Atoh8 (atonal bHLH transcription factor 8)

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Gene: Atoh8 (atonal bHLH transcription factor 8) Mus musculus

Analyze

Symbol:

Atoh8

Name:

atonal bHLH transcription factor 8

RGD ID:

1557505

MGI Page

MGI

Description:

Is expressed in several structures, including central nervous system; genitourinary system; heart; limb; and lung. Orthologous to human ATOH8 (atonal bHLH transcription factor 8); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

4933425C05Rik; atonal homolog 8; basic helix-loop-helix transcription factor 6; bHLHa; bHLHa21; Hath6; helix-loop-helix protein mATH-6; Math; Math6; ok; okadin; protein atonal homolog 8

RGD Orthologs

Human

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ATOH8 (atonal bHLH transcription factor 8)	HGNC	Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Atoh8 (atonal bHLH transcription factor 8)	HGNC	Treefam, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Atoh8 (atonal bHLH transcription factor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ATOH8 (atonal bHLH transcription factor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ATOH8 (atonal bHLH transcription factor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Atoh8 (atonal bHLH transcription factor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ATOH8 (atonal bHLH transcription factor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	ATOH8 (atonal bHLH transcription factor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Atoh8 (atonal bHLH transcription factor 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	ATOH8 (atonal bHLH transcription factor 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam)
Rattus norvegicus (Norway rat):	Atoh8 (atonal bHLH transcription factor 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	atoh8 (atonal bHLH transcription factor 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|Roundup\|TreeFam\|ZFIN)
Drosophila melanogaster (fruit fly):	net	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|Roundup\|TreeFam)

Latest Assembly:

GRCm38 - Mouse Genome Assembly GRCm38

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	72,183,158 - 72,212,765 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	72,183,161 - 72,212,561 (-)	Ensembl
GRCm38	6	72,206,174 - 72,235,780 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	72,206,177 - 72,235,577 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	72,156,171 - 72,185,571 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	72,135,686 - 72,165,086 (-)	NCBI			mm8
Celera	6	74,294,593 - 74,323,803 (-)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

(R)-pantothenic acid (ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

4-hydroxyphenyl retinamide (EXP)

5-bromo-2'-deoxyuridine (EXP)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[b]fluoranthene (EXP)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (EXP,ISO)

cyclosporin A (ISO)

daidzein (ISO)

daidzein 7-O-beta-D-glucoside (ISO)

dibutyl phthalate (ISO)

doxorubicin (ISO)

endosulfan (ISO)

fluoranthene (EXP)

flutamide (ISO)

formaldehyde (ISO)

genistein (ISO)

genistein 7-O-beta-D-glucoside (ISO)

glycitein (ISO)

glycitin (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

leflunomide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methapyrilene (ISO)

nefazodone (ISO)

oxaliplatin (ISO)

paracetamol (EXP,ISO)

phenobarbital (EXP)

picene (ISO)

pirinixic acid (EXP)

potassium chromate (ISO)

silicon dioxide (ISO)

Soman (ISO)

sulforaphane (ISO)

tebuconazole (ISO)

tetrachloromethane (ISO)

topotecan (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

troglitazone (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

formation of primary germ layer (IMP)

multicellular organism development (IEA)

myoblast proliferation (IDA)

negative regulation of endothelial cell proliferation (ISO)

negative regulation of gene expression (ISO)

negative regulation of transcription, DNA-templated (IDA)

nervous system development (IEA)

neuron differentiation (IBA)

positive regulation of endothelial cell differentiation (ISO)

positive regulation of endothelial cell migration (ISO)

positive regulation of pri-miRNA transcription by RNA polymerase II (ISO)

positive regulation of transcription, DNA-templated (ISO)

regulation of transcription by RNA polymerase II (IBA)

regulation of transcription, DNA-templated (IEA)

SMAD protein signal transduction (ISO)

tube formation (ISO)

Cellular Component

cytoplasm (IDA)

nucleoplasm (ISO)

nucleus (IBA,IDA,ISO)

Molecular Function

activating transcription factor binding (IPI)

DNA binding (IEA)

DNA-binding transcription factor activity (IDA,ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

E-box binding (ISO)

protein binding (ISO)

protein dimerization activity (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

transcription factor binding (IPI)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

embryonic lethality between implantation and somite formation, complete penetrance (IAGP)

lethality during fetal growth through weaning, incomplete penetrance (IAGP)

References

References - curated


1.	Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3.	MGD data from the GO Consortium
4.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5.	RGD automated import pipeline
6.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:10349636	PMID:11042159	PMID:11076861	PMID:11733035	PMID:12477932	PMID:16141072	PMID:16141073	PMID:16937370	PMID:18287559	PMID:18539898	PMID:18557763
PMID:18560595	PMID:19521566	PMID:20059953	PMID:20065295	PMID:21267068	PMID:21676531	PMID:21779533	PMID:21873635	PMID:22696295	PMID:23449628	PMID:23836893	PMID:23938248
PMID:24186058	PMID:24463812	PMID:25578518	PMID:26752640	PMID:28405918	PMID:30301918	PMID:31066042	PMID:31159500	PMID:31449527	PMID:31719172

Genomics

Comparative Map Data

Atoh8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	72,183,158 - 72,212,765 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	6	72,183,161 - 72,212,561 (-)	Ensembl
GRCm38	6	72,206,174 - 72,235,780 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	72,206,177 - 72,235,577 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	72,156,171 - 72,185,571 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	6	72,135,686 - 72,165,086 (-)	NCBI			mm8
Celera	6	74,294,593 - 74,323,803 (-)	NCBI		Celera
Cytogenetic Map	6	C1	NCBI

ATOH8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	85,751,344 - 85,791,383 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	85,753,786 - 85,791,383 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	85,981,114 - 86,018,506 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	85,834,531 - 85,868,700 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	85,892,679 - 85,926,843	NCBI
Celera	2	85,808,992 - 85,846,589 (+)	NCBI
Cytogenetic Map	2	p11.2	NCBI
HuRef	2	85,877,969 - 85,915,872 (+)	NCBI		HuRef
CHM1_1	2	85,910,490 - 85,948,082 (+)	NCBI		CHM1_1

Atoh8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	104,259,992 - 104,292,168 (-)	NCBI
Rnor_6.0 Ensembl	4	100,067,341 - 100,099,517 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	4	100,067,341 - 100,099,517 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	4	164,837,904 - 164,870,076 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	105,499,942 - 105,532,118 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	4	93,414,104 - 93,446,186 (-)	NCBI		Celera
Cytogenetic Map	4	q31	NCBI

Atoh8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	1,776,127 - 1,802,763 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	1,775,139 - 1,803,106 (-)	NCBI	ChiLan1.0	ChiLan1.0

ATOH8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	87,352,506 - 87,386,824 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	87,352,904 - 87,362,938 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	85,803,414 - 85,837,858 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

ATOH8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	39,255,725 - 39,280,022 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Atoh8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936712	1,529,508 - 1,552,148 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATOH8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	58,964,541 - 59,001,146 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	58,964,541 - 59,001,620 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	62,023,957 - 62,037,650 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATOH8
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	21,368,197 - 21,402,650 (-)	NCBI

Atoh8
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624749	17,397,332 - 17,428,980 (-)	NCBI

Position Markers

PMC196074P2

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	6	72,235,019 - 72,235,250	UniSTS	GRCm38
MGSCv37	6	72,185,013 - 72,185,244	UniSTS	GRCm37
Celera	6	74,323,245 - 74,323,476	UniSTS
Cytogenetic Map	6	C1	UniSTS

Atoh8

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	6	C1	UniSTS
cM Map	6	32.27	UniSTS

