Dnajb8 (DnaJ heat shock protein family (Hsp40) member B8) - Rat Genome Database
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Gene: Dnajb8 (DnaJ heat shock protein family (Hsp40) member B8) Mus musculus
Analyze
Symbol: Dnajb8
Name: DnaJ heat shock protein family (Hsp40) member B8
RGD ID: 1557173
MGI Page MGI
Description: Is expressed in brain. Orthologous to human DNAJB8 (DnaJ heat shock protein family (Hsp40) member B8); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 1700016F14Rik; 1700031F10Rik; AI326313; DnaJ (Hsp40) homolog, subfamily B, member 8; DnaJ homolog 6; dnaJ homolog subfamily B member 8; mDj6
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,199,250 - 88,200,238 (+)NCBIGRCm39mm39
GRCm39 Ensembl688,199,250 - 88,231,397 (+)Ensembl
GRCm38688,222,268 - 88,223,256 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,222,268 - 88,254,415 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,172,262 - 88,173,250 (+)NCBIGRCm37mm9NCBIm37
MGSCv36688,187,909 - 88,188,897 (+)NCBImm8
Celera690,159,479 - 90,160,467 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
nucleus  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11147971   PMID:12477932   PMID:15489334   PMID:15542836   PMID:16141072   PMID:16141073   PMID:22552285   PMID:26751205  


Genomics

Comparative Map Data
Dnajb8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39688,199,250 - 88,200,238 (+)NCBIGRCm39mm39
GRCm39 Ensembl688,199,250 - 88,231,397 (+)Ensembl
GRCm38688,222,268 - 88,223,256 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl688,222,268 - 88,254,415 (+)EnsemblGRCm38mm10GRCm38
MGSCv37688,172,262 - 88,173,250 (+)NCBIGRCm37mm9NCBIm37
MGSCv36688,187,909 - 88,188,897 (+)NCBImm8
Celera690,159,479 - 90,160,467 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map639.25NCBI
DNAJB8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3128,462,439 - 128,467,248 (-)EnsemblGRCh38hg38GRCh38
GRCh383128,462,434 - 128,467,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373128,181,280 - 128,186,091 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363129,663,972 - 129,668,781 (-)NCBINCBI36hg18NCBI36
Build 343129,663,979 - 129,668,789NCBI
Celera3126,609,282 - 126,614,086 (-)NCBI
Cytogenetic Map3q21.3NCBI
HuRef3125,565,298 - 125,570,109 (-)NCBIHuRef
CHM1_13128,144,266 - 128,149,077 (-)NCBICHM1_1
Dnajb8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24120,681,918 - 120,685,108 (+)NCBI
Rnor_6.0 Ensembl4120,156,659 - 120,159,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04120,156,640 - 120,159,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04185,398,092 - 185,401,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,302,712 - 122,303,707 (+)NCBIRGSC3.4rn4RGSC3.4
Celera4109,638,313 - 109,639,308 (+)NCBICelera
Cytogenetic Map4q34NCBI
Dnajb8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542915,349,564 - 15,350,268 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542915,349,346 - 15,350,343 (+)NCBIChiLan1.0ChiLan1.0
DNAJB8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13132,873,768 - 132,878,639 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3132,873,880 - 132,874,578 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03125,509,528 - 125,514,393 (-)NCBIMhudiblu_PPA_v0panPan3
DNAJB8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl202,453,297 - 2,453,650 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1202,453,100 - 2,454,152 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dnajb8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936798425,156 - 425,916 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJB8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1372,010,609 - 72,014,814 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11372,010,213 - 72,015,376 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21379,559,447 - 79,560,473 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNAJB8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12252,579,012 - 52,580,072 (+)NCBI
ChlSab1.1 Ensembl2252,579,259 - 52,579,957 (+)Ensembl
Dnajb8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624961170,909 - 171,985 (+)NCBI

Position Markers
Dnajb8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D2UniSTS
cM Map638.6UniSTS
AI326313  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38688,222,821 - 88,222,986UniSTSGRCm38
MGSCv37688,172,815 - 88,172,980UniSTSGRCm37
Celera690,160,032 - 90,160,197UniSTS
Cytogenetic Map6D1UniSTS
Cytogenetic Map6D2UniSTS
cM Map638.6UniSTS
Whitehead/MRC_RH6910.7UniSTS
Dnajb8  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6D2UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse
15039373Adip28_madiposity 28 (mouse)65630821190308211Mouse
15039375Bw41_mbody weight QTL 41 (mouse)65630821190308211Mouse
1558977Skmw10_mskeletal muscle weight 10 (mouse)Not determined65844758392447710Mouse
10043972Obq28_mobesity QTL 28 (mouse)Not determined65854043392540433Mouse
1301740Bwq2_mbody weight QTL 2 (mouse)Not determined66005768094057799Mouse
1301369Im4_mimmunoregulatory 4 (mouse)Not determined66348473897484905Mouse
1300650Bw18_mbody weight QTL 18 (mouse)Not determined666713869100714031Mouse
1301876Bits2_mbitterness sensitivity 2 (mouse)Not determined670425898104426034Mouse
1301813Skl3_mskeletal size (tail length) 3 (mouse)Not determined670425898104426034Mouse
1301034Egrm2_mearly growth rate (mouse)Not determined670425898104426034Mouse
1302020Bbaa20_mB.burgdorferi-associated arthritis 20 (mouse)Not determined67132262193464093Mouse
1300869Stheal5_msoft tissue heal 5 (mouse)Not determined671575060105575178Mouse
1300954Fcsa1_mfemoral cross-sectional area 1 (mouse)Not determined671981024105981170Mouse
1301521Pas1c_mpulmonary adenoma susceptibility 1c (mouse)Not determined671981024105981170Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1301320Ots1_movarian teratoma susceptibility 1 (mouse)Not determined675447583104503555Mouse
1301571Arrd1_mage-related retinal degeneration 1 (mouse)Not determined67554435692607450Mouse
1300674Nidd3n_mnon-insulin-dependent diabetes mellitus 3 in NSY (mouse)Not determined67554435694225955Mouse
10412195Efw_mepididymal fat weight (mouse)Not determined67554435694225955Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse
14697704Stsl4_mSalmonella typhimurium susceptibility locus 4 (mouse)67710000090000000Mouse
13824985Alh1_mamplitude of lateral head displacement 1 (mouse)67800000097000000Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
14696731Pairq1_mP. aeruginosa infection resistance QTL 1 (mouse)681500000102200000Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:184
Interacting mature miRNAs:194
Transcripts:ENSMUST00000061866
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000061866   ⟹   ENSMUSP00000056592
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,222,268 - 88,223,257 (+)Ensembl
RefSeq Acc Id: ENSMUST00000203827   ⟹   ENSMUSP00000145239
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl688,222,885 - 88,254,415 (+)Ensembl
RefSeq Acc Id: NM_019964   ⟹   NP_064348
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39688,199,250 - 88,200,238 (+)NCBI
GRCm38688,222,268 - 88,223,256 (+)ENTREZGENE
MGSCv37688,172,262 - 88,173,250 (+)RGD
Celera690,159,479 - 90,160,467 (+)RGD
cM Map6 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_064348   ⟸   NM_019964
- UniProtKB: Q9QYI7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000145239   ⟸   ENSMUST00000203827
RefSeq Acc Id: ENSMUSP00000056592   ⟸   ENSMUST00000061866
Protein Domains
J

Promoters
RGD ID:6890368
Promoter ID:EPDNEW_M8635
Type:initiation region
Name:Dnajb8_1
Description:Mus musculus DnaJ heat shock protein family member B8 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38688,222,285 - 88,222,345EPDNEW
RGD ID:15093114
Promoter ID:EPDNEWNC_M1026
Type:single initiation site
Name:1700031F10Rik_1
Description:RIKEN cDNA 1700031F10 gene [Source:MGISymbol;Acc:MGI:1920567]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38688,225,678 - 88,225,738EPDNEWNC

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922801 AgrOrtholog
Ensembl Genes ENSMUSG00000048206 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000056592 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145239 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000061866 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000203827 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/Swiss-Prot
InterPro DnaJ_domain UniProtKB/Swiss-Prot
  DnaJ_domain_CS UniProtKB/Swiss-Prot
  J_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:56691 UniProtKB/Swiss-Prot
MGD MGI:1922801 ENTREZGENE
NCBI Gene 56691 ENTREZGENE
Pfam DnaJ UniProtKB/Swiss-Prot
PhenoGen Dnajb8 PhenoGen
PRINTS JDOMAIN UniProtKB/Swiss-Prot
PROSITE DNAJ_1 UniProtKB/Swiss-Prot
  DNAJ_2 UniProtKB/Swiss-Prot
SMART DnaJ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46565 UniProtKB/Swiss-Prot
UniProt A0A0N4SVT8_MOUSE UniProtKB/TrEMBL
  DNJB8_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-22 Dnajb8  DnaJ heat shock protein family (Hsp40) member B8    DnaJ (Hsp40) homolog, subfamily B, member 8  Symbol and/or name change 5135510 APPROVED