Sdhc (succinate dehydrogenase complex, subunit C, integral membrane protein) - Rat Genome Database

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Gene: Sdhc (succinate dehydrogenase complex, subunit C, integral membrane protein) Mus musculus
Analyze
Symbol: Sdhc
Name: succinate dehydrogenase complex, subunit C, integral membrane protein
RGD ID: 1553681
MGI Page MGI
Description: Predicted to enable heme binding activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Located in mitochondrion. Part of respiratory chain complex II (succinate dehydrogenase). Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study Leigh disease. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 0610010E03Rik; AI316496; AU019277; integral membrane protein CII-3; malate dehydrogenase [quinone] cytochrome b560 subunit; MGC103103; QPs-1; QPs1; succinate dehydrogenase cytochrome b560 subunit, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,956,726 - 170,978,209 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,954,734 - 170,978,172 (-)EnsemblGRCm39 Ensembl
GRCm381171,129,157 - 171,150,640 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,127,165 - 171,150,603 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,059,288 - 173,080,734 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,965,840 - 172,987,277 (-)NCBIMGSCv36mm8
Celera1173,578,731 - 173,598,849 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
4-chlorobiphenyl  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (ISO)
amiodarone  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cadmium atom  (EXP,ISO)
cannabidiol  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clobetasol  (EXP)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichloromethane  (EXP)
doxorubicin  (EXP,ISO)
fenthion  (EXP)
flutamide  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
gentamycin  (ISO)
glyphosate  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ethionine  (ISO)
lead(0)  (ISO)
mancozeb  (EXP)
melittin  (EXP)
methidathion  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
nefazodone  (ISO)
nimesulide  (ISO)
omeprazole  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-1,2-dichloropropane  (EXP)
silicon dioxide  (ISO)
thalidomide  (EXP)
thapsigargin  (ISO)
thioacetamide  (ISO)
thiram  (ISO)
toluene  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
tungsten  (EXP)
tunicamycin  (ISO)
valproic acid  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Succinate dehydrogenase deficiency in human. Briere JJ, etal., Cell Mol Life Sci. 2005 Oct;62(19-20):2317-24.
2. Genetic variants in genes of tricarboxylic acid cycle key enzymes are associated with prognosis of patients with non-small cell lung cancer. Guo X, etal., Lung Cancer. 2015 Feb;87(2):162-8. doi: 10.1016/j.lungcan.2014.12.005. Epub 2014 Dec 18.
3. A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis. Ishii T, etal., Cancer Res 2005 Jan 1;65(1):203-9.
4. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
8. Mutations in SDHC cause autosomal dominant paraganglioma, type 3. Niemann S and Muller U, Nat Genet. 2000 Nov;26(3):268-70.
9. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. Mouse MP Annotation Import Pipeline RGD automated import pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:3003061   PMID:8889548   PMID:10349636   PMID:10512203   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12676762   PMID:12904583   PMID:12925748   PMID:14610273   PMID:14681479  
PMID:15489334   PMID:15597075   PMID:15741512   PMID:15840001   PMID:16120479   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17626619   PMID:18554416   PMID:18614015   PMID:18799693  
PMID:19808025   PMID:21677750   PMID:21873635   PMID:23142169   PMID:24194600   PMID:25290690   PMID:25737280   PMID:25985299   PMID:27215380   PMID:27623715   PMID:27626380   PMID:28204537  
PMID:28245920   PMID:28619824   PMID:29222160   PMID:30030361   PMID:30973865   PMID:31469588   PMID:33247500   PMID:33358867   PMID:33909984   PMID:35881479   PMID:38355793   PMID:38418556  


Genomics

Comparative Map Data
Sdhc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,956,726 - 170,978,209 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,954,734 - 170,978,172 (-)EnsemblGRCm39 Ensembl
GRCm381171,129,157 - 171,150,640 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1171,127,165 - 171,150,603 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,059,288 - 173,080,734 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,965,840 - 172,987,277 (-)NCBIMGSCv36mm8
Celera1173,578,731 - 173,598,849 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.99NCBI
SDHC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,314,381 - 161,363,206 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,314,381 - 161,363,206 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,284,171 - 161,332,996 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,550,790 - 159,601,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 341158,097,242 - 158,146,049NCBI
Celera1134,351,304 - 134,401,671 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,641,002 - 132,691,319 (+)NCBIHuRef
CHM1_11162,680,387 - 162,730,796 (+)NCBICHM1_1
T2T-CHM13v2.01160,451,814 - 160,500,650 (+)NCBIT2T-CHM13v2.0
Sdhc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81386,077,133 - 86,098,025 (-)NCBIGRCr8
mRatBN7.21383,544,652 - 83,565,560 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,544,652 - 83,566,253 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1386,050,394 - 86,071,277 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,448,631 - 87,469,514 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,680,351 - 84,701,243 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,498,047 - 89,518,979 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,498,048 - 89,518,939 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01394,125,548 - 94,146,440 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,014,569 - 87,035,239 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11387,203,453 - 87,224,123 (-)NCBI
Celera1383,176,204 - 83,197,047 (-)NCBICelera
Cytogenetic Map13q24NCBI
Sdhc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546813,049,848 - 13,083,156 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546813,050,359 - 13,083,932 (+)NCBIChiLan1.0ChiLan1.0
SDHC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,491,404 - 88,542,144 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1188,181,669 - 88,232,415 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01136,724,663 - 136,773,038 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,635,250 - 140,683,390 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,635,685 - 140,682,736 (+)Ensemblpanpan1.1panPan2
SDHC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,162,850 - 21,200,429 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3821,162,421 - 21,200,333 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3821,237,330 - 21,275,269 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03821,280,197 - 21,318,198 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3821,275,939 - 21,318,141 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13821,177,285 - 21,215,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,583,510 - 21,621,477 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03821,991,569 - 22,029,750 (-)NCBIUU_Cfam_GSD_1.0
Sdhc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,383,971 - 7,428,187 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936903601,355 - 636,092 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936903592,641 - 636,845 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SDHC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl489,130,379 - 89,169,118 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1489,135,410 - 89,169,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,992,639 - 97,026,545 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SDHC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,613,618 - 2,658,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,670,467 - 1,715,438 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sdhc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479454,143 - 98,292 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479455,907 - 97,991 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sdhc
848 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1116
Count of miRNA genes:576
Interacting mature miRNAs:683
Transcripts:ENSMUST00000081560, ENSMUST00000111336, ENSMUST00000155798
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
1302037Nktcn1_mnatural killer T cell numbers 1 (mouse)Not determined1168186243171632257Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
4141878Qrr1_mQTL rich region on chromosome 1 (mouse)Not determined170878743175320066Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
1357854Sle16_msystematic lupus erythematosus susceptibility 16 (mouse)Not determined1169038741177377587Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
1301016Szs1_mseizure susceptibility 1 (mouse)Not determined1170878743174456436Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
10412205Bbaa30_mB.burgdorferi-associated arthritis 30 (mouse)Not determined1169038741174456436Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153557406175468938Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156602037176262693Mouse
12910522Scgq2_mspontaneous crescentic glomerulonephritis QTL 2 (mouse)1147125258171632257Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
38456000Lick2_mlick rate 2, sucralose (mouse)1170397438173397435Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
38456001Lick1_mlick rate 1, water (mouse)1170397438173397435Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
13452393Ity3b_mimmunity to S. typhimurium 3b (mouse)1156497439172097436Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
1302201Alcw1_malcohol withdrawal 1 (mouse)Not determined1170868354171966357Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
4142065Bmd5b_mbone mineral density 5b (mouse)Not determined168835111171765633Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
13207571Tcq11_mtotal cholesterol QTL 11 (mouse)1169137569179647565Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
13207587Mwmlpt1_mMorris water maze latency to platform, training, 1 (mouse)1169597438173397435Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
13207591Mwmlpa1_mMorris water maze latency to platform, all, 1 (mouse)1169797438173297435Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse

Markers in Region
RH136553  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381171,129,509 - 171,129,681UniSTSGRCm38
MGSCv371173,059,640 - 173,059,812UniSTSGRCm37
Celera1173,579,085 - 173,579,257UniSTS
Cytogenetic Map1H3UniSTS
24.MMHAP87FRH9.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381171,152,162 - 171,152,333UniSTSGRCm38
MGSCv371173,082,293 - 173,082,464UniSTSGRCm37
Celera1173,600,409 - 173,600,580UniSTS
Cytogenetic Map1H3UniSTS
cM Map192.4UniSTS
Whitehead_YAC1 UniSTS
AI316496  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381171,129,611 - 171,129,691UniSTSGRCm38
MGSCv371173,059,742 - 173,059,822UniSTSGRCm37
Celera1173,579,187 - 173,579,267UniSTS
Cytogenetic Map1H3UniSTS
Whitehead/MRC_RH12123.41UniSTS
Sdhc  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H3UniSTS
cM Map1 UniSTS
AW742715  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381171,129,343 - 171,129,591UniSTSGRCm38
MGSCv371173,059,474 - 173,059,722UniSTSGRCm37
Celera1173,578,919 - 173,579,167UniSTS
Cytogenetic Map1H3UniSTS
Whitehead/MRC_RH12123.31UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000081560   ⟹   ENSMUSP00000080273
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,956,976 - 170,978,160 (-)Ensembl
GRCm38.p6 Ensembl1171,129,407 - 171,150,591 (-)Ensembl
Ensembl Acc Id: ENSMUST00000111336   ⟹   ENSMUSP00000106968
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,954,734 - 170,978,172 (-)Ensembl
GRCm38.p6 Ensembl1171,127,165 - 171,150,603 (-)Ensembl
Ensembl Acc Id: ENSMUST00000155798   ⟹   ENSMUSP00000122062
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1170,966,295 - 170,978,157 (-)Ensembl
GRCm38.p6 Ensembl1171,138,726 - 171,150,588 (-)Ensembl
RefSeq Acc Id: NM_025321   ⟹   NP_079597
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,956,726 - 170,978,172 (-)NCBI
GRCm381171,129,157 - 171,150,603 (-)NCBI
MGSCv371173,059,288 - 173,080,734 (-)RGD
Celera1173,578,731 - 173,598,849 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496955   ⟹   XP_006497018
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,956,733 - 170,978,209 (-)NCBI
GRCm381171,129,164 - 171,150,640 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030241961   ⟹   XP_030097821
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391170,956,733 - 170,978,167 (-)NCBI
GRCm381171,129,164 - 171,150,598 (-)NCBI
Sequence:
RefSeq Acc Id: NP_079597   ⟸   NM_025321
- Peptide Label: precursor
- UniProtKB: Q99JP2 (UniProtKB/Swiss-Prot),   Q544Q9 (UniProtKB/Swiss-Prot),   Q9DCU7 (UniProtKB/Swiss-Prot),   Q9CZB0 (UniProtKB/Swiss-Prot),   Q5XK33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006497018   ⟸   XM_006496955
- Peptide Label: isoform X1
- UniProtKB: Q5XK33 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030097821   ⟸   XM_030241961
- Peptide Label: isoform X2
- UniProtKB: F8WGB3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000106968   ⟸   ENSMUST00000111336
Ensembl Acc Id: ENSMUSP00000080273   ⟸   ENSMUST00000081560
Ensembl Acc Id: ENSMUSP00000122062   ⟸   ENSMUST00000155798

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9CZB0-F1-model_v2 AlphaFold Q9CZB0 1-169 view protein structure

Promoters
RGD ID:6875650
Promoter ID:EPDNEW_M1276
Type:multiple initiation site
Name:Sdhc_1
Description:Mus musculus succinate dehydrogenase complex, subunit C, integralmembrane protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381171,150,603 - 171,150,663EPDNEW
RGD ID:6818115
Promoter ID:MM_KWN:2824
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000081560,   OTTMUST00000051092,   OTTMUST00000051420,   OTTMUST00000051422
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361173,079,621 - 173,081,332 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1913302 AgrOrtholog
Ensembl Genes ENSMUSG00000058076 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081560.5 UniProtKB/TrEMBL
  ENSMUST00000111336 ENTREZGENE
  ENSMUST00000111336.10 UniProtKB/Swiss-Prot
  ENSMUST00000155798.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1300.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Single helix bin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SQR/QFR_C/D UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Succ_DH_cyt_bsu_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Succ_DH_cytb556 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SuccDH_FuR_B_TM-su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:66052 UniProtKB/Swiss-Prot
MGD MGI:1913302 ENTREZGENE
NCBI Gene 66052 ENTREZGENE
PANTHER PTHR10978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sdh_cyt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sdhc PhenoGen
PIRSF SDH_cyt_b560 UniProtKB/TrEMBL
PROSITE SDH_CYT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDH_CYT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C560_MOUSE UniProtKB/Swiss-Prot
  D3Z1A8_MOUSE UniProtKB/TrEMBL
  F8WGB3 ENTREZGENE, UniProtKB/TrEMBL
  Q544Q9 ENTREZGENE
  Q5XK33 ENTREZGENE, UniProtKB/TrEMBL
  Q99JP2 ENTREZGENE
  Q9CZB0 ENTREZGENE
  Q9DCU7 ENTREZGENE
UniProt Secondary Q544Q9 UniProtKB/Swiss-Prot
  Q99JP2 UniProtKB/Swiss-Prot
  Q9DCU7 UniProtKB/Swiss-Prot