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Gene: Bpnt2 (3'(2'), 5'-bisphosphate nucleotidase 2) Mus musculus

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Symbol:

Bpnt2

Name:

3'(2'), 5'-bisphosphate nucleotidase 2

RGD ID:

1553656

MGI Page

MGI

Description:

Enables 3',5'-nucleotide bisphosphate phosphatase activity and 3'-nucleotidase activity. Acts upstream of or within several processes, including chondroitin sulfate metabolic process; embryonic digit morphogenesis; and skeletal system development. Located in trans-Golgi network membrane. Is expressed in brain; metanephros; respiratory system; rib; and spinal cord. Used to study chondrodysplasia with joint dislocations gPAPP type. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Orthologous to human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1110001C20Rik; AA408880; AI451589; AL022796; B230207P20; g; Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; golgi-resident PAP phosphatase; gPAPP; Imp; IMP 3; Impad1; IMPase 3; inositol monophosphatase 3; inositol monophosphatase domain containing 1; inositol monophosphatase domain-containing protein 1; inositol-1(or 4)-monophosphatase 3; Ja; Jaws; myo-inositol monophosphatase A3; phosphoadenosine phosphate 3'-nucleotidase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Bpnt2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bpnt2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Bpnt2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bpnt2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Bpnt2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	impad1 (inositol monophosphatase domain containing 1)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Drosophila melanogaster (fruit fly):	CG15743	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gpap-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MET22	Alliance	DIOPT (Ensembl Compara\|Hieranoid)
Xenopus tropicalis (tropical clawed frog):	bpnt2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	4,762,484 - 4,793,306 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	4,762,484 - 4,793,355 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	4,762,484 - 4,793,306 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	4,762,484 - 4,793,355 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	4,691,489 - 4,720,453 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	4,691,489 - 4,720,453 (-)	NCBI		MGSCv36	mm8
Celera	4	4,712,407 - 4,741,376 (-)	NCBI		Celera
Cytogenetic Map	4	A1	NCBI
cM Map	4	2.56	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

chondrodysplasia with joint dislocations gPAPP type (IAGP,ISO)

osteochondrodysplasia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (EXP)

3,4-methylenedioxymethamphetamine (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (ISO)

Bisphenol B (ISO)

bisphenol F (EXP,ISO)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

calciol (EXP)

carbamazepine (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

choline (EXP)

cisplatin (ISO)

cytarabine (ISO)

dexamethasone (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethyl methanesulfonate (ISO)

flutamide (ISO)

folic acid (EXP)

formaldehyde (ISO)

gentamycin (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

ivermectin (ISO)

L-methionine (EXP)

methapyrilene (ISO)

N-acetyl-1,4-benzoquinone imine (ISO)

nefazodone (ISO)

nickel atom (ISO)

paracetamol (EXP,ISO)

phenobarbital (EXP)

phenylmercury acetate (ISO)

potassium chromate (ISO)

propiconazole (EXP)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

sodium arsenate (EXP)

sodium arsenite (ISO)

succimer (EXP)

tetrachloromethane (EXP)

thioacetamide (ISO)

titanium dioxide (EXP)

trichloroethene (ISO)

trimellitic anhydride (EXP)

triphenyl phosphate (ISO)

troglitazone (EXP)

valproic acid (EXP,ISO)

vinclozolin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chondrocyte development (IMP)

chondroitin sulfate metabolic process (IMP)

embryonic digit morphogenesis (IMP)

endochondral ossification (IMP)

phosphatidylinositol phosphate biosynthetic process (IEA)

post-embryonic development (IMP)

skeletal system development (IBA,IMP)

Cellular Component

cytosol (IEA,ISO)

endomembrane system (IBA)

Golgi apparatus (ISO)

nuclear body (IEA,ISO)

nucleoplasm (ISO)

trans-Golgi network membrane (IDA)

Molecular Function

3'(2'),5'-bisphosphate nucleotidase activity (IEA)

3',5'-nucleotide bisphosphate phosphatase activity (IDA)

