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Gene: Myo6 (myosin VI) Mus musculus
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Symbol: Myo6
Name: myosin VI
Description: Predicted to have actin filament binding activity and identical protein binding activity. Involved in several processes, including inner ear development; modulation of chemical synaptic transmission; and protein transport. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; cochlear hair cell ribbon synapse; and postsynaptic actin cytoskeleton. Predicted to colocalize with the clathrin-coated endocytic vesicle. Used to study autosomal dominant nonsyndromic deafness 22 and autosomal recessive nonsyndromic deafness 37. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Is expressed in inner ear. Orthologous to human MYO6 (myosin VI); PARTICIPATES IN auditory mechanotransduction pathway; E-cadherin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; acetaldehyde.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BC029719; Myo6; myosin-VI; rsv; Snell's waltzer; sv; tailchaser; Tlc; unconventional myosin-6; unconventional myosin-VI
Orthologs:
Homo sapiens (human) : MYO6 (myosin VI)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Myo6 (myosin VI)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo6 (myosin VI)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO6 (myosin VI)
Canis lupus familiaris (dog) : MYO6 (myosin VI)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo6 (myosin VI)
Sus scrofa (pig) : MYO6 (myosin VI)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38980,164,976 - 80,311,729 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37980,012,841 - 80,159,536 (+)NCBIGRCm37mm9NCBIm37
MGSCv36979,950,724 - 80,097,413 (+)NCBImm8
Celera977,304,677 - 77,455,393 (+)NCBICelera
Cytogenetic Map9 E1NCBI
cM Map943.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Myo6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557473
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.