Atp23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog) - Rat Genome Database
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Gene: Atp23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog) Mus musculus
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Symbol: Atp23
Name: ATP23 metallopeptidase and ATP synthase assembly factor homolog
RGD ID: 1557369
Description: Predicted to have metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing and mitochondrial proton-transporting ATP synthase complex assembly. Predicted to localize to several cellular components, including cell junction; cytosol; and extrinsic component of mitochondrial inner membrane. Orthologous to human ATP23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110068E08Rik; 2410012H02Rik; mitochondrial inner membrane protease ATP23 homolog; XRCC6 binding protein 1; XRCC6-binding protein 1; Xrcc6b; Xrcc6bp1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910126,703,698 - 126,737,893 (-)NCBI
GRCm3810126,867,829 - 126,902,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10126,868,427 - 126,901,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,305,483 - 126,338,427 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,271,379 - 126,304,304 (-)NCBImm8
Celera10129,259,555 - 129,292,365 (-)NCBICelera
Cytogenetic Map10D3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11812828   PMID:12477932   PMID:14610273   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21873635  


Genomics

Comparative Map Data
Atp23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910126,703,698 - 126,737,893 (-)NCBI
GRCm3810126,867,829 - 126,902,024 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10126,868,427 - 126,901,355 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,305,483 - 126,338,427 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610126,271,379 - 126,304,304 (-)NCBImm8
Celera10129,259,555 - 129,292,365 (-)NCBICelera
Cytogenetic Map10D3NCBI
ATP23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,906,039 - 57,959,148 (+)EnsemblGRCh38hg38GRCh38
GRCh381257,941,567 - 57,959,148 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371258,335,324 - 58,351,052 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,621,712 - 56,637,319 (+)NCBINCBI36hg18NCBI36
Celera1257,994,050 - 58,009,658 (+)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1255,371,766 - 55,387,373 (+)NCBIHuRef
CHM1_11258,303,067 - 58,318,831 (+)NCBICHM1_1
Atp23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0770,183,625 - 70,198,655 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,183,625 - 70,198,655 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,360,825 - 70,375,828 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera759,862,752 - 59,877,891 (-)NCBICelera
Cytogenetic Map7q22NCBI
Atp23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,632,165 - 5,651,519 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,632,679 - 5,650,270 (+)NCBIChiLan1.0ChiLan1.0
ATP23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,231,287 - 31,247,026 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,231,287 - 31,247,020 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01230,969,266 - 30,985,043 (-)NCBIMhudiblu_PPA_v0panPan3
ATP23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl101,981,685 - 1,994,831 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1101,981,577 - 1,994,972 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Atp23
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366462,057,112 - 2,074,382 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATP23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl523,226,814 - 23,276,043 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1523,176,854 - 23,276,251 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,934,289 - 24,977,755 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATP23
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1153,854,418 - 53,868,628 (+)Ensembl
ChlSab1.11153,854,424 - 53,868,494 (+)NCBI
Atp23
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248029,994,788 - 10,066,927 (-)NCBI

