Vwc2 (von Willebrand factor C domain containing 2) - Rat Genome Database

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Gene: Vwc2 (von Willebrand factor C domain containing 2) Mus musculus
Analyze
Symbol: Vwc2
Name: von Willebrand factor C domain containing 2
RGD ID: 1557545
MGI Page MGI
Description: Involved in negative regulation of BMP signaling pathway and positive regulation of neuron differentiation. Acts upstream of or within positive regulation of cell-substrate adhesion. Located in basement membrane; extracellular space; and interstitial matrix. Part of AMPA glutamate receptor complex. Is expressed in several structures, including alimentary system; cardiovascular system; hemolymphoid system gland; liver; and nervous system. Orthologous to human VWC2 (von Willebrand factor C domain containing 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A930041G11Rik; B; brain-specific chordin-like protein; brorin; cr; CR (chordin-like cysteine-rich) domain-containing adhesive protein; cradin; G11; PSST739; RP23-305B2.1; UNQ739; von Willebrand factor C domain-containing protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,063,836 - 11,219,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1111,064,223 - 11,218,931 (+)EnsemblGRCm39 Ensembl
GRCm381111,113,868 - 11,269,295 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,114,223 - 11,268,931 (+)EnsemblGRCm38mm10GRCm38
MGSCv371111,014,019 - 11,163,529 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,014,747 - 11,167,726 (+)NCBIMGSCv36mm8
Celera1111,572,129 - 11,719,075 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map116.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:17400546   PMID:18757743   PMID:19852960   PMID:20562862   PMID:21677750  
PMID:21873635   PMID:22632720   PMID:24496616   PMID:30074079   PMID:37414952   PMID:37591201  


Genomics

Comparative Map Data
Vwc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,063,836 - 11,219,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1111,064,223 - 11,218,931 (+)EnsemblGRCm39 Ensembl
GRCm381111,113,868 - 11,269,295 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,114,223 - 11,268,931 (+)EnsemblGRCm38mm10GRCm38
MGSCv371111,014,019 - 11,163,529 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,014,747 - 11,167,726 (+)NCBIMGSCv36mm8
Celera1111,572,129 - 11,719,075 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map116.27NCBI
VWC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38749,773,638 - 49,922,205 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl749,773,638 - 49,921,950 (+)EnsemblGRCh38hg38GRCh38
GRCh37749,813,234 - 49,961,546 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36749,783,803 - 49,922,684 (+)NCBINCBI36Build 36hg18NCBI36
Celera749,907,441 - 50,046,308 (+)NCBICelera
Cytogenetic Map7p12.2NCBI
HuRef749,694,094 - 49,833,168 (+)NCBIHuRef
CHM1_1749,815,530 - 49,954,428 (+)NCBICHM1_1
T2T-CHM13v2.0749,934,695 - 50,083,976 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2749,850,406 - 49,989,256 (+)NCBI
Vwc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81489,897,543 - 90,038,732 (+)NCBIGRCr8
mRatBN7.21485,683,670 - 85,825,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1485,684,414 - 85,818,524 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,094,126 - 90,234,756 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01491,338,869 - 91,479,511 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01487,806,017 - 87,946,689 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01491,201,141 - 91,348,219 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1491,201,730 - 91,348,219 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01490,987,662 - 91,137,489 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1484,692,637 - 84,825,429 (+)NCBICelera
Cytogenetic Map14q21NCBI
Vwc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554563,951,428 - 4,075,624 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554563,949,885 - 4,075,622 (-)NCBIChiLan1.0ChiLan1.0
VWC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2654,649,664 - 54,800,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17102,974,392 - 103,124,851 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0750,412,363 - 50,562,837 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1750,661,384 - 50,810,596 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl750,661,384 - 50,800,814 (+)Ensemblpanpan1.1panPan2
VWC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1181,248,612 - 1,350,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl181,257,357 - 1,350,856 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,248,381 - 1,346,106 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,314,358 - 1,412,133 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,312,740 - 1,408,185 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1181,289,016 - 1,386,728 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0181,285,780 - 1,383,481 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0181,421,893 - 1,519,636 (+)NCBIUU_Cfam_GSD_1.0
Vwc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118104,506,578 - 104,681,083 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366861,861,537 - 2,015,255 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366861,844,435 - 2,016,953 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VWC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9135,982,227 - 136,083,616 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19135,982,814 - 136,083,069 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29149,507,786 - 149,609,257 (+)NCBISscrofa10.2Sscrofa10.2susScr3
VWC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,876,382 - 9,027,007 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,885,377 - 9,025,229 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606213,227,901 - 13,385,430 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vwc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247404,109,100 - 4,234,009 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247404,100,196 - 4,234,098 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Vwc2
5703 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1320
Count of miRNA genes:651
Interacting mature miRNAs:801
Transcripts:ENSMUST00000056344, ENSMUST00000109681, ENSMUST00000129670, ENSMUST00000154155
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
10053676Eae44a_mexperimental allergic encephalomyelitis susceptibility 44a (mouse)Not determined11450789621379532Mouse
27226741Metcl5_mmetatarsal-calcaneal length 5, 5 week (mouse)11465000046290827Mouse
27226735Metcl16_mmetatarsal-calcaneal length 16, 16 week (mouse)11525000035090827Mouse
1357518Tgyl1_mtriglyceride level 1 (mouse)Not determined11688027733916219Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226794Feml9_mfemur length 9, 5 week (mouse)11705000016750000Mouse
1300990Bits3_mbitterness sensitivity 3 (mouse)Not determined11837212142372260Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1302171Pgia28_mproteoglycan induced arthritis 28 (mouse)Not determined11890609742906218Mouse
4141047Nilac1_mnicotine induced locomotor activity 1 (mouse)Not determined11901178043011942Mouse
13524844Ppiq9_mprepulse inhibition QTL 9 (mouse)11904999735077325Mouse
13463472Mcvq15_mmean corpuscular volume QTL 15 (mouse)111095123244951464Mouse
13463479Mchq19_mmean corpuscular hemoglobin QTL 19 (mouse)111095123244951464Mouse

Markers in Region
02.MMHAP90FLA2.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381111,171,112 - 11,171,266UniSTSGRCm38
MGSCv371111,071,115 - 11,071,269UniSTSGRCm37
Celera1111,626,783 - 11,626,937UniSTS
Cytogenetic Map11A1UniSTS
Whitehead_YAC11 UniSTS
07.MMHAP66FLC1.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381111,219,035 - 11,219,197UniSTSGRCm38
MGSCv371111,119,038 - 11,119,200UniSTSGRCm37
Celera1111,674,674 - 11,674,836UniSTS
Cytogenetic Map11A1UniSTS
Whitehead_YAC11 UniSTS
Vwc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11A1UniSTS
cM Map11 UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_177033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036156760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001780018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_380970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_380971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB292670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK033944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141514 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC120564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC137825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ421811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000056344   ⟹   ENSMUSP00000049692
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,065,851 - 11,216,638 (+)Ensembl
GRCm38.p6 Ensembl1111,115,851 - 11,266,638 (+)Ensembl
RefSeq Acc Id: ENSMUST00000109681   ⟹   ENSMUSP00000105303
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,064,223 - 11,213,526 (+)Ensembl
GRCm38.p6 Ensembl1111,114,223 - 11,263,526 (+)Ensembl
RefSeq Acc Id: ENSMUST00000129670   ⟹   ENSMUSP00000128761
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,064,744 - 11,218,931 (+)Ensembl
GRCm38.p6 Ensembl1111,114,744 - 11,268,931 (+)Ensembl
RefSeq Acc Id: ENSMUST00000154155
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1111,066,485 - 11,081,183 (+)Ensembl
GRCm38.p6 Ensembl1111,116,485 - 11,131,183 (+)Ensembl
RefSeq Acc Id: NM_177033   ⟹   NP_796007
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,064,016 - 11,213,526 (+)NCBI
GRCm381111,114,016 - 11,263,526 (+)NCBI
MGSCv371111,014,019 - 11,163,529 (+)RGD
Celera1111,572,129 - 11,719,075 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036156760   ⟹   XP_036012653
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,063,875 - 11,214,654 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001780018
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,063,836 - 11,216,510 (+)NCBI
GRCm381111,113,873 - 11,266,510 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004936977
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,063,875 - 11,219,295 (+)NCBI
Sequence:
RefSeq Acc Id: XR_380970
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,063,836 - 11,219,295 (+)NCBI
GRCm381111,113,873 - 11,269,295 (+)NCBI
Sequence:
RefSeq Acc Id: XR_380971
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391111,063,836 - 11,219,295 (+)NCBI
GRCm381111,113,873 - 11,269,295 (+)NCBI
Sequence:
RefSeq Acc Id: NP_796007   ⟸   NM_177033
- Peptide Label: precursor
- UniProtKB: B2RQ98 (UniProtKB/Swiss-Prot),   Q5SSH5 (UniProtKB/Swiss-Prot),   Q8C8N3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000128761   ⟸   ENSMUST00000129670
RefSeq Acc Id: ENSMUSP00000049692   ⟸   ENSMUST00000056344
RefSeq Acc Id: ENSMUSP00000105303   ⟸   ENSMUST00000109681
RefSeq Acc Id: XP_036012653   ⟸   XM_036156760
- Peptide Label: isoform X1
- UniProtKB: Q8C8N3 (UniProtKB/Swiss-Prot),   B2RQ98 (UniProtKB/Swiss-Prot),   Q5SSH5 (UniProtKB/Swiss-Prot)
Protein Domains
VWFC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C8N3-F1-model_v2 AlphaFold Q8C8N3 1-324 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442987 AgrOrtholog
Ensembl Genes ENSMUSG00000050830 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056344.5 UniProtKB/Swiss-Prot
  ENSMUST00000109681 ENTREZGENE
  ENSMUST00000109681.8 UniProtKB/Swiss-Prot
  ENSMUST00000129670 ENTREZGENE
  ENSMUST00000129670.8 UniProtKB/Swiss-Prot
Gene3D-CATH 6.20.200.20 UniProtKB/Swiss-Prot
InterPro VWC2/VWC2L UniProtKB/Swiss-Prot
  VWF_dom UniProtKB/Swiss-Prot
KEGG Report mmu:319922 UniProtKB/Swiss-Prot
MGD MGI:2442987 ENTREZGENE
NCBI Gene 319922 ENTREZGENE
PANTHER BRORIN UniProtKB/Swiss-Prot
  PTHR46252 UniProtKB/Swiss-Prot
Pfam VWC UniProtKB/Swiss-Prot
PhenoGen Vwc2 PhenoGen
PROSITE VWFC_1 UniProtKB/Swiss-Prot
  VWFC_2 UniProtKB/Swiss-Prot
SMART VWC UniProtKB/Swiss-Prot
Superfamily-SCOP FnI-like domain UniProtKB/Swiss-Prot
UniProt B2RQ98 ENTREZGENE
  Q5SSH5 ENTREZGENE
  Q8C8N3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RQ98 UniProtKB/Swiss-Prot
  Q5SSH5 UniProtKB/Swiss-Prot