Med9 (mediator complex subunit 9) - Rat Genome Database

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Gene: Med9 (mediator complex subunit 9) Mus musculus
Analyze
Symbol: Med9
Name: mediator complex subunit 9
RGD ID: 1557335
MGI Page MGI
Description: Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Part of mediator complex. Orthologous to human MED9 (mediator complex subunit 9).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BC019367; FLJ10193; Med25; mediator of RNA polymerase II transcription subunit 9; mediator of RNA polymerase II transcription, subunit 9 homolog; MGC30366
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,839,040 - 59,854,132 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,839,032 - 59,853,031 (+)EnsemblGRCm39 Ensembl
GRCm381159,948,214 - 59,963,306 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,948,206 - 59,962,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv371159,761,716 - 59,776,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,484,794 - 60,499,886 (+)NCBIMGSCv36mm8
MGSCv361159,764,409 - 59,779,501 (+)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1137.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. The Mediator complex and transcription regulation. Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11559591   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14638676   PMID:16141072   PMID:16141073   PMID:17273973  
PMID:21124890   PMID:21677750   PMID:21873635   PMID:32968282   PMID:34161765  


Genomics

Comparative Map Data
Med9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391159,839,040 - 59,854,132 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1159,839,032 - 59,853,031 (+)EnsemblGRCm39 Ensembl
GRCm381159,948,214 - 59,963,306 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1159,948,206 - 59,962,205 (+)EnsemblGRCm38mm10GRCm38
MGSCv371159,761,716 - 59,776,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,484,794 - 60,499,886 (+)NCBIMGSCv36mm8
MGSCv361159,764,409 - 59,779,501 (+)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1137.81NCBI
MED9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381717,477,000 - 17,493,221 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1717,476,994 - 17,493,221 (+)EnsemblGRCh38hg38GRCh38
GRCh371717,380,314 - 17,396,535 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,321,025 - 17,337,259 (+)NCBINCBI36Build 36hg18NCBI36
Build 341717,321,024 - 17,337,259NCBI
Celera1718,319,685 - 18,335,921 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,132,586 - 17,148,822 (+)NCBIHuRef
CHM1_11717,388,947 - 17,405,182 (+)NCBICHM1_1
T2T-CHM13v2.01717,423,576 - 17,439,799 (+)NCBIT2T-CHM13v2.0
Med9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,250,229 - 45,264,988 (+)NCBIGRCr8
mRatBN7.21044,750,667 - 44,765,464 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,750,698 - 44,765,464 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1049,451,029 - 49,465,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01048,941,392 - 48,956,034 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01044,445,001 - 44,459,643 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01046,314,639 - 46,329,374 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,314,375 - 46,329,373 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,071,310 - 46,086,081 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,274,791 - 46,290,414 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,011,092 - 44,025,801 (+)NCBICelera
Cytogenetic Map10q22NCBI
Med9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955577454,715 - 470,152 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955577455,879 - 470,126 (-)NCBIChiLan1.0ChiLan1.0
MED9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21951,992,797 - 52,009,001 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11756,704,794 - 56,720,996 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01733,802,916 - 33,819,107 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,749,397 - 38,765,618 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1738,749,397 - 38,765,618 (-)Ensemblpanpan1.1panPan2
MED9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,967,951 - 41,982,354 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,967,651 - 41,982,349 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha542,106,027 - 42,120,418 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0542,074,169 - 42,088,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl542,074,178 - 42,088,594 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1542,041,185 - 42,055,568 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,988,575 - 42,002,980 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0542,180,485 - 42,194,883 (-)NCBIUU_Cfam_GSD_1.0
Med9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,747,281 - 61,783,426 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,106,741 - 1,120,053 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,083,822 - 1,119,967 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MED9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1260,906,718 - 60,933,944 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11260,925,161 - 60,933,999 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21263,124,513 - 63,133,351 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MED9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11616,513,144 - 16,527,880 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1616,512,898 - 16,527,875 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660594,385,612 - 4,400,663 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Med9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,920,268 - 3,934,777 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,920,046 - 3,934,748 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Med9
317 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:513
Count of miRNA genes:385
Interacting mature miRNAs:429
Transcripts:ENSMUST00000081980
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5528498572209927Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115849055574754758Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
11532697Sluc36_msusceptibility to lung cancer 36 (mouse)115925661769482699Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
13513917Heal54_mwound healing/ regeneration 54 (mouse)115787291759879610Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse

Markers in Region
UniSTS:236590  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381159,963,261 - 59,963,503UniSTSGRCm38
MGSCv371159,776,763 - 59,777,005UniSTSGRCm37
Cytogenetic Map11B1.3UniSTS
Cytogenetic Map11B2UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000081980   ⟹   ENSMUSP00000080641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1159,839,032 - 59,853,031 (+)Ensembl
GRCm38.p6 Ensembl1159,948,206 - 59,962,205 (+)Ensembl
RefSeq Acc Id: NM_138675   ⟹   NP_619616
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391159,839,040 - 59,854,132 (+)NCBI
GRCm381159,948,214 - 59,963,306 (+)ENTREZGENE
MGSCv371159,761,716 - 59,776,808 (+)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_619616 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH19367 (Get FASTA)   NCBI Sequence Viewer  
  AAL77034 (Get FASTA)   NCBI Sequence Viewer  
  BAC36735 (Get FASTA)   NCBI Sequence Viewer  
  BAE27694 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000080641
  ENSMUSP00000080641.7
GenBank Protein Q8VCS6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_619616   ⟸   NM_138675
- UniProtKB: Q8BHQ8 (UniProtKB/Swiss-Prot),   Q8R5H4 (UniProtKB/Swiss-Prot),   Q8VCS6 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000080641   ⟸   ENSMUST00000081980

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCS6-F1-model_v2 AlphaFold Q8VCS6 1-142 view protein structure

Promoters
RGD ID:6821952
Promoter ID:MM_KWN:7676
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day2,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung
Transcripts:OTTMUST00000018404,   OTTMUST00000018405,   OTTMUST00000018406,   OTTMUST00000018413
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361159,761,751 - 59,762,257 (-)MPROMDB
RGD ID:8674854
Promoter ID:EPDNEW_M15458
Type:initiation region
Name:Med9_1
Description:Mus musculus mediator complex subunit 9 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381159,948,243 - 59,948,303EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2183151 AgrOrtholog
Ensembl Genes ENSMUSG00000061650 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000081980 ENTREZGENE
  ENSMUST00000081980.7 UniProtKB/Swiss-Prot
Gene3D-CATH Mediator complex, subunit Med21 UniProtKB/Swiss-Prot
InterPro Med7/Med21-like UniProtKB/Swiss-Prot
  Med9 UniProtKB/Swiss-Prot
  MED9_metazoa UniProtKB/Swiss-Prot
KEGG Report mmu:192191 UniProtKB/Swiss-Prot
MGD MGI:2183151 ENTREZGENE
NCBI Gene 192191 ENTREZGENE
PANTHER MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9 UniProtKB/Swiss-Prot
  PTHR20844 UniProtKB/Swiss-Prot
Pfam Med9 UniProtKB/Swiss-Prot
PhenoGen Med9 PhenoGen
Superfamily-SCOP SSF140718 UniProtKB/Swiss-Prot
UniProt MED9_MOUSE UniProtKB/Swiss-Prot
  Q8BHQ8 ENTREZGENE
  Q8R5H4 ENTREZGENE
  Q8VCS6 ENTREZGENE
UniProt Secondary Q8BHQ8 UniProtKB/Swiss-Prot
  Q8R5H4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-26 Med9  mediator complex subunit 9    mediator of RNA polymerase II transcription, subunit 9 homolog (yeast)  Symbol and/or name change 5135510 APPROVED