Porcn (porcupine O-acyltransferase) - Rat Genome Database

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Gene: Porcn (porcupine O-acyltransferase) Mus musculus
Analyze
Symbol: Porcn
Name: porcupine O-acyltransferase
RGD ID: 1557351
MGI Page MGI
Description: Enables Wnt-protein binding activity and palmitoleoyltransferase activity. Involved in Wnt signaling pathway and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within glycoprotein metabolic process. Located in endoplasmic reticulum membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including anterior visceral endoderm; genitourinary system; nervous system; primitive streak; and sensory organ. Used to study focal dermal hypoplasia. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Orthologous to human PORCN (porcupine O-acyltransferase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2410004O13Rik; AW045557; DXHXS7465; DXHXS7465e; Mg61; mMg61; Mp; Mporc; Mporc-a; Mporc-b; Mporc-c; Mporc-d; p; porc; porcupine homolog; porcupine homolog (Drosophila); porcupine-A; porcupine-B; porcupine-C; porcupine-D; Ppn; probable protein-cysteine N-palmitoyltransferase porcupine; protein-cysteine N-palmitoyltransferase porcupine; protein-serine O-palmitoleoyltransferase porcupine
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X8,060,085 - 8,072,794 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX8,060,087 - 8,072,764 (-)EnsemblGRCm39 Ensembl
GRCm38X8,193,846 - 8,206,548 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX8,193,848 - 8,206,525 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,770,976 - 7,783,651 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,350,809 - 7,363,466 (-)NCBIMGSCv36mm8
CeleraX3,263,557 - 3,276,203 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal allantois morphology  (IAGP)
abnormal anterior eye segment morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal caudal vertebrae morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal dermal layer morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryonic tissue morphology  (IEA)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal hair follicle development  (IAGP)
abnormal hair growth  (IAGP)
abnormal hypodermis fat layer morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal midbrain-hindbrain boundary morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal retina pigmentation  (IAGP)
abnormal skin morphology  (IAGP)
abnormal tail morphology  (IAGP)
abnormal tooth morphology  (IAGP)
abnormal umbilical cord morphology  (IAGP)
abnormal uterine horn morphology  (IAGP)
abnormal vas deferens morphology  (IAGP)
abnormal ventral body wall morphology  (IAGP)
absent amnion  (IAGP)
absent chorion  (IAGP)
absent ulna  (IAGP)
alopecia  (IAGP)
brachydactyly  (IAGP)
caudal body truncation  (IAGP)
cleft palate  (IAGP)
coloboma  (IAGP)
curly tail  (IAGP)
decreased autopod size  (IAGP)
decreased body size  (IAGP)
decreased cornea thickness  (IAGP)
decreased embryo size  (IAGP)
decreased length of long bones  (IAGP)
dermal cyst  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
failure of eyelid fusion  (IAGP)
failure of ventral body wall closure  (IAGP)
failure to gastrulate  (IAGP)
forelimb oligodactyly  (IAGP)
fused phalanges  (IAGP)
hairless  (IAGP)
hydronephrosis  (IAGP)
infertility  (IAGP)
iris hypoplasia  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
microphthalmia  (IAGP)
midline cleft upper lip  (IAGP)
no abnormal phenotype detected  (IAGP)
oligodactyly  (IAGP)
omphalocele  (IAGP)
open neural tube  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
postnatal growth retardation  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
short limbs  (IAGP)
short tail  (IAGP)
skin hypoplasia  (IAGP)
skin lesions  (IAGP)
small testis  (IAGP)
sternum hypoplasia  (IAGP)
syndactyly  (IAGP)
thin dermal layer  (IAGP)
thin epidermis  (IAGP)
thin skin  (IAGP)
true hermaphroditism  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Wntless in Wnt secretion: molecular, cellular and genetic aspects. Das S, etal., Front Biol (Beijing). 2012 Dec 1;7(6):587-593.
2. Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com. Derry JM, etal., Nat Genet 1999 Jul;22(3):286-90.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation. Means GD, etal., Genomics 2000 May 1;65(3):213-23.
