Tmem70 (transmembrane protein 70) - Rat Genome Database

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Gene: Tmem70 (transmembrane protein 70) Mus musculus
Analyze
Symbol: Tmem70
Name: transmembrane protein 70
RGD ID: 1557127
MGI Page MGI
Description: Predicted to enable mitochondrial proton-transporting ATP synthase complex binding activity. Involved in mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrion. Is expressed in several structures, including brain; gut; nasal cavity epithelium; orbito-sphenoid; and urinary system. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 2. Orthologous to human TMEM70 (transmembrane protein 70).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1110020A09Rik; 2210416J16Rik; transmembrane protein 70, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,735,415 - 16,748,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,735,431 - 16,748,499 (+)EnsemblGRCm39 Ensembl
GRCm38116,665,191 - 16,678,275 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,665,207 - 16,678,275 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,655,272 - 16,668,356 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,650,432 - 16,663,487 (+)NCBIMGSCv36mm8
Celera116,597,042 - 16,611,752 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:18614015   PMID:21267068   PMID:21677750   PMID:21873635  
PMID:28173120   PMID:30550785   PMID:31652072  


Genomics

Comparative Map Data
Tmem70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39116,735,415 - 16,748,501 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl116,735,431 - 16,748,499 (+)EnsemblGRCm39 Ensembl
GRCm38116,665,191 - 16,678,275 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl116,665,207 - 16,678,275 (+)EnsemblGRCm38mm10GRCm38
MGSCv37116,655,272 - 16,668,356 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36116,650,432 - 16,663,487 (+)NCBIMGSCv36mm8
Celera116,597,042 - 16,611,752 (+)NCBICelera
Cytogenetic Map1A3NCBI
cM Map15.1NCBI
TMEM70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38873,976,195 - 73,982,783 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl873,972,437 - 73,982,783 (+)EnsemblGRCh38hg38GRCh38
GRCh37874,888,430 - 74,895,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36875,050,984 - 75,057,570 (+)NCBINCBI36Build 36hg18NCBI36
Celera870,886,069 - 70,892,868 (+)NCBICelera
Cytogenetic Map8q21.11NCBI
HuRef870,379,298 - 70,385,926 (+)NCBIHuRef
CHM1_1874,940,306 - 74,946,947 (+)NCBICHM1_1
T2T-CHM13v2.0874,405,457 - 74,412,045 (+)NCBIT2T-CHM13v2.0
Tmem70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr857,420,396 - 7,438,023 (-)NCBIGRCr8
mRatBN7.252,637,102 - 2,654,729 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl52,637,102 - 2,654,729 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx54,755,660 - 4,773,292 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.056,394,524 - 6,412,156 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.056,093,125 - 6,110,745 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.052,019,852 - 2,037,038 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl52,019,852 - 2,037,038 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.052,019,520 - 2,036,983 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.451,983,166 - 2,007,544 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera52,258,902 - 2,277,040 (-)NCBICelera
Cytogenetic Map5q11NCBI
Tmem70
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554446,393,023 - 6,397,115 (-)NCBIChiLan1.0ChiLan1.0
TMEM70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2789,718,029 - 89,724,599 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1865,346,042 - 65,352,613 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0870,509,897 - 70,515,605 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1872,154,872 - 72,161,500 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl872,154,872 - 72,163,239 (+)Ensemblpanpan1.1panPan2
TMEM70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12922,475,961 - 22,487,920 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2922,478,941 - 22,487,741 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2922,741,251 - 22,752,935 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02922,586,852 - 22,598,751 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12922,645,846 - 22,657,537 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02922,680,708 - 22,692,691 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02922,964,370 - 22,976,052 (+)NCBIUU_Cfam_GSD_1.0
Tmem70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530356,798,273 - 56,811,914 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366482,636,667 - 2,650,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl461,958,605 - 61,966,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1461,958,605 - 61,966,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2467,664,533 - 67,671,743 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1869,576,786 - 69,582,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl869,576,808 - 69,583,308 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603971,789,274 - 71,794,974 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474417,259,245 - 17,266,115 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474417,256,749 - 17,265,507 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem70
232 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:665
Count of miRNA genes:349
Interacting mature miRNAs:384
Transcripts:ENSMUST00000065373, ENSMUST00000176451, ENSMUST00000177501, ENSMUST00000177532
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412226Alpq4_malcohol preference QTL 4 (mouse)Not determined1122976684Mouse
1301891Alcp25_malcohol preference locus 25 (mouse)Not determined1125203185Mouse
1300834Cia20_mcollagen induced arthritis 20 (mouse)Not determined1125203185Mouse
1301482Morph1_mmorphine antinociception 1 (mouse)Not determined1130367747Mouse
1301275Sle10_msystematic lupus erythematosus susceptibility 10 (mouse)Not determined1288219436882352Mouse
1301370Adip1_madiposity 1 (mouse)Not determined1288219436882352Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
15092044Wtgrme1_mweek ten growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092046Wngrme1_mweek nine growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092048Wsigrme1_mweek six growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092050Wsegrme1_mweek seven growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092051Wegrme1_mweek eight growth rate, maternal effect 1 (mouse)1328014237782236Mouse
15092055Lgrme1_mlate growth rate, maternal effect 1 (mouse)1328014237782236Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301471Obq2_mobesity QTL 2 (mouse)Not determined1394162037941887Mouse
10043970Obq23_mobesity QTL 23 (mouse)Not determined1501266539012665Mouse
1301011Cplaq4_mcircadian period of locomotor activity 4 (mouse)Not determined1967344243673601Mouse
14700685Civq2_mcerebral infarct volume QTL 2 (mouse)11134048245340482Mouse
4141646Fecq3_mfecundity QTL 3 (mouse)Not determined11291692026517685Mouse

