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Gene: Edn3 (endothelin 3) Mus musculus
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Symbol: Edn3
Name: endothelin 3
Description: Predicted to have endothelin B receptor binding activity and hormone activity. Involved in several processes, including cellular divalent inorganic cation homeostasis; melanocyte differentiation; and neural crest cell migration. Predicted to localize to the extracellular space. Used to study Hirschsprung's disease and Waardenburg syndrome type 4B. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome type 4B; Waardenburg's syndrome; and congenital central hypoventilation syndrome. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut; and spleen. Orthologous to human EDN3 (endothelin 3).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 114-CH19; 114CH19; endothelin-3; ET-3; lethal spotting; ls; PPET3; preproendothelin-3; tmgc48
Orthologs:
Homo sapiens (human) : EDN3 (endothelin 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Edn3 (endothelin 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Edn3 (endothelin 3)
Pan paniscus (bonobo/pygmy chimpanzee) : EDN3 (endothelin 3)
Canis lupus familiaris (dog) : EDN3 (endothelin 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Edn3 (endothelin 3)
Sus scrofa (pig) : EDN3 (endothelin 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382174,760,619 - 174,784,042 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372174,586,274 - 174,609,543 (+)NCBIGRCm37mm9NCBIm37
MGSCv362174,403,712 - 174,426,981 (+)NCBImm8
Celera2180,720,509 - 180,743,869 (+)NCBICelera
Cytogenetic Map2 H4NCBI
cM Map298.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Edn3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557152
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.