Dmrtc2 (doublesex and mab-3 related transcription factor like family C2) - Rat Genome Database

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Gene: Dmrtc2 (doublesex and mab-3 related transcription factor like family C2) Mus musculus
Analyze
Symbol: Dmrtc2
Name: doublesex and mab-3 related transcription factor like family C2
RGD ID: 1557115
MGI Page MGI
Description: Exhibits identical protein binding activity and sequence-specific DNA binding activity. Involved in male gamete generation and positive regulation of histone H3-K9 methylation. Localizes to XY body. Is expressed in branchial arch; genital tubercle; gonad; heart; and limb. Orthologous to human DMRTC2 (DMRT like family C2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4933432E21Rik; Dmrt; Dmrt7; doublesex and mab-3 related transcription factor 7; doublesex- and mab-3-related transcription factor C2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,569,242 - 24,577,080 (+)NCBIGRCm39mm39
GRCm39 Ensembl724,569,482 - 24,577,076 (+)Ensembl
GRCm38724,869,817 - 24,877,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,870,057 - 24,877,651 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,655,076 - 25,662,670 (+)NCBIGRCm37mm9NCBIm37
MGSCv36724,578,820 - 24,586,407 (+)NCBImm8
Celera719,485,959 - 19,493,548 (+)NCBICelera
Cytogenetic Map7A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10349636   PMID:11076861   PMID:12477932   PMID:12609607   PMID:14681479   PMID:15489334   PMID:15618518   PMID:16141072   PMID:16141073   PMID:17098235   PMID:17447844   PMID:17605809  
PMID:17720152   PMID:18287559   PMID:18369153   PMID:18391541   PMID:20059953   PMID:20211142   PMID:21060727   PMID:21267068   PMID:21873635   PMID:22972322   PMID:24146773   PMID:25082981  


Genomics

Comparative Map Data
Dmrtc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,569,242 - 24,577,080 (+)NCBIGRCm39mm39
GRCm39 Ensembl724,569,482 - 24,577,076 (+)Ensembl
GRCm38724,869,817 - 24,877,655 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,870,057 - 24,877,651 (+)EnsemblGRCm38mm10GRCm38
MGSCv37725,655,076 - 25,662,670 (+)NCBIGRCm37mm9NCBIm37
MGSCv36724,578,820 - 24,586,407 (+)NCBImm8
Celera719,485,959 - 19,493,548 (+)NCBICelera
Cytogenetic Map7A3NCBI
DMRTC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1941,844,743 - 41,852,333 (+)EnsemblGRCh38hg38GRCh38
GRCh381941,844,743 - 41,852,333 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371942,349,105 - 42,356,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361947,040,926 - 47,048,238 (+)NCBINCBI36hg18NCBI36
Build 341947,040,863 - 47,048,235NCBI
Celera1939,148,773 - 39,156,084 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1938,780,459 - 38,787,770 (+)NCBIHuRef
CHM1_11942,350,558 - 42,357,865 (+)NCBICHM1_1
Dmrtc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2180,466,259 - 80,473,883 (+)NCBI
Rnor_6.0 Ensembl181,736,335 - 81,741,345 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,815,498 - 16,823,064 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0181,734,256 - 81,741,419 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0182,991,217 - 82,998,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4180,161,778 - 80,168,956 (+)NCBIRGSC3.4rn4RGSC3.4
Celera174,914,975 - 74,922,177 (+)NCBICelera
Cytogenetic Map1q21NCBI
Dmrtc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955555983,272 - 988,950 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955555983,451 - 989,044 (-)NCBIChiLan1.0ChiLan1.0
DMRTC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11947,239,166 - 47,246,713 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01938,735,791 - 38,741,017 (+)NCBIMhudiblu_PPA_v0panPan3
DMRTC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11112,434,046 - 112,439,712 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1112,434,485 - 112,439,088 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1111,870,364 - 111,876,041 (-)NCBI
ROS_Cfam_1.01113,057,980 - 113,063,658 (-)NCBI
UMICH_Zoey_3.11112,611,346 - 112,617,022 (-)NCBI
UNSW_CanFamBas_1.01112,247,294 - 112,252,972 (-)NCBI
UU_Cfam_GSD_1.01113,173,978 - 113,179,655 (-)NCBI
Dmrtc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934916,235,240 - 16,240,623 (-)NCBI
SpeTri2.0NW_004936706582,541 - 586,735 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMRTC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl649,871,136 - 50,016,315 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1650,011,312 - 50,017,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2646,065,161 - 46,070,822 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DMRTC2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1636,052,497 - 36,060,277 (+)NCBI
ChlSab1.1 Ensembl636,055,088 - 36,059,830 (+)Ensembl
Vero_WHO_p1.0NW_02366607314,287,254 - 14,295,092 (+)NCBI
Dmrtc2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624907825,010 - 830,770 (-)NCBI