5. MGDs mouse GO annotations MGD data from the GO Consortium
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Tanaka K, etal., Eur J Biochem 2000 Jul;267(13):4300-11.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11309666   PMID:12466305   PMID:12477932   PMID:12520002   PMID:12842094   PMID:14610273   PMID:15489334   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:17141155   PMID:18287559   PMID:18799693   PMID:19515997   PMID:19521566   PMID:20548051   PMID:21267068   PMID:21554866   PMID:21768372   PMID:21873635  
PMID:22357957   PMID:22412863   PMID:22632720   PMID:22888000   PMID:23760955   PMID:24223895   PMID:24277854   PMID:24527386   PMID:24619415   PMID:24798332   PMID:24821987   PMID:24952961  
PMID:25451153   PMID:26089398   PMID:26273529   PMID:26776514   PMID:27083283   PMID:27492485   PMID:27734833   PMID:27965056   PMID:28655768   PMID:29036275   PMID:29066530   PMID:29559533  
PMID:29720649   PMID:30146480   PMID:30692207   PMID:31462532   PMID:31585741   PMID:32394892   PMID:32721381   PMID:32907846   PMID:34108937   PMID:34321999   PMID:34547456   PMID:37028407  
PMID:37553620  


Genomics

Comparative Map Data
Porcn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X8,060,085 - 8,072,794 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX8,060,087 - 8,072,764 (-)EnsemblGRCm39 Ensembl
GRCm38X8,193,846 - 8,206,548 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX8,193,848 - 8,206,525 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X7,770,976 - 7,783,651 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X7,350,809 - 7,363,466 (-)NCBIMGSCv36mm8
CeleraX3,263,557 - 3,276,203 (+)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.7NCBI
PORCN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X48,508,992 - 48,520,814 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX48,508,959 - 48,520,814 (+)EnsemblGRCh38hg38GRCh38
GRCh37X48,367,380 - 48,379,202 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,252,315 - 48,264,146 (+)NCBINCBI36Build 36hg18NCBI36
CeleraX53,286,529 - 53,298,360 (-)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,031,046 - 46,042,328 (+)NCBIHuRef
CHM1_1X48,398,636 - 48,410,463 (+)NCBICHM1_1
T2T-CHM13v2.0X47,917,895 - 47,929,826 (+)NCBIT2T-CHM13v2.0
Porcn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X16,957,811 - 16,970,440 (+)NCBIGRCr8
mRatBN7.2X14,285,864 - 14,298,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,285,871 - 14,298,481 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,099,404 - 19,111,968 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,971,114 - 20,983,682 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X17,236,311 - 17,248,880 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,035,569 - 15,048,440 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,035,569 - 15,048,440 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X15,819,241 - 15,831,751 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,317,388 - 26,330,177 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,371,304 - 14,383,919 (+)NCBICelera
Cytogenetic MapXq12NCBI
Porcn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495554375,875 - 91,975 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495554375,870 - 91,575 (+)NCBIChiLan1.0ChiLan1.0
PORCN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,997,751 - 50,009,669 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,001,123 - 50,013,041 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,807,151 - 40,819,069 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X48,670,973 - 48,683,318 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX48,671,829 - 48,682,980 (+)Ensemblpanpan1.1panPan2
PORCN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,763,126 - 41,773,892 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,762,692 - 41,779,476 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,139,338 - 16,150,113 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,899,285 - 41,910,059 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,899,264 - 42,014,404 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,886,207 - 41,896,981 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,874,498 - 41,885,274 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,968,061 - 41,978,839 (+)NCBIUU_Cfam_GSD_1.0
