Lrrc2 (leucine rich repeat containing 2) - Rat Genome Database
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Gene: Lrrc2 (leucine rich repeat containing 2) Mus musculus
Analyze
Symbol: Lrrc2
Name: leucine rich repeat containing 2
RGD ID: 1556954
MGI Page MGI
Description: Predicted to have protein serine/threonine phosphatase activity. Involved in cellular response to leukemia inhibitory factor. Predicted to localize to cytoplasm and intracellular membrane-bounded organelle. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human LRRC2 (leucine rich repeat containing 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-aza-2'-deoxycytidine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2400002D05Rik; 4933431K03Rik; leucine-rich repeat-containing 2; leucine-rich repeat-containing protein 2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,780,613 - 110,813,134 (+)NCBIGRCm39mm39
GRCm389110,951,545 - 110,984,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,951,545 - 110,984,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,854,049 - 110,886,570 (+)NCBIGRCm37mm9NCBIm37
MGSCv369110,796,361 - 110,828,878 (+)NCBImm8
MGSCv369112,061,477 - 112,093,604 (+)NCBImm8
Celera9110,676,980 - 110,707,487 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12461651   PMID:12904583   PMID:14610273   PMID:16141072   PMID:16141073   PMID:17967808   PMID:18799693   PMID:20439489   PMID:21267068  
PMID:21677750   PMID:21731673   PMID:21873635   PMID:27626380   PMID:29997285  


Genomics

Comparative Map Data
Lrrc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,780,613 - 110,813,134 (+)NCBIGRCm39mm39
GRCm389110,951,545 - 110,984,066 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9110,951,545 - 110,984,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv379110,854,049 - 110,886,570 (+)NCBIGRCm37mm9NCBIm37
MGSCv369110,796,361 - 110,828,878 (+)NCBImm8
MGSCv369112,061,477 - 112,093,604 (+)NCBImm8
Celera9110,676,980 - 110,707,487 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.79NCBI
LRRC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl346,515,385 - 46,580,099 (-)EnsemblGRCh38hg38GRCh38
GRCh38346,515,385 - 46,580,099 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,556,875 - 46,621,589 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,531,917 - 46,596,576 (-)NCBINCBI36hg18NCBI36
Build 34346,534,875 - 46,596,576NCBI
Celera346,494,616 - 46,545,734 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,599,115 - 46,650,230 (-)NCBIHuRef
CHM1_1346,507,038 - 46,558,224 (-)NCBICHM1_1
Lrrc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08119,226,651 - 119,259,649 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,228,612 - 119,259,645 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,565,954 - 118,602,413 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,355,358 - 115,387,125 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18115,374,812 - 115,406,576 (+)NCBI
Celera8110,220,169 - 110,251,534 (+)NCBICelera
Cytogenetic Map8q32NCBI
Lrrc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542025,491,010 - 25,528,530 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542025,492,277 - 25,528,530 (+)NCBIChiLan1.0ChiLan1.0
LRRC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1347,518,600 - 47,567,020 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,518,600 - 47,567,020 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,413,776 - 46,463,131 (-)NCBIMhudiblu_PPA_v0panPan3
LRRC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2042,156,154 - 42,191,681 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12042,156,097 - 42,193,523 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Lrrc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936596420,678 - 440,937 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,478,115 - 29,598,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,477,790 - 29,524,177 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,727,338 - 32,749,034 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,937,167 - 7,987,249 (-)NCBI
ChlSab1.1 Ensembl227,934,217 - 7,986,666 (-)Ensembl
Lrrc2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,564,889 - 74,594,276 (+)NCBI

Position Markers
UniSTS:236263  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv379110,882,739 - 110,882,925UniSTSGRCm37
MGSCv379110,882,709 - 110,882,925UniSTSGRCm37
Celera9110,703,660 - 110,703,876UniSTS
Celera9110,702,306 - 110,702,492UniSTS
Celera9110,702,277 - 110,702,492UniSTS
Celera9110,703,690 - 110,703,876UniSTS
Cytogenetic Map9F2UniSTS
cM Map970.4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse
13515058Adip20d_madiposity 20d (mouse)9108915010118915010Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:640
Count of miRNA genes:400
Interacting mature miRNAs:474
Transcripts:ENSMUST00000035076
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035076   ⟹   ENSMUSP00000035076
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,951,545 - 110,984,066 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196598   ⟹   ENSMUSP00000143319
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,960,834 - 110,979,530 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196834   ⟹   ENSMUSP00000142360
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9110,953,799 - 110,970,138 (+)Ensembl
RefSeq Acc Id: NM_028838   ⟹   NP_083114
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,780,613 - 110,813,134 (+)NCBI
GRCm389110,951,545 - 110,984,066 (+)ENTREZGENE
MGSCv379110,854,049 - 110,886,570 (+)RGD
Celera9110,676,980 - 110,707,487 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006512364   ⟹   XP_006512427
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,782,188 - 110,812,627 (+)NCBI
GRCm389110,953,120 - 110,984,066 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006512365   ⟹   XP_006512428
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399110,782,188 - 110,812,627 (+)NCBI
GRCm389110,953,120 - 110,984,066 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_083114   ⟸   NM_028838
- UniProtKB: Q8VDB8 (UniProtKB/Swiss-Prot),   A0A0R4J0F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006512427   ⟸   XM_006512364
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006512428   ⟸   XM_006512365
- Peptide Label: isoform X2
- UniProtKB: Q8VDB8 (UniProtKB/Swiss-Prot),   A0A0R4J0F2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035076   ⟸   ENSMUST00000035076
RefSeq Acc Id: ENSMUSP00000142360   ⟸   ENSMUST00000196834
RefSeq Acc Id: ENSMUSP00000143319   ⟸   ENSMUST00000196598

Promoters
RGD ID:6844756
Promoter ID:MM_KWN:58951
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell,   Lung
Transcripts:NM_028838
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,853,926 - 110,854,426 (+)MPROMDB
RGD ID:6848425
Promoter ID:MM_ACW:52164
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:LRRC2.CSEP07,   LRRC2.DSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369110,856,291 - 110,856,791 (+)MPROMDB
RGD ID:8671044
Promoter ID:EPDNEW_M13553
Type:initiation region
Name:Lrrc2_1
Description:Mus musculus leucine rich repeat containing 2 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389110,953,782 - 110,953,842EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1921499 AgrOrtholog
Ensembl Genes ENSMUSG00000032495 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035076 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000142360 UniProtKB/TrEMBL
  ENSMUSP00000143319 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035076 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000196598 UniProtKB/TrEMBL
  ENSMUST00000196834 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74249 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1921499 ENTREZGENE
NCBI Gene 74249 ENTREZGENE
Pfam LRR_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrrc2 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.307615 ENTREZGENE
UniProt A0A0G2JDG6_MOUSE UniProtKB/TrEMBL
  A0A0G2JFV2_MOUSE UniProtKB/TrEMBL
  A0A0R4J0F2 ENTREZGENE, UniProtKB/TrEMBL
  LRRC2_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9CX04 UniProtKB/Swiss-Prot