Zfp354b (zinc finger protein 354B) - Rat Genome Database

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Gene: Zfp354b (zinc finger protein 354B) Mus musculus
Analyze
Symbol: Zfp354b
Name: zinc finger protein 354B
RGD ID: 1557079
MGI Page MGI
Description: Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human ZNF354B (zinc finger protein 354B).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kid; Kid2; kidney, ischemia, and developmentally-regulated protein 2; MGC130408; MGC130409; Tcf17l1; transcription factor 17-like 1; Znf354b
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,812,613 - 50,822,486 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,812,650 - 50,822,460 (-)EnsemblGRCm39 Ensembl
GRCm381150,921,786 - 50,931,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,921,823 - 50,931,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,735,288 - 50,745,137 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,765,246 - 50,774,408 (-)NCBIMGSCv36mm8
MGSCv361151,341,268 - 51,350,430 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1130.95NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
2. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:10564808   PMID:11042159   PMID:11076861   PMID:12477932   PMID:15489334   PMID:16141072   PMID:16141073   PMID:18287559   PMID:20059953   PMID:21267068   PMID:21677750  
PMID:21873635   PMID:22174793   PMID:24105743  


Genomics

Comparative Map Data
Zfp354b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391150,812,613 - 50,822,486 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1150,812,650 - 50,822,460 (-)EnsemblGRCm39 Ensembl
GRCm381150,921,786 - 50,931,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,921,823 - 50,931,633 (-)EnsemblGRCm38mm10GRCm38
MGSCv371150,735,288 - 50,745,137 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361150,765,246 - 50,774,408 (-)NCBIMGSCv36mm8
MGSCv361151,341,268 - 51,350,430 (-)NCBIMGSCv36mm8
Cytogenetic Map11B1.3NCBI
cM Map1130.95NCBI
ZNF354B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385178,859,953 - 178,885,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5178,859,953 - 178,888,122 (+)EnsemblGRCh38hg38GRCh38
GRCh375178,286,954 - 178,312,021 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365178,219,607 - 178,244,021 (+)NCBINCBI36Build 36hg18NCBI36
Build 345178,219,606 - 178,244,021NCBI
Celera5173,914,525 - 173,938,862 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5173,013,482 - 173,037,948 (+)NCBIHuRef
CHM1_15177,720,108 - 177,744,632 (+)NCBICHM1_1
T2T-CHM13v2.05179,413,219 - 179,438,286 (+)NCBIT2T-CHM13v2.0
Znf354b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81035,734,794 - 35,752,882 (-)NCBIGRCr8
mRatBN7.21035,233,783 - 35,251,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1035,185,028 - 35,245,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1039,922,655 - 39,933,784 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01039,412,966 - 39,424,095 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01034,916,338 - 34,927,467 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01036,411,730 - 36,423,346 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1036,411,963 - 36,419,926 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01036,184,506 - 36,201,761 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1034,592,474 - 34,604,090 (-)NCBICelera
Cytogenetic Map10q22NCBI
ZNF354B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24173,778,244 - 173,833,973 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15171,917,784 - 171,973,513 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05174,022,352 - 174,046,169 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15181,278,382 - 181,303,119 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5181,278,382 - 181,303,119 (+)Ensemblpanpan1.1panPan2
LOC119863940
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha112,804,501 - 2,817,336 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0112,609,208 - 2,674,308 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl112,657,328 - 2,674,990 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1112,580,454 - 2,645,509 (-)NCBIUMICH_Zoey_3.1
LOC101958065
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213120,569,573 - 120,626,419 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367391,821,721 - 1,835,192 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367391,778,016 - 1,836,177 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF354B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl279,579,753 - 79,601,137 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1279,579,737 - 79,602,080 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2281,245,570 - 81,272,296 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF354B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12380,607,607 - 80,637,849 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2380,622,444 - 80,636,458 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607511,946,927 - 11,969,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp354b
329 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:362
Count of miRNA genes:303
Interacting mature miRNAs:323
Transcripts:ENSMUST00000109124, ENSMUST00000152296, ENSMUST00000164280
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
12801459Leuf1_mleukocyte filtration 1 (mouse)111857861652578716Mouse
12801460Intim2_mintima modifier 2 (mouse)111857861652578716Mouse
12801457Intmrm2_mintima/media ratio modifier 2 (mouse)111857861652578716Mouse
1300938Bulb3_mbulb size 3 (mouse)Not determined111857861652578716Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
1300579Thypr1_mthymocyte proliferative response 1 (mouse)Not determined111928257753282715Mouse
14746971Manh70_mmandible shape 70 (mouse)111990589053905890Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
10053675Eae44b_mexperimental allergic encephalomyelitis susceptibility 44b (mouse)Not determined113995072854094448Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
1300713Vmbic10_mventral midbrain iron content 10 (mouse)Not determined114277262654081064Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000109124   ⟹   ENSMUSP00000104752
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,812,650 - 50,822,460 (-)Ensembl
GRCm38.p6 Ensembl1150,921,823 - 50,931,633 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152296
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,819,391 - 50,821,476 (-)Ensembl
GRCm38.p6 Ensembl1150,928,564 - 50,930,649 (-)Ensembl
RefSeq Acc Id: ENSMUST00000164280   ⟹   ENSMUSP00000127671
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1150,813,118 - 50,821,760 (-)Ensembl
GRCm38.p6 Ensembl1150,922,291 - 50,930,933 (-)Ensembl
RefSeq Acc Id: NM_013744   ⟹   NP_038772
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391150,812,613 - 50,822,462 (-)NCBI
GRCm381150,921,786 - 50,931,635 (-)NCBI
MGSCv371150,735,288 - 50,745,137 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030246044   ⟹   XP_030101904
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391150,814,680 - 50,822,486 (-)NCBI
GRCm381150,923,853 - 50,931,661 (-)NCBI
Sequence:
RefSeq Acc Id: NP_038772   ⟸   NM_013744
- UniProtKB: Q9CV15 (UniProtKB/Swiss-Prot),   Q9QXT9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030101904   ⟸   XM_030246044
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000127671   ⟸   ENSMUST00000164280
RefSeq Acc Id: ENSMUSP00000104752   ⟸   ENSMUST00000109124
Protein Domains
KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QXT9-F1-model_v2 AlphaFold Q9QXT9 1-601 view protein structure

Promoters
RGD ID:6822495
Promoter ID:MM_KWN:7273
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Liver,   Lung,   MEF_B4
Transcripts:OTTMUST00000017955
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,744,734 - 50,745,234 (-)MPROMDB
RGD ID:6822494
Promoter ID:MM_KWN:7274
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:MEF_B6
Transcripts:NM_013744
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361150,744,801 - 50,745,301 (-)MPROMDB
RGD ID:8674528
Promoter ID:EPDNEW_M15295
Type:multiple initiation site
Name:Zfp354b_1
Description:Mus musculus zinc finger protein 354B , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381150,931,626 - 50,931,686EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351476 AgrOrtholog
Ensembl Genes ENSMUSG00000020335 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000109124 ENTREZGENE
  ENSMUST00000109124.10 UniProtKB/Swiss-Prot
  ENSMUST00000164280.2 UniProtKB/Swiss-Prot
Gene3D-CATH 6.10.140.140 UniProtKB/Swiss-Prot
  Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro KRAB UniProtKB/Swiss-Prot
  KRAB_dom_sf UniProtKB/Swiss-Prot
  Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report mmu:27274 UniProtKB/Swiss-Prot
MGD MGI:1351476 ENTREZGENE
NCBI Gene 27274 ENTREZGENE
PANTHER KRAB AND ZINC FINGER DOMAIN-CONTAINING UniProtKB/Swiss-Prot
  SIMILAR TO ZINC FINGER PROTEIN 84 (HPF2) UniProtKB/Swiss-Prot
Pfam KRAB UniProtKB/Swiss-Prot
  zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Zfp354b PhenoGen
PROSITE KRAB UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART KRAB UniProtKB/Swiss-Prot
  ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF109640 UniProtKB/Swiss-Prot
  SSF57667 UniProtKB/Swiss-Prot
UniProt Q9CV15 ENTREZGENE
  Q9QXT9 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q9CV15 UniProtKB/Swiss-Prot