Porcn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,254,739 - 34,267,952 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936721495,093 - 508,347 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936721495,132 - 508,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PORCN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,653,789 - 42,669,517 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,653,696 - 42,669,526 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,628,531 - 47,644,354 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PORCN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X45,639,836 - 45,652,301 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX45,640,125 - 45,651,974 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607611,091,880 - 11,104,116 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Porcn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893327,587 - 339,877 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893327,801 - 339,879 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Porcn
201 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1911
Count of miRNA genes:584
Interacting mature miRNAs:676
Transcripts:ENSMUST00000077595, ENSMUST00000082320, ENSMUST00000089402, ENSMUST00000089403, ENSMUST00000122943, ENSMUST00000139744, ENSMUST00000154695
Prediction methods:Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302195Pbwg10_mpostnatal body weight growth 10 (mouse)Not determinedX126202173Mouse
1357433Dbts2_mdiabetes 2 (mouse)Not determinedX7226295150107038Mouse

Markers in Region
BB265815  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X8,193,949 - 8,194,059UniSTSGRCm38
MGSCv37X7,771,075 - 7,771,185UniSTSGRCm37
CeleraX3,275,994 - 3,276,104UniSTS
Cytogenetic MapXA1.1UniSTS
Whitehead/MRC_RHX72.21UniSTS
Ppn-pending  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X8,201,538 - 8,203,237UniSTSGRCm38
MGSCv37X7,778,664 - 7,780,363UniSTSGRCm37
CeleraX3,266,845 - 3,268,544UniSTS
Cytogenetic MapXA1.1UniSTS
cM MapUN UniSTS
cM MapX UniSTS
AW045557  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38X8,193,949 - 8,194,060UniSTSGRCm38
MGSCv37X7,771,075 - 7,771,186UniSTSGRCm37
CeleraX3,275,993 - 3,276,104UniSTS
Cytogenetic MapXA1.1UniSTS
Whitehead/MRC_RHX67.59UniSTS
Porcn  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic MapXA1.1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001308474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_023638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_131893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006527644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030251383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_003953014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004940353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_878030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB036746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB036747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB036748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB036749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI839581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK010405 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL663032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF462782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ556448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU707440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000077595   ⟹   ENSMUSP00000076790
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX8,060,089 - 8,072,740 (-)Ensembl
GRCm38.p6 EnsemblX8,193,850 - 8,206,501 (-)Ensembl
RefSeq Acc Id: ENSMUST00000082320   ⟹   ENSMUSP00000080937
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX8,060,087 - 8,072,764 (-)Ensembl
GRCm38.p6 EnsemblX8,193,848 - 8,206,525 (-)Ensembl
RefSeq Acc Id: ENSMUST00000089402   ⟹   ENSMUSP00000086824
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX8,060,089 - 8,072,740 (-)Ensembl
GRCm38.p6 EnsemblX8,193,850 - 8,206,501 (-)Ensembl
RefSeq Acc Id: ENSMUST00000089403   ⟹   ENSMUSP00000086825
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX8,060,089 - 8,072,740 (-)Ensembl
GRCm38.p6 EnsemblX8,193,850 - 8,206,501 (-)Ensembl
RefSeq Acc Id: ENSMUST00000122943   ⟹   ENSMUSP00000138626
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX8,060,092 - 8,072,736 (-)Ensembl
GRCm38.p6 EnsemblX8,193,853 - 8,206,497 (-)Ensembl
RefSeq Acc Id: ENSMUST00000139744
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX8,069,678 - 8,072,752 (-)Ensembl
GRCm38.p6 EnsemblX8,203,439 - 8,206,513 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154695   ⟹   ENSMUSP00000138661
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 EnsemblX8,060,088 - 8,072,730 (-)Ensembl
GRCm38.p6 EnsemblX8,193,849 - 8,206,491 (-)Ensembl
RefSeq Acc Id: NM_001308474   ⟹   NP_001295403
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,085 - 8,072,764 (-)NCBI
GRCm38X8,193,846 - 8,206,525 (-)NCBI
Sequence:
RefSeq Acc Id: NM_016913   ⟹   NP_058609
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,085 - 8,072,764 (-)NCBI
GRCm38X8,193,846 - 8,206,525 (-)NCBI
MGSCv37X7,770,976 - 7,783,651 (-)RGD
CeleraX3,263,557 - 3,276,203 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_023638   ⟹   NP_076127
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,085 - 8,072,764 (-)NCBI
GRCm38X8,193,846 - 8,206,525 (-)NCBI
MGSCv37X7,770,976 - 7,783,651 (-)RGD
CeleraX3,263,557 - 3,276,203 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_145907   ⟹   NP_665914
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,085 - 8,072,764 (-)NCBI
GRCm38X8,193,846 - 8,206,525 (-)NCBI
MGSCv37X7,770,976 - 7,783,651 (-)RGD
CeleraX3,263,557 - 3,276,203 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NM_145908   ⟹   NP_665915
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,085 - 8,072,764 (-)NCBI
GRCm38X8,193,846 - 8,206,525 (-)NCBI
MGSCv37X7,770,976 - 7,783,651 (-)RGD
CeleraX3,263,557 - 3,276,203 (+)RGD
cM MapX ENTREZGENE
Sequence:
RefSeq Acc Id: NR_131893
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,085 - 8,072,764 (-)NCBI
GRCm38X8,193,846 - 8,206,525 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006527644   ⟹   XP_006527707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,072,794 (-)NCBI
GRCm38X8,193,848 - 8,206,546 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030251383   ⟹   XP_030107243
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,072,794 (-)NCBI
GRCm38X8,193,848 - 8,206,546 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162014   ⟹   XP_036017907
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,072,794 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162015   ⟹   XP_036017908
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,071,961 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036162016   ⟹   XP_036017909
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,072,753 (-)NCBI
Sequence:
RefSeq Acc Id: XR_003953014
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,072,794 (-)NCBI
GRCm38X8,193,848 - 8,206,544 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940352
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,072,794 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004940353
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,072,794 (-)NCBI
Sequence:
RefSeq Acc Id: XR_878030
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39X8,060,087 - 8,072,794 (-)NCBI
GRCm38X8,193,848 - 8,206,548 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001295403 (Get FASTA)   NCBI Sequence Viewer  
  NP_058609 (Get FASTA)   NCBI Sequence Viewer  
  NP_076127 (Get FASTA)   NCBI Sequence Viewer  
  NP_665914 (Get FASTA)   NCBI Sequence Viewer  
  NP_665915 (Get FASTA)   NCBI Sequence Viewer  
  XP_006527707 (Get FASTA)   NCBI Sequence Viewer  
  XP_030107243 (Get FASTA)   NCBI Sequence Viewer  
  XP_036017907 (Get FASTA)   NCBI Sequence Viewer  
  XP_036017908 (Get FASTA)   NCBI Sequence Viewer  
  XP_036017909 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH27292 (Get FASTA)   NCBI Sequence Viewer  
  AAH32284 (Get FASTA)   NCBI Sequence Viewer  
  BAA89467 (Get FASTA)   NCBI Sequence Viewer  
  BAA89468 (Get FASTA)   NCBI Sequence Viewer  
  BAA89469 (Get FASTA)   NCBI Sequence Viewer  
  BAA89470 (Get FASTA)   NCBI Sequence Viewer  
  BAB26914 (Get FASTA)   NCBI Sequence Viewer  
  EDL33964 (Get FASTA)   NCBI Sequence Viewer  
  EDL33965 (Get FASTA)   NCBI Sequence Viewer  
  EDL33966 (Get FASTA)   NCBI Sequence Viewer  
  EDL33967 (Get FASTA)   NCBI Sequence Viewer  
  EDL33968 (Get FASTA)   NCBI Sequence Viewer  
  EDL33969 (Get FASTA)   NCBI Sequence Viewer  
  EDL33970 (Get FASTA)   NCBI Sequence Viewer  
  EDL33971 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000076790
  ENSMUSP00000076790.6
  ENSMUSP00000080937
  ENSMUSP00000080937.6
  ENSMUSP00000086824
  ENSMUSP00000086824.4
  ENSMUSP00000086825
  ENSMUSP00000086825.4
  ENSMUSP00000138626.2
  ENSMUSP00000138661.2
GenBank Protein Q9JJJ7 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_076127   ⟸   NM_023638
- Peptide Label: isoform D
- UniProtKB: Q9JJJ9 (UniProtKB/Swiss-Prot),   Q9JJJ8 (UniProtKB/Swiss-Prot),   Q9CWT0 (UniProtKB/Swiss-Prot),   A2AC33 (UniProtKB/Swiss-Prot),   A2AC32 (UniProtKB/Swiss-Prot),   A2AC30 (UniProtKB/Swiss-Prot),   Q9JJK0 (UniProtKB/Swiss-Prot),   Q9JJJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_665915   ⟸   NM_145908
- Peptide Label: isoform B
- UniProtKB: Q9JJJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_665914   ⟸   NM_145907
- Peptide Label: isoform C
- UniProtKB: Q9JJJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_058609   ⟸   NM_016913
- Peptide Label: isoform A
- UniProtKB: Q9JJJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006527707   ⟸   XM_006527644
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001295403   ⟸   NM_001308474
- Peptide Label: isoform E
- UniProtKB: Q9JJJ7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030107243   ⟸   XM_030251383
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000138661   ⟸   ENSMUST00000154695
RefSeq Acc Id: ENSMUSP00000086824   ⟸   ENSMUST00000089402
RefSeq Acc Id: ENSMUSP00000086825   ⟸   ENSMUST00000089403
RefSeq Acc Id: ENSMUSP00000138626   ⟸   ENSMUST00000122943
RefSeq Acc Id: ENSMUSP00000076790   ⟸   ENSMUST00000077595
RefSeq Acc Id: ENSMUSP00000080937   ⟸   ENSMUST00000082320
RefSeq Acc Id: XP_036017907   ⟸   XM_036162014
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036017909   ⟸   XM_036162016
- Peptide Label: isoform X5
RefSeq Acc Id: XP_036017908   ⟸   XM_036162015
- Peptide Label: isoform X4

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJJ7-F1-model_v2 AlphaFold Q9JJJ7 1-461 view protein structure

Promoters
RGD ID:6846131
Promoter ID:MM_KWN:59487
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000077595,   ENSMUST00000082320,   ENSMUST00000089402,   ENSMUST00000089403,   ENSMUST00000115602,   OTTMUST00000043791,   UC009SON.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36X7,783,451 - 7,783,951 (-)MPROMDB
RGD ID:13680044
Promoter ID:EPDNEW_M24171
Type:multiple initiation site
Name:Porcn_1
Description:Mus musculus porcupine O-acyltransferase , transcript variante, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38X8,206,491 - 8,206,551EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890212 AgrOrtholog
Ensembl Genes ENSMUSG00000031169 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000077595 ENTREZGENE
  ENSMUST00000077595.12 UniProtKB/Swiss-Prot
  ENSMUST00000082320 ENTREZGENE
  ENSMUST00000082320.12 UniProtKB/Swiss-Prot
  ENSMUST00000089402 ENTREZGENE
  ENSMUST00000089402.10 UniProtKB/Swiss-Prot
  ENSMUST00000089403 ENTREZGENE
  ENSMUST00000089403.10 UniProtKB/Swiss-Prot
  ENSMUST00000122943 ENTREZGENE
  ENSMUST00000122943.2 UniProtKB/TrEMBL
  ENSMUST00000154695.8 UniProtKB/TrEMBL
InterPro MBOAT_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:53627 UniProtKB/Swiss-Prot
MGD MGI:1890212 ENTREZGENE
NCBI Gene 53627 ENTREZGENE
PANTHER PORCUPINE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN-SERINE O-PALMITOLEOYLTRANSFERASE PORCUPINE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MBOAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Porcn PhenoGen
UniProt A2AC30 ENTREZGENE
  A2AC32 ENTREZGENE
  A2AC33 ENTREZGENE
  PORCN_MOUSE UniProtKB/Swiss-Prot
  Q05CC9_MOUSE UniProtKB/TrEMBL
  Q9CWT0 ENTREZGENE
  Q9JJJ7 ENTREZGENE
  Q9JJJ8 ENTREZGENE
  Q9JJJ9 ENTREZGENE
  Q9JJK0 ENTREZGENE
  S4R2F8_MOUSE UniProtKB/TrEMBL
  S4R2I7_MOUSE UniProtKB/TrEMBL
UniProt Secondary A2AC30 UniProtKB/Swiss-Prot
  A2AC32 UniProtKB/Swiss-Prot
  A2AC33 UniProtKB/Swiss-Prot
  Q9CWT0 UniProtKB/Swiss-Prot
  Q9JJJ8 UniProtKB/Swiss-Prot
  Q9JJJ9 UniProtKB/Swiss-Prot
  Q9JJK0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-24 Porcn  porcupine O-acyltransferase    porcupine homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED