Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ZZEF1 mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ZZEF1 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | decreases expression | EXP | | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of ZZEF1 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | Estradiol results in decreased expression of ZZEF1 mRNA | CTD | PMID:32145629 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:27291303 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ZZEF1 mRNA | CTD | PMID:33387578 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:32109520 | 2-methylcholine | affects expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of ZZEF1 mRNA | CTD | PMID:21179406 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZZEF1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ZZEF1 mRNA | CTD | PMID:28628672 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ZZEF1 mRNA | CTD | PMID:28628672 | aflatoxin B1 | increases methylation | ISO | ZZEF1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of ZZEF1 intron | CTD | PMID:30157460 | aristolochic acid A | increases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of ZZEF1 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to ZZEF1 mRNA] | CTD | PMID:32406909 | atrazine | decreases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of ZZEF1 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | decreases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of ZZEF1 mRNA | CTD | PMID:26238291 | benzo[a]pyrene | affects methylation | ISO | ZZEF1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of ZZEF1 intron | CTD | PMID:30157460 | benzo[a]pyrene | increases methylation | ISO | ZZEF1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of ZZEF1 3' UTR | CTD | PMID:27901495 | benzo[e]pyrene | increases methylation | ISO | ZZEF1 (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of ZZEF1 intron | CTD | PMID:30157460 | bisphenol A | affects expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of ZZEF1 mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | decreases methylation | ISO | ZZEF1 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of ZZEF1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ZZEF1 mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | bisphenol A results in decreased expression of ZZEF1 mRNA | CTD | PMID:30816183 | bisphenol F | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZZEF1 mRNA | CTD | PMID:28628672 | cadmium dichloride | decreases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | Cadmium Chloride results in decreased expression of ZZEF1 mRNA | CTD | PMID:33453195 | caffeine | affects phosphorylation | ISO | ZZEF1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of ZZEF1 protein | CTD | PMID:35688186 | CGP 52608 | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ZZEF1 gene] | CTD | PMID:28238834 | cisplatin | decreases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of ZZEF1 mRNA | CTD | PMID:27392435 and PMID:27594783 | cisplatin | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | Cisplatin promotes the reaction [jinfukang results in decreased expression of ZZEF1 mRNA] and jinfukang promotes the reaction [Cisplatin results in decreased expression of ZZEF1 mRNA] | CTD | PMID:27392435 | clobetasol | decreases expression | EXP | | 6480464 | Clobetasol results in decreased expression of ZZEF1 mRNA | CTD | PMID:27462272 | cobalt dichloride | increases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of ZZEF1 mRNA | CTD | PMID:19376846 | coumarin | increases phosphorylation | ISO | ZZEF1 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of ZZEF1 protein | CTD | PMID:35688186 | cyclophosphamide | increases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | Cyclophosphamide results in increased expression of ZZEF1 mRNA | CTD | PMID:27281708 | dexamethasone | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZZEF1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ZZEF1 mRNA | CTD | PMID:28628672 | elemental selenium | increases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Selenium results in increased expression of ZZEF1 mRNA | CTD | PMID:19244175 | elemental selenium | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of ZZEF1 mRNA | CTD | PMID:19244175 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of ZZEF1 mRNA | CTD | PMID:35436446 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of ZZEF1 mRNA | CTD | PMID:30319688 | fenvalerate | increases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of ZZEF1 mRNA | CTD | PMID:30307764 | folic acid | decreases expression | EXP | | 6480464 | Folic Acid results in decreased expression of ZZEF1 mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | EXP | | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ZZEF1 mRNA | CTD | PMID:22206623 | indometacin | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ZZEF1 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ZZEF1 mRNA | CTD | PMID:28628672 | ivermectin | decreases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of ZZEF1 protein | CTD | PMID:32959892 | methamphetamine | increases expression | EXP | | 6480464 | Methamphetamine results in increased expression of ZZEF1 mRNA | CTD | PMID:26307267 | methapyrilene | increases methylation | ISO | ZZEF1 (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of ZZEF1 intron | CTD | PMID:30157460 | methotrexate | decreases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Methotrexate results in decreased expression of ZZEF1 mRNA | CTD | PMID:24449571 | methyl methanesulfonate | increases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of ZZEF1 mRNA | CTD | PMID:23649840 | N-methyl-4-phenylpyridinium | increases expression | EXP | | 6480464 | 1-Methyl-4-phenylpyridinium results in increased expression of ZZEF1 mRNA | CTD | PMID:17475336 | ozone | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of ZZEF1 mRNA | CTD | PMID:35430440 | paracetamol | decreases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of ZZEF1 mRNA | CTD | PMID:21420995 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ZZEF1 mRNA | CTD | PMID:36331819 | selenium atom | increases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Selenium results in increased expression of ZZEF1 mRNA | CTD | PMID:19244175 | selenium atom | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of ZZEF1 mRNA | CTD | PMID:19244175 | sunitinib | increases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of ZZEF1 mRNA | CTD | PMID:31533062 | thioacetamide | decreases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | Thioacetamide results in decreased expression of ZZEF1 mRNA | CTD | PMID:23411599 | toluene | increases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | Toluene results in increased expression of ZZEF1 mRNA | CTD | PMID:22967744 | tungsten | decreases expression | EXP | | 6480464 | Tungsten results in decreased expression of ZZEF1 mRNA | CTD | PMID:30912803 | valproic acid | increases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of ZZEF1 mRNA | CTD | PMID:23179753 | valproic acid | affects splicing | ISO | Zzef1 (Rattus norvegicus) | 6480464 | Valproic Acid affects the splicing of ZZEF1 mRNA | CTD | PMID:29427782 | valproic acid | decreases expression | ISO | Zzef1 (Rattus norvegicus) | 6480464 | Valproic Acid results in decreased expression of ZZEF1 mRNA | CTD | PMID:29427782 | vitamin E | multiple interactions | ISO | ZZEF1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in increased expression of ZZEF1 mRNA | CTD | PMID:19244175 | vitamin E | decreases expression | ISO | ZZEF1 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of ZZEF1 mRNA | CTD | PMID:19244175 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
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Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Gene-Chemical Interaction Annotations
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Biological Process
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Phenotype Annotations
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Mammalian Phenotype
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Functional annotation of a full-length mouse cDNA collection. | Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90. |
| 2. | Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. | Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 3. | Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. | Okazaki N, etal., DNA Res 2003 Aug 31;10(4):167-80. |
| 4. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 5. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:8889548 | PMID:10349636 | PMID:10922068 | PMID:11042159 | PMID:11076861 | PMID:12477932 | PMID:12904583 | PMID:16141072 | PMID:16141073 | PMID:21267068 | PMID:21677750 | PMID:21873635 |
| PMID:24194600 | PMID:25709106 | PMID:27480124 | PMID:27626380 | PMID:28700664 | PMID:33158444 |
Genomics
Comparative Map Data
| Zzef1 (Mus musculus - house mouse) |
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| ZZEF1 (Homo sapiens - human) |
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| Zzef1 (Rattus norvegicus - Norway rat) |
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| Zzef1 (Chinchilla lanigera - long-tailed chinchilla) |
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| ZZEF1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| ZZEF1 (Canis lupus familiaris - dog) |
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| Zzef1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| ZZEF1 (Sus scrofa - pig) |
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| ZZEF1 (Chlorocebus sabaeus - green monkey) |
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| Zzef1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Zzef1
3101 total Variants 
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