QTLs in Region (GRCm38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
25440480	Moaq2_m	modifier of alien QTL 2 (mouse)					6	1	117500000	Mouse
26884414	Bzwq12_m	bi-zygomatic width QTL 12, 16 week (mouse)					6	3400000	139100000	Mouse
1300556	Cia6_m	collagen induced arthritis QTL 6 (mouse)			Not determined		6	4464884	87426034	Mouse
4142126	W3q3_m	weight 3 weeks QTL 3 (mouse)			Not determined			4503823	96656149	Mouse
4142361	W10q11_m	weight 10 weeks QTL 11 (mouse)			Not determined			4503823	96656149	Mouse
4142271	Egq8_m	early growth QTL 8 (mouse)			Not determined			4503823	96656149	Mouse
4142232	W6q4_m	weight 6 weeks QTL 4 (mouse)			Not determined			4503823	96656149	Mouse
26884441	Sklq3_m	skull length QTL 3, 5 week (mouse)					6	7600000	80600000	Mouse
1357442	Dbts1_m	diabetes 1 (mouse)			Not determined		6	18234148	73387692	Mouse
13208564	Bmiq7_m	body mass index QTL 7 (mouse)					6	25000000	80000000	Mouse
4141782	Mrdq5_m	modifier of retinal degeneration QTL 5 (mouse)			Not determined			32850650	78238974	Mouse
1558984	Cplaq9_m	circadian period of locomotor activity 9 (mouse)			Not determined		6	38669625	92607450	Mouse
12880424	V25Dq4_m	vitamin D inactive form serum level QTL 4 (mouse)					6	41600000	75600000	Mouse
1301266	Lmr4_m	leishmaniasis resistance 4 (mouse)			Not determined		6	42116373	76116515	Mouse
11040600	Lmr4c_m	leishmaniasis resistance 4c (mouse)					6	42116373	76116515	Mouse
11040601	Lmr4a_m	leishmaniasis resistance 4a (mouse)					6	42116373	76116515	Mouse
11533915	Mts4_m	mammary tumor susceptibility 4 (mouse)					6	42116373	76116515	Mouse
12910785	Pwgrq16_m	post-weaning growth rate QTL 16 (mouse)					6	43826813	77811523	Mouse
12910798	Pwgrq5_m	pre-weaning growth rate QTL 5 (mouse)					6	43826813	77811523	Mouse
12910802	Pwbwq12_m	post-weaning body weight QTL 12 (mouse)					6	43826813	77811523	Mouse
12910807	Pwbwq11_m	post-weaning body weight QTL 11 (mouse)					6	43826813	77811523	Mouse
12910809	Pwbwq10_m	post-weaning body weight QTL 10 (mouse)					6	43826813	77811523	Mouse
12910820	Ogrq3_m	overall growth rate QTL 3 (mouse)					6	43826813	77811523	Mouse
1300618	Pgia19_m	proteoglycan induced arthritis 19 (mouse)			Not determined		6	45314059	87426034	Mouse
10412157	Fl1n_m	fatty liver 1 in NSY (mouse)			Not determined		6	45314059	128835032	Mouse
4142259	Tabw2_m	tally ho associated body weight 2 (mouse)			Not determined			46935985	136423692	Mouse
25314319	Histh6_m	histamine hypersensitivity 6 (mouse)					6	48720000	125360000	Mouse
25314320	Histh5_m	histamine hypersensitivity 5 (mouse)					6	48720000	148450000	Mouse
4140983	Srilp_m	sleep response to influenza, light phase (mouse)			Not determined			48726556	75447710	Mouse
1301962	Eila2_m	ethanol induced locomotor activity 2 (mouse)			Not determined		6	48726556	125356785	Mouse
1301254	Skts11_m	skin tumor susceptibility 11 (mouse)			Not determined		6	51179150	85179300	Mouse
1357683	Igf1sl1_m	IGF-1 serum levels 1 (mouse)			Not determined		6	52161713	116155267	Mouse
4141028	Mclr_m	methylcholanthrene lymphoma resistance (mouse)			Not determined			54373427	88379171	Mouse
15039373	Adip28_m	adiposity 28 (mouse)					6	56308211	90308211	Mouse
15039375	Bw41_m	body weight QTL 41 (mouse)					6	56308211	90308211	Mouse
1558977	Skmw10_m	skeletal muscle weight 10 (mouse)			Not determined		6	58447583	92447710	Mouse
10043972	Obq28_m	obesity QTL 28 (mouse)			Not determined		6	58540433	92540433	Mouse
1301740	Bwq2_m	body weight QTL 2 (mouse)			Not determined		6	60057680	94057799	Mouse
1301369	Im4_m	immunoregulatory 4 (mouse)			Not determined		6	63484738	97484905	Mouse
1300650	Bw18_m	body weight QTL 18 (mouse)			Not determined		6	66713869	100714031	Mouse
1301876	Bits2_m	bitterness sensitivity 2 (mouse)			Not determined		6	70425898	104426034	Mouse
1301813	Skl3_m	skeletal size (tail length) 3 (mouse)			Not determined		6	70425898	104426034	Mouse
1301034	Egrm2_m	early growth rate (mouse)			Not determined		6	70425898	104426034	Mouse
4141990	Etax6_m	ethanol induced ataxia 6 (mouse)			Not determined			71322621	86275719	Mouse
1302020	Bbaa20_m	B.burgdorferi-associated arthritis 20 (mouse)			Not determined		6	71322621	93464093	Mouse
1300869	Stheal5_m	soft tissue heal 5 (mouse)			Not determined		6	71575060	105575178	Mouse
1300954	Fcsa1_m	femoral cross-sectional area 1 (mouse)			Not determined		6	71981024	105981170	Mouse
1301521	Pas1c_m	pulmonary adenoma susceptibility 1c (mouse)			Not determined		6	71981024	105981170	Mouse

