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Gene: Dis3l2 (DIS3 like 3'-5' exoribonuclease 2) Mus musculus
Symbol: Dis3l2
Name: DIS3 like 3'-5' exoribonuclease 2
Description: Exhibits 3'-5'-exoribonuclease activity; magnesium ion binding activity; and poly(U) RNA binding activity. Involved in miRNA catabolic process and stem cell population maintenance. Localizes to the cytoplasm. Used to study Perlman syndrome. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Is expressed in several structures, including alimentary system; central nervous system; ganglia; nose; and vibrissa. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930429A22Rik; 8030493P09Rik; DIS3 mitotic control homolog (S. cerevisiae)-like 2; DIS3 mitotic control homolog-like 2; DIS3-like exonuclease 2; MGC37640
Homo sapiens (human) : DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dis3l2 (DIS3-like 3'-5' exoribonuclease 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dis3l2 (DIS3 like 3'-5' exoribonuclease 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
Canis lupus familiaris (dog) : DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dis3l2 (DIS3 like 3'-5' exoribonuclease 2)
Sus scrofa (pig) : DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl186,703,808 - 87,050,095 (+)Ensembl
GRCm38186,701,924 - 87,050,097 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37188,600,379 - 88,946,672 (+)NCBIGRCm37mm9NCBIm37
MGSCv36188,535,014 - 88,881,263 (+)NCBImm8
Celera189,673,472 - 90,022,293 (+)NCBICelera
Cytogenetic Map1 C5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Dis3l2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557512
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.