Prss39 (serine protease 39) - Rat Genome Database

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Gene: Prss39 (serine protease 39) Mus musculus
Analyze
Symbol: Prss39
Name: serine protease 39
RGD ID: 1557135
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in acrosomal vesicle and extracellular region. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inactive serine protease 39; inactive testicular serine protease 1; MGC144580; MGC144581; protease, serine 39; protease, serine, 39; Tes; Tesp1; testicular serine protease 1
RGD Orthologs
Human
Rat
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,537,493 - 34,542,143 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,537,491 - 34,542,144 (+)EnsemblGRCm39 Ensembl
GRCm38134,498,412 - 34,503,062 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,498,410 - 34,503,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,555,275 - 34,559,907 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,442,976 - 34,447,608 (+)NCBIMGSCv36mm8
Celera134,261,738 - 34,266,371 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map113.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
proteolysis  (IBA,IEA)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
Additional References at PubMed
PMID:9588171   PMID:12477932   PMID:21267068   PMID:21873635   PMID:34524424  


Genomics

Comparative Map Data
Prss39
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,537,493 - 34,542,143 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,537,491 - 34,542,144 (+)EnsemblGRCm39 Ensembl
GRCm38134,498,412 - 34,503,062 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,498,410 - 34,503,063 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,555,275 - 34,559,907 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,442,976 - 34,447,608 (+)NCBIMGSCv36mm8
Celera134,261,738 - 34,266,371 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map113.29NCBI
PRSS40B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382130,536,570 - 130,549,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2130,539,839 - 130,549,085 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p14 Ensembl2130,539,095 - 130,549,883 (-)EnsemblGRCh38hg38GRCh38
GRCh372131,294,143 - 131,307,501 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,013,138 - 131,023,951 (-)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map2q21.1NCBI
HuRef2123,477,702 - 123,485,241 (+)NCBIHuRef
CHM1_12131,298,557 - 131,299,559 (-)NCBICHM1_1
T2T-CHM13v2.02130,970,470 - 130,983,812 (-)NCBIT2T-CHM13v2.0
Prss39
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,190,959 - 44,208,923 (+)NCBIGRCr8
mRatBN7.2936,695,037 - 36,713,004 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,707,328 - 36,713,001 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx945,204,252 - 45,209,927 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0950,335,428 - 50,341,103 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0948,617,339 - 48,623,014 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0940,999,027 - 41,012,607 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,006,800 - 41,013,965 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,669,817 - 40,683,065 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,241,164 - 33,247,320 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1933,242,577 - 33,248,731 (+)NCBI
Celera934,497,415 - 34,499,509 (+)NCBICelera
Cytogenetic Map9q21NCBI
LOC100513889
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.215155,310,999 - 155,323,777 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:141
Interacting mature miRNAs:146
Transcripts:ENSMUST00000027299
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
1301073Orch5_mautoimmune orchitis resistance 5 (mouse)Not determined11906535153065454Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
11100001Col4a1m1_mcollagen, type IV, alpha 1 modifier 1 (mouse)12555019162946882Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1301240Sluc15_msusceptibility to lung cancer 15 (mouse)Not determined11906535153065454Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
1301756Pgia1_mproteoglycan induced arthritis 1 (mouse)Not determined11906535153065454Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
12880407V125Dq2_mvitamin D active form serum level QTL 2 (mouse)11933908153339081Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
1357475w3q13_mweight 3 weeks QTL 13 (mouse)Not determined12310959173976915Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
12880409V125Dq1_mvitamin D active form serum level QTL 1 (mouse)12603916060039160Mouse
4142433Hbnr1_mHeligmosomoides bakeri nematode resistance 1 (mouse)Not determined2555019158273271Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000027299   ⟹   ENSMUSP00000027299
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl134,537,491 - 34,542,144 (+)Ensembl
GRCm38.p6 Ensembl134,498,410 - 34,503,063 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191604   ⟹   ENSMUSP00000140460
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl134,537,502 - 34,539,213 (+)Ensembl
GRCm38.p6 Ensembl134,498,421 - 34,500,132 (+)Ensembl
RefSeq Acc Id: NM_001360855   ⟹   NP_001347784
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39134,537,493 - 34,542,143 (+)NCBI
GRCm38134,498,412 - 34,503,062 (+)NCBI
Sequence:
RefSeq Acc Id: NM_009355   ⟹   NP_033381
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39134,537,493 - 34,542,143 (+)NCBI
GRCm38134,498,412 - 34,503,062 (+)NCBI
MGSCv37134,555,275 - 34,559,907 (+)RGD
Celera134,261,738 - 34,266,371 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_033381   ⟸   NM_009355
- Peptide Label: isoform 1 precursor
- UniProtKB: Q80YD5 (UniProtKB/Swiss-Prot),   O70169 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001347784   ⟸   NM_001360855
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000027299   ⟸   ENSMUST00000027299
Ensembl Acc Id: ENSMUSP00000140460   ⟸   ENSMUST00000191604
Protein Domains
Peptidase S1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70169-F1-model_v2 AlphaFold O70169 1-367 view protein structure

Promoters
RGD ID:6873398
Promoter ID:EPDNEW_M150
Type:initiation region
Name:Prss39_1
Description:Mus musculus protease, serine 39 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38134,498,412 - 34,498,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1270856 AgrOrtholog
Ensembl Genes ENSMUSG00000026125 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027299 ENTREZGENE
  ENSMUST00000027299.10 UniProtKB/Swiss-Prot
  ENSMUST00000191604.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report mmu:21755 UniProtKB/Swiss-Prot
MGD MGI:1270856 ENTREZGENE
NCBI Gene 21755 ENTREZGENE
PANTHER CHYMOTRYPSIN-RELATED UniProtKB/TrEMBL
  PROTEASE, SERINE 47 UniProtKB/Swiss-Prot
  SERINE PROTEASE 38 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEASE SERINE UniProtKB/Swiss-Prot
Pfam Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prss39 PhenoGen
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WR41_MOUSE UniProtKB/TrEMBL
  O70169 ENTREZGENE, UniProtKB/Swiss-Prot
  Q80YD5 ENTREZGENE
UniProt Secondary Q80YD5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-08-29 Prss39  serine protease 39  Prss39  protease, serine 39  Symbol and/or name change 5135510 APPROVED
2013-11-26 Prss39  protease, serine 39    protease, serine, 39  Symbol and/or name change 5135510 APPROVED
2011-07-27 Prss39  protease, serine, 39  Tesp1  testicular serine protease 1  Symbol and/or name change 5135510 APPROVED