Bhlhe23 (basic helix-loop-helix family, member e23) - Rat Genome Database

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Gene: Bhlhe23 (basic helix-loop-helix family, member e23) Mus musculus
Analyze
Symbol: Bhlhe23
Name: basic helix-loop-helix family, member e23
RGD ID: 1557310
MGI Page MGI
Description: Predicted to enable DNA-binding transcription factor activity and E-box binding activity. Acts upstream of or within eye morphogenesis; negative regulation of retinal cell programmed cell death; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including brain; branchial arch; limb; maxillary process; and urinary system. Orthologous to human BHLHE23 (basic helix-loop-helix family member e23).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A930001L02Rik; basic helix-loop-helix domain containing, class B4; beta-cell E-box transactivating factor 4; Beta3b; BETA4; Bhlhb; Bhlhb4; class B basic helix-loop-helix protein 4; class E basic helix-loop-helix protein 23
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,416,174 - 180,418,693 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,416,174 - 180,418,693 (-)EnsemblGRCm39 Ensembl
GRCm382180,774,381 - 180,776,900 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,774,381 - 180,776,900 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,509,086 - 180,511,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,704,066 - 180,706,308 (-)NCBIMGSCv36mm8
Celera2184,860,531 - 184,863,050 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. MGD IEA MGD IEA
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11863370   PMID:12477932   PMID:14681479   PMID:15342729   PMID:15363390   PMID:15618518   PMID:16141072  
PMID:16141073   PMID:16602821   PMID:16702404   PMID:17255172   PMID:17729296   PMID:18260140   PMID:18287559   PMID:18479186   PMID:19279136   PMID:19357274   PMID:19521566   PMID:20018684  
PMID:20059953   PMID:20463215   PMID:21267068   PMID:21858141   PMID:21873635   PMID:23756994   PMID:24528677   PMID:24952961   PMID:25556712   PMID:29394901   PMID:29615777   PMID:30872278  


Genomics

Comparative Map Data
Bhlhe23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392180,416,174 - 180,418,693 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2180,416,174 - 180,418,693 (-)EnsemblGRCm39 Ensembl
GRCm382180,774,381 - 180,776,900 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2180,774,381 - 180,776,900 (-)EnsemblGRCm38mm10GRCm38
MGSCv372180,509,086 - 180,511,605 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362180,704,066 - 180,706,308 (-)NCBIMGSCv36mm8
Celera2184,860,531 - 184,863,050 (-)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.34NCBI
BHLHE23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,005,927 - 63,006,964 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,005,927 - 63,007,035 (-)EnsemblGRCh38hg38GRCh38
GRCh372061,637,279 - 61,638,316 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,107,846 - 61,108,787 (-)NCBINCBI36Build 36hg18NCBI36
Build 342061,107,846 - 61,108,787NCBI
Celera2058,313,980 - 58,315,036 (-)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2058,354,584 - 58,355,640 (-)NCBIHuRef
CHM1_12061,538,035 - 61,539,091 (-)NCBICHM1_1
T2T-CHM13v2.02064,806,267 - 64,807,304 (-)NCBIT2T-CHM13v2.0
Bhlhe23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,266,572 - 188,268,786 (-)NCBIGRCr8
mRatBN7.23167,889,009 - 167,891,223 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,889,009 - 167,891,223 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3172,268,753 - 172,270,967 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,227,851 - 181,230,065 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,889,943 - 177,892,157 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03176,279,997 - 176,282,211 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3176,279,997 - 176,282,211 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03179,978,577 - 179,980,791 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,886,343 - 169,888,557 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3164,692,856 - 164,695,070 (+)NCBICelera
Cytogenetic Map3q43NCBI
Bhlhe23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555281,094,234 - 1,094,674 (+)NCBIChiLan1.0ChiLan1.0
BHLHE23
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22168,789,672 - 68,792,505 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12068,783,116 - 68,785,624 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02059,385,608 - 59,392,078 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12060,681,496 - 60,681,988 (-)NCBIpanpan1.1PanPan1.1panPan2
BHLHE23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12446,791,368 - 46,792,019 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2445,975,704 - 45,976,372 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02447,663,555 - 47,669,166 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.02446,884,708 - 46,885,377 (-)NCBIUNSW_CanFamBas_1.0
BHLHE23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,227,916 - 62,228,638 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,217,583 - 62,228,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BHLHE23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121,215,909 - 1,221,960 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21,216,206 - 1,216,883 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605049,005,375 - 49,006,567 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bhlhe23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474128,766,303 - 28,766,920 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474128,762,079 - 28,766,989 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bhlhe23
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:580
Count of miRNA genes:416
Interacting mature miRNAs:453
Transcripts:ENSMUST00000061098, ENSMUST00000108878
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
1300867Lore2_mloss of righting induced by ethanol 2 (mouse)Not determined2144515861180896594Mouse
12790983Bwq12_mbody weight QTL 12 (mouse)2148238204181755017Mouse
4142211Nilac3_mnicotine induced locomotor activity 3 (mouse)Not determined2148664893181755017Mouse
1558917Gct8_mgranulosa cell tumorigenesis 8 (mouse)Not determined2149236907181755017Mouse
1300751Bdt1_mbone density traits 1 (mouse)Not determined2149988902181755017Mouse
1301085Lrnx10_mlearning-contextual 10 (mouse)Not determined2150212221181755017Mouse
11038701Ltpr2e_mLeishmania tropica response 2e (mouse)2150212221181755017Mouse
4142450Lmr16_mleishmaniasis resistance 16 (mouse)Not determined2150212221181755017Mouse
1301019Bmd6_mbone mineral density 6 (mouse)Not determined2151778297181755017Mouse
14747002Mancz3_mmandible centroid size 3 (mouse)2152329820181755017Mouse
1300622Cfld1_mcystic fibrosis lung disease 1 (mouse)Not determined2155823920181755017Mouse
1357537Lith12_mlithogenic gene 12 (mouse)Not determined2156196464181755017Mouse
1302003Sluc17_msusceptibility to lung cancer 17 (mouse)Not determined2162433493181755017Mouse
1301677Alcp6_malcohol preference locus 6 (mouse)Not determined2163486407181755017Mouse
1301348Alcp5_malcohol preference locus 5 (mouse)Not determined2163486407181755017Mouse
1300676Prdt2_mprion disease incubation time 2 (mouse)Not determined2164515154181755017Mouse
1558748Vacq1_mvoluntary alcohol consumption QTL 1 (mouse)Not determined2178442338181515280Mouse

Markers in Region
UniSTS:491544  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382180,775,416 - 180,776,810UniSTSGRCm38
MGSCv372180,510,121 - 180,511,515UniSTSGRCm37
Celera2184,861,566 - 184,862,960UniSTS
Cytogenetic Map2H3-H4UniSTS
Bhlhe23  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map2H3-H4UniSTS
cM Map2103.34UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000108878   ⟹   ENSMUSP00000104506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2180,416,174 - 180,418,693 (-)Ensembl
GRCm38.p6 Ensembl2180,774,381 - 180,776,900 (-)Ensembl
RefSeq Acc Id: NM_080641   ⟹   NP_542372
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392180,416,174 - 180,418,693 (-)NCBI
GRCm382180,774,381 - 180,776,900 (-)ENTREZGENE
MGSCv372180,509,086 - 180,511,605 (-)RGD
Celera2184,860,531 - 184,863,050 (-)RGD
cM Map2 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_542372   ⟸   NM_080641
- UniProtKB: Q71MB7 (UniProtKB/Swiss-Prot),   Q8BGW3 (UniProtKB/Swiss-Prot),   Q0VEJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000104506   ⟸   ENSMUST00000108878
Protein Domains
bHLH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8BGW3-F1-model_v2 AlphaFold Q8BGW3 1-223 view protein structure

Promoters
RGD ID:6880088
Promoter ID:EPDNEW_M3495
Type:single initiation site
Name:Bhlhe23_1
Description:Mus musculus basic helix-loop-helix family, member e23 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382180,776,900 - 180,776,960EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2153710 AgrOrtholog
Ensembl Genes ENSMUSG00000045493 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000108878 ENTREZGENE
  ENSMUST00000108878.2 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.280.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:140489 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2153710 ENTREZGENE
NCBI Gene 140489 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19290:SF53 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bhlhe23 PhenoGen
PROSITE BHLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HLH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt BHE23_MOUSE UniProtKB/Swiss-Prot
  Q0VEJ8 ENTREZGENE, UniProtKB/TrEMBL
  Q71MB7 ENTREZGENE
  Q8BGW3 ENTREZGENE
UniProt Secondary Q71MB7 UniProtKB/Swiss-Prot