Oscar (osteoclast associated receptor) - Rat Genome Database

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Gene: Oscar (osteoclast associated receptor) Mus musculus
Analyze
Symbol: Oscar
Name: osteoclast associated receptor
RGD ID: 1556936
MGI Page MGI
Description: Enables collagen receptor activity. Acts upstream of or within Fc-gamma receptor signaling pathway; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Located in cell surface. Is expressed in testis. Orthologous to human OSCAR (osteoclast associated Ig-like receptor).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: mO; mOSCAR; mOSCAR-M1; mOSCAR-M2; mOSCAR-M3; ocl178; osteoclast-associated immunoglobulin-like receptor; osteoclast-associated receptor OSCAR
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,612,812 - 3,619,156 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,612,812 - 3,619,156 (-)EnsemblGRCm39 Ensembl
GRCm3873,609,813 - 3,616,157 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,609,813 - 3,616,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv3773,561,415 - 3,567,735 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3673,212,900 - 3,219,220 (-)NCBIMGSCv36mm8
Celera73,520,876 - 3,527,938 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.08NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11805147   PMID:12477932   PMID:12695521   PMID:15184345   PMID:16046394   PMID:16109714   PMID:16322470   PMID:17442941   PMID:18762192   PMID:20939024   PMID:21677750   PMID:21841309  
PMID:21873635   PMID:23817038   PMID:24194600   PMID:32859940  


Genomics

Comparative Map Data
Oscar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3973,612,812 - 3,619,156 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl73,612,812 - 3,619,156 (-)EnsemblGRCm39 Ensembl
GRCm3873,609,813 - 3,616,157 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl73,609,813 - 3,616,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv3773,561,415 - 3,567,735 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3673,212,900 - 3,219,220 (-)NCBIMGSCv36mm8
Celera73,520,876 - 3,527,938 (-)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.08NCBI
OSCAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,094,668 - 54,100,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,094,668 - 54,102,692 (-)EnsemblGRCh38hg38GRCh38
GRCh371954,597,933 - 54,604,094 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361959,289,745 - 59,295,960 (-)NCBINCBI36Build 36hg18NCBI36
Celera1951,637,613 - 51,643,830 (-)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1950,913,817 - 50,920,134 (-)NCBIHuRef
CHM1_11954,599,687 - 54,605,876 (-)NCBICHM1_1
T2T-CHM13v2.01957,173,230 - 57,179,492 (-)NCBIT2T-CHM13v2.0
Oscar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,521,626 - 74,529,119 (+)NCBIGRCr8
mRatBN7.2165,607,214 - 65,615,395 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,607,410 - 65,613,758 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx171,055,647 - 71,061,883 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,478,623 - 79,484,859 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0172,805,613 - 72,811,842 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0164,182,174 - 64,188,658 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl164,182,422 - 64,188,658 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0163,173,549 - 63,180,129 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,920,506 - 63,925,535 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera163,331,535 - 63,337,783 (+)NCBICelera
Cytogenetic Map1q12NCBI
OSCAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22060,099,494 - 60,105,451 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,021,240 - 62,028,314 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01951,027,449 - 51,033,972 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11959,870,810 - 59,873,139 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1959,871,394 - 59,876,370 (-)Ensemblpanpan1.1panPan2
OSCAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11103,101,462 - 103,113,593 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1103,101,819 - 103,106,974 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1103,162,912 - 103,168,962 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,746,274 - 103,752,320 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,747,000 - 103,752,155 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11103,384,153 - 103,396,647 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01103,145,559 - 103,158,053 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,859,686 - 103,865,735 (+)NCBIUU_Cfam_GSD_1.0
Oscar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,705,658 - 2,711,508 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936994226,424 - 312,143 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936994226,318 - 232,143 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSCAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl656,022,256 - 56,030,646 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1656,021,434 - 56,029,398 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2653,187,447 - 53,195,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OSCAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1646,772,335 - 46,777,606 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607326,859,779 - 26,866,516 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Oscar
244 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1895
Count of miRNA genes:541
Interacting mature miRNAs:644
Transcripts:ENSMUST00000039507, ENSMUST00000108645, ENSMUST00000148012, ENSMUST00000148645
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301177Vent3_mventricular size 3 (mouse)Not determined7120511925Mouse
10054067Sle20_msystematic lupus erythematosus susceptibility 20 (mouse)Not determined7120511925Mouse
1302188Lxw6_mlupus BXSB x NZW 6 (mouse)Not determined7121698146Mouse
12904941Edlmmq6_mextensor digitorum longus muscle mass QTL 6 (mouse)7121821047Mouse
12904948Tammq5_mtibialis anterior muscle mass QTL 5 (mouse)7121821047Mouse
12904953Gmmq5_mgastrocnemius muscle mass QTL 5 (mouse)7121821047Mouse
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7243169636431844Mouse
1302115Abhr3_mallergen-induced bronchial hyperresponsiveness 3 (mouse)Not determined7331599616637423Mouse
1301115Lrdm1_mlymphoproliferation (Fas) renal disease modifier 1 (mouse)Not determined7335204824879418Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
25394570Skmw58_mskeletal muscle weight 58, TA (mouse)735524286281481Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse


Expression


Sequence


RefSeq Acc Id: ENSMUST00000039507   ⟹   ENSMUSP00000041306
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,612,812 - 3,619,132 (-)Ensembl
GRCm38.p6 Ensembl73,609,813 - 3,616,133 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108645   ⟹   ENSMUSP00000104285
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,612,812 - 3,619,156 (-)Ensembl
GRCm38.p6 Ensembl73,609,813 - 3,616,157 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148012   ⟹   ENSMUSP00000123672
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,612,812 - 3,619,156 (-)Ensembl
GRCm38.p6 Ensembl73,609,813 - 3,616,157 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148645
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl73,614,170 - 3,619,084 (-)Ensembl
GRCm38.p6 Ensembl73,611,171 - 3,616,085 (-)Ensembl
RefSeq Acc Id: NM_001290377   ⟹   NP_001277306
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3973,612,812 - 3,619,156 (-)NCBI
GRCm3873,609,813 - 3,616,157 (-)NCBI
Celera73,520,876 - 3,527,962 (-)NCBI
Sequence:
RefSeq Acc Id: NM_175632   ⟹   NP_783440
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3973,612,812 - 3,619,156 (-)NCBI
GRCm3873,609,813 - 3,616,157 (-)NCBI
MGSCv3773,561,415 - 3,567,735 (-)RGD
Celera73,520,876 - 3,527,962 (-)NCBI
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_783440   ⟸   NM_175632
- Peptide Label: isoform 1 precursor
- UniProtKB: B2RQ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001277306   ⟸   NM_001290377
- Peptide Label: isoform 2 precursor
- UniProtKB: Q8VHT9 (UniProtKB/Swiss-Prot),   Q8VBT3 (UniProtKB/Swiss-Prot),   B2RQ61 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000123672   ⟸   ENSMUST00000148012
RefSeq Acc Id: ENSMUSP00000104285   ⟸   ENSMUST00000108645
RefSeq Acc Id: ENSMUSP00000041306   ⟸   ENSMUST00000039507
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VBT3-F1-model_v2 AlphaFold Q8VBT3 1-265 view protein structure

Promoters
RGD ID:6891610
Promoter ID:EPDNEW_M9256
Type:initiation region
Name:Oscar_1
Description:Mus musculus osteoclast associated receptor , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3873,616,111 - 3,616,171EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2179720 AgrOrtholog
Ensembl Genes ENSMUSG00000054594 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039507 ENTREZGENE
  ENSMUST00000039507.15 UniProtKB/Swiss-Prot
  ENSMUST00000108645 ENTREZGENE
  ENSMUST00000108645.8 UniProtKB/Swiss-Prot
  ENSMUST00000148012.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:232790 UniProtKB/Swiss-Prot
MGD MGI:2179720 ENTREZGENE
NCBI Gene 232790 ENTREZGENE
PANTHER MHC CLASS I NK CELL RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Oscar PhenoGen
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RQ61 ENTREZGENE, UniProtKB/TrEMBL
  D3YXX9_MOUSE UniProtKB/TrEMBL
  OSCAR_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8VHT9 ENTREZGENE
UniProt Secondary Q8VHT9 UniProtKB/Swiss-Prot