Atoh8 (atonal bHLH transcription factor 8) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Atoh8 (atonal bHLH transcription factor 8) Mus musculus
Analyze
Symbol: Atoh8
Name: atonal bHLH transcription factor 8
RGD ID: 1557505
MGI Page MGI
Description: Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and lung. Orthologous to human ATOH8 (atonal bHLH transcription factor 8); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 4933425C05Rik; atonal homolog 8; basic helix-loop-helix transcription factor 6; bHLHa; bHLHa21; Hath6; helix-loop-helix protein mATH-6; Math; Math6; ok; okadin; protein atonal homolog 8
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,183,158 - 72,212,765 (-)NCBIGRCm39mm39
GRCm39 Ensembl672,183,161 - 72,212,561 (-)Ensembl
GRCm38672,206,174 - 72,235,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,206,177 - 72,235,577 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,156,171 - 72,185,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36672,135,686 - 72,165,086 (-)NCBImm8
Celera674,294,593 - 74,323,803 (-)NCBICelera
Cytogenetic Map6C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
nucleoplasm  (ISO)
nucleus  (IBA,IDA,ISO)

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11733035   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16937370   PMID:18287559   PMID:18539898   PMID:18557763  
PMID:18560595   PMID:19521566   PMID:20059953   PMID:20065295   PMID:21267068   PMID:21676531   PMID:21779533   PMID:21873635   PMID:22696295   PMID:23449628   PMID:23836893   PMID:23938248  
PMID:24186058   PMID:24463812   PMID:25578518   PMID:26752640   PMID:28405918   PMID:30301918   PMID:31066042   PMID:31159500   PMID:31449527   PMID:31719172  


Genomics

Comparative Map Data
Atoh8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39672,183,158 - 72,212,765 (-)NCBIGRCm39mm39
GRCm39 Ensembl672,183,161 - 72,212,561 (-)Ensembl
GRCm38672,206,174 - 72,235,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl672,206,177 - 72,235,577 (-)EnsemblGRCm38mm10GRCm38
MGSCv37672,156,171 - 72,185,571 (-)NCBIGRCm37mm9NCBIm37
MGSCv36672,135,686 - 72,165,086 (-)NCBImm8
Celera674,294,593 - 74,323,803 (-)NCBICelera
Cytogenetic Map6C1NCBI
ATOH8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl285,751,344 - 85,791,383 (+)EnsemblGRCh38hg38GRCh38
GRCh38285,753,786 - 85,791,383 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37285,981,114 - 86,018,506 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36285,834,531 - 85,868,700 (+)NCBINCBI36hg18NCBI36
Build 34285,892,679 - 85,926,843NCBI
Celera285,808,992 - 85,846,589 (+)NCBI
Cytogenetic Map2p11.2NCBI
HuRef285,877,969 - 85,915,872 (+)NCBIHuRef
CHM1_1285,910,490 - 85,948,082 (+)NCBICHM1_1
Atoh8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24104,259,992 - 104,292,168 (-)NCBI
Rnor_6.0 Ensembl4100,067,341 - 100,099,517 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04100,067,341 - 100,099,517 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04164,837,904 - 164,870,076 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44105,499,942 - 105,532,118 (-)NCBIRGSC3.4rn4RGSC3.4
Celera493,414,104 - 93,446,186 (-)NCBICelera
Cytogenetic Map4q31NCBI
Atoh8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554241,776,127 - 1,802,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554241,775,139 - 1,803,106 (-)NCBIChiLan1.0ChiLan1.0
ATOH8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A87,352,506 - 87,386,824 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A87,352,904 - 87,362,938 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A85,803,414 - 85,837,858 (+)NCBIMhudiblu_PPA_v0panPan3
ATOH8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11739,255,725 - 39,280,022 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Atoh8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367121,529,508 - 1,552,148 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATOH8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl358,964,541 - 59,001,146 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1358,964,541 - 59,001,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2362,023,957 - 62,037,650 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATOH8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11421,368,197 - 21,402,650 (-)NCBI
Atoh8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474917,397,332 - 17,428,980 (-)NCBI

Position Markers
PMC196074P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38672,235,019 - 72,235,250UniSTSGRCm38
MGSCv37672,185,013 - 72,185,244UniSTSGRCm37
Celera674,323,245 - 74,323,476UniSTS
Cytogenetic Map6C1UniSTS
Atoh8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6C1UniSTS
cM Map632.27UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64382681377811523Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64382681377811523Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64382681377811523Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64382681377811523Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64382681377811523Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64382681377811523Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4872655675447710Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
4141990Etax6_methanol induced ataxia 6 (mouse)Not determined7132262186275719Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:534
Count of miRNA genes:360
Interacting mature miRNAs:410
Transcripts:ENSMUST00000042646
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042646   ⟹   ENSMUSP00000036981
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,206,177 - 72,235,577 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206425   ⟹   ENSMUSP00000145790
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,206,177 - 72,234,537 (-)Ensembl
RefSeq Acc Id: ENSMUST00000206553
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl672,223,742 - 72,235,230 (-)Ensembl
RefSeq Acc Id: NM_153778   ⟹   NP_722473
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,183,161 - 72,212,561 (-)NCBI
GRCm38672,206,177 - 72,235,577 (-)NCBI
MGSCv37672,156,171 - 72,185,571 (-)RGD
Celera674,294,593 - 74,323,803 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_377494
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39672,183,158 - 72,212,765 (-)NCBI
GRCm38672,206,174 - 72,235,780 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_722473   ⟸   NM_153778
- UniProtKB: Q99NA2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000145790   ⟸   ENSMUST00000206425
RefSeq Acc Id: ENSMUSP00000036981   ⟸   ENSMUST00000042646
Protein Domains
bHLH

Promoters
RGD ID:6838961
Promoter ID:MM_KWN:46446
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   Brain,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:ENSMUST00000042646
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36672,184,461 - 72,185,447 (-)MPROMDB
RGD ID:6890000
Promoter ID:EPDNEW_M8451
Type:initiation region
Name:Atoh8_2
Description:Mus musculus atonal bHLH transcription factor 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8452  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38672,235,252 - 72,235,312EPDNEW
RGD ID:6890002
Promoter ID:EPDNEW_M8452
Type:initiation region
Name:Atoh8_1
Description:Mus musculus atonal bHLH transcription factor 8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8451  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38672,235,578 - 72,235,638EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918343 AgrOrtholog
Ensembl Genes ENSMUSG00000037621 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000036981 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145790 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000042646 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000206425 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATOH8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bHLH_dom UniProtKB/Swiss-Prot
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:71093 UniProtKB/Swiss-Prot
MGD MGI:1918343 ENTREZGENE
NCBI Gene 71093 ENTREZGENE
PANTHER PTHR19290:SF102 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot
PhenoGen Atoh8 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot
SMART HLH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0U1RP16_MOUSE UniProtKB/TrEMBL
  ATOH8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8C1I7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Atoh8  atonal bHLH transcription factor 8    atonal homolog 8 (Drosophila)  Symbol and/or name change 5135510 APPROVED