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	534
Count of miRNA genes:	360
Interacting mature miRNAs:	410
Transcripts:	ENSMUST00000042646
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_153778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_377494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB046527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB046528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB046529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB046530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB049066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC122864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK016909	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY349615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC023684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466523	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSMUST00000042646 ⟹ ENSMUSP00000036981

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	72,206,177 - 72,235,577 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000206425 ⟹ ENSMUSP00000145790

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	72,206,177 - 72,234,537 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000206553

RefSeq Status:

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38.p6 Ensembl	6	72,223,742 - 72,235,230 (-)	Ensembl

RefSeq Acc Id:

NM_153778 ⟹ NP_722473

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	72,183,161 - 72,212,561 (-)	NCBI
GRCm38	6	72,206,177 - 72,235,577 (-)	NCBI
MGSCv37	6	72,156,171 - 72,185,571 (-)	RGD
Celera	6	74,294,593 - 74,323,803 (-)	RGD
cM Map	6		ENTREZGENE

Sequence:

show sequence

GGCTCGGGAGGCGGCAGCGGCGGCGGCGGGAGCTGCCTCCTCTCCGGGCGGGCGGCGCTGAGTG
ATCTTGCGAACTGGGCTTCTGTGTAAACTGAGGCTAAACAAACACAGATGGAGCGCAGCGGGCG
TTCTGCAGAAATGCTGGCAGGGCGGCAGCGACTTCAGATGACACTCTGAGCTCTCCCGGGGAAC
CGGCAGCCTCCAAGGCTTCACGGAGCCGGAGGCGCAGCTGCCCCGGGAGTGGGGGTGCGAGGGA
GGGACCCGGGGAGGGAGGGTAGGAGGAGAGAGCGCGGCGACAAGGCGGCGCTCAGCGCGGCGGC
CACCCGGCACAGCCAGGCGCGCGGCGTGCAGAGTGATCGCTGCGGGCGCGCGTCCCGGGCAGTC
CCACGCCCCAGCCTCACGCCGTCCTCGCCATGAAGCACATCCCGGTCCTCGAGGACGGGCCGTG
GAAGACTGTGTGCGTTAAAGAACTGAACGGCCTCAAGAAGCTCAAGCGGAAAGGCAAGGAGCCG
GTGCGGCGCGCGAATGGCTATAAAACTTTCCGATTGGACTTGGAAGCTCCCGAGCTCGGCGCCA
CAGTCAGCACCACCGCCGCCACCAACGGGCTTCGGGACAGGACACAACCGTTCCCGATCGCGAC
CCCAGTACCAGCCTCAGTGGCGCCGGCGGTTCCTCCAGGTGGAGGCACAGACACAGCCAGGGAA
TTCCGGGGCATCAGAGCGCCTGAGGTCTCTGACGCGCGCAAACGCGGTTTCGCTCTGGGCACAG
TGGGACCGGGACTACCCACGCCACCGCCGCCTCCCGCATCTCAGAGCTTGGCACCCGGGGATCC
CGAGGCGCACTCCTTCCGCGAGCAGGCTCTGCGTCCCCGCATCTTGCTGTGCGCCCCTCCCGCG
CGTCCCACACAATCCGCGCCTCTCGCACCCCCAGCGGCGCCACAAGAGTCCCCCGTGCGCCCTG
CGCCCCCCACGCGCCCGGGGGAAAGTTCCTACTCGTCAATTTCACACGTAATTTACAATAACCA
CCCGGATTCTTCCGCGTCGCCTAGGAAACGGCCAGGCGAAGCGACCGCCGCCTCAACGGAGATC
AAAGCCCTGCAGCAGACCCGGAGGCTTCTGGCCAACGCCAGGGAGCGGACGCGGGTGCACACCA
TCAGCGCAGCCTTCGAGGCGCTGAGGAAGCAGGTGCCGTGCTACTCCTATGGGCAGAAGCTCTC
CAAACTGGCCATCCTGAGGATTGCCTGTAACTACATCTTGTCCCTGGCACGGCTGGCTGACCTG
GACTACAGTGCCGACCACAGCAACCTCAGCTTCTCCGAGTGTGTGCAGCGCTGCACCCGCACCC
TGCAGGCAGAAGGGCGAGCCAAGAAACGGAAGGAGTGACCTGCCACAGGCTAGACCACAGACAC
CACTGTGAGTCTCTTCCCAGTTGGGACTGAGGAGAAAGCTGGGACCACCAGGAGACGACCAGCC
TCATTCCTTGTCTTCCTCAAGATGCTGCCAGATACTCAGCCCGTGTACCATCTCTCAGGGTCAC
TTAGAACCAGCACAAGGGCCGCCGGCCTCCCTCTCCGTCTCCTGCCATCCAGGGTTACTTCAGA
TTTTGCCTTCTGCCTGGTGGGGCGGGCTATTGCCAAAGATTCTACAGAGATCGTCCAAGGAAAT
TATGGATGAGGCCCCAACAGCACAAAACCACATCATTGCTGCCCTACCAAGTCCACCTCAAGCC
AAAGATGGATTAGCACTACTGCTAGGAACCCATGCAGTGGGCACCTGGTGACCATCAGAAGCAC
TTAACCCTCCAAGCCAGTGCTCGCTCTGTGCTGGGCCCTGAGCAGCTGGTTGTCTTCGAGACAA
GCTTCCTAGAGCCACGACAAGCAGGCTGCTGGTGGAAGGTGGAGCCCGAGATCCTTGGCCCTTC
CCATTAGCTACCCAGACCTCTGACTCCTGTTCCCGATACTCTTTGGGTCCTGGCTCCTTCTTGG
ACCCCAAGCCTCCTGAGAGAGGAGGGAAGGGGGAGACTAAAGAAGCAATATTGCCCCATACCCC
ACCCGGGATGTGCCCCAAGGAAATCTTTCTGACAGTCCTTGCTCCCAGCCCCTGCCCCAGCAGG
TGCGCCTCACCAGTGGTCAGGTTCAGGCTAACACTTAAATTAGCACTCTGCTGGAGAGCAGCTG
CCTGTGGACAGGCCAGGCAGGAGGACTTAGGGAGGAAGGGACCAGGGGAATGGGCCAGGATGTG
GGGGAAGGGGCACGTTCAAAGCCAAGGCCTGCTCCTTGTGCTCCAGAGGCCAAAGCTGTTCACA
TCTGTGTGCAACCATCTGCTTCAAATTGAAGTAAAAGCGGCAACATATAAA

hide sequence

RefSeq Acc Id:

XR_377494

RefSeq Status:

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	6	72,183,158 - 72,212,765 (-)	NCBI
GRCm38	6	72,206,174 - 72,235,780 (-)	NCBI

Sequence:

