Lrrn1 (leucine rich repeat protein 1, neuronal) - Rat Genome Database

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Gene: Lrrn1 (leucine rich repeat protein 1, neuronal) Mus musculus
Analyze
Symbol: Lrrn1
Name: leucine rich repeat protein 1, neuronal
RGD ID: 1557480
MGI Page MGI
Description: Involved in positive regulation of synapse assembly. Predicted to localize to extracellular matrix and extracellular space. Is expressed in several structures, including central nervous system; dorsal root ganglion; embryo mesenchyme; lip; and sensory organ. Orthologous to human LRRN1 (leucine rich repeat neuronal 1); INTERACTS WITH 1,1-dichloroethene; acetohydrazide; choline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2810047E21Rik; leucine-rich repeat neuronal protein 1; neuronal leucine-rich repeat protein 1; NL; NLRR-1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396107,506,687 - 107,547,189 (+)NCBIGRCm39mm39
GRCm39 Ensembl6107,506,729 - 107,547,175 (+)Ensembl
GRCm386107,529,726 - 107,570,228 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6107,529,768 - 107,570,214 (+)EnsemblGRCm38mm10GRCm38
MGSCv376107,479,779 - 107,520,204 (+)NCBIGRCm37mm9NCBIm37
MGSCv366107,495,560 - 107,535,987 (+)NCBImm8
Celera6109,345,386 - 109,385,852 (+)NCBICelera
Cytogenetic Map6E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:8717337   PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12923295   PMID:15368895   PMID:15489334   PMID:15890332   PMID:15893969   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:16893423   PMID:17145500   PMID:17273929   PMID:18554416   PMID:18848646   PMID:19139271   PMID:19208226   PMID:20562862   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:22008794   PMID:22235033   PMID:24613359   PMID:24705356   PMID:25826454   PMID:27604320   PMID:30305733  


Genomics

Comparative Map Data
Lrrn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396107,506,687 - 107,547,189 (+)NCBIGRCm39mm39
GRCm39 Ensembl6107,506,729 - 107,547,175 (+)Ensembl
GRCm386107,529,726 - 107,570,228 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6107,529,768 - 107,570,214 (+)EnsemblGRCm38mm10GRCm38
MGSCv376107,479,779 - 107,520,204 (+)NCBIGRCm37mm9NCBIm37
MGSCv366107,495,560 - 107,535,987 (+)NCBImm8
Celera6109,345,386 - 109,385,852 (+)NCBICelera
Cytogenetic Map6E1NCBI
LRRN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl33,799,431 - 3,849,834 (+)EnsemblGRCh38hg38GRCh38
GRCh3833,799,431 - 3,849,834 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3733,841,115 - 3,891,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3633,816,121 - 3,864,387 (+)NCBINCBI36hg18NCBI36
Build 3433,816,549 - 3,864,303NCBI
Celera33,781,602 - 3,829,467 (+)NCBI
Cytogenetic Map3p26.2NCBI
HuRef33,776,569 - 3,824,447 (+)NCBIHuRef
CHM1_133,791,248 - 3,841,327 (+)NCBICHM1_1
Lrrn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24140,476,752 - 140,520,210 (+)NCBI
Rnor_6.0 Ensembl4139,670,092 - 139,673,143 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04139,633,310 - 139,679,730 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04204,105,032 - 204,146,746 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44143,005,870 - 143,008,925 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4129,203,204 - 129,206,259 (+)NCBICelera
Cytogenetic Map4q41NCBI
Lrrn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554219,519,468 - 9,558,038 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554219,519,468 - 9,558,038 (-)NCBIChiLan1.0ChiLan1.0
LRRN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.133,850,802 - 3,900,727 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl33,895,540 - 3,897,690 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v033,743,026 - 3,993,794 (+)NCBIMhudiblu_PPA_v0panPan3
LRRN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12013,612,829 - 13,651,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2013,617,196 - 13,619,346 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2013,580,502 - 13,619,610 (-)NCBI
ROS_Cfam_1.02013,645,454 - 13,684,832 (-)NCBI
UMICH_Zoey_3.12013,348,313 - 13,387,426 (-)NCBI
UNSW_CanFamBas_1.02013,683,051 - 13,722,396 (-)NCBI
UU_Cfam_GSD_1.02013,672,116 - 13,711,238 (-)NCBI
Lrrn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494210,388,026 - 10,426,559 (+)NCBI
SpeTri2.0NW_0049365773,343,371 - 3,381,757 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1360,393,647 - 60,432,808 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11360,393,622 - 60,436,076 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21366,680,366 - 66,718,528 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRN1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12239,898,203 - 39,945,968 (+)NCBI
ChlSab1.1 Ensembl2239,942,901 - 39,945,051 (+)Ensembl
Lrrn1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477314,047,768 - 14,092,615 (+)NCBI

Position Markers
D45913  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386107,569,755 - 107,569,835UniSTSGRCm38
MGSCv376107,519,749 - 107,519,829UniSTSGRCm37
Celera6109,385,397 - 109,385,477UniSTS
Cytogenetic Map6E1UniSTS
Whitehead/MRC_RH61108.63UniSTS
Lrrn1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386107,567,480 - 107,568,461UniSTSGRCm38
MGSCv376107,517,474 - 107,518,455UniSTSGRCm37
Celera6109,383,122 - 109,384,103UniSTS
Cytogenetic Map6E1UniSTS
cM Map6 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92607306112004738Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103777444136423692Mouse
12910776Hcga4b_mhome cage activity 4b (mouse)6104503360110960065Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104503360127042975Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104503360136423692Mouse
1357793Pnhdlc1_mplasma non-HDL cholesterol 1 (mouse)Not determined6105564822114368849Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined106005405120917141Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:559
Count of miRNA genes:331
Interacting mature miRNAs:399
Transcripts:ENSMUST00000049285
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049285   ⟹   ENSMUSP00000037096
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6107,529,768 - 107,570,214 (+)Ensembl
RefSeq Acc Id: NM_008516   ⟹   NP_032542
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396107,506,687 - 107,547,189 (+)NCBI
GRCm386107,529,726 - 107,570,228 (+)ENTREZGENE
MGSCv376107,479,779 - 107,520,204 (+)RGD
Celera6109,345,327 - 109,385,870 (+)ENTREZGENE
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032542   ⟸   NM_008516
- Peptide Label: precursor
- UniProtKB: Q61809 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000037096   ⟸   ENSMUST00000049285
Promoters
RGD ID:6839588
Promoter ID:MM_KWN:47093
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:ENSMUST00000049285
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366107,479,656 - 107,480,156 (+)MPROMDB
RGD ID:6890574
Promoter ID:EPDNEW_M8738
Type:initiation region
Name:Lrrn1_1
Description:Mus musculus leucine rich repeat protein 1, neuronal , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8739  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386107,529,770 - 107,529,830EPDNEW
RGD ID:6890576
Promoter ID:EPDNEW_M8739
Type:single initiation site
Name:Lrrn1_2
Description:Mus musculus leucine rich repeat protein 1, neuronal , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M8738  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386107,554,439 - 107,554,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:106038 AgrOrtholog
Ensembl Genes ENSMUSG00000034648 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000037096 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049285 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16979 UniProtKB/Swiss-Prot
MGD MGI:106038 ENTREZGENE
NCBI Gene 16979 ENTREZGENE
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrrn1 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt LRRN1_MOUSE UniProtKB/Swiss-Prot
  Q3TNZ6_MOUSE UniProtKB/TrEMBL
  Q3TSQ3_MOUSE UniProtKB/TrEMBL
  Q61809 ENTREZGENE
UniProt Secondary Q3USY1 UniProtKB/Swiss-Prot
  Q69ZI0 UniProtKB/Swiss-Prot