Pigw (phosphatidylinositol glycan anchor biosynthesis, class W) - Rat Genome Database

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Gene: Pigw (phosphatidylinositol glycan anchor biosynthesis, class W) Mus musculus
Analyze
Symbol: Pigw
Name: phosphatidylinositol glycan anchor biosynthesis, class W
RGD ID: 1553736
MGI Page MGI
Description: Predicted to enable glucosaminyl-phosphatidylinositol O-acyltransferase activity. Predicted to be involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Predicted to be located in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 5. Orthologous to human PIGW (phosphatidylinositol glycan anchor biosynthesis class W).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610044A17Rik; Gwt1; phosphatidylinositol glycan, class W; phosphatidylinositol-glycan biosynthesis class W protein; PIG-W
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,767,139 - 84,771,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,767,141 - 84,771,111 (-)EnsemblGRCm39 Ensembl
GRCm381184,876,313 - 84,880,285 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,876,315 - 84,880,285 (-)EnsemblGRCm38mm10GRCm38
MGSCv371184,689,815 - 84,693,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,692,508 - 84,696,390 (-)NCBIMGSCv36mm8
Celera1194,496,333 - 94,532,662 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11544199   PMID:12477932   PMID:14517336   PMID:14610273   PMID:14681479   PMID:16141072   PMID:16141073   PMID:17062627   PMID:17967808  
PMID:18799693   PMID:21267068   PMID:21367863   PMID:21873635   PMID:32554809  


Genomics

Comparative Map Data
Pigw
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391184,767,139 - 84,771,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1184,767,141 - 84,771,111 (-)EnsemblGRCm39 Ensembl
GRCm381184,876,313 - 84,880,285 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1184,876,315 - 84,880,285 (-)EnsemblGRCm38mm10GRCm38
MGSCv371184,689,815 - 84,693,787 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,692,508 - 84,696,390 (-)NCBIMGSCv36mm8
Celera1194,496,333 - 94,532,662 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.34NCBI
PIGW
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381736,534,987 - 36,539,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1736,534,987 - 36,539,310 (+)EnsemblGRCh38hg38GRCh38
GRCh371734,890,814 - 34,895,152 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,965,516 - 31,969,263 (+)NCBINCBI36Build 36hg18NCBI36
Build 341731,965,515 - 31,969,263NCBI
Celera1731,713,466 - 31,717,424 (+)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,828,170 - 30,831,918 (+)NCBIHuRef
CHM1_11734,927,118 - 34,930,864 (+)NCBICHM1_1
T2T-CHM13v2.01737,520,740 - 37,525,056 (+)NCBIT2T-CHM13v2.0
Pigw
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81070,246,904 - 70,248,412 (-)NCBIGRCr8
mRatBN7.21069,746,996 - 69,782,656 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1069,748,789 - 69,790,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1074,369,482 - 74,370,990 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01073,874,249 - 73,875,757 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01069,338,916 - 69,340,424 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01072,194,774 - 72,198,415 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1072,194,929 - 72,196,437 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01072,101,633 - 72,105,238 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41073,152,849 - 73,154,357 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11073,167,218 - 73,168,727 (-)NCBI
Celera1068,677,469 - 68,678,977 (-)NCBICelera
Cytogenetic Map10q26NCBI
Pigw
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554511,388,474 - 1,391,559 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554511,388,474 - 1,391,671 (-)NCBIChiLan1.0ChiLan1.0
PIGW
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,221,856 - 28,226,353 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,103,675 - 30,107,981 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,542,694 - 20,547,347 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11720,837,103 - 20,841,608 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1720,837,769 - 20,839,283 (-)Ensemblpanpan1.1panPan2
PIGW
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1936,419,807 - 36,424,596 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl936,421,216 - 36,424,218 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha935,604,282 - 35,650,605 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0937,191,002 - 37,233,529 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl937,230,555 - 37,233,526 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1935,969,672 - 36,016,035 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0936,256,607 - 36,303,225 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0936,344,864 - 36,391,468 (+)NCBIUU_Cfam_GSD_1.0
Pigw
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560235,396,190 - 35,399,536 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364901,675,765 - 1,677,279 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364901,675,592 - 1,678,494 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIGW
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1238,061,927 - 38,065,713 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11238,059,674 - 38,065,702 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PIGW
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11631,267,404 - 31,279,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1631,267,562 - 31,269,073 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660772,007,516 - 2,010,858 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pigw
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248713,616,359 - 3,619,560 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248713,616,335 - 3,619,668 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pigw
128 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:238
Count of miRNA genes:168
Interacting mature miRNAs:172
Transcripts:ENSMUST00000067058, ENSMUST00000108080
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115775466091754758Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15850803087695238Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5871926685066529Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116168682088699728Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116215600596156153Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116331940794063918Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116483033698830473Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116483033698830473Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116483033698830473Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000067058   ⟹   ENSMUSP00000064547
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,767,141 - 84,771,021 (-)Ensembl
GRCm38.p6 Ensembl1184,876,315 - 84,880,195 (-)Ensembl
RefSeq Acc Id: ENSMUST00000108080   ⟹   ENSMUSP00000103715
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1184,767,669 - 84,771,111 (-)Ensembl
GRCm38.p6 Ensembl1184,876,843 - 84,880,285 (-)Ensembl
RefSeq Acc Id: NM_001077636   ⟹   NP_001071104
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391184,767,139 - 84,771,111 (-)NCBI
GRCm381184,876,313 - 84,880,285 (-)NCBI
MGSCv371184,689,815 - 84,693,787 (-)RGD
Celera1194,496,333 - 94,532,662 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001363112   ⟹   NP_001350041
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391184,767,139 - 84,771,021 (-)NCBI
GRCm381184,876,313 - 84,880,195 (-)NCBI
Sequence:
RefSeq Acc Id: NM_027388   ⟹   NP_081664
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391184,767,139 - 84,771,021 (-)NCBI
GRCm381184,876,313 - 84,880,195 (-)NCBI
MGSCv371184,689,815 - 84,693,787 (-)RGD
Celera1194,496,333 - 94,532,662 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001071104   ⟸   NM_001077636
- UniProtKB: Q8C4S0 (UniProtKB/Swiss-Prot),   Q9CSX1 (UniProtKB/Swiss-Prot),   Q8C398 (UniProtKB/Swiss-Prot),   B7ZN11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_081664   ⟸   NM_027388
- UniProtKB: Q8C4S0 (UniProtKB/Swiss-Prot),   Q9CSX1 (UniProtKB/Swiss-Prot),   Q8C398 (UniProtKB/Swiss-Prot),   B7ZN11 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001350041   ⟸   NM_001363112
- UniProtKB: Q8C4S0 (UniProtKB/Swiss-Prot),   Q8C398 (UniProtKB/Swiss-Prot),   Q9CSX1 (UniProtKB/Swiss-Prot),   B7ZN11 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000103715   ⟸   ENSMUST00000108080
RefSeq Acc Id: ENSMUSP00000064547   ⟸   ENSMUST00000067058

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8C398-F1-model_v2 AlphaFold Q8C398 1-503 view protein structure

Promoters
RGD ID:6821551
Promoter ID:MM_KWN:8961
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:NM_001077636,   NM_027388
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361184,693,266 - 84,694,707 (-)MPROMDB
RGD ID:8675972
Promoter ID:EPDNEW_M16017
Type:initiation region
Name:Pigw_1
Description:Mus musculus phosphatidylinositol glycan anchor biosynthesis,class W , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381184,880,262 - 84,880,322EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1917575 AgrOrtholog
Ensembl Genes ENSMUSG00000045140 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000067058 ENTREZGENE
  ENSMUST00000067058.3 UniProtKB/Swiss-Prot
  ENSMUST00000108080 ENTREZGENE
  ENSMUST00000108080.3 UniProtKB/Swiss-Prot
InterPro PIGW/GWT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:70325 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1917575 ENTREZGENE
NCBI Gene 70325 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR20661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GWT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pigw PhenoGen
PIRSF GWT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B7ZN11 ENTREZGENE, UniProtKB/TrEMBL
  PIGW_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8C4S0 ENTREZGENE
  Q9CSX1 ENTREZGENE
UniProt Secondary Q8C4S0 UniProtKB/Swiss-Prot
  Q9CSX1 UniProtKB/Swiss-Prot