show sequence

GCGGACTGTTTTTGGAGAGAGAAGGCGCGCCCCCAACTTGGGTAGGGGGCAGAGAGGGCGAGCA
GGAGGAGGCAGGTTCCGGCACAAGGCATGAGGGGTGGGGGGAGGCCGAGAGCACGCGGACAAAG
GAGGCGGCCCTCAGCCCAGCTGTTTTGAAAAATGCTTCCTGTTTCTTTAAAGGCGCTCGCTGCT
CGGGCGGCCTGGGCTCGGGAGGCGGCAGCGGCGGCGGCGGGAGCTGCCTCCTCTCCGGGCGGGC
GGCGCTGAGTGATCTTGCGAACTGGGCTTCTGTGTAAACTGAGGCTAAACAAACACAGATGGAG
CGCAGCGGGCGTTCTGCAGAAATGCTGGCAGGGCGGCAGCGACTTCAGATGACACTCTGAGCTC
TCCCGGGGAACCGGCAGCCTCCAAGGCTTCACGGAGCCGGAGGCGCAGCTGCCCCGGGAGTGGG
GGTGCGAGGGAGGGACCCGGGGAGGGAGGGTAGGAGGAGAGAGCGCGGCGACAAGGCGGCGCTC
AGCGCGGCGGCCACCCGGCACAGCCAGGCGCGCGGCGTGCAGAGTGATCGCTGCGGGCGCGCGT
CCCGGGCAGTCCCACGCCCCAGCCTCACGCCGTCCTCGCCATGAAGCACATCCCGGTCCTCGAG
GACGGGCCGTGGAAGACTGTGTGCGTTAAAGAACTGAACGGCCTCAAGAAGCTCAAGCGGAAAG
GCAAGGAGCCGGTGCGGCGCGCGAATGGCTATAAAACTTTCCGATTGGACTTGGAAGCTCCCGA
GCTCGGCGCCACAGTCAGCACCACCGCCGCCACCAACGGGCTTCGGGACAGGACACAACCGTTC
CCGATCGCGACCCCAGTACCAGCCTCAGTGGCGCCGGCGGTTCCTCCAGGTGGAGGCACAGACA
CAGCCAGGGAATTCCGGGGCATCAGAGCGCCTGAGGTCTCTGACGCGCGCAAACGCGGTTTCGC
TCTGGGCACAGTGGGACCGGGACTACCCACGCCACCGCCGCCTCCCGCATCTCAGAGCTTGGCA
CCCGGGGATCCCGAGGCGCACTCCTTCCGCGAGCAGGCTCTGCGTCCCCGCATCTTGCTGTGCG
CCCCTCCCGCGCGTCCCACACAATCCGCGCCTCTCGCACCCCCAGCGGCGCCACAAGAGTCCCC
CGTGCGCCCTGCGCCCCCCACGCGCCCGGGGGAAAGTTCCTACTCGTCAATTTCACACGTAATT
TACAATAACCACCCGGATTCTTCCGCGTCGCCTAGGAAACGGCCAGGCGAAGCGACCGCCGCCT
CAACGGAGATCAAAGCCCTGCAGCAGACCCGGAGGCTTCTGGCCAACGCCAGGGAGCGGACGCG
GGTGCACACCATCAGCGCAGCCTTCGAGGCGCTGAGGAAGCAGGCTTGCTGTGTACAATGCCTG
CCATCAACTGAGTCCCCACTGCCTTGTGAGGTCAGTTTTGTGCCCAGTGTACAAGGGCTGAGTG
AATATGTCATTCACTGGGACGTACGCTGGGCAGAGTCAGAGCCAGGCATTGAACCCAGGAGACA
AAGGTGCCGTGCTACTCCTATGGGCAGAAGCTCTCCAAACTGGCCATCCTGAGGATTGCCTGTA
ACTACATCTTGTCCCTGGCACGGCTGGCTGACCTGGACTACAGTGCCGACCACAGCAACCTCAG
CTTCTCCGAGTGTGTGCAGCGCTGCACCCGCACCCTGCAGGCAGAAGGGCGAGCCAAGAAACGG
AAGGAGTGACCTGCCACAGGCTAGACCACAGACACCACTGTGAGTCTCTTCCCAGTTGGGACTG
AGGAGAAAGCTGGGACCACCAGGAGACGACCAGCCTCATTCCTTGTCTTCCTCAAGATGCTGCC
AGATACTCAGCCCGTGTACCATCTCTCAGGGTCACTTAGAACCAGCACAAGGGCCGCCGGCCTC
CCTCTCCGTCTCCTGCCATCCAGGGTTACTTCAGATTTTGCCTTCTGCCTGGTGGGGCGGGCTA
TTGCCAAAGATTCTACAGAGATCGTCCAAGGAAATTATGGATGAGGCCCCAACAGCACAAAACC
ACATCATTGCTGCCCTACCAAGTCCACCTCAAGCCAAAGATGGATTAGCACTACTGCTAGGAAC
CCATGCAGTGGGCACCTGGTGACCATCAGAAGCACTTAACCCTCCAAGCCAGTGCTCGCTCTGT
GCTGGGCCCTGAGCAGCTGGTTGTCTTCGAGACAAGCTTCCTAGAGCCACGACAAGCAGGCTGC
TGGTGGAAGGTGGAGCCCGAGATCCTTGGCCCTTCCCATTAGCTACCCAGACCTCTGACTCCTG
TTCCCGATACTCTTTGGGTCCTGGCTCCTTCTTGGACCCCAAGCCTCCTGAGAGAGGAGGGAAG
GGGGAGACTAAAGAAGCAATATTGCCCCATACCCCACCCGGGATGTGCCCCAAGGAAATCTTTC
TGACAGTCCTTGCTCCCAGCCCCTGCCCCAGCAGGTGCGCCTCACCAGTGGTCAGGTTCAGGCT
AACACTTAAATTAGCACTCTGCTGGAGAGCAGCTGCCTGTGGACAGGCCAGGCAGGAGGACTTA
GGGAGGAAGGGACCAGGGGAATGGGCCAGGATGTGGGGGAAGGGGCACGTTCAAAGCCAAGGCC
TGCTCCTTGTGCTCCAGAGGCCAAAGCTGTTCACATCTGTGTGCAACCATCTGCTTCAAATTGA
AGTAAAAGCGGCAACATATAAAGGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_722473	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH23684	(Get FASTA)	NCBI Sequence Viewer
	AAQ54689	(Get FASTA)	NCBI Sequence Viewer
	BAB39468	(Get FASTA)	NCBI Sequence Viewer
	BAC25499	(Get FASTA)	NCBI Sequence Viewer
	BAC57617	(Get FASTA)	NCBI Sequence Viewer
	BAC57618	(Get FASTA)	NCBI Sequence Viewer
	EDK98962	(Get FASTA)	NCBI Sequence Viewer
	EDK98963	(Get FASTA)	NCBI Sequence Viewer
	Q99NA2	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_722473 ⟸ NM_153778