Position Markers
Dmrtc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map7 UniSTS
Dmrtc2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7269777136697919Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7330353225179993Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360000072900000Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined71028944244289559Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71060637344606511Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71278145246781452Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71278145246781452Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1333306047333196Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71343577947435779Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71360000047700000Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71690336849509583Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71899486940024609Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71958059053580679Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined72014282554142942Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72302446357024609Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72323914857239292Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72341710757417107Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:152
Count of miRNA genes:130
Interacting mature miRNAs:146
Transcripts:ENSMUST00000011493
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000011493   ⟹   ENSMUSP00000011493
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl724,870,057 - 24,877,651 (+)Ensembl
RefSeq Acc Id: NM_027732   ⟹   NP_082008
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,569,482 - 24,577,076 (+)NCBI
GRCm38724,870,057 - 24,877,651 (+)NCBI
MGSCv37725,655,076 - 25,662,670 (+)RGD
Celera719,485,959 - 19,493,548 (+)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540358   ⟹   XP_006540421
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,569,604 - 24,577,080 (+)NCBI
GRCm38724,870,179 - 24,877,655 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006540359   ⟹   XP_006540422
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,569,242 - 24,577,080 (+)NCBI
GRCm38724,869,817 - 24,877,655 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017312307   ⟹   XP_017167796
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39724,571,165 - 24,577,080 (+)NCBI
GRCm38724,871,740 - 24,877,655 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_082008   ⟸   NM_027732
- UniProtKB: Q8CGW9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540422   ⟸   XM_006540359
- Peptide Label: isoform X3
- UniProtKB: Q8CGW9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006540421   ⟸   XM_006540358
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017167796   ⟸   XM_017312307
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000011493   ⟸   ENSMUST00000011493

Promoters
RGD ID:6892218
Promoter ID:EPDNEW_M9560
Type:initiation region
Name:Dmrtc2_1
Description:Mus musculus doublesex and mab-3 related transcription factorlike family C2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38724,870,109 - 24,870,169EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1918491 AgrOrtholog
Ensembl Genes ENSMUSG00000011349 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000011493 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000011493 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1040.10 UniProtKB/Swiss-Prot
InterPro DM_DNA-bd UniProtKB/Swiss-Prot
  DM_DNA-bd_sf UniProtKB/Swiss-Prot
  DMRT-C1/C2_C UniProtKB/Swiss-Prot
  DMRT/dsx/mab-3 UniProtKB/Swiss-Prot
KEGG Report mmu:71241 UniProtKB/Swiss-Prot
MGD MGI:1918491 ENTREZGENE
NCBI Gene 71241 ENTREZGENE
PANTHER PTHR12322 UniProtKB/Swiss-Prot
Pfam DMRT-like UniProtKB/Swiss-Prot
  PF00751 UniProtKB/Swiss-Prot
PhenoGen Dmrtc2 PhenoGen
PROSITE DM_1 UniProtKB/Swiss-Prot
  DM_2 UniProtKB/Swiss-Prot
SMART SM00301 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF82927 UniProtKB/Swiss-Prot
UniProt DMRTD_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A6H6T0 UniProtKB/Swiss-Prot