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Gene: Macroh2a2 (macroH2A.2 histone) Mus musculus
Symbol: Macroh2a2
Name: macroH2A.2 histone
Description: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation. [provided by RefSeq, Nov 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: core histone macro-H2A.2; H2A histone family, member Y2; H2afy2; histone macroH2A2; MGC130227; MGC130228; mH2A2
Homo sapiens (human) : MACROH2A2 (macroH2A.2 histone)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Macroh2a2 (macroH2A.2 histone)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102017503 (core histone macro-H2A.2)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100974647 (core histone macro-H2A.2)
Canis lupus familiaris (dog) : MACROH2A2 (macroH2A.2 histone)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101956559 (core histone macro-H2A.2)
Sus scrofa (pig) : LOC100738475 (core histone macro-H2A.2)
more info ...
Related Pseudogenes: Gm8637   H2afy3  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381061,738,640 - 61,784,604 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371061,201,395 - 61,246,612 (-)NCBIGRCm37mm9NCBIm37
MGSCv361061,134,004 - 61,179,221 (-)NCBImm8
Celera1062,840,139 - 62,885,803 (-)NCBICelera
Cytogenetic Map10 B4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Macroh2a2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1557111
Created: 2005-11-30
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.