- UniProtKB:

Q99NA2 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPVRRANGYKTFRLDLEAPELGATVSTTAATNG
LRDRTQPFPIATPVPASVAPAVPPGGGTDTAREFRGIRAPEVSDARKRGFALGTVGPGLPTPPP
PPASQSLAPGDPEAHSFREQALRPRILLCAPPARPTQSAPLAPPAAPQESPVRPAPPTRPGESS
YSSISHVIYNNHPDSSASPRKRPGEATAASTEIKALQQTRRLLANARERTRVHTISAAFEALRK
QVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKR
KE

hide sequence

RefSeq Acc Id:

ENSMUSP00000145790 ⟸ ENSMUST00000206425

RefSeq Acc Id:

ENSMUSP00000036981 ⟸ ENSMUST00000042646

Protein Domains

bHLH

Promoters

RGD ID:

6838961

Promoter ID:

MM_KWN:46446

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day1, Brain, Kidney, Liver, Lung, MEF_B4

Transcripts:

ENSMUST00000042646

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	6	72,184,461 - 72,185,447 (-)	MPROMDB

RGD ID:

6890000

Promoter ID:

EPDNEW_M8451

Type:

initiation region

Name:

Atoh8_2

Description:

Mus musculus atonal bHLH transcription factor 8 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M8452

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	6	72,235,252 - 72,235,312	EPDNEW

RGD ID:

6890002

Promoter ID:

EPDNEW_M8452

Type:

initiation region

Name:

Atoh8_1

Description:

Mus musculus atonal bHLH transcription factor 8 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M8451

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	6	72,235,578 - 72,235,638	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1918343	AgrOrtholog
Ensembl Genes	ENSMUSG00000037621	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSMUSP00000036981	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUSP00000145790	UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000042646	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSMUST00000206425	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	ATOH8	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	bHLH_dom	UniProtKB/Swiss-Prot
	HLH_DNA-bd_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:71093	UniProtKB/Swiss-Prot
MGD	MGI:1918343	ENTREZGENE
NCBI Gene	71093	ENTREZGENE
PANTHER	PTHR19290:SF102	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/Swiss-Prot
PhenoGen	Atoh8	PhenoGen
PROSITE	BHLH	UniProtKB/Swiss-Prot
SMART	HLH	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47459	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0U1RP16_MOUSE	UniProtKB/TrEMBL
	ATOH8_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q8C1I7	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-22	Atoh8	atonal bHLH transcription factor 8		atonal homolog 8 (Drosophila)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD