Dtx3l (deltex 3-like, E3 ubiquitin ligase) - Rat Genome Database

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Gene: Dtx3l (deltex 3-like, E3 ubiquitin ligase) Mus musculus
Analyze
Symbol: Dtx3l
Name: deltex 3-like, E3 ubiquitin ligase
RGD ID: 1557213
MGI Page MGI
Description: Predicted to enable several functions, including STAT family protein binding activity; histone H4K91 ubiquitin ligase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization; and protein ubiquitination. Predicted to act upstream of or within several processes, including DNA repair; chromatin organization; and defense response to symbiont. Predicted to be located in cytosol; lysosome; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to colocalize with early endosome. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and oral cavity. Orthologous to human DTX3L (deltex E3 ubiquitin ligase 3L).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AU042200; BC023741; deltex 3-like; E3 ubiquitin-protein ligase DTX3L; MGC103262; protein deltex-3-like; RING-type E3 ubiquitin transferase DTX3L
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,746,885 - 35,759,397 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1635,746,881 - 35,759,521 (-)EnsemblGRCm39 Ensembl
GRCm381635,926,515 - 35,939,027 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,926,511 - 35,939,151 (-)EnsemblGRCm38mm10GRCm38
MGSCv371635,926,601 - 35,939,113 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361635,846,258 - 35,858,670 (-)NCBIMGSCv36mm8
Celera1636,406,742 - 36,419,270 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10725249   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:14691545   PMID:16141072   PMID:16141073   PMID:18069692   PMID:18287559  
PMID:18799693   PMID:21267068   PMID:21873635   PMID:26479788   PMID:28263185   PMID:32554809  


Genomics

Comparative Map Data
Dtx3l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391635,746,885 - 35,759,397 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1635,746,881 - 35,759,521 (-)EnsemblGRCm39 Ensembl
GRCm381635,926,515 - 35,939,027 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1635,926,511 - 35,939,151 (-)EnsemblGRCm38mm10GRCm38
MGSCv371635,926,601 - 35,939,113 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361635,846,258 - 35,858,670 (-)NCBIMGSCv36mm8
Celera1636,406,742 - 36,419,270 (-)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1625.43NCBI
DTX3L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383122,564,338 - 122,575,203 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3122,564,338 - 122,575,203 (+)EnsemblGRCh38hg38GRCh38
GRCh373122,283,185 - 122,294,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363123,765,956 - 123,775,973 (+)NCBINCBI36Build 36hg18NCBI36
Build 343123,765,955 - 123,775,966NCBI
Celera3120,692,995 - 120,703,860 (+)NCBICelera
Cytogenetic Map3q21.1NCBI
HuRef3119,656,463 - 119,667,327 (+)NCBIHuRef
CHM1_13122,246,867 - 122,257,728 (+)NCBICHM1_1
T2T-CHM13v2.03125,283,584 - 125,294,443 (+)NCBIT2T-CHM13v2.0
Dtx3l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81178,320,225 - 78,329,837 (+)NCBIGRCr8
mRatBN7.21164,814,926 - 64,824,539 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1164,814,926 - 64,824,538 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1173,639,962 - 73,649,453 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,302,229 - 66,311,720 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01165,333,475 - 65,342,966 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,758,093 - 67,767,623 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01167,768,542 - 67,772,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,757,928 - 67,767,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01170,846,234 - 70,855,845 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41166,649,508 - 66,659,119 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1164,280,848 - 64,290,468 (+)NCBICelera
Cytogenetic Map11q22NCBI
Dtx3l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542721,806,192 - 21,815,031 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542721,806,170 - 21,812,701 (+)NCBIChiLan1.0ChiLan1.0
DTX3L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22120,459,715 - 120,519,800 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13120,464,495 - 120,521,883 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03119,654,019 - 119,664,918 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13126,510,372 - 126,569,813 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3126,558,924 - 126,569,807 (+)Ensemblpanpan1.1panPan2
DTX3L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13325,676,686 - 25,684,270 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3325,677,076 - 25,684,175 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3325,700,998 - 25,708,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03325,911,755 - 25,919,417 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3325,912,140 - 25,919,608 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13325,708,920 - 25,716,524 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03325,752,223 - 25,759,866 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03326,309,779 - 26,317,453 (+)NCBIUU_Cfam_GSD_1.0
Dtx3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602128,668,583 - 128,677,233 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365368,844,575 - 8,851,146 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365368,844,778 - 8,853,442 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DTX3L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13137,950,272 - 137,961,343 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113137,950,266 - 137,961,381 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213147,572,591 - 147,581,251 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DTX3L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12258,287,331 - 58,298,519 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2258,290,764 - 58,298,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041108,048,854 - 108,059,822 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dtx3l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624912871,584 - 880,626 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624912871,024 - 880,299 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dtx3l
527 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1283
Count of miRNA genes:678
Interacting mature miRNAs:828
Transcripts:ENSMUST00000081933, ENSMUST00000114885
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16331786439820362Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16331786451420363Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16431786444520363Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16464631438646414Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16577525239775440Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16577525239775440Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16577525239775440Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16577525239775440Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16822605242226052Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined16988163143881631Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161184882445848923Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161222536046225471Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161480292148803032Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161552290949523112Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1300534Bmd15_mbone mineral density 15 (mouse)Not determined162193838355938574Mouse
4141179Ipng3_mimprinted postnatal growth 3 (mouse)Not determined2277525257594076Mouse
15092062Egrme4_mearly growth rate, maternal effect 4 (mouse)162521866444220250Mouse
11059559Lmr12a_mleishmaniasis resistance 12a (mouse)162879281362792952Mouse
11059560Lmr12b_mleishmaniasis resistance 12b (mouse)162879281362792952Mouse
11049571Lmr12c_mleishmaniasis resistance 12c (mouse)162879281362792952Mouse
1300915Lmr12_mleishmaniasis resistance 12 (mouse)Not determined162879281362792952Mouse
25671380Hrsq2_mhost response to SARS QTL 2, titer (mouse)163140250136540273Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse

Markers in Region
UniSTS:237503  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381635,926,577 - 35,926,796UniSTSGRCm38
MGSCv371635,926,663 - 35,926,882UniSTSGRCm37
Celera1636,406,804 - 36,407,023UniSTS
Cytogenetic Map16B3UniSTS
Dtx3l  
Mouse AssemblyChrPosition (strand)SourceJBrowse
cM Map16 UniSTS


Expression


Sequence


RefSeq Acc Id: ENSMUST00000081933   ⟹   ENSMUSP00000080601
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1635,746,881 - 35,759,521 (-)Ensembl
GRCm38.p6 Ensembl1635,926,511 - 35,939,151 (-)Ensembl
RefSeq Acc Id: ENSMUST00000114885   ⟹   ENSMUSP00000110535
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1635,752,230 - 35,759,521 (-)Ensembl
GRCm38.p6 Ensembl1635,931,860 - 35,939,151 (-)Ensembl
RefSeq Acc Id: NM_001013371   ⟹   NP_001013389
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391635,746,885 - 35,759,397 (-)NCBI
GRCm381635,926,515 - 35,939,027 (-)ENTREZGENE
MGSCv371635,926,601 - 35,939,113 (-)RGD
Celera1636,406,742 - 36,419,270 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_001013389   ⟸   NM_001013371
- UniProtKB: Q8BN11 (UniProtKB/Swiss-Prot),   Q3UIR3 (UniProtKB/Swiss-Prot),   I6L9G8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000080601   ⟸   ENSMUST00000081933
RefSeq Acc Id: ENSMUSP00000110535   ⟸   ENSMUST00000114885
Protein Domains
RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3UIR3-F1-model_v2 AlphaFold Q3UIR3 1-748 view protein structure

Promoters
RGD ID:8686090
Promoter ID:EPDNEW_M21076
Type:initiation region
Name:Dtx3l_1
Description:Mus musculus deltex 3-like, E3 ubiquitin ligase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381635,938,900 - 35,938,960EPDNEW
RGD ID:6826986
Promoter ID:MM_KWN:20887
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000055814,   ENSMUST00000114885,   OTTMUST00000057688
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361635,938,961 - 35,939,997 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2656973 AgrOrtholog
Ensembl Genes ENSMUSG00000049502 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000081933 ENTREZGENE
  ENSMUST00000081933.14 UniProtKB/Swiss-Prot
  ENSMUST00000114885.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.390.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Deltex_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Deltex_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Deltex_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DTX3L_a/b_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DTX3L_KH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2656973 ENTREZGENE
NCBI Gene 209200 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE DTX3L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12622 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DTC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DTX3L_a-b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DTX3L_KH-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C3HC4_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dtx3l PhenoGen
PROSITE ZF_RING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DTX3L_MOUSE UniProtKB/Swiss-Prot
  I6L9G8 ENTREZGENE, UniProtKB/TrEMBL
  Q3UIR3 ENTREZGENE
  Q8BN11 ENTREZGENE
UniProt Secondary Q8BN11 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-29 Dtx3l  deltex 3-like, E3 ubiquitin ligase    deltex 3-like (Drosophila)  Symbol and/or name change 5135510 APPROVED