Taar2 (trace amine-associated receptor 2) - Rat Genome Database

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Gene: Taar2 (trace amine-associated receptor 2) Mus musculus
Analyze
Symbol: Taar2
Name: trace amine-associated receptor 2
RGD ID: 1557087
MGI Page MGI
Description: Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; lung; male reproductive gland or organ; and nose. Orthologous to human TAAR2 (trace amine associated receptor 2).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor 58; G-protein coupled receptor 58; Gm224; Gm225; Gpr; Gpr58; mTaar2; taR-2; Tarr2; trace amine associated receptor 2; trace amine receptor 2
RGD Orthologs
Human
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391023,814,470 - 23,817,481 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1023,814,470 - 23,817,481 (+)EnsemblGRCm39 Ensembl
GRCm381023,938,572 - 23,941,583 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1023,938,572 - 23,941,583 (+)EnsemblGRCm38mm10GRCm38
MGSCv371023,658,378 - 23,661,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361023,627,988 - 23,630,999 (+)NCBIMGSCv36mm8
Celera1024,872,067 - 24,875,079 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1011.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
membrane  (RCA)
plasma membrane  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors. Lindemann L, etal., Genomics 2005 Mar;85(3):372-85.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12679517   PMID:16602821   PMID:16878137   PMID:17556730   PMID:21267068   PMID:21873635   PMID:24194600   PMID:27626380   PMID:35431833   PMID:38355793  


