Clpp (caseinolytic mitochondrial matrix peptidase proteolytic subunit) - Rat Genome Database

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Gene: Clpp (caseinolytic mitochondrial matrix peptidase proteolytic subunit) Mus musculus
Analyze
Symbol: Clpp
Name: caseinolytic mitochondrial matrix peptidase proteolytic subunit
RGD ID: 1557209
MGI Page MGI
Description: Predicted to enable ATPase binding activity; identical protein binding activity; and peptidase activity. Predicted to be involved in membrane protein proteolysis and protein quality control for misfolded or incompletely synthesized proteins. Located in mitochondrion. Is expressed in several structures, including early conceptus; heart; liver; pancreas; and placenta. Used to study Perrault syndrome. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human CLPP (caseinolytic mitochondrial matrix peptidase proteolytic subunit).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-dependent Clp protease proteolytic subunit, mitochondrial; AU019820; caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog; caseinolytic protease, ATP-dependent, proteolytic subunit homolog; ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit; D17Wsu160; D17Wsu160e; endopeptidase Clp; putative ATP-dependent Clp protease proteolytic subunit, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,297,264 - 57,303,371 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,297,305 - 57,303,188 (+)EnsemblGRCm39 Ensembl
GRCm381756,990,264 - 56,996,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,990,305 - 56,996,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv371757,129,687 - 57,135,794 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,675,433 - 56,681,311 (+)NCBIMGSCv36mm8
Celera1761,338,190 - 61,344,297 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
endopeptidase Clp complex  (IBA,ISO,ISS)
mitochondrial matrix  (ISO,ISS)
mitochondrion  (HDA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal auditory brainstem response  (IEA)
abnormal bone structure  (IEA)
abnormal cellular respiration  (IAGP)
abnormal granulosa cell morphology  (IAGP)
abnormal oogenesis  (IAGP)
abnormal seminiferous tubule epithelium morphology  (IAGP)
abnormal T cell activation  (IAGP)
arrest of spermatogenesis  (IAGP)
azoospermia  (IAGP)
decreased body length  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased CD4-positive NK T cell number  (IEA)
decreased circulating fructosamine level  (IEA)
decreased circulating glucose level  (IEA)
decreased corpora lutea number  (IAGP)
decreased effector memory CD8-positive, alpha-beta T cell number  (IEA)
decreased fibroblast proliferation  (IAGP)
decreased gamma-delta T cell number  (IEA)
decreased lean body mass  (IEA)
decreased locomotor activity  (IAGP)
decreased memory-marker CD4-negative NK T cell number  (IEA)
decreased memory-marker CD4-positive NK T cell number  (IEA)
decreased NK T cell number  (IEA)
decreased red blood cell distribution width  (IEA)
decreased startle reflex  (IAGP)
decreased susceptibility to weight gain  (IAGP)
decreased total body fat amount  (IEA)
decreased vertical activity  (IAGP)
dermatitis  (IAGP)
disorganized mitochondrial cristae  (IAGP)
early cellular replicative senescence  (IAGP)
female infertility  (IAGP)
increased B cell number  (IEA)
increased circulating alkaline phosphatase level  (IEA)
increased circulating aspartate transaminase level  (IEA)
increased circulating bilirubin level  (IEA)
increased circulating cholesterol level  (IEA)
increased circulating glycerol level  (IEA)
increased circulating iron level  (IEA)
increased circulating serum albumin level  (IEA)
increased embryonic tissue cell apoptosis  (IAGP)
increased granulosa cell apoptosis  (IAGP)
increased hematocrit  (IEA)
increased hemoglobin content  (IEA)
increased KLRG1-positive NK cell number  (IEA)
increased lean body mass  (IEA)
increased leukocyte cell number  (IEA)
increased Ly6C high monocyte number  (IEA)
increased Ly6C low monocyte number  (IEA)
increased mature B cell number  (IEA)
increased mean corpuscular hemoglobin  (IEA)
increased mitochondrial DNA content  (IAGP)
increased mitochondrial size  (IAGP)
increased monocyte cell number  (IEA)
increased total body fat amount  (IEA)
male infertility  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
small ovary  (IAGP)
small testis  (IAGP)
thrombocytopenia  (IEA)
tremors  (IEA)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, etal., Hum Mol Genet 1998 Nov;7(12):1967-78.
4. MGDs mouse GO annotations MGD data from the GO Consortium
5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10347188   PMID:10349636   PMID:10754102   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:18614015   PMID:18799693   PMID:19154341   PMID:21677750   PMID:21873635   PMID:22673621   PMID:23851121   PMID:25921334   PMID:26058080   PMID:26721594   PMID:27154400  
PMID:27797820   PMID:29420235   PMID:29588285   PMID:29851234   PMID:30457570   PMID:30550785   PMID:30877431   PMID:30973865   PMID:31939198   PMID:32242014   PMID:32342250   PMID:32467259  
PMID:33731338   PMID:34943861   PMID:34974310   PMID:35240691   PMID:35293971   PMID:35385313   PMID:35794401   PMID:36167966   PMID:36611846   PMID:36841836   PMID:37798322   PMID:38139332  
PMID:38266827   PMID:38339144   PMID:38355793   PMID:38397478   PMID:38927630  


Genomics

Comparative Map Data
Clpp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,297,264 - 57,303,371 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,297,305 - 57,303,188 (+)EnsemblGRCm39 Ensembl
GRCm381756,990,264 - 56,996,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,990,305 - 56,996,188 (+)EnsemblGRCm38mm10GRCm38
MGSCv371757,129,687 - 57,135,794 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,675,433 - 56,681,311 (+)NCBIMGSCv36mm8
Celera1761,338,190 - 61,344,297 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.61NCBI
CLPP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,361,531 - 6,370,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,361,531 - 6,370,242 (+)EnsemblGRCh38hg38GRCh38
GRCh37196,361,542 - 6,370,253 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,312,463 - 6,319,915 (+)NCBINCBI36Build 36hg18NCBI36
Build 34196,312,462 - 6,319,915NCBI
Celera196,300,249 - 6,307,702 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,121,624 - 6,129,060 (+)NCBIHuRef
CHM1_1196,361,087 - 6,368,540 (+)NCBICHM1_1
T2T-CHM13v2.0196,350,432 - 6,359,144 (+)NCBIT2T-CHM13v2.0
Clpp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,917,305 - 1,924,706 (+)NCBIGRCr8
mRatBN7.291,831,680 - 1,837,700 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,830,311 - 1,837,693 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,265,916 - 2,271,581 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,615,274 - 7,620,940 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,571,135 - 6,576,801 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,048,715 - 10,056,068 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,048,886 - 10,054,359 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,049,365 - 9,055,397 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,679,585 - 6,686,938 (-)NCBICelera
Cytogenetic Map9q11NCBI
Clpp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,223,709 - 3,233,562 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,224,968 - 3,233,482 (-)NCBIChiLan1.0ChiLan1.0
CLPP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,762,202 - 10,769,604 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,988,131 - 9,995,526 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,382,323 - 5,389,788 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,304,462 - 6,312,077 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,304,462 - 6,312,077 (+)Ensemblpanpan1.1panPan2
CLPP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,788,114 - 53,794,217 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,788,164 - 53,794,174 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,535,022 - 53,541,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,442,379 - 54,448,486 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,440,903 - 54,448,555 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,508,841 - 53,514,945 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,957,180 - 53,963,271 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,186,933 - 54,193,048 (-)NCBIUU_Cfam_GSD_1.0
Clpp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,106,746 - 214,111,595 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,722,941 - 3,731,439 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,723,188 - 3,728,037 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLPP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,707,158 - 72,713,475 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,707,363 - 72,713,481 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,220,872 - 73,226,365 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLPP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,977,339 - 5,984,926 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,977,450 - 5,986,919 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660812,038,458 - 2,046,910 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Clpp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248283,498,794 - 3,505,769 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248283,499,141 - 3,505,774 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Clpp
222 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:142
Interacting mature miRNAs:160
Transcripts:ENSMUST00000002735
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
4142243Lfnq5_mlung function QTL 5 (mouse)Not determined5173897957534623Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
14700692Cihvtq1_mcoxsackieviral infection heart viral titre QTL 1 (mouse)175000702870006995Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse

Markers in Region
RH136298  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381756,995,930 - 56,996,130UniSTSGRCm38
MGSCv371757,135,353 - 57,135,553UniSTSGRCm37
Celera1761,343,856 - 61,344,056UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17E1.1UniSTS
cM Map1734.0UniSTS
Clpp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371757,129,305 - 57,129,515UniSTSGRCm37
Celera1761,337,808 - 61,338,018UniSTS
Cytogenetic Map17DUniSTS
cM Map1734.0UniSTS
D17Wsu160e  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381756,995,984 - 56,996,176UniSTSGRCm38
MGSCv371757,135,407 - 57,135,599UniSTSGRCm37
Celera1761,343,910 - 61,344,102UniSTS
Cytogenetic Map17DUniSTS
Cytogenetic Map17E1.1UniSTS
cM Map1734.0UniSTS
cM Map1737.0UniSTS
Clpp  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381756,989,882 - 56,990,092UniSTSGRCm38
MGSCv371757,129,305 - 57,129,515UniSTSGRCm37
Celera1761,337,808 - 61,338,018UniSTS
Cytogenetic Map17DUniSTS
cM Map1734.0UniSTS


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC073683 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ005253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ012253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ238606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK002238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK147719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY294002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000002735   ⟹   ENSMUSP00000002735
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,297,305 - 57,303,188 (+)Ensembl
GRCm38.p6 Ensembl1756,990,305 - 56,996,188 (+)Ensembl
Ensembl Acc Id: ENSMUST00000233845
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,297,392 - 57,297,825 (+)Ensembl
GRCm38.p6 Ensembl1756,990,392 - 56,990,825 (+)Ensembl
RefSeq Acc Id: NM_017393   ⟹   NP_059089
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391757,297,264 - 57,303,371 (+)NCBI
GRCm381756,990,264 - 56,996,371 (+)ENTREZGENE
MGSCv371757,129,687 - 57,135,794 (+)RGD
Celera1761,338,190 - 61,344,297 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_059089   ⟸   NM_017393
- Peptide Label: precursor
- UniProtKB: Q3TI13 (UniProtKB/Swiss-Prot),   O88696 (UniProtKB/Swiss-Prot),   Q3UGW4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000002735   ⟸   ENSMUST00000002735

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88696-F1-model_v2 AlphaFold O88696 1-272 view protein structure

Promoters
RGD ID:13676556
Promoter ID:EPDNEW_M22427
Type:initiation region
Name:Clpp_1
Description:Mus musculus caseinolytic mitochondrial matrix peptidase proteolyticsubunit , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381756,990,313 - 56,990,373EPDNEW
RGD ID:6827945
Promoter ID:MM_KWN:23923
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_017393,   NM_017393_CLPP
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361757,129,231 - 57,129,847 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858213 AgrOrtholog
Ensembl Genes ENSMUSG00000002660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000002735 ENTREZGENE
  ENSMUST00000002735.9 UniProtKB/Swiss-Prot
InterPro ClpP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ClpP/crotonase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ClpP/TepA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ClpP_His_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ClpP_Ser_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:53895 UniProtKB/Swiss-Prot
MGD MGI:1858213 ENTREZGENE
NCBI Gene 53895 ENTREZGENE
PANTHER ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10381 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CLP_protease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Clpp PhenoGen
PRINTS CLPPROTEASEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CLP_PROTEASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLP_PROTEASE_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CLPP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TI13 ENTREZGENE
  Q3UGW4 ENTREZGENE, UniProtKB/TrEMBL
  Q8CF81_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TI13 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-10 Clpp  caseinolytic mitochondrial matrix peptidase proteolytic subunit    ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit  Symbol and/or name change 5135510 APPROVED
2012-07-10 Clpp  ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit  Clpp  caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)  Symbol and/or name change 5135510 APPROVED