Reg4 (regenerating islet-derived family, member 4) - Rat Genome Database

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Gene: Reg4 (regenerating islet-derived family, member 4) Mus musculus
Analyze
Symbol: Reg4
Name: regenerating islet-derived family, member 4
RGD ID: 1553892
MGI Page MGI
Description: Predicted to enable heparin binding activity; mannan binding activity; and signaling receptor activity. Acts upstream of or within response to bacterium. Predicted to be located in cytoplasm and extracellular space. Is expressed in appendicular skeleton; axial skeleton; and midbrain ventricular layer. Orthologous to human REG4 (regenerating family member 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2010002L15Rik; GISP; R; REG-4; regenerating islet-derived protein 4; RELP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,129,454 - 98,144,064 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,129,472 - 98,144,064 (+)EnsemblGRCm39 Ensembl
GRCm38398,222,138 - 98,236,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,222,156 - 98,236,748 (+)EnsemblGRCm38mm10GRCm38
MGSCv37398,026,079 - 98,040,671 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36398,307,558 - 98,322,153 (+)NCBIMGSCv36mm8
Celera399,621,376 - 99,635,984 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.73NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12819006   PMID:14610273   PMID:15186480   PMID:15489334   PMID:16141072   PMID:16141073   PMID:19834624   PMID:19900450  
PMID:20562862   PMID:21193457   PMID:21267068   PMID:21873635   PMID:23012479   PMID:27573849   PMID:29850784   PMID:33899235   PMID:36274484   PMID:36293268  


Genomics

Comparative Map Data
Reg4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,129,454 - 98,144,064 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl398,129,472 - 98,144,064 (+)EnsemblGRCm39 Ensembl
GRCm38398,222,138 - 98,236,748 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,222,156 - 98,236,748 (+)EnsemblGRCm38mm10GRCm38
MGSCv37398,026,079 - 98,040,671 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36398,307,558 - 98,322,153 (+)NCBIMGSCv36mm8
Celera399,621,376 - 99,635,984 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.73NCBI
REG4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381119,794,017 - 119,811,460 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1119,794,017 - 119,811,580 (-)EnsemblGRCh38hg38GRCh38
GRCh371120,336,640 - 120,354,083 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,138,231 - 120,155,726 (-)NCBINCBI36Build 36hg18NCBI36
Build 341120,048,750 - 120,066,245NCBI
Celera1118,567,357 - 118,584,911 (-)NCBICelera
Cytogenetic Map1p12NCBI
HuRef1118,195,171 - 118,212,723 (-)NCBIHuRef
CHM1_11120,452,143 - 120,469,705 (-)NCBICHM1_1
T2T-CHM13v2.01119,807,250 - 119,824,685 (-)NCBIT2T-CHM13v2.0
Reg4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82188,507,684 - 188,521,990 (+)NCBIGRCr8
mRatBN7.22185,818,946 - 185,833,252 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2185,821,210 - 185,833,353 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2193,469,977 - 193,481,571 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02191,278,758 - 191,290,273 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02186,102,549 - 186,114,143 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02200,395,253 - 200,410,009 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,397,967 - 200,409,528 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,871,507 - 219,885,867 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42193,066,427 - 193,077,988 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12193,029,180 - 193,040,742 (+)NCBI
Celera2178,310,036 - 178,321,597 (+)NCBICelera
Cytogenetic Map2q34NCBI
Reg4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543522,886,351 - 22,895,884 (-)NCBIChiLan1.0ChiLan1.0
REG4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21112,417,443 - 112,434,874 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11112,019,785 - 112,037,219 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0182,735,390 - 82,753,262 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,733,515 - 117,751,044 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,733,515 - 117,751,044 (+)Ensemblpanpan1.1panPan2
LOC480786
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,728,398 - 56,772,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,358,130 - 56,401,548 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01757,607,371 - 57,651,483 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11756,643,715 - 56,688,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01756,668,944 - 56,713,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01757,286,313 - 57,330,468 (-)NCBIUU_Cfam_GSD_1.0
Reg4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050589,966,375 - 9,976,280 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366274,512,726 - 4,520,080 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366274,512,726 - 4,520,080 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REG4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4101,337,282 - 101,357,025 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14101,337,295 - 101,354,550 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24111,239,504 - 111,256,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
REG4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12013,975,721 - 13,995,645 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2013,978,512 - 13,993,678 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603816,606,542 - 16,624,406 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Reg4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477215,386,024 - 15,398,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477215,385,265 - 15,399,281 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Reg4
445 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:122
Interacting mature miRNAs:129
Transcripts:ENSMUST00000029469
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse
1301349Pgia26_mproteoglycan induced arthritis 26 (mouse)Not determined392251533126251650Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396607316147805636Mouse
1301277nctm1_mNakano cataract modifier 1 (mouse)Not determined397698638100373060Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000029469   ⟹   ENSMUSP00000029469
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl398,129,472 - 98,144,064 (+)Ensembl
GRCm38.p6 Ensembl398,222,156 - 98,236,748 (+)Ensembl
RefSeq Acc Id: NM_026328   ⟹   NP_080604
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39398,129,472 - 98,144,064 (+)NCBI
GRCm38398,222,156 - 98,236,748 (+)NCBI
MGSCv37398,026,079 - 98,040,671 (+)RGD
Celera399,621,376 - 99,635,984 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017319697   ⟹   XP_017175186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39398,129,454 - 98,144,060 (+)NCBI
GRCm38398,222,138 - 98,236,744 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_080604   ⟸   NM_026328
- Peptide Label: precursor
- UniProtKB: Q3TS25 (UniProtKB/Swiss-Prot),   Q9D858 (UniProtKB/Swiss-Prot),   Q9D8G5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017175186   ⟸   XM_017319697
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000029469   ⟸   ENSMUST00000029469
Protein Domains
C-type lectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9D8G5-F1-model_v2 AlphaFold Q9D8G5 1-157 view protein structure

Promoters
RGD ID:6881758
Promoter ID:EPDNEW_M4330
Type:multiple initiation site
Name:Reg4_1
Description:Mus musculus regenerating islet-derived family, member 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38398,222,156 - 98,222,216EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914959 AgrOrtholog
Ensembl Genes ENSMUSG00000027876 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000029469 ENTREZGENE
  ENSMUST00000029469.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.100.10 UniProtKB/Swiss-Prot
InterPro C-type_lectin-like UniProtKB/Swiss-Prot
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot
  CTDL_fold UniProtKB/Swiss-Prot
KEGG Report mmu:67709 UniProtKB/Swiss-Prot
MGD MGI:1914959 ENTREZGENE
NCBI Gene 67709 ENTREZGENE
PANTHER MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED UniProtKB/Swiss-Prot
  REGENERATING ISLET-DERIVED PROTEIN 3-GAMMA UniProtKB/Swiss-Prot
Pfam Lectin_C UniProtKB/Swiss-Prot
PhenoGen Reg4 PhenoGen
PRINTS PNCREATITSAP UniProtKB/Swiss-Prot
PROSITE C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot
SMART CLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot
UniProt Q3TS25 ENTREZGENE
  Q9D858 ENTREZGENE
  Q9D8G5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TS25 UniProtKB/Swiss-Prot
  Q9D858 UniProtKB/Swiss-Prot