Genomics

Comparative Map Data
Taar2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391023,814,470 - 23,817,481 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1023,814,470 - 23,817,481 (+)EnsemblGRCm39 Ensembl
GRCm381023,938,572 - 23,941,583 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1023,938,572 - 23,941,583 (+)EnsemblGRCm38mm10GRCm38
MGSCv371023,658,378 - 23,661,389 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361023,627,988 - 23,630,999 (+)NCBIMGSCv36mm8
Celera1024,872,067 - 24,875,079 (+)NCBICelera
Cytogenetic Map10A4NCBI
cM Map1011.4NCBI
TAAR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386132,617,150 - 132,624,275 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6132,617,022 - 132,624,275 (-)EnsemblGRCh38hg38GRCh38
GRCh376132,938,289 - 132,945,414 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366132,979,982 - 132,987,107 (-)NCBINCBI36Build 36hg18NCBI36
Celera6133,685,125 - 133,692,251 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6130,513,205 - 130,520,335 (-)NCBIHuRef
CHM1_16133,201,961 - 133,209,075 (-)NCBICHM1_1
T2T-CHM13v2.06133,812,108 - 133,819,243 (-)NCBIT2T-CHM13v2.0
Taar2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,319,526 - 23,323,495 (-)NCBIGRCr8
mRatBN7.2121,500,290 - 21,504,259 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,500,067 - 21,504,299 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx121,277,273 - 21,281,245 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,277,318 - 27,281,290 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0121,476,907 - 21,480,882 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,578,025 - 22,581,994 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,578,025 - 22,581,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,052,952 - 24,056,922 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,027,912 - 22,031,881 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,030,856 - 22,034,826 (-)NCBI
Celera120,243,653 - 20,247,622 (-)NCBICelera
Cytogenetic Map1p12NCBI
TAAR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25152,599,973 - 152,600,967 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16150,507,054 - 150,508,048 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06130,393,716 - 130,394,710 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16134,501,267 - 134,502,261 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6134,501,267 - 134,508,387 (-)Ensemblpanpan1.1panPan2
LOC100686959
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha126,653,606 - 26,654,633 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,577,519 - 25,578,547 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1125,623,590 - 25,624,617 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,522,382 - 25,523,409 (-)NCBIUNSW_CanFamBas_1.0
TAAR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl131,073,654 - 31,074,574 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1131,067,713 - 31,074,574 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2134,587,889 - 34,594,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TAAR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11340,901,944 - 40,929,519 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1340,921,295 - 40,928,506 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604013,110,187 - 13,117,320 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Taar2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624952721,912 - 727,169 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Taar2
123 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:81
Interacting mature miRNAs:83
Transcripts:ENSMUST00000079134
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11532718Sluc44f_msusceptibility to lung cancer 44f (mouse)10126289265Mouse
11532717Sluc44g_msusceptibility to lung cancer 44g (mouse)10126289265Mouse
1300881Sluc29_msusceptibility to lung cancer 29 (mouse)Not determined10126289265Mouse
12879494Facq1_mfear acquisition QTL 1 (mouse)10131279130Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
1300759Geot_mgeotaxia (mouse)Not determined10126289265Mouse
1558865Lith21_mlithogenic gene 21 (mouse)Not determined10852500342525126Mouse
15039341Nmrs28_mNAFLD-associated magnetic resonance shift 28 (mouse)1035100134351001Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
1301659Arrd2_mage-related retinal degeneration 2 (mouse)Not determined102028318526890391Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1300997Eae15_msusceptibility to experimental allergic encephalomyelitis 15 (mouse)Not determined10440815438408276Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
11532725Sluc44b_msusceptibility to lung cancer 44b (mouse)10126289265Mouse
1301129Alcp15_malcohol preference locus 15 (mouse)Not determined10989026443890391Mouse
10755518Chol16_mcholesterol 16 (mouse)101891504352915043Mouse
11532724Sluc44c_msusceptibility to lung cancer 44c (mouse)10126289265Mouse
1301448Pas11_mpulmonary adenoma susceptibility 11 (mouse)Not determined10989026443890391Mouse
11532723Sluc44d_msusceptibility to lung cancer 44d (mouse)10126289265Mouse
11532722Sluc44e_msusceptibility to lung cancer 44e (mouse)10126289265Mouse
11532721Sluc44_msusceptibility to lung cancer 44 (mouse)10126289265Mouse
1558857Igan1_mIgA nephropathy 1 (mouse)Not determined101771831329704155Mouse
11532720Sluc44a_msusceptibility to lung cancer 44a (mouse)10126289265Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
1357813Ath20_matherosclerosis 20 (mouse)Not determined10328318537283334Mouse
1300790Pgia6_mproteoglycan induced arthritis 6 (mouse)Not determined10381017137810295Mouse
1302133Alcp16_malcohol preference locus 16 (mouse)Not determined10989026443890391Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884394Humsd3_mhumerus midshaft diameter 3, 10 week (mouse)102237589951076096Mouse
11533917Mts2_mmammary tumor susceptibility 2 (mouse)10126289265Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
13208570Bmiq9_mbody mass index QTL 9 (mouse)101287574424875898Mouse
1301796Mop2_mmorphine preference 2 (mouse)Not determined10928911929028424Mouse
13208561Wght8_mweight 8 (mouse)10495000043875996Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
Taar2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381023,940,616 - 23,941,400UniSTSGRCm38
MGSCv371023,660,422 - 23,661,206UniSTSGRCm37
Celera1024,874,112 - 24,874,896UniSTS
Cytogenetic Map10A4UniSTS
cM Map10 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000079134   ⟹   ENSMUSP00000078137
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1023,814,470 - 23,817,481 (+)Ensembl
GRCm38.p6 Ensembl1023,938,572 - 23,941,583 (+)Ensembl
RefSeq Acc Id: NM_001007266   ⟹   NP_001007267
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391023,814,470 - 23,817,481 (+)NCBI
GRCm381023,938,572 - 23,941,583 (+)NCBI
MGSCv371023,658,378 - 23,661,389 (+)RGD
Celera1024,872,067 - 24,875,079 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001007267 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI39119 (Get FASTA)   NCBI Sequence Viewer  
  AAI45815 (Get FASTA)   NCBI Sequence Viewer  
  AAO85101 (Get FASTA)   NCBI Sequence Viewer  
  AAV70136 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000078137
  ENSMUSP00000078137.5
GenBank Protein Q5QD17 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001007267   ⟸   NM_001007266
- UniProtKB: A6H6B2 (UniProtKB/Swiss-Prot),   Q80T53 (UniProtKB/Swiss-Prot),   Q5QD17 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000078137   ⟸   ENSMUST00000079134

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QD17-F1-model_v2 AlphaFold Q5QD17 1-339 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685071 AgrOrtholog
Ensembl Genes ENSMUSG00000059763 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000079134 ENTREZGENE
  ENSMUST00000079134.5 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  TAAR UniProtKB/Swiss-Prot
  TAAR_fam UniProtKB/Swiss-Prot
KEGG Report mmu:209512 UniProtKB/Swiss-Prot
MGD MGI:2685071 ENTREZGENE
NCBI Gene 209512 ENTREZGENE
PANTHER HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
  TRACE AMINE-ASSOCIATED RECEPTOR 2 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Taar2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  TRACEAMINER UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6H6B2 ENTREZGENE
  Q5QD17 ENTREZGENE
  Q80T53 ENTREZGENE
  TAAR2_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary A6H6B2 UniProtKB/Swiss-Prot
  Q80T53 UniProtKB/Swiss-Prot