3'-nucleotidase activity (IBA,IDA)

metal ion binding (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal axial skeleton morphology (IAGP)

abnormal cartilage development (IAGP)

abnormal joint morphology (IAGP)

abnormal knee joint morphology (IAGP)

abnormal respiratory system physiology (IAGP)

abnormal skeleton morphology (IAGP)

abnormal thoracic cage morphology (IAGP)

atelectasis (IAGP)

axial skeleton hypoplasia (IAGP)

cleft palate (IAGP)

cleft secondary palate (IAGP)

decreased birth body size (IAGP)

disorganized long bone epiphyseal plate (IAGP)

disproportionate dwarf (IAGP)

increased body weight (IEA)

neonatal lethality, complete penetrance (IAGP)

perinatal lethality (IAGP)

perinatal lethality, complete penetrance (IAGP)

respiratory distress (IAGP)

round head (IAGP)

short femur (IAGP)

short fibula (IAGP)

short humerus (IAGP)

short limbs (IAGP)

short radius (IAGP)

short ribs (IAGP)

short scapula (IAGP)

short snout (IAGP)

short sternum (IAGP)

short tibia (IAGP)

short ulna (IAGP)

shortened head (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Database resources of the National Center for Biotechnology Information.	Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.

Additional References at PubMed

PMID:7671812	PMID:8889548	PMID:10349636	PMID:10922068	PMID:11042159	PMID:11076861	PMID:11356033	PMID:12477932	PMID:12520002	PMID:16141072	PMID:16141073	PMID:18539921
PMID:18641651	PMID:18695242	PMID:21677750	PMID:21873635	PMID:23479625	PMID:25921334	PMID:28378742	PMID:30865697	PMID:30973865	PMID:34634304	PMID:34920982	PMID:38355793

Genomics

Comparative Map Data

Bpnt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	4,762,484 - 4,793,306 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	4,762,484 - 4,793,355 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	4,762,484 - 4,793,306 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	4,762,484 - 4,793,355 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	4,691,489 - 4,720,453 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	4,691,489 - 4,720,453 (-)	NCBI		MGSCv36	mm8
Celera	4	4,712,407 - 4,741,376 (-)	NCBI		Celera
Cytogenetic Map	4	A1	NCBI
cM Map	4	2.56	NCBI

BPNT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	56,957,931 - 56,993,867 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	56,957,931 - 56,993,867 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	57,870,490 - 57,906,426 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	58,033,042 - 58,068,981 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	8	53,861,222 - 53,897,192 (-)	NCBI		Celera
Cytogenetic Map	8	q12.1	NCBI
HuRef	8	53,338,861 - 53,374,799 (-)	NCBI		HuRef
CHM1_1	8	57,922,244 - 57,958,186 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	57,335,005 - 57,370,940 (-)	NCBI		T2T-CHM13v2.0

Bpnt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	22,573,241 - 22,600,126 (-)	NCBI		GRCr8
mRatBN7.2	5	17,775,684 - 17,802,570 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	17,772,608 - 17,802,570 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	20,008,545 - 20,035,424 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	21,607,051 - 21,633,933 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	21,357,304 - 21,388,134 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	17	90,191,119 - 90,218,013 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	17,633,766 - 17,663,589 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	17	90,188,043 - 90,218,013 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	22,419,595 - 22,446,480 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	18,086,121 - 18,109,691 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	5	17,116,716 - 17,144,147 (-)	NCBI		Celera
Cytogenetic Map	5	q12	NCBI

Bpnt2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955454	15,899,820 - 15,918,222 (-)	NCBI	ChiLan1.0	ChiLan1.0

BPNT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	72,600,102 - 72,635,725 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	48,323,401 - 48,359,034 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	53,385,837 - 53,417,019 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	50,753,792 - 50,785,055 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	50,753,792 - 50,785,055 (-)	Ensembl	panpan1.1		panPan2

BPNT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	8,176,977 - 8,215,561 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	8,182,508 - 8,215,868 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	8,489,359 - 8,527,888 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	8,248,236 - 8,286,775 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	8,248,495 - 8,286,727 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	8,265,711 - 8,304,249 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	8,391,268 - 8,430,020 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	8,670,438 - 8,708,972 (-)	NCBI		UU_Cfam_GSD_1.0

Bpnt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	71,263,529 - 71,285,901 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936496	3,500,303 - 3,521,673 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936496	3,498,534 - 3,521,939 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BPNT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	75,191,257 - 75,215,906 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	75,191,256 - 75,210,988 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	82,110,550 - 82,130,272 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BPNT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	52,962,686 - 52,999,006 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	52,968,532 - 52,998,996 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	88,779,510 - 88,815,872 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bpnt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624886	2,983,121 - 3,005,596 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624886	2,983,077 - 3,005,596 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Bpnt2
1489 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1615
Count of miRNA genes:	681
Interacting mature miRNAs:	904
Transcripts:	ENSMUST00000084949
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10412079	Sm1_m	susceptibility to Schistosoma mansoni infection 1 (mouse)			Not determined		4	1	22955614	Mouse
11567249	Elorr3_m	ethanol induced loss of righting response 3 (mouse)					4	3722677	156268235	Mouse
11049579	Lmr9b_m	leishmaniasis resistance 9b (mouse)					4	1	20657234	Mouse
11049580	Lmr9a_m	leishmaniasis resistance 9 (mouse)					4	1	20657234	Mouse
1301510	Bbaa13_m	B.burgdorferi-associated arthritis 13 (mouse)			Not determined		4	1	26395649	Mouse
1301274	Lmr9_m	leishmaniasis resistance 9 (mouse)			Not determined		4	1	20657234	Mouse

Markers in Region

AI451589

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	4,762,831 - 4,762,915	UniSTS	GRCm38
MGSCv37	4	4,689,978 - 4,690,062	UniSTS	GRCm37
Celera	4	4,710,896 - 4,710,980	UniSTS
Cytogenetic Map	4	A1	UniSTS
Whitehead/MRC_RH	4	23.15	UniSTS

RH124786

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	4,764,553 - 4,764,648	UniSTS	GRCm38
MGSCv37	4	4,691,700 - 4,691,795	UniSTS	GRCm37
Celera	4	4,712,618 - 4,712,713	UniSTS
Cytogenetic Map	4	A1	UniSTS

RH125433

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	4	4,764,594 - 4,764,858	UniSTS	GRCm38
MGSCv37	4	4,691,741 - 4,692,005	UniSTS	GRCm37
Celera	4	4,712,659 - 4,712,923	UniSTS
Cytogenetic Map	4	A1	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_177730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AK003208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK039735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK041202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK045075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK045511	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK147096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL772346	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC048776	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC138209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC145952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466538	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000084949 ⟹ ENSMUSP00000082013

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	4	4,762,484 - 4,793,355 (-)	Ensembl
GRCm38.p6 Ensembl	4	4,762,484 - 4,793,355 (-)	Ensembl

RefSeq Acc Id:

NM_177730 ⟹ NP_808398

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	4	4,762,484 - 4,793,306 (-)	NCBI
GRCm38	4	4,762,484 - 4,793,306 (-)	NCBI
MGSCv37	4	4,691,489 - 4,720,453 (-)	RGD
Celera	4	4,712,407 - 4,741,376 (-)	RGD
cM Map	4		ENTREZGENE

Sequence:

show sequence

GGCCGACCGTTGGCCTACGCGGAAGGCCGATCGGCCAGCTGCTGGCTGCTGCAAGGCAGGGCCG
TGGGGTACGGGGCGTGGGAGGCGGCGGCGGCGCGGCTTTCCCTGAGCGGTGATGGCGCGGGAGG
GCGCCAGGAAGCGGGCGCCTTTGTAGCGGACTCAGCGGCGGGCCTGAAGCGGCCTTAGCGCCGG
TCGCGCGCGCCATGGCCCCCATGGGCATCCGCCTGTCCCCGCTGGGGGTGGCCGTATTTTTCCT
GCTGGGGCTCGGGGTGCTCTACCACCTCTACTCGGGCTTCCTGGCCGGCCGCTTCAGCCTCTTC
GGCCTGGGCAGCGAGCCGGCGGCAGGGGAGGCCGAGGTGGCGTCCGACGGGGGCACGGTGGACC
TGCGCGAGATGCTGGCCGTGGCCGTGCTGGCGGCCGAGCGCGGCGGCGACGAGGTGAGGCGGGT
CCGCGAGAGCAATGTCCTTCACGAGAAGTCCAAGGGGAAGACGCGCGAGGGCGCCGATGATAAG
ATGACCAGCGGCGACGTACTGTCCAACCGCAAGATGTTCTACCTGCTCAAGACGGCCTTCCCCA
ACGTGCAGATAAATACTGAGGAACATGTGGATGCCTCTGACAAGGAGGTCATTGTATGGAACCG
GAAGATTCCTGAGGACATCCTGAAGGAAATCGCTGCTCCTAAGGAGGTACCAGCAGAAAGTGTG
ACAGTTTGGATTGACCCACTTGATGCTACACAGGAATACACAGAGGATCTTCGAAAGTATGTCA
CTACCATGGTGTGTGTAGCTGTGAATGGCAAACCTGTGTTAGGAGTTATTCATAAGCCATTTTC
TGAATATACAGCTTGGGCAATGGTAGATGGTGGTTCAAATGTGAAAGCCCGTTCTTCCTACAAT
GAGAAGACCCCAAAGATCATTGTGTCTCGCTCTCATGCAGGAATGGTCAAACAGGTTGCTCTTC
AGACGTTTGGAAACCAGACTTCAATTATCCCAGCTGGGGGTGCTGGTTATAAAGTTTTAGCACT
CTTGGATGTGCCTGATATGACTCAAGAAAAAGCAGATCTATATATTCATGTGACATACATCAAA
AAGTGGGATATATGTGCTGGCAATGCCATCTTAAAAGCCCTTGGTGGCCATATGACCACTCTGA
ATGGAGAAGAGATCAGTTACACTGGGTCTGATGGCATTGAAGGGGGACTTCTTGCTAGCATCAG
AATGAACCACCAAGCTCTGGTCAGAAAACTTCCGGATTTAGAAAAGTCAGGACATTAGTAAGCA
TTCCTGACCACAAGATGCACCTCTTCCAGATGTGAATTATTCGGCCTGAGCTGTTGGAACTGTT
GAAGTGCTGGTGGAGATGATGCATGGTTAAGGCCGCCCTGAAGTACTTTGGAAGTACTTATGAA
GCAGCAGAGACTTACTTTCCCTGTAATAGGATACAAAATCAGGGAAATTAGATTGCTTCATTTC
TCAAGTATTGTCTTTATTTTTGAGACTATTTTCATACAGTTGTCATATACAAGGTGCATATATA
TATATGTATGTATGTATATATATACATATATATATATTTGTGAATTAATATCTAGAACTGAGTC
TACACTGTTATGAGTCACCATTTTCACACAACAAATGATGAGTCTGCATTGTTGATACTTCCAT
ATAGAATGGGATTTGAGAAAGGGAAGGTTTTGTTTTATGTAGAGTTTAGTGTAACTTCTAGGTT
GTATATTATTAAAAATAAAATCATTGGTGATTTTTACTCCTCAGATGGAAAGCACAAGAAGTCT
CATATTCATTAATATGCAACAAGTGCTCTGTTCATCTGCCTTTCTATGGATTTCATAGAAATGG
CTTAAGTCGGTTATTTTCTTTGAAATTGTACTAACAGATTGACCAGCTGGTAGAAGGTAGACAG
ATGACTGAATTATACTGGAATTGTCTGAGTGTTGCAGTTGATTTTCATTTCCCTATGAAAGGGG
CCATTGTTCATCCTTTCTCCACTGATCAGGATTTAGTCTTCACCAGGAAAGTTGGTTCAAGTTT
CAGTATTAGTCTCATGATATGCATATTTTCTCTTCAGAGATGAACTATGTTGTAAGATGCTCTA
AGAATATAAATGATTCTATGATTGTTGAAAGTTACTTGACATATAGATTGAATAGTTTTAGCTA
TTTTTCAAGAATTATGTTTTGTTTATGTAATAATGTTTCTTAATTTTTGAAACCTTGCCAGGTT
TATCTCTAGACATTCTCTTATCATCAAGAATGGCTATGACTTTTTTCTTAGCTATTAATAGACT
TAAAAGAACCAAATTATCAGAGGAATTACTTTTGACATAATTCTAGTTTTCTCATTGATAAAAT
TTTTTTTCCCACTCAGTTGACAGAATGTGGTTAAAAAAAGATATGGTAGCATTTGTCGTGTTGC
TATAACTCAGAACTTGTTTTTTTGAGCTGTATTTGTTGGTGTGAGTAGTTTTTCTTAGTATGGC
CTAGAAAATTGGTATAAATAATAAATCATGGTTTTTTTCATGTGGCTTTGATGCCCTTGTAAAC
GTTAATGAGGAATTTCTCATTTTTTCTTTTTTAAAAATGTAAGCCTAAAGAAAATTTCTATTTA
TTTTCCTATTTCAGAGCTAAAATTGAGCAAAGGATGGACATTCTAGTCTGGTATATTGTGCATA
CTTTAGGTTTGCATGTCATAGAGCCCAAAGCCTGGCACTCCTCAGCAGGGGACTGAATCTTAAT
GCAGCACAAGTGCTTTTCCCCGTACTTAACAGTATGTAACAGTATGTTACAGTATGTAACGGCA
CTAAATTGGCCTTTGTGTGATGAAAATTCAGTTTTGGTGTTTGGAAACTTGGTATTAATTTAAT
AGGAGTTGTTAGTTTTTAAAACAGTTTCAGACAACTAGTCTAATCACCAGATAATATGACAGGA
GAAAGGAAATCCTGCTTTCTCTGGCGAGATGCCAGAGCAGATCGTCTCACCAGAATCCTGTATT
AGGAACCTCTGTGTCACTGTAACATGTCAACGCAGAAAATAGAACTTAATTGGGTAATTTTTTA
ATGTGCAGAAACTTTATCATTTATTACAAGTAAAACTAGTTCATATTTTGTAAGCACAATTGCT
TTTGTTTTTAGTTTCATTAACAGTTATCACTAAGAATAGGAACATTGTGTGTTGGGCTCAGAAG
CAAAGATGCTGGCTGAGAGGTGGAAGTAGTTTTTATAATTTGTTCGTGTTATCTAATGATTTTA
CGTACTTTTATAGACAGTTCATTTTTTAATATAATTTTGTTTCAAAGCCAATATACATTACAAG
GAAAACAGTATTTATTTATATGAGGTATTATTGTGCCAGAACATATCTGCTGTGGAGTATGTAA
TATCTCTCAGAATTAATGTTAAATTGTTTTATTTCTAAAACATACCAAAACAAGTTTCTATTTA
GAAACTTACCTGTTTTTCCTTTAGTAGAAGCAGAGACATCCACAGCCTCAACAGATCACACCAG
CTGTCTCCTCCTCACTCACGATATCCCAGCTCCATTTTTTTTTCTTTTTTTGGCTCTCTTTCTT
AGCTAGTATGCTACCTTGCCCCACGCTTAACCAAAATTTTCTTATAAACTCTTTCTTCTGTATA
TTGGCCACTGAACAGGTAGAATTGAGACTTTGGTAAAGTTCACAATGAAAGTGTTCAATCCTGG
AAGAGGTTTAGTTAACCATTATTTTTTAGGCTTCATGAGATGTAAAGAAAATTGCCTTGGGAAC
CATAAACAATTCATGCTCTTATATGACTCAATACTAACATTTTTACAAAGTACCTCTTCCTGCC
CATCTCAAGAATATAAGCCTGGAATATGCTAGGGAATTGGATAGGTAAGCCCACTTGAAGAACC
TTGTTTTTCTGTTGGTTTTCATTCTTACATCCCAGCCTCCACTTCAGTTGAGTTTACAAGGCTG
TACAAACAGTCATATTTGTCTTTGTGGTTTTTCTCCTTTCCCCAATTTTATGTTTTGTTTTGTT
TTGTTTTGTTTTGTTTACTAAAATACTTAATGAGATATTAGTGATAACTAATGAACTGTCAAGA
ACATCTAGATTTATGTTTATATGACAGTTATGGGGCTTGTTTCCTGAGGCTCCTTTGGACTGTC
TACAGATTATGTCAGAAGAAATAGGTAGGGCCAAGGTTAGGAAGAGATGGAAGATTCAGAAGCC
CAGGGCAGAGAGATCAGTGAGGGTGAGAGGCTAGCATTTGCCCTGGCTCCTGTCCTCACCCTGC
TCTTAGATCCGAGTTCAAAAATAAGATAAAACTCTACCTATGATGGCAGTGCTCAGGTAACTCA
GGCAGAAGTACAGTCAAGTGCCAACCATTTTAACTTTCTTGATCATAGCTGATGGCCTTCCTGG
GACAACCTGGAAGGTCAAAGCAAGAACTCTTGAGATTATTCTAGCTGCAACTACCAGTGGTGGC
TGTGTATATTACTGCTGTGTAGAAACATTAGTAGTGTTTTCATTTTAGGTCCAAGTAAGATGTT
TTTAGTGATATACCTGCAGAATGGCTCTGTCTTAAAACTGTGTAGAAAAACCCTAATCTTTAGG
AGCTTTCCCTAAGGAAAAAAAAAAAAAAGTTGTGCCTTACATAGGGCGTTGTGTGTTAATTATA
TTAATAAGTGGGGGTAGCTTGTTCCCATTAAATGTAAGTTCTGTTAATGTGTTTTTATCAGAGT
TGGGGGAAAGTCATTAAAATTAAATAAAACTGATGGATTATTTTTGCATAATGTAGCATTTATA
GTTGAAGTACATTTTTCTAAGAATTGGATCATGATGTATATAAGTCTGAAATGATGTTTCATCA
TTTGGTTTTTAATTAAATGTAAGACCAGGATAGATTGGATTTTAAAAATCTTACTTTTCAATAA
ATTATTTCAGACAACTTCATATTTCTCTAATTCTCTGGAGTAACTTTGGTTAAAAAATAGCTGT
TAGTGGTACAAATTTGGTGGTCTCTTAGTTAAATGATATTGTGTGTTGTTCCTAATGAGGGAAG
GATTCTAATCTTGACCAGCAATGGTTGTGAGGGCTGCTTCTTCACAGTAGTGAAGTTCAGCAAC
AACATGGTTCTGTGAGGTGCTGATATGCATGTAAATTGTTCTTTTCTTTCATTATCAAAGCCCA
GCAGGTATATGTATTCTGACTTCCCATTGACAGGATTTTTGTTTGTTTGTTTATTTTTTATTGT
TATTTTTTTGTTGGGCAGTAAATTAATTTAATGGAAGAAATGAGATGTTTGCCTTTGAAATAAT
ACAGGACAAACTCTGAAGAATGATGAATAATACTAAGACAGCTGATTATATATTGTGTTTGTGG
TCATTCCCTAAAGTTATTATATAATATATCTTATAAAGTGCAAAAGCAGGGGTTGTAATGTTTT
GTCAGTATATTTAATTAATATTTTAAGGTGTAAAACAGAGGTCATTCTGGAAAGACTTGTTCCT
CTGTTTAAAGAAAAAAAAAAAAAAACCTAGGAAAGAAACACACTAAGTTAACATGAGATACTTA
ACCTGAAAGAAATCTCATGTCCTCACATATGGTCTTCAGCCTTTATAGTGTGGAGACATTTAGA
GAAGGACCCTTCGTGTCCTGTACTTGCAGTGACCAGCACCGGCCTTTGTAGTGTAACAGGGTGT
TGAGAGTGATGGACTACATGTTCATAGGACTTGTTCACATTGACAGTGCTGCCTTGACCAGCCT
ATGCCTGTGTCACCAGAACTGTGTCCTTTCCCTAATATTTTAAACTATTTTTTTATCCTCTCTT
CCTGTTAATGCATTTCTTAAAATGGGTCAACGGTGAGAGAAATTTAAATATTTACCTTTGAATA
CTTCTCTCTTTTCATATATATAAAGCCATGGAAGAAATAAGCTGTTTTCCTTTGGCAGAGATGC
CACATTTTCTTAACAGGCTCTGACCTGCCAACCCACTTCACCAGATTGAAGTGGAGGTCAGTGG
TGTTACCTGAAGAAACATCTCCATCCATGGCCTTAGAAGAGTGCTTTATGCCTCACCACACCAC
TTTTATAAATGCTATTAGTGTTCTTGCTAAGGAGATGGAGGATGTCTGGTTTTGTGTGTGCGTT
TTCACCATATCCCCAGTACCTAGAGTCTTGCACAAACTCAGTCCAGACTGTGTGTTGAGTTGAA
CTAAAGGGTCACTACTAGTGTTAGCATGCTTCATACCTCAGTAGTATAAGCTAGTTGTTTCCTT
TGCTGATATTTGTAATTATTACCCATACACACTACATTGTTTTTGTTGTTGTTTTAAAAGTTAG
GCCTTTTCGCTAGATACTACACCATGGTCAATTAACTGTAAAAAAAATAAAAATGTGATTGCTT
CTAATGAAATAATTTCCCCAAACCCTGCCCCTGAATATACTTTGACAAGTGAAATTTGAATTCA
TCAAATAAATCAGTCATGTCTGAAAAGGTT

hide sequence

Protein Sequences


Protein RefSeqs	NP_808398	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH48776	(Get FASTA)	NCBI Sequence Viewer
	AAI38210	(Get FASTA)	NCBI Sequence Viewer
	AAI45953	(Get FASTA)	NCBI Sequence Viewer
	EDL05698	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000082013
	ENSMUSP00000082013.3
GenBank Protein	Q80V26	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_808398 ⟸ NM_177730

- UniProtKB:

Q80V26 (UniProtKB/Swiss-Prot), A6H6P6 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAPMGIRLSPLGVAVFFLLGLGVLYHLYSGFLAGRFSLFGLGSEPAAGEAEVASDGGTVDLREM
LAVAVLAAERGGDEVRRVRESNVLHEKSKGKTREGADDKMTSGDVLSNRKMFYLLKTAFPNVQI
NTEEHVDASDKEVIVWNRKIPEDILKEIAAPKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMV
CVAVNGKPVLGVIHKPFSEYTAWAMVDGGSNVKARSSYNEKTPKIIVSRSHAGMVKQVALQTFG
NQTSIIPAGGAGYKVLALLDVPDMTQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLNGEE
ISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKSGH

hide sequence

Ensembl Acc Id:

ENSMUSP00000082013 ⟸ ENSMUST00000084949

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q80V26-F1-model_v2	AlphaFold	Q80V26	1-356	view protein structure

Promoters

RGD ID:

6835499

Promoter ID:

MM_KWN:36567

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day1, 3T3L1_Day2, 3T3L1_Day3, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver, Lung, MEF_B6, Spleen

Transcripts:

OTTMUST00000009508

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	4	4,719,901 - 4,720,482 (-)	MPROMDB

RGD ID:

6882748

Promoter ID:

EPDNEW_M4824

Type:

initiation region

Name:

Impad1_1

Description:

Mus musculus inositol monophosphatase domain containing 1 , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	4	4,793,313 - 4,793,373	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1915720	AgrOrtholog
Ensembl Genes	ENSMUSG00000066324	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000084949	ENTREZGENE
	ENSMUST00000084949.3	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.190.80	UniProtKB/Swiss-Prot
	Fructose-1,6-Bisphosphatase, subunit A, domain 1	UniProtKB/Swiss-Prot
InterPro	CysQ/Inositol_MonoPase	UniProtKB/Swiss-Prot
	Inositol_monophosphatase-like	UniProtKB/Swiss-Prot
	Inositol_monophosphatase_CS	UniProtKB/Swiss-Prot
KEGG Report	mmu:242291	UniProtKB/Swiss-Prot
MGD	MGI:1915720	ENTREZGENE
NCBI Gene	Bpnt2	ENTREZGENE
PANTHER	3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1	UniProtKB/Swiss-Prot
	GOLGI-RESIDENT ADENOSINE 3',5'-BISPHOSPHATE 3'-PHOSPHATASE	UniProtKB/Swiss-Prot
Pfam	Inositol_P	UniProtKB/Swiss-Prot
PhenoGen	Bpnt2	PhenoGen
PROSITE	IMP_2	UniProtKB/Swiss-Prot
Superfamily-SCOP	Carbohydrate phosphatase	UniProtKB/Swiss-Prot
UniProt	A6H6P6	ENTREZGENE
	IMPA3_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A6H6P6	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-08-26	Bpnt2	3'(2'), 5'-bisphosphate nucleotidase 2	1110001C20Rik	RIKEN cDNA 1110001C20 gene	Symbol and/or name updated	27372883	PROVISIONAL
2024-08-21	1110001C20Rik	RIKEN cDNA 1110001C20 gene	Bpnt2	3'(2'), 5'-bisphosphate nucleotidase 2	Symbol and/or name change	5135510	APPROVED
2020-04-07	Bpnt2	3'(2'), 5'-bisphosphate nucleotidase 2	Impad1	inositol monophosphatase domain containing 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Mammalian Phenotype