Chst5 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5) - Rat Genome Database

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Gene: Chst5 (carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5) Mus musculus
Analyze
Symbol: Chst5
Name: carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
RGD ID: 1557219
MGI Page MGI
Description: Enables N-acetylglucosamine 6-O-sulfotransferase activity. Involved in N-acetylglucosamine metabolic process and keratan sulfate biosynthetic process. Predicted to be located in Golgi apparatus. Predicted to be active in trans-Golgi network. Is expressed in several structures, including limb; pharynx; respiratory system; skeleton; and tail. Human ortholog(s) of this gene implicated in macular corneal dystrophy. Orthologous to several human genes including CHST6 (carbohydrate sulfotransferase 6).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI173964; carbohydrate sulfotransferase 5; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4; glcNAc6ST-3; Gn6st-3; GST-; GST-4; GST4; I-GlcN; I-GlcNAc-6-ST; I-GlcNAc6ST; intestinal GlcNAc-6-sulfotransferase; intestinal N-acetylglucosamine-6-O-sulfotransferase; mIGn6ST; N-acetylglucosamine 6-O-sulfotransferase 3
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,615,767 - 112,636,831 (-)NCBIGRCm39mm39
GRCm39 Ensembl8112,615,768 - 112,637,079 (-)Ensembl
GRCm388111,889,135 - 111,910,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,889,136 - 111,910,447 (-)EnsemblGRCm38mm10GRCm38
MGSCv378114,413,035 - 114,434,099 (-)NCBIGRCm37mm9NCBIm37
MGSCv368114,775,809 - 114,815,449 (-)NCBImm8
Celera8116,117,689 - 116,138,892 (-)NCBICelera
Cytogenetic Map8E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10491328   PMID:11181564   PMID:11278593   PMID:12218059   PMID:14610273   PMID:14681479   PMID:16938851   PMID:18799693   PMID:21267068   PMID:21440637   PMID:21677750   PMID:21873635  
PMID:27626380   PMID:30867513  


Genomics

Comparative Map Data
Chst5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398112,615,767 - 112,636,831 (-)NCBIGRCm39mm39
GRCm39 Ensembl8112,615,768 - 112,637,079 (-)Ensembl
GRCm388111,889,135 - 111,910,199 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,889,136 - 111,910,447 (-)EnsemblGRCm38mm10GRCm38
MGSCv378114,413,035 - 114,434,099 (-)NCBIGRCm37mm9NCBIm37
MGSCv368114,775,809 - 114,815,449 (-)NCBImm8
Celera8116,117,689 - 116,138,892 (-)NCBICelera
Cytogenetic Map8E1NCBI
CHST6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381675,472,042 - 75,495,441 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1675,472,052 - 75,495,445 (-)EnsemblGRCh38hg38GRCh38
GRCh371675,505,940 - 75,529,339 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361674,064,523 - 74,086,427 (-)NCBINCBI36hg18NCBI36
Build 341674,064,525 - 74,086,427NCBI
Celera1659,801,332 - 59,823,234 (-)NCBI
Cytogenetic Map16q23.1NCBI
HuRef1661,258,395 - 61,267,163 (-)NCBIHuRef
CHM1_11676,919,368 - 76,941,254 (-)NCBICHM1_1
T2T-CHM13v2.01681,520,232 - 81,543,637 (-)NCBI
Chst5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21939,860,729 - 39,881,019 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1939,860,501 - 39,881,064 (-)Ensembl
Rnor_6.01944,115,065 - 44,136,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1944,115,120 - 44,135,387 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,922,189 - 54,942,505 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41941,830,419 - 41,850,686 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1939,220,192 - 39,241,612 (-)NCBICelera
Cytogenetic Map19q12NCBI
CHST6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11675,389,610 - 75,410,263 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1675,394,187 - 75,395,374 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01656,041,518 - 56,062,463 (-)NCBIMhudiblu_PPA_v0panPan3
LOC489707
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1575,266,932 - 75,280,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha575,243,924 - 75,257,918 (+)NCBI
ROS_Cfam_1.0575,580,429 - 75,594,782 (+)NCBI
UMICH_Zoey_3.1575,516,316 - 75,530,593 (+)NCBI
UNSW_CanFamBas_1.0575,351,643 - 75,365,789 (+)NCBI
UU_Cfam_GSD_1.0575,842,944 - 75,856,924 (+)NCBI
LOC100522551
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1612,166,178 - 12,188,165 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2612,006,544 - 12,029,057 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHST6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,962,903 - 60,979,834 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604715,080,448 - 15,098,439 (+)NCBIVero_WHO_p1.0
Chst6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474611,429,970 - 11,444,277 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AI173964  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388111,889,229 - 111,889,517UniSTSGRCm38
MGSCv378114,413,129 - 114,413,417UniSTSGRCm37
Celera8116,117,783 - 116,118,071UniSTS
Cytogenetic Map8E1UniSTS
Whitehead/MRC_RH81345.78UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832506572117965439Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined835109930115563747Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871740461124622354Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71740461124622354Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)874126628126826739Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined879245241113245331Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879808806113809031Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881819296115819296Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)882345783116345783Mouse
1301766Desp1_mdespair 1 (mouse)Not determined885486208119486373Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined886443553120443701Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined886443553120443701Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined886443553120443701Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889726628130027694Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined896245241129745061Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)897626632130127694Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)898390634130127694Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined898563635130127694Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899828531130127694Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899828531130127694Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100965309130127694Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8102486208116025457Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8103443553127781786Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8105033977130127694Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8105033977130127694Mouse
14746994Manh65_mmandible shape 65 (mouse)8106489629130127694Mouse
36049780Ars12_mantibody response to SARS-CoV 12, 4 days post-rechallenge, IgM (mouse)8109426632113826632Mouse
36049781Arc1_mantibody response to CHIKV 1, day 7, IgG (mouse)8109426632113826632Mouse
36049782Arc2_mantibody response to CHIKV 2, day 7, IgM (mouse)8109426632113826632Mouse
36049783Arc3_mantibody response to CHIKV 3, day 7, FRNT50 (mouse)8109426632113826632Mouse
35673316Ari3_mantibody response to influenza 3, day 15, IgM (mouse)8109426632113826632Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8110415083130127694Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8110415083130127694Mouse
11079194Tpnr6_mthermal pain response 6 (mouse)8111166632114956740Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8111481497130127694Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8111481497130127694Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:244
Count of miRNA genes:202
Interacting mature miRNAs:217
Transcripts:ENSMUST00000034430
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034430   ⟹   ENSMUSP00000034430
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl8112,615,768 - 112,637,079 (-)Ensembl
GRCm38.p6 Ensembl8111,889,136 - 111,910,447 (-)Ensembl
RefSeq Acc Id: NM_019950   ⟹   NP_064334
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398112,615,767 - 112,636,831 (-)NCBI
GRCm388111,889,135 - 111,910,199 (-)ENTREZGENE
MGSCv378114,413,035 - 114,434,099 (-)RGD
Celera8116,117,689 - 116,138,892 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_064334 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD56002 (Get FASTA)   NCBI Sequence Viewer  
  AAD56003 (Get FASTA)   NCBI Sequence Viewer  
  EDL11517 (Get FASTA)   NCBI Sequence Viewer  
  Q9QUP4 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_064334   ⟸   NM_019950
- Peptide Label: precursor
- UniProtKB: Q9QUP4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000034430   ⟸   ENSMUST00000034430

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUP4-F1-model_v2 AlphaFold Q9QUP4 1-395 view protein structure

Promoters
RGD ID:8668331
Promoter ID:EPDNEW_M12196
Type:single initiation site
Name:Chst5_1
Description:Mus musculus carbohydrate (N-acetylglucosamine 6-O) sulfotransferase5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388111,910,177 - 111,910,237EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1931825 AgrOrtholog
Ensembl Genes ENSMUSG00000031952 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000034430 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000034430 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro Carbohydrate_sulfotransferase UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Sulfotransferase_dom UniProtKB/Swiss-Prot
KEGG Report mmu:56773 UniProtKB/Swiss-Prot
MGD MGI:1931825 ENTREZGENE
NCBI Gene 56773 ENTREZGENE
Pfam Sulfotransfer_1 UniProtKB/Swiss-Prot
PhenoGen Chst5 PhenoGen
PIRSF Carbohydrate_sulfotransferase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt CHST5_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE