Bsx (brain specific homeobox) - Rat Genome Database
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Gene: Bsx (brain specific homeobox) Mus musculus
Analyze
Symbol: Bsx
Name: brain specific homeobox
RGD ID: 1557168
MGI Page MGI
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including eating behavior; mammary gland involution; and positive regulation of transcription by RNA polymerase II. Localizes to cytoplasm; nucleus; and transcription regulator complex. Is expressed in brain; metanephros; and renal vasculature. Orthologous to human BSX (brain specific homeobox); INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: brain-specific homeobox protein homolog; Bsx1; Bsx1a; Bsx1b; MGC129478; MGC129479
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,782,994 - 40,790,258 (+)NCBIGRCm39mm39
GRCm38940,874,127 - 40,878,962 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,874,127 - 40,880,057 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,682,210 - 40,686,055 (+)NCBIGRCm37mm9NCBIm37
MGSCv36940,625,196 - 40,629,041 (+)NCBImm8
Celera938,108,339 - 38,112,231 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Dwarfism  (ISO)
schizophrenia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:14678827   PMID:16602821   PMID:17353277   PMID:17485440   PMID:17550780   PMID:17944879   PMID:18287559   PMID:21267068   PMID:21677750   PMID:21873635   PMID:23276958  
PMID:23671185   PMID:24952961   PMID:25864637   PMID:27133129   PMID:27209204   PMID:27578785   PMID:29795232   PMID:30063881  


Genomics

Comparative Map Data
Bsx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39940,782,994 - 40,790,258 (+)NCBIGRCm39mm39
GRCm38940,874,127 - 40,878,962 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl940,874,127 - 40,880,057 (+)EnsemblGRCm38mm10GRCm38
MGSCv37940,682,210 - 40,686,055 (+)NCBIGRCm37mm9NCBIm37
MGSCv36940,625,196 - 40,629,041 (+)NCBImm8
Celera938,108,339 - 38,112,231 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
BSX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11122,977,570 - 122,981,834 (-)EnsemblGRCh38hg38GRCh38
GRCh3811122,977,570 - 122,981,834 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711122,848,357 - 122,852,379 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611122,353,567 - 122,357,589 (-)NCBINCBI36hg18NCBI36
Celera11120,007,843 - 120,011,864 (-)NCBI
Cytogenetic Map11q24.1NCBI
HuRef11118,791,194 - 118,795,215 (-)NCBIHuRef
CHM1_111122,734,114 - 122,738,138 (-)NCBICHM1_1
Bsx
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0845,061,670 - 45,065,430 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,061,670 - 45,065,430 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0843,548,484 - 43,552,239 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4843,855,822 - 43,860,107 (+)NCBIRGSC3.4rn4RGSC3.4
Celera840,853,382 - 40,857,138 (+)NCBICelera
Cytogenetic Map8q22NCBI
Bsx
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541223,797,630 - 23,801,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541223,796,973 - 23,801,479 (-)NCBIChiLan1.0ChiLan1.0
BSX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111121,731,049 - 121,735,101 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11121,731,049 - 121,735,101 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011117,807,856 - 117,815,571 (-)NCBIMhudiblu_PPA_v0panPan3
BSX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl511,365,805 - 11,369,575 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1511,365,635 - 11,369,575 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Bsx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365427,511,760 - 7,515,477 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BSX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,905,428 - 49,909,226 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,873,031 - 49,910,581 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2955,249,305 - 55,254,781 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BSX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,366,225 - 114,373,943 (-)NCBI
ChlSab1.1 Ensembl1114,368,217 - 114,372,282 (-)Ensembl
Bsx
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248802,128,744 - 2,137,465 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13504833Bglu19_mblood glucose level 19 (mouse)9999947243999472Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91550045549500594Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91550045549500594Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91550045549500594Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91550045549500594Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91583833149838331Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91583833149838331Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91583833149838331Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91610000050100000Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91610000050100000Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91679834550798345Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91706754451067647Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined92003211054032229Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92024206654242196Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92039490154395074Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92039490154395074Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92039490154395074Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92039490154395074Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92094144454941444Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92500000069000000Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92567618959676285Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92567618959676285Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92567618959676285Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92567618959676285Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92688512460885255Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92688512460885255Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92688512460885255Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92733989761340026Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92859203741888030Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92938163163381774Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92938163163381774Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93014186664141979Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93082861764828723Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93252326366523557Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93254112166541246Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93259987266600121Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93297840266978536Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93319972567199840Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93406754473531973Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93419332342853570Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93512317869123299Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93512317869123299Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93512317869123299Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93682494749509211Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93703211050199840Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93724206644340026Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93739490198819654Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93791224471912244Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93819229172192291Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93819229172192291Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93819229172192291Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93949260173492601Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94050829851897370Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94050829874700643Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94073407848440176Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:224
Count of miRNA genes:202
Interacting mature miRNAs:223
Transcripts:ENSMUST00000067375
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000067375   ⟹   ENSMUSP00000068057
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl940,874,127 - 40,880,057 (+)Ensembl
RefSeq Acc Id: NM_178245   ⟹   NP_839976
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39940,785,423 - 40,789,268 (+)NCBI
GRCm38940,874,127 - 40,877,972 (+)NCBI
MGSCv37940,682,210 - 40,686,055 (+)RGD
Celera938,108,339 - 38,112,231 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510306   ⟹   XP_006510369
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39940,785,696 - 40,790,258 (+)NCBI
GRCm38940,874,400 - 40,878,962 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154982   ⟹   XP_036010875
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39940,782,994 - 40,790,258 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_839976   ⟸   NM_178245
- UniProtKB: Q810B3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006510369   ⟸   XM_006510306
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000068057   ⟸   ENSMUST00000067375
RefSeq Acc Id: XP_036010875   ⟸   XM_036154982
- Peptide Label: isoform X1

Promoters
RGD ID:8669296
Promoter ID:EPDNEW_M12679
Type:multiple initiation site
Name:Bsx_1
Description:Mus musculus brain specific homeobox , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38940,874,084 - 40,874,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2669849 AgrOrtholog
Ensembl Genes ENSMUSG00000054360 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000068057 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000067375 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot
  Homeobox_CS UniProtKB/Swiss-Prot
  Homeobox_dom UniProtKB/Swiss-Prot
  Homeobox_metazoa UniProtKB/Swiss-Prot
KEGG Report mmu:244813 UniProtKB/Swiss-Prot
MGD MGI:2669849 ENTREZGENE
NCBI Gene 244813 ENTREZGENE
Pfam Homeodomain UniProtKB/Swiss-Prot
PhenoGen Bsx PhenoGen
PRINTS HOMEOBOX UniProtKB/Swiss-Prot
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot
  HOMEOBOX_2 UniProtKB/Swiss-Prot
SMART HOX UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot
UniGene Mm.261652 ENTREZGENE
UniProt BSH_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3SXB1 UniProtKB/Swiss-Prot