (IAGP)
increased lymphocyte cell number  (IEA)
increased ovary tumor incidence  (IAGP)
increased sarcoma incidence  (IAGP)
internal hemorrhage  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
postnatal growth retardation  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
reduced fertility  (IAGP)
thrombocytosis  (IEA)
References

Additional References at PubMed
PMID:7743921   PMID:8889548   PMID:9988268   PMID:9988269   PMID:10349636   PMID:10528150   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14610273   PMID:15031102  
PMID:15343267   PMID:16141072   PMID:16141073   PMID:18369314   PMID:18640976   PMID:19289085   PMID:19656388   PMID:19786569   PMID:20407010   PMID:20643348   PMID:21145499   PMID:21233212  
PMID:21267068   PMID:21303848   PMID:21808298   PMID:21873635   PMID:22187428   PMID:22641346   PMID:23071096   PMID:23230145   PMID:23593160   PMID:23620511   PMID:23644383   PMID:23824537  
PMID:24255096   PMID:25218637   PMID:25393475   PMID:25912685   PMID:26040669   PMID:26109051   PMID:26235047   PMID:26503053   PMID:27160901   PMID:27358050   PMID:27405641   PMID:27480037  
PMID:27531557   PMID:27912060   PMID:28087714   PMID:28115535   PMID:28457749   PMID:28486106   PMID:28492365   PMID:28805663   PMID:28943241   PMID:28973878   PMID:29249622   PMID:29438698  
PMID:29632206   PMID:29669762   PMID:29689192   PMID:29849151   PMID:30092342   PMID:30286078   PMID:30305289   PMID:30348677   PMID:30523785   PMID:30582452   PMID:30912742   PMID:31067451  
PMID:31268774   PMID:31323030   PMID:31474569   PMID:31513574   PMID:31558567   PMID:31575647   PMID:31754005   PMID:31801083   PMID:31848340   PMID:31980640   PMID:32015438   PMID:32243503  
PMID:32289155   PMID:32325033   PMID:32341094   PMID:32404936   PMID:32451369   PMID:32482884  


Genomics

Comparative Map Data
Lats1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,556,964 - 7,592,225 (+)NCBIGRCm39mm39
GRCm38107,681,200 - 7,716,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,681,214 - 7,716,460 (+)EnsemblGRCm38mm10GRCm38
MGSCv37107,401,007 - 7,436,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv36107,371,399 - 7,403,706 (+)NCBImm8
Celera107,558,767 - 7,594,190 (+)NCBICelera
Cytogenetic Map10A1NCBI
LATS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6149,658,153 - 149,718,105 (-)EnsemblGRCh38hg38GRCh38
GRCh386149,658,153 - 149,718,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376149,979,289 - 150,039,237 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh376149,979,289 - 150,039,392 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366150,023,744 - 150,081,085 (-)NCBINCBI36hg18NCBI36
Build 346150,023,743 - 150,131,506NCBI
Celera6150,717,306 - 150,774,645 (-)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6147,545,928 - 147,605,163 (-)NCBIHuRef
CHM1_16150,243,964 - 150,304,031 (-)NCBICHM1_1
Lats1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.212,160,411 - 2,193,640 (+)NCBI
Rnor_6.0 Ensembl11,784,078 - 1,817,310 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.011,784,078 - 1,817,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013,480,828 - 3,514,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,375,233 - 2,383,106 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1708,453 - 741,716 (+)NCBICelera
Cytogenetic Map1p13NCBI
Lats1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,559,657 - 11,611,660 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543911,559,655 - 11,611,287 (+)NCBIChiLan1.0ChiLan1.0
LATS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16152,182,394 - 152,239,276 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6152,182,394 - 152,239,276 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06147,476,913 - 147,533,491 (-)NCBIMhudiblu_PPA_v0panPan3
LATS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl140,260,064 - 40,457,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1140,430,096 - 40,475,193 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lats1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364892,607,114 - 2,649,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LATS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,274,970 - 16,320,619 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,274,955 - 16,320,980 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,600,766 - 18,633,991 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LATS1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11321,901,153 - 21,966,227 (+)NCBI
ChlSab1.1 Ensembl1321,919,280 - 21,967,117 (+)Ensembl
Lats1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247858,356,238 - 8,405,877 (+)NCBI

