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Gene: Timd2 (T cell immunoglobulin and mucin domain containing 2) Mus musculus
Analyze
Symbol:
Timd2
Name:
T cell immunoglobulin and mucin domain containing 2
RGD ID:
1557019
MGI Page
MGI
Description:
Exhibits ferritin receptor activity. Involved in iron ion transport. Localizes to cell surface. Is expressed in 4-cell stage embryo; liver; liver left lobe; liver right lobe; and metanephros. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AA816106; AU019358; AU019662; C78111; G9D3; T-cell immunoglobulin and mucin domain containing 2; T-cell immunoglobulin and mucin domain-containing protein 2; T-cell immunoglobulin mucin receptor 2; T-cell membrane protein 2; Tim; TIM-; TIM-2; Tim2; TIMD-2
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Related Pseudogenes:
Gm4926
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 11 46,559,787 - 46,597,934 (-) NCBI GRCm39 mm39 GRCm38 11 46,668,960 - 46,707,107 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 11 46,668,960 - 46,707,061 (-) Ensembl GRCm38 mm10 GRCm38 MGSCv37 11 46,482,462 - 46,520,606 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 11 46,513,437 - 46,550,484 (-) NCBI mm8 Celera 11 51,257,001 - 51,295,891 (-) NCBI Celera Cytogenetic Map 11 B1.1 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,2-dichloroethane decreases expression EXP 6480464 ethylene dichloride results in decreased expression of TIMD2 mRNA CTD PMID:28960355 1,2-dimethylhydrazine decreases expression EXP 6480464 1, 2-Dimethylhydrazine results in decreased expression of TIMD2 mRNA CTD PMID:22206623 1-chloro-2,4-dinitrobenzene affects expression EXP 6480464 Dinitrochlorobenzene affects the expression of TIMD2 mRNA CTD PMID:22302311 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TIMD2 mRNA CTD PMID:21570461 4,4'-sulfonyldiphenol increases expression EXP 6480464 bis4-hydroxyphenylsulfone results in increased expression of TIMD2 mRNA CTD PMID:30951980 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of TIMD2 mRNA CTD PMID:19770486 alpha-hexylcinnamaldehyde affects expression EXP 6480464 hexyl cinnamic aldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 Benzo[k]fluoranthene decreases expression EXP 6480464 benzokfluoranthene results in decreased expression of TIMD2 mRNA CTD PMID:26377693 bisphenol A decreases expression ISO RGD:1359571 6480464 bisphenol A results in decreased expression of TIMD2 mRNA CTD PMID:25181051 bisphenol A affects expression ISO RGD:1359571 6480464 bisphenol A affects the expression of TIMD2 mRNA CTD PMID:30903817 bisphenol A multiple interactions ISO RGD:1359571 6480464 [bisphenol A co-treated with Genistein] results in decreased methylation of TIMD2 gene CTD PMID:28505145 bisphenol F increases expression EXP 6480464 bisphenol F results in increased expression of TIMD2 mRNA CTD PMID:30951980 carbon nanotube decreases expression EXP 6480464 Nanotubes, Carbon analog results in decreased expression of TIMD2 mRNA CTD PMID:25620056 ciguatoxin CTX1B affects expression EXP 6480464 Ciguatoxins affects the expression of TIMD2 mRNA CTD PMID:18353800 cisplatin multiple interactions EXP 6480464 TIMD2 inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA] more ... CTD PMID:20702592 cisplatin decreases response to substance EXP 6480464 TIMD2 results in decreased susceptibility to Cisplatin CTD PMID:20702592 clofibrate multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of TIMD2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TIMD2 mRNA] CTD PMID:17585979 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of TIMD2 mRNA CTD PMID:17585979 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of TIMD2 mRNA CTD PMID:19770486 endosulfan decreases expression ISO RGD:1359571 6480464 Endosulfan results in decreased expression of TIMD2 mRNA CTD PMID:29391264 genistein multiple interactions ISO RGD:1359571 6480464 [bisphenol A co-treated with Genistein] results in decreased methylation of TIMD2 gene CTD PMID:28505145 genistein decreases expression EXP 6480464 Genistein results in decreased expression of TIMD2 mRNA CTD PMID:32186404 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of TIMD2 mRNA CTD PMID:22609695 methyl salicylate affects expression EXP 6480464 methyl salicylate affects the expression of TIMD2 mRNA CTD PMID:22302311 nonanoic acid affects expression EXP 6480464 pelargonic acid affects the expression of TIMD2 mRNA CTD PMID:22302311 paracetamol multiple interactions EXP 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of TIMD2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TIMD2 mRNA] CTD PMID:17585979 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of TIMD2 mRNA CTD PMID:17562736 phthalaldehyde affects expression EXP 6480464 o-Phthalaldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of TIMD2 mRNA CTD PMID:23811191 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of TIMD2 mRNA CTD PMID:27339419 , PMID:31919559 trimellitic anhydride increases expression EXP 6480464 trimellitic anhydride results in increased expression of TIMD2 mRNA CTD PMID:19042947 trimellitic anhydride affects expression EXP 6480464 trimellitic anhydride affects the expression of TIMD2 mRNA CTD PMID:22302311 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of TIMD2 mRNA CTD PMID:17963808 vancomycin decreases expression EXP 6480464 Vancomycin results in decreased expression of TIMD2 mRNA CTD PMID:18930951
References
Additional References at PubMed
Genomics
QTLs in Region (GRCm38)
27226798 Scvln18_m sacral vertebrae length 2, 16 week (mouse) 11 3300000 60800000 Mouse 26884446 Sklq10_m skull length QTL 10, 10 week (mouse) 11 3300000 63000000 Mouse 26884453 Sklq16_m skull length QTL 16, 16 week (mouse) 11 3300000 72800000 Mouse 13208559 Wght10_m weight 10 (mouse) 11 4000000 89000000 Mouse 13208558 Lgth12_m body length 12 (mouse) 11 4000000 95000000 Mouse 1300905 Scc6_m colon tumor susceptibility 6 (mouse) Not determined 11 6930277 89128908 Mouse 27226738 Metcl11_m metatarsal-calcaneal length 11, 10 week (mouse) 11 8900000 61500000 Mouse 26884401 Huml4_m humerus length 4, 10 week (mouse) 11 11600000 68600000 Mouse 27226762 Feml21_m femur length 21, 16 week (mouse) 11 11800000 66100000 Mouse 4141966 Tailq1_m tail length QTL 1 (mouse) Not determined 12318637 68609504 Mouse 1357851 Scfq3_m subcutaneous fat pad weight QTL 3 (mouse) Not determined 11 12318637 68609504 Mouse 1357437 Epfq4_m epididymal fat pad weight QTL 4 (mouse) Not determined 11 12318637 68609504 Mouse 4141127 W3q4_m weight 3 weeks QTL 4 (mouse) Not determined 12318637 68609504 Mouse 4142216 Lgq1_m late growth QTL 1 (mouse) Not determined 12318637 68609504 Mouse 4142308 W6q3_m weight 6 weeks QTL 3 (mouse) Not determined 11 12318637 68609504 Mouse 4141582 Lgaq1_m late growth adjusted QTL 1 (mouse) Not determined 12318637 68609504 Mouse 4142109 W10q2_m weight 10 weeks QTL 2 (mouse) Not determined 12318637 68609504 Mouse 4141470 Egq4_m early growth QTL 4 (mouse) Not determined 12318637 68609504 Mouse 1357640 Orq2_m ovulation rate QTL 2 (mouse) Not determined 11 12318637 68609504 Mouse 1357720 Kidpq1_m kidney weight percentage QTL 1 (mouse) Not determined 11 12318637 68609504 Mouse 1559002 Lmrq4_m Leishmania major resistance QTL 4 (mouse) Not determined 11 12318637 69794121 Mouse 1357859 Lvrq7_m liver weight QTL 7 (mouse) Not determined 11 12318637 118131898 Mouse 39128214 Lwq20_m liver weight QTL 20 (mouse) 11 12318637 118131898 Mouse 1558945 Orgwq8_m organ weight QTL 8 (mouse) Not determined 11 17106175 67187585 Mouse 10053687 Eae6_m susceptibility to experimental allergic encephalomyelitis 6 (mouse) Not determined 11 17831966 68609504 Mouse 1300938 Bulb3_m bulb size 3 (mouse) Not determined 11 18687789 52687889 Mouse 12801457 Intmrm2_m intima/media ratio modifier 2 (mouse) 11 18687789 52687889 Mouse 12801459 Leuf1_m leukocyte filtration 1 (mouse) 11 18687789 52687889 Mouse 12801460 Intim2_m intima modifier 2 (mouse) 11 18687789 52687889 Mouse 4141894 Nidd6k_m Nidd6 on KK-A (mouse) Not determined 19174204 97007000 Mouse 1300579 Thypr1_m thymocyte proliferative response 1 (mouse) Not determined 11 19391750 53391888 Mouse 14746971 Manh70_m mandible shape 70 (mouse) 11 20015063 54015063 Mouse 4141398 Tgq22_m triglyceride QTL 22 (mouse) Not determined 21272579 55272579 Mouse 10412246 Dfs2_m dental fluorosis suseptibility 2 (mouse) Not determined 11 21857364 95990405 Mouse 10044006 Hbnr13_m Heligmosomoides bakeri nematode resistance 13 (mouse) Not determined 11 25881799 59881914 Mouse 12910801 Pwbwq14_m post-weaning body weight QTL 14 (mouse) 11 27248057 50745267 Mouse 12910804 Pwbwq16_m post-weaning body weight QTL 16 (mouse) 11 27248057 50745267 Mouse 12910806 Pwbwq15_m post-weaning body weight QTL 15 (mouse) 11 27248057 50745267 Mouse 12910817 Pwgrq20_m post-weaning growth rate QTL 20 (mouse) 11 27248057 50745267 Mouse 12910818 Ogrq5_m overall growth rate QTL 5 (mouse) 11 27248057 50745267 Mouse 1357844 Si5lq5_m serum IGFBP-5 level QTL 5 (mouse) Not determined 11 28275046 62275149 Mouse 13524848 Ppiq7_m prepulse inhibition QTL 7 (mouse) 11 28678320 62678320 Mouse 1301426 Desp2_m despair 2 (mouse) Not determined 11 28817754 62817873 Mouse 11522752 Cocia18_m cocaine-induced activity, QTL 18 (mouse) 11 31117382 65117382 Mouse 11059563 Lmr31_m leishmaniasis resistance 31 (mouse) 11 32209750 66209867 Mouse 1357782 Char8_m P. chabaudi malaria resistance QTL 8 (mouse) Not determined 11 35687789 69794161 Mouse 13208569 Bmiq10_m body mass index QTL 10 (mouse) 11 36000000 85000000 Mouse 1301328 Mol4_m modifier of LPS-response 4 (mouse) Not determined 11 36391750 83590530 Mouse 1301788 Lbw8_m lupus NZB x NZW 8 (mouse) Not determined 11 36612460 70618665 Mouse 1301896 Tria1_m T-cell receptor induced activation 1 (mouse) Not determined 11 36722738 70723028 Mouse 4141853 Skmw17_m skeletal muscle weight 17 (mouse) Not determined 11 37190115 71190238 Mouse 4142475 Ity2a_m immunity to S. typhimurium 2a (mouse) Not determined 11 37877753 60511890 Mouse 10766457 Nwa3_m New Zealand White autoimmunity 3 (mouse) 11 38125289 72125383 Mouse 1300569 Eae6b_m susceptibility to experimental allergic encephalomyelitis 6b (mouse) Not determined 11 40059901 54203622 Mouse 10053675 Eae44b_m experimental allergic encephalomyelitis susceptibility 44b (mouse) Not determined 11 40059901 54203622 Mouse 11532698 Sluc36a_m susceptibility to lung cancer 36a (mouse) 11 42365791 76365904 Mouse 11532699 Sluc36b_m susceptibility to lung cancer 36b (mouse) 11 42365791 76365904 Mouse 1300713 Vmbic10_m ventral midbrain iron content 10 (mouse) Not determined 11 42881799 54190238 Mouse 4142300 Ctrq3_m C. trachomatis resistance QTL 3 (mouse) Not determined 11 44739211 76963931 Mouse 4141367 Inf1_m acute ozone induced inflammation (mouse) Not determined 44739211 113167183 Mouse 4141000 Nidd3_m non-insulin-dependent diabetes mellitus 3 (mouse) Not determined 45151201 79151308 Mouse 1302021 Nidd1n_m non-insulin-dependent diabetes mellitus 1 in NSY (mouse) Not determined 11 45275046 80087498 Mouse 1357878 Mastr_m modifier of astrocytoma (mouse) Not determined 11 45817754 89927907 Mouse 1300765 Bbaa4_m B.burgdorferi-associated arthritis 4 (mouse) Not determined 11 46294341 80294436 Mouse 1301988 Bmd11_m bone mineral density 11 (mouse) Not determined 11 46428581 80428696 Mouse