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Gene: Myo6 (myosin VI) Mus musculus
Symbol: Myo6
Name: myosin VI
Description: Predicted to have actin filament binding activity and identical protein binding activity. Involved in several processes, including inner ear development; modulation of chemical synaptic transmission; and protein transport. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; cochlear hair cell ribbon synapse; and postsynaptic actin cytoskeleton. Predicted to colocalize with the clathrin-coated endocytic vesicle. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Is expressed in inner ear. Orthologous to human MYO6 (myosin VI); PARTICIPATES IN auditory mechanotransduction pathway; E-cadherin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; acetaldehyde.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BC029719; Myo6; myosin-VI; rsv; Snell's waltzer; sv; tailchaser; Tlc; unconventional myosin-6; unconventional myosin-VI
Homo sapiens (human) : MYO6 (myosin VI)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Myo6 (myosin VI)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo6 (myosin VI)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO6 (myosin VI)
Canis lupus familiaris (dog) : MYO6 (myosin VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo6 (myosin VI)
Sus scrofa (pig) : MYO6 (myosin VI)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38980,164,976 - 80,311,729 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37980,012,841 - 80,159,536 (+)NCBIGRCm37mm9NCBIm37
MGSCv36979,950,724 - 80,097,413 (+)NCBImm8
Celera977,304,677 - 77,455,393 (+)NCBICelera
Cytogenetic Map9 E1NCBI
cM Map943.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Myo6
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557473
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.