Rnf185 (ring finger protein 185) - Rat Genome Database

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Gene: Rnf185 (ring finger protein 185) Mus musculus
Analyze
Symbol: Rnf185
Name: ring finger protein 185
RGD ID: 1557095
MGI Page MGI
Description: Predicted to enable ubiquitin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Predicted to be involved in several processes, including positive regulation of ERAD pathway; protein ubiquitination; and proteolysis involved in protein catabolic process. Predicted to act upstream of or within autophagy and innate immune response. Predicted to be located in endoplasmic reticulum. Is expressed in central nervous system; genitourinary system; and olfactory epithelium. Orthologous to human RNF185 (ring finger protein 185).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 1700022N24Rik; AL033296; E3 ubiquitin-protein ligase RNF185; MGC19394; RING-type E3 ubiquitin transferase RNF185
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18286  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,365,973 - 3,402,956 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,365,982 - 3,402,363 (-)EnsemblGRCm39 Ensembl
GRCm38113,415,973 - 3,452,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,415,982 - 3,452,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,315,986 - 3,352,328 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,315,986 - 3,352,328 (-)NCBIMGSCv36mm8
Celera113,906,097 - 3,942,520 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7671812   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12904583   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072  
PMID:16141073   PMID:18287559   PMID:18799693   PMID:20059953   PMID:21267068   PMID:21677750   PMID:21873635   PMID:28190767   PMID:32554809   PMID:32968282  


Genomics

Comparative Map Data
Rnf185
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39113,365,973 - 3,402,956 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl113,365,982 - 3,402,363 (-)EnsemblGRCm39 Ensembl
GRCm38113,415,973 - 3,452,956 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl113,415,982 - 3,452,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37113,315,986 - 3,352,328 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36113,315,986 - 3,352,328 (-)NCBIMGSCv36mm8
Celera113,906,097 - 3,942,520 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.4NCBI
RNF185
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382231,160,182 - 31,207,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2231,160,182 - 31,207,019 (+)EnsemblGRCh38hg38GRCh38
GRCh372231,556,168 - 31,603,005 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362229,886,179 - 29,933,000 (+)NCBINCBI36Build 36hg18NCBI36
Celera2215,356,214 - 15,403,106 (+)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2214,517,777 - 14,564,817 (+)NCBIHuRef
CHM1_12231,515,988 - 31,562,845 (+)NCBICHM1_1
T2T-CHM13v2.02231,623,670 - 31,670,571 (+)NCBIT2T-CHM13v2.0
Rnf185
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81482,516,153 - 82,554,199 (-)NCBIGRCr8
mRatBN7.21478,292,517 - 78,329,832 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1478,292,516 - 78,329,864 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1482,733,515 - 82,771,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01483,973,618 - 84,011,123 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01480,419,375 - 80,456,882 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01483,648,400 - 83,685,273 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1483,648,402 - 83,685,273 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01484,336,667 - 84,373,469 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,043,727 - 84,081,442 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1477,205,739 - 77,243,010 (-)NCBICelera
Cytogenetic Map14q21NCBI
Rnf185
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554555,351,488 - 5,395,026 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554555,351,530 - 5,394,615 (+)NCBIChiLan1.0ChiLan1.0
RNF185
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22341,115,374 - 41,162,146 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12243,813,920 - 43,860,689 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02212,183,591 - 12,230,371 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12230,020,353 - 30,066,266 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2230,020,353 - 30,066,266 (+)Ensemblpanpan1.1panPan2
RNF185
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12624,146,172 - 24,177,747 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2624,146,005 - 24,240,653 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2624,016,013 - 24,048,667 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02624,528,662 - 24,562,031 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2624,527,922 - 24,624,066 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12624,232,140 - 24,265,067 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02624,494,085 - 24,527,022 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02624,555,332 - 24,588,724 (+)NCBIUU_Cfam_GSD_1.0
Rnf185
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118117,074,118 - 117,110,063 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936755331,619 - 367,533 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936755331,658 - 367,604 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LIMK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,951,481 - 47,979,699 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,946,370 - 47,979,702 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21451,057,248 - 51,090,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RNF185
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11914,050,271 - 14,095,819 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1914,076,113 - 14,093,410 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,021,366 - 112,068,433 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnf185
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247477,641,916 - 7,694,033 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247477,642,198 - 7,693,944 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnf185
1035 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1996
Count of miRNA genes:582
Interacting mature miRNAs:683
Transcripts:ENSMUST00000064364, ENSMUST00000077078, ENSMUST00000144055
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357722Vtbt11_mvertebral trabecular bone trait 11 (mouse)Not determined11123880487Mouse
1300768Tshp9_mtooth shape 9 (mouse)Not determined11125976374Mouse
1301765Skull15_mskull morphology 15 (mouse)Not determined11125976374Mouse
1300661Lmr6_mleishmaniasis resistance 6 (mouse)Not determined11125976374Mouse
10044008Hbnr15_mHeligmosomoides bakeri nematode resistance 15 (mouse)Not determined1122705234227232Mouse
1300599Cocrb11_mcocaine related behavior 11 (mouse)Not determined11267035536671472Mouse
27095914Pglq16_mpelvic girdle length QTL 16, 16 week (mouse)11325000018150000Mouse
27095919Pglq10_mpelvic girdle length QTL 10, 10 week (mouse)11325000018450000Mouse
27095925Pglq5_mpelvic girdle length QTL 5, 5 week (mouse)11325000019750000Mouse
27095904Scvln12_msacral vertebrae length 2, 10 week (mouse)11325000034495048Mouse
27095909Scvln6_msacral vertebrae length 2, 5 week (mouse)11325000044090827Mouse
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse

Markers in Region
RH124196  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38113,416,069 - 3,416,189UniSTSGRCm38
MGSCv37113,316,072 - 3,316,192UniSTSGRCm37
Celera113,906,183 - 3,906,303UniSTS
Cytogenetic Map11A1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001290472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001290473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_110959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006514594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK034108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK075756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK167455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL713875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV347010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSMUST00000064364   ⟹   ENSMUSP00000067053
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,365,982 - 3,402,363 (-)Ensembl
GRCm38.p6 Ensembl113,415,982 - 3,452,363 (-)Ensembl
RefSeq Acc Id: ENSMUST00000077078   ⟹   ENSMUSP00000076333
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,365,982 - 3,402,363 (-)Ensembl
GRCm38.p6 Ensembl113,415,982 - 3,452,363 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144055
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl113,367,876 - 3,402,334 (-)Ensembl
GRCm38.p6 Ensembl113,417,876 - 3,452,334 (-)Ensembl
RefSeq Acc Id: NM_001290472   ⟹   NP_001277401
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,365,973 - 3,402,956 (-)NCBI
GRCm38113,415,973 - 3,452,956 (-)NCBI
Celera113,906,087 - 3,943,151 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001290473   ⟹   NP_001277402
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,365,973 - 3,402,956 (-)NCBI
GRCm38113,415,973 - 3,452,956 (-)NCBI
Celera113,906,087 - 3,943,151 (-)NCBI
Sequence:
RefSeq Acc Id: NM_145355   ⟹   NP_663330
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,365,973 - 3,402,956 (-)NCBI
GRCm38113,415,973 - 3,452,956 (-)NCBI
MGSCv37113,315,986 - 3,352,328 (-)RGD
Celera113,906,087 - 3,943,151 (-)NCBI
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_110959
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,365,973 - 3,402,956 (-)NCBI
GRCm38113,415,973 - 3,452,956 (-)NCBI
Celera113,906,087 - 3,943,151 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006514594   ⟹   XP_006514657
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39113,365,981 - 3,402,450 (-)NCBI
GRCm38113,415,981 - 3,452,294 (-)NCBI
Sequence:
RefSeq Acc Id: NP_663330   ⟸   NM_145355
- Peptide Label: isoform 1
- UniProtKB: Q91YT2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006514657   ⟸   XM_006514594
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001277402   ⟸   NM_001290473
- Peptide Label: isoform 3
- UniProtKB: Q91YT2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001277401   ⟸   NM_001290472
- Peptide Label: isoform 2
- UniProtKB: Q6ZWS3 (UniProtKB/Swiss-Prot),   Q91YT2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000067053   ⟸   ENSMUST00000064364
RefSeq Acc Id: ENSMUSP00000076333   ⟸   ENSMUST00000077078

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91YT2-F1-model_v2 AlphaFold Q91YT2 1-192 view protein structure

Promoters
RGD ID:6821753
Promoter ID:MM_KWN:6165
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000064364,   NR_028317,   OTTMUST00000011148,   OTTMUST00000011149,   OTTMUST00000011151,   OTTMUST00000011152,   OTTMUST00000011191,   OTTMUST00000011193
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36113,352,161 - 3,352,661 (-)MPROMDB
RGD ID:8673726
Promoter ID:EPDNEW_M14894
Type:initiation region
Name:Rnf185_2
Description:Mus musculus ring finger protein 185 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14896  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,452,307 - 3,452,367EPDNEW
RGD ID:8673730
Promoter ID:EPDNEW_M14896
Type:multiple initiation site
Name:Rnf185_1
Description:Mus musculus ring finger protein 185 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M14894  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38113,452,894 - 3,452,954EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922078 AgrOrtholog
Ensembl Genes ENSMUSG00000020448 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000064364 ENTREZGENE
  ENSMUST00000064364.3 UniProtKB/Swiss-Prot
  ENSMUST00000077078 ENTREZGENE
  ENSMUST00000077078.12 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.40.10 UniProtKB/Swiss-Prot
InterPro RNF5/RNF185-like UniProtKB/Swiss-Prot
  Znf_C3HC4_RING-type UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
KEGG Report mmu:193670 UniProtKB/Swiss-Prot
MGD MGI:1922078 ENTREZGENE
NCBI Gene 193670 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE RNF185 UniProtKB/Swiss-Prot
  PTHR12313 UniProtKB/Swiss-Prot
Pfam zf-C3HC4 UniProtKB/Swiss-Prot
PhenoGen Rnf185 PhenoGen
PROSITE ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
SMART RING UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
UniProt Q6ZWS3 ENTREZGENE
  Q91YT2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6ZWS3 UniProtKB/Swiss-Prot