Ryk (receptor-like tyrosine kinase) - Rat Genome Database
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Gene: Ryk (receptor-like tyrosine kinase) Mus musculus
Analyze
Symbol: Ryk
Name: receptor-like tyrosine kinase
RGD ID: 1553888
MGI Page MGI
Description: Exhibits Wnt-activated receptor activity; Wnt-protein binding activity; and frizzled binding activity. Involved in corpus callosum development; generation of neurons; and skeletal system morphogenesis. Localizes to cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human RYK (receptor like tyrosine kinase); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW536699; ERK-; ERK-3; growth factor receptor; kinase VIK; met-related kinase; NYK-R; tyrosine-protein kinase RYK; V; Vik
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Ryk-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399102,712,119 - 102,785,506 (+)NCBIGRCm39mm39
GRCm389102,834,920 - 102,908,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9102,834,917 - 102,908,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv379102,737,250 - 102,810,637 (+)NCBIGRCm37mm9NCBIm37
MGSCv369102,693,139 - 102,765,678 (+)NCBImm8
Celera9102,375,302 - 102,457,932 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map954.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:1281989   PMID:1333503   PMID:1334548   PMID:2466296   PMID:3291115   PMID:7542761   PMID:7613029   PMID:7822791   PMID:7893599   PMID:8034026   PMID:8346215   PMID:8380921  
PMID:8386829   PMID:8394755   PMID:10030667   PMID:10066802   PMID:10349636   PMID:10922068   PMID:10932185   PMID:11042159   PMID:11076861   PMID:11114734   PMID:11135307   PMID:12466851  
PMID:12477932   PMID:14610273   PMID:14681479   PMID:15454084   PMID:15489334   PMID:15520276   PMID:15796903   PMID:16116452   PMID:16141072   PMID:16141073   PMID:16280981   PMID:16602821  
PMID:16723543   PMID:18973680   PMID:19000841   PMID:19269974   PMID:20004982   PMID:20084116   PMID:21106844   PMID:21205786   PMID:21677750   PMID:21873635   PMID:21875946   PMID:22773843  
PMID:23144463   PMID:23517308   PMID:23939973   PMID:24471468   PMID:24952961   PMID:24960609   PMID:26490861   PMID:26921296   PMID:27065364   PMID:27882948   PMID:28729735   PMID:29180410  
PMID:29576390   PMID:30516471   PMID:30642948   PMID:30642949   PMID:31257105   PMID:31776260   PMID:32994164  


Genomics

Comparative Map Data
Ryk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399102,712,119 - 102,785,506 (+)NCBIGRCm39mm39
GRCm389102,834,920 - 102,908,307 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9102,834,917 - 102,908,305 (+)EnsemblGRCm38mm10GRCm38
MGSCv379102,737,250 - 102,810,637 (+)NCBIGRCm37mm9NCBIm37
MGSCv369102,693,139 - 102,765,678 (+)NCBImm8
Celera9102,375,302 - 102,457,932 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map954.72NCBI
RYK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3134,065,303 - 134,250,859 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3134,065,303 - 134,250,744 (-)EnsemblGRCh38hg38GRCh38
GRCh383134,157,133 - 134,250,859 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373133,875,978 - 133,969,586 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363135,358,668 - 135,452,276 (-)NCBINCBI36hg18NCBI36
Build 343135,358,675 - 135,452,284NCBI
Celera3132,299,259 - 132,364,742 (-)NCBI
Cytogenetic Map3q22.2NCBI
HuRef3131,253,894 - 131,347,303 (-)NCBIHuRef
CHM1_13133,840,146 - 133,933,826 (-)NCBICHM1_1
Ryk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08111,326,339 - 111,398,640 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8111,326,433 - 111,397,867 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08110,718,666 - 110,790,096 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48107,822,823 - 107,894,331 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18107,893,366 - 107,905,413 (+)NCBI
Celera8102,827,084 - 102,871,070 (+)NCBICelera
Cytogenetic Map8q32NCBI
Ryk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555014,328,682 - 4,419,307 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555014,360,051 - 4,419,083 (+)NCBIChiLan1.0ChiLan1.0
RYK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13138,648,867 - 138,742,316 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v03131,174,507 - 131,296,815 (-)NCBIMhudiblu_PPA_v0panPan3
RYK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2330,968,231 - 31,051,605 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12330,968,105 - 31,051,353 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ryk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365297,273,070 - 7,344,372 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RYK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1375,287,111 - 75,390,525 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11375,285,482 - 75,390,314 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21382,824,703 - 82,935,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RYK
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11556,127,048 - 56,217,407 (+)NCBI
ChlSab1.1 Ensembl1556,127,130 - 56,216,407 (+)Ensembl
Ryk
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473010,462,590 - 10,568,780 (-)NCBI