Position Markers
AU021720  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38107,711,314 - 7,711,518UniSTSGRCm38
MGSCv37107,431,112 - 7,431,316UniSTSGRCm37
Celera107,589,044 - 7,589,248UniSTS
Cytogenetic Map10A1UniSTS
Whitehead/MRC_RH10116.45UniSTS
RH127107  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38107,706,330 - 7,706,564UniSTSGRCm38
MGSCv37107,426,128 - 7,426,362UniSTSGRCm37
Celera107,584,073 - 7,584,307UniSTS
Cytogenetic Map10A1UniSTS
Whitehead/MRC_RH10116.45UniSTS
AW208599  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38107,716,187 - 7,716,300UniSTSGRCm38
MGSCv37107,435,985 - 7,436,098UniSTSGRCm37
Celera107,593,916 - 7,594,029UniSTS
Cytogenetic Map10A1UniSTS
Whitehead/MRC_RH10117.69UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126413521Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126413521Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126413521Mouse
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126413521Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126413521Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126413521Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126413521Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126413521Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126413521Mouse
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126413521Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126413521Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131403386Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1047525334475253Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10340743937407588Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10393427237934396Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10453225538532377Mouse
13208561Wght8_mweight 8 (mouse)10500000044000000Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10620194558857699Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1260
Count of miRNA genes:584
Interacting mature miRNAs:719
Transcripts:ENSMUST00000040043, ENSMUST00000165952
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000040043   ⟹   ENSMUSP00000041915
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl107,691,247 - 7,713,586 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165952   ⟹   ENSMUSP00000132078
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl107,681,214 - 7,716,460 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217931   ⟹   ENSMUSP00000151533
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl107,691,247 - 7,713,586 (+)Ensembl
RefSeq Acc Id: NM_010690   ⟹   NP_034820
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,556,973 - 7,592,225 (+)NCBI
GRCm38107,681,209 - 7,716,461 (+)ENTREZGENE
MGSCv37107,401,007 - 7,436,259 (+)RGD
Celera107,558,767 - 7,594,190 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_004936108
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39107,556,964 - 7,581,537 (+)NCBI
Protein Sequences
Protein RefSeqs NP_034820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD16883 (Get FASTA)   NCBI Sequence Viewer  
  AAI58093 (Get FASTA)   NCBI Sequence Viewer  
  AAI58124 (Get FASTA)   NCBI Sequence Viewer  
  BAC30063 (Get FASTA)   NCBI Sequence Viewer  
  Q8BYR2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_034820   ⟸   NM_010690
- UniProtKB: Q8BYR2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000151533   ⟸   ENSMUST00000217931
RefSeq Acc Id: ENSMUSP00000041915   ⟸   ENSMUST00000040043
RefSeq Acc Id: ENSMUSP00000132078   ⟸   ENSMUST00000165952
Protein Domains
AGC-kinase C-terminal   Protein kinase   UBA

Promoters
RGD ID:6819503
Promoter ID:MM_KWN:3485
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_010690,   NR_033219,   UC007EIF.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36107,400,691 - 7,401,732 (+)MPROMDB
RGD ID:6819492
Promoter ID:MM_KWN:3487
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:UC007EIG.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36107,420,541 - 7,422,377 (+)MPROMDB
RGD ID:6818933
Promoter ID:MM_KWN:3488
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Brain,   Lung,   MEF_B6
Transcripts:UC007EIH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36107,434,729 - 7,435,229 (+)MPROMDB
RGD ID:8671452
Promoter ID:EPDNEW_M13757
Type:multiple initiation site
Name:Lats1_1
Description:Mus musculus large tumor suppressor , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38107,681,209 - 7,681,269EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1333883 AgrOrtholog
Ensembl Genes ENSMUSG00000040021 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000116422 UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000041915 UniProtKB/Swiss-Prot
  ENSMUSP00000132078 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000151533 UniProtKB/Swiss-Prot
  ENSMUSP00000155011 UniProtKB/Swiss-Prot
  ENSMUSP00000155296 UniProtKB/Swiss-Prot
  ENSMUSP00000155578 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000040043 UniProtKB/Swiss-Prot
  ENSMUST00000165952 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000217931 UniProtKB/Swiss-Prot
  ENSMUST00000229089 UniProtKB/Swiss-Prot
  ENSMUST00000229932 UniProtKB/Swiss-Prot
  ENSMUST00000230889 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  LATS1 UniProtKB/Swiss-Prot
  LATS1_STKc UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
  UBA-like_sf UniProtKB/Swiss-Prot
KEGG Report mmu:16798 UniProtKB/Swiss-Prot
MGD MGI:1333883 ENTREZGENE
NCBI Gene 16798 ENTREZGENE
PANTHER PTHR24356:SF138 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
PhenoGen Lats1 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  UBA UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46934 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
UniProt LATS1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B2RY46 UniProtKB/Swiss-Prot
  Q9Z0W4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Lats1  large tumor suppressor  AW208599  expressed sequence AW208599  Data Merged 737654 PROVISIONAL