Markers in Region
RH126878  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38116,677,885 - 16,678,127UniSTSGRCm38
MGSCv37116,667,966 - 16,668,208UniSTSGRCm37
Celera116,611,362 - 16,611,604UniSTS
Cytogenetic Map1A3UniSTS
Whitehead/MRC_RH1280.25UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000065373   ⟹   ENSMUSP00000070497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,735,434 - 16,748,499 (+)Ensembl
GRCm38.p6 Ensembl116,665,210 - 16,678,275 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176451
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,735,460 - 16,736,035 (+)Ensembl
GRCm38.p6 Ensembl116,665,236 - 16,665,811 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177501   ⟹   ENSMUSP00000135483
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,735,431 - 16,748,419 (+)Ensembl
GRCm38.p6 Ensembl116,665,207 - 16,678,195 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177532
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl116,735,434 - 16,747,439 (+)Ensembl
GRCm38.p6 Ensembl116,665,210 - 16,677,215 (+)Ensembl
RefSeq Acc Id: NM_026392   ⟹   NP_080668
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,735,415 - 16,748,499 (+)NCBI
GRCm38116,665,191 - 16,678,275 (+)ENTREZGENE
MGSCv37116,655,272 - 16,668,356 (+)RGD
Celera116,597,042 - 16,611,752 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_027415   ⟹   NP_081691
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,735,415 - 16,748,499 (+)NCBI
GRCm38116,665,191 - 16,678,275 (+)ENTREZGENE
MGSCv37116,655,272 - 16,668,356 (+)RGD
Celera116,597,042 - 16,611,752 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036153613   ⟹   XP_036009506
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39116,736,574 - 16,748,501 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080668   ⟸   NM_026392
- Peptide Label: isoform 2
- UniProtKB: A0A0R4J272 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_081691   ⟸   NM_027415
- Peptide Label: isoform 1
- UniProtKB: Q9CQY4 (UniProtKB/Swiss-Prot),   Q3UAP8 (UniProtKB/Swiss-Prot),   Q3TKB6 (UniProtKB/Swiss-Prot),   Q9D7R8 (UniProtKB/Swiss-Prot),   Q921N7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000070497   ⟸   ENSMUST00000065373
RefSeq Acc Id: ENSMUSP00000135483   ⟸   ENSMUST00000177501
RefSeq Acc Id: XP_036009506   ⟸   XM_036153613
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q921N7-F1-model_v2 AlphaFold Q921N7 1-253 view protein structure

Promoters
RGD ID:6818611
Promoter ID:MM_KWN:192
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_026392,   NM_027415
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36116,655,074 - 16,655,574 (+)MPROMDB
RGD ID:6873234
Promoter ID:EPDNEW_M68
Type:initiation region
Name:Tmem70_1
Description:Mus musculus transmembrane protein 70 , transcript variant 1,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38116,665,249 - 16,665,309EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1915068 AgrOrtholog
Ensembl Genes ENSMUSG00000025940 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000065373 ENTREZGENE
  ENSMUST00000065373.6 UniProtKB/Swiss-Prot
  ENSMUST00000177501 ENTREZGENE
  ENSMUST00000177501.2 UniProtKB/TrEMBL
InterPro TMEM70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TMEM70/TMEM186/TMEM223 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70397 UniProtKB/Swiss-Prot
MGD MGI:1915068 ENTREZGENE
NCBI Gene 70397 ENTREZGENE
PANTHER PTHR13281 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TMEM70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tmem70 PhenoGen
UniProt A0A0R4J272 ENTREZGENE, UniProtKB/TrEMBL
  Q3TKB6 ENTREZGENE
  Q3UAP8 ENTREZGENE
  Q921N7 ENTREZGENE
  Q9CQY4 ENTREZGENE
  Q9D7R8 ENTREZGENE
  TMM70_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q3TKB6 UniProtKB/Swiss-Prot
  Q3UAP8 UniProtKB/Swiss-Prot
  Q9CQY4 UniProtKB/Swiss-Prot
  Q9D7R8 UniProtKB/Swiss-Prot