Position Markers
AW536699  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389102,907,568 - 102,907,680UniSTSGRCm38
MGSCv379102,809,898 - 102,810,010UniSTSGRCm37
Celera9102,457,193 - 102,457,305UniSTS
Cytogenetic Map9F1UniSTS
cM Map961.0UniSTS
Whitehead/MRC_RH91054.95UniSTS
RH77856  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389102,864,394 - 102,864,519UniSTSGRCm38
MGSCv379102,766,724 - 102,766,849UniSTSGRCm37
Celera9102,414,386 - 102,414,511UniSTS
Cytogenetic Map9F1UniSTS
cM Map961.0UniSTS
Ryk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm389102,906,926 - 102,907,093UniSTSGRCm38
MGSCv379102,809,256 - 102,809,423UniSTSGRCm37
Celera9102,456,553 - 102,456,720UniSTS
Cytogenetic Map9F1UniSTS
cM Map961.0UniSTS
Ryk  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map9F1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1802
Count of miRNA genes:650
Interacting mature miRNAs:822
Transcripts:ENSMUST00000035142, ENSMUST00000175788, ENSMUST00000175883, ENSMUST00000176198, ENSMUST00000176573, ENSMUST00000177274
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035142   ⟹   ENSMUSP00000035142
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9102,834,972 - 102,907,953 (+)Ensembl
RefSeq Acc Id: ENSMUST00000175788
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9102,869,066 - 102,881,662 (+)Ensembl
RefSeq Acc Id: ENSMUST00000175883   ⟹   ENSMUSP00000135858
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9102,834,917 - 102,907,542 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176198   ⟹   ENSMUSP00000135396
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9102,834,982 - 102,908,305 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176573
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9102,845,833 - 102,861,897 (+)Ensembl
RefSeq Acc Id: ENSMUST00000177274
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9102,898,555 - 102,899,546 (+)Ensembl
RefSeq Acc Id: NM_001042607   ⟹   NP_001036072
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399102,712,119 - 102,785,506 (+)NCBI
GRCm389102,834,920 - 102,908,307 (+)ENTREZGENE
MGSCv379102,737,250 - 102,810,637 (+)RGD
Celera9102,375,302 - 102,457,932 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001284258   ⟹   NP_001271187
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399102,712,119 - 102,785,506 (+)NCBI
GRCm389102,834,920 - 102,908,307 (+)NCBI
Celera9102,375,302 - 102,457,932 (+)NCBI
Sequence:
RefSeq Acc Id: NM_013649   ⟹   NP_038677
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399102,712,119 - 102,785,506 (+)NCBI
GRCm389102,834,920 - 102,908,307 (+)ENTREZGENE
MGSCv379102,737,250 - 102,810,637 (+)RGD
Celera9102,375,302 - 102,457,932 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001036072   ⟸   NM_001042607
- Peptide Label: isoform 2 precursor
- UniProtKB: Q01887 (UniProtKB/Swiss-Prot),   H9H9R6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_038677   ⟸   NM_013649
- Peptide Label: isoform 1 precursor
- UniProtKB: Q01887 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001271187   ⟸   NM_001284258
- Peptide Label: isoform 3
- UniProtKB: Q8K272 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000035142   ⟸   ENSMUST00000035142
RefSeq Acc Id: ENSMUSP00000135396   ⟸   ENSMUST00000176198
RefSeq Acc Id: ENSMUSP00000135858   ⟸   ENSMUST00000175883
Protein Domains
Protein kinase   WIF

Promoters
RGD ID:6845111
Promoter ID:MM_KWN:58568
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour
Transcripts:NM_001042607,   NM_013649
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369102,737,061 - 102,737,561 (+)MPROMDB
RGD ID:8670620
Promoter ID:EPDNEW_M13341
Type:initiation region
Name:Ryk_1
Description:Mus musculus receptor-like tyrosine kinase , transcript variant3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389102,834,901 - 102,834,961EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101766 AgrOrtholog
Ensembl Genes ENSMUSG00000032547 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035142 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000135396 UniProtKB/TrEMBL
  ENSMUSP00000135858 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000035142 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000175883 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000176198 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:20187 UniProtKB/Swiss-Prot
MGD MGI:101766 ENTREZGENE
NCBI Gene 20187 ENTREZGENE
Pfam Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ryk PhenoGen
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H3BKH8_MOUSE UniProtKB/TrEMBL
  H9H9R6 ENTREZGENE, UniProtKB/TrEMBL
  Q01887 ENTREZGENE
  Q8K272 ENTREZGENE, UniProtKB/TrEMBL
  RYK_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary Q61890 UniProtKB/Swiss-Prot