Position Markers
UniSTS:236494  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3810126,895,067 - 126,895,151UniSTSGRCm38
MGSCv3710126,332,123 - 126,332,207UniSTSGRCm37
Celera10129,286,087 - 129,286,171UniSTS
Cytogenetic Map10D3UniSTS
AU048711  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv3710126,315,170 - 126,315,522UniSTSGRCm37
MGSCv37738,912,278 - 38,912,719UniSTSGRCm37
Celera733,291,144 - 33,291,569UniSTS
Celera10129,269,135 - 129,269,487UniSTS
Celera6138,175,534 - 138,175,580UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
4142461Bmd25_mbone mineral density 25 (mouse)Not determined1097381196130694993Mouse
1357544Vtbt10_mvertebral trabecular bone trait 10 (mouse)Not determined1097381196130694993Mouse
11533919Mvb4_mmodifier of vibrator 4 (mouse)397381196130694993Mouse
11533921Mvb2_mmodifier of vibrator 2 (mouse)1097381196130694993Mouse
12880413V125Dq9_mvitamin D active form serum level QTL 9 (mouse)1097700000130694993Mouse
4141402T2dm1sa_mtype 2 diabetes mellitus 1 in SMXA RI mice (mouse)Not determined97922739130694993Mouse
11040593Lmr5e_mleishmaniasis resistance 5e (mouse)1099384730130694993Mouse
11040595Lmr5c_mleishmaniasis resistance 5c (mouse)1099384730130694993Mouse
11040597Lmr5a_mleishmaniasis resistance 5a (mouse)1099384730130694993Mouse
1301968Estq4_mestradiol regulated response QTL 4 (mouse)Not determined10101150611130694993Mouse
1357744Cfbw4_mcystic fibrosis body weight 4 (mouse)Not determined10101150611130694993Mouse
1301901Im5_mimmunoregulatory 5 (mouse)Not determined10101661259130694993Mouse
4141361Cfmq3_mcystic fibrosis modifier QTL 3 (mouse)Not determined10101661259130694993Mouse
1300678Leg2_mlongevity extending gene 2 (mouse)Not determined10102671003130694993Mouse
1301895Exq1_mexploratory and excitability QTL 1 (mouse)Not determined10103011947130694993Mouse
14696727Kidrq2_mkidney weight, right QTL 2 (mouse)10103066603130694993Mouse
4141007Obrq10_mobesity resistance QTL 10 (mouse)Not determined103407822130694993Mouse
4141487Tgq21_mtriglyceride QTL 21 (mouse)Not determined104274116130694993Mouse
14746996Manh69_mmandible shape 69 (mouse)10104927733130694993Mouse
1357482Nhdlq4_mnon-HDL QTL 4 (mouse)Not determined10105205399130694993Mouse
1300679Nociq2_mnociceptive sensitivity inflammatory QTL 2 (mouse)Not determined10105205399130694993Mouse
1302200Sle12_msystematic lupus erythematosus susceptibility 12 (mouse)Not determined10105205399130694993Mouse
11040594Lmr5f_mleishmaniasis resistance 5f (mouse)10105343808130694993Mouse
11040596Lmr5d_mleishmaniasis resistance 5d (mouse)10105343808130694993Mouse
11040598Lmr5b_mleishmaniasis resistance 5b (mouse)10105343808130694993Mouse
4142089Obrq9_mobesity resistance QTL 9 (mouse)Not determined108680038130694993Mouse
4141153Ltgq2_mliver triglyceride QTL 2 (mouse)Not determined108680038130694993Mouse
11039496Ltpr5b_mLeishmania tropica response 5b (mouse)10108739225130694993Mouse
11041664Lmr25_mleishmaniasis resistance 25 (mouse)10108739225130694993Mouse
11049563Lmr25a_mleishmaniasis resistance 25a (mouse)10108739225130694993Mouse
11049570Lmr25b_mleishmaniasis resistance 25b (mouse)10108739225130694993Mouse
12911218Frct3a_mfear conditioning traits 3a (mouse)10122950065129631127Mouse
12911220Frct3c_mfear conditioning traits 3c (mouse)10122950065129631127Mouse
12879490Frct3_mfear conditioning traits 3 (mouse)10122950065129631127Mouse
12904001Opfaq10_mopen field activity QTL 10 (mouse)10125797802129630506Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:131
Interacting mature miRNAs:141
Transcripts:ENSMUST00000026504, ENSMUST00000168520
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001159559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001358969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001358970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_026858 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003948791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004936268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA221211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC122018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC129304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK185071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030630 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE863276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG801921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY704635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB203044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000026504   ⟹   ENSMUSP00000026504
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10126,868,427 - 126,901,355 (-)Ensembl
RefSeq Acc Id: ENSMUST00000168520   ⟹   ENSMUSP00000128382
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10126,887,249 - 126,901,348 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220051
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl10126,887,970 - 126,901,350 (-)Ensembl
RefSeq Acc Id: NM_001159559   ⟹   NP_001153031
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,723,117 - 126,737,240 (-)NCBI
GRCm3810126,887,248 - 126,901,371 (-)NCBI
MGSCv3710126,305,483 - 126,338,427 (-)RGD
Celera10129,259,555 - 129,292,365 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001358969   ⟹   NP_001345898
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,723,117 - 126,737,240 (-)NCBI
GRCm3810126,887,248 - 126,901,371 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001358970   ⟹   NP_001345899
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,723,117 - 126,737,240 (-)NCBI
GRCm3810126,887,248 - 126,901,371 (-)NCBI
Sequence:
RefSeq Acc Id: NM_026858   ⟹   NP_081134
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,704,296 - 126,737,240 (-)NCBI
GRCm3810126,868,427 - 126,901,371 (-)NCBI
MGSCv3710126,305,483 - 126,338,427 (-)RGD
Celera10129,259,555 - 129,292,365 (-)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: XR_003948790
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,723,115 - 126,737,893 (-)NCBI
GRCm3810126,887,246 - 126,902,024 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003948791
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,703,698 - 126,737,578 (-)NCBI
GRCm3810126,867,829 - 126,902,024 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004936268
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3910126,723,747 - 126,737,578 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_081134   ⟸   NM_026858
- Peptide Label: isoform 2
- UniProtKB: Q9CWQ3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001153031   ⟸   NM_001159559
- Peptide Label: isoform 1
- UniProtKB: G3UW46 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001345898   ⟸   NM_001358969
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001345899   ⟸   NM_001358970
- Peptide Label: isoform 4
RefSeq Acc Id: ENSMUSP00000026504   ⟸   ENSMUST00000026504
RefSeq Acc Id: ENSMUSP00000128382   ⟸   ENSMUST00000168520

Promoters
RGD ID:6820102
Promoter ID:MM_KWN:5849
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung
Transcripts:NM_001159559,   NM_026858,   UC007HHH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3610126,338,116 - 126,338,616 (-)MPROMDB
RGD ID:8673440
Promoter ID:EPDNEW_M14750
Type:initiation region
Name:Atp23_1
Description:Mus musculus ATP23 metallopeptidase and ATP synthase assemblyfactor homolog , transcript variant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3810126,901,340 - 126,901,400EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916984 AgrOrtholog
Ensembl Genes ENSMUSG00000025436 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000026504 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000128382 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000026504 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000168520 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000220051 ENTREZGENE
InterPro Peptidase_M76_ATP23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:68876 UniProtKB/Swiss-Prot
MGD MGI:1916984 ENTREZGENE
NCBI Gene 68876 ENTREZGENE
PANTHER PTHR21711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Peptidase_M76 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atp23 PhenoGen
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
UniGene Mm.276769 ENTREZGENE
UniProt ATP23_MOUSE UniProtKB/Swiss-Prot
  G3UW46 ENTREZGENE, UniProtKB/TrEMBL
  Q9CWQ3 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-07 Atp23  ATP23 metallopeptidase and ATP synthase assembly factor homolog  Xrcc6bp1  XRCC6 binding protein 1  Symbol and/or name change 5135510 APPROVED