Nudt18 (nudix (nucleoside diphosphate linked moiety X)-type motif 18) - Rat Genome Database

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Gene: Nudt18 (nudix (nucleoside diphosphate linked moiety X)-type motif 18) Mus musculus
Analyze
Symbol: Nudt18
Name: nudix (nucleoside diphosphate linked moiety X)-type motif 18
RGD ID: 1553634
MGI Page MGI
Description: Predicted to enable magnesium ion binding activity and nucleoside-diphosphatase activity. Predicted to be involved in GDP catabolic process; dADP catabolic process; and dGDP catabolic process. Predicted to act upstream of or within nucleotide metabolic process. Is expressed in several structures, including central nervous system; embryo endoderm; and retina. Orthologous to human NUDT18 (nudix hydrolase 18).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; 8-oxo-dGDP phosphatase NUDT18; BC036718; MGC38179; mutT homolog 3; nucleoside diphosphate-linked moiety X motif 18; nudix motif 18
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,815,264 - 70,820,128 (+)NCBIGRCm39mm39
GRCm39 Ensembl1470,815,077 - 70,820,128 (+)Ensembl
GRCm381470,577,824 - 70,582,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,577,637 - 70,582,688 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,977,654 - 70,982,378 (+)NCBIGRCm37mm9NCBIm37
MGSCv361469,312,927 - 69,317,651 (+)NCBImm8
Celera1468,119,373 - 68,124,096 (+)NCBICelera
Cytogenetic Map14D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:15226823   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21677750   PMID:21873635   PMID:22008794  
PMID:32325033  


Genomics

Comparative Map Data
Nudt18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,815,264 - 70,820,128 (+)NCBIGRCm39mm39
GRCm39 Ensembl1470,815,077 - 70,820,128 (+)Ensembl
GRCm381470,577,824 - 70,582,688 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,577,637 - 70,582,688 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,977,654 - 70,982,378 (+)NCBIGRCm37mm9NCBIm37
MGSCv361469,312,927 - 69,317,651 (+)NCBImm8
Celera1468,119,373 - 68,124,096 (+)NCBICelera
Cytogenetic Map14D2NCBI
NUDT18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,106,878 - 22,110,482 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl822,106,874 - 22,109,419 (-)EnsemblGRCh38hg38GRCh38
GRCh37821,964,389 - 21,966,932 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,020,328 - 22,022,877 (-)NCBINCBI36hg18NCBI36
Celera820,926,679 - 20,929,248 (-)NCBI
Cytogenetic Map8p21.3NCBI
HuRef820,506,929 - 20,509,498 (-)NCBIHuRef
CHM1_1822,166,045 - 22,168,614 (-)NCBICHM1_1
T2T-CHM13v2.0822,380,831 - 22,383,394 (-)NCBI
Nudt18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,650,597 - 45,653,985 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1545,650,664 - 45,653,963 (+)Ensembl
Rnor_6.01552,265,557 - 52,268,081 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,265,557 - 52,268,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,989,074 - 55,991,598 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,977,124 - 50,979,648 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11550,992,839 - 50,996,120 (+)NCBI
Celera1545,328,967 - 45,331,491 (+)NCBICelera
Cytogenetic Map15p11NCBI
Nudt18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540345,598,813 - 45,601,940 (-)NCBIChiLan1.0ChiLan1.0
NUDT18
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1818,293,555 - 18,299,540 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,293,555 - 18,297,078 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0821,351,840 - 21,356,915 (-)NCBIMhudiblu_PPA_v0panPan3
NUDT18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12535,139,580 - 35,144,066 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2535,140,969 - 35,143,063 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,729,138 - 35,733,637 (+)NCBI
ROS_Cfam_1.02535,351,117 - 35,355,601 (+)NCBI
ROS_Cfam_1.0 Ensembl2535,352,416 - 35,355,503 (+)Ensembl
UMICH_Zoey_3.12535,296,344 - 35,300,845 (+)NCBI
UNSW_CanFamBas_1.02535,150,896 - 35,155,376 (+)NCBI
UU_Cfam_GSD_1.02535,306,384 - 35,310,868 (+)NCBI
Nudt18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,638,163 - 12,641,252 (+)NCBI
SpeTri2.0NW_0049365555,929,262 - 5,932,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUDT18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,377,815 - 6,381,596 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,378,987 - 6,381,712 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2146,814,635 - 6,817,363 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUDT18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,176,500 - 20,184,637 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605222,057,257 - 22,060,315 (+)NCBIVero_WHO_p1.0
Nudt18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,691,803 - 17,694,945 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462475817,691,790 - 17,695,027 (-)NCBIHetGla_female_1.0hetGla2


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1020
Count of miRNA genes:563
Interacting mature miRNAs:691
Transcripts:ENSMUST00000089049
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000089049   ⟹   ENSMUSP00000086450
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,815,077 - 70,820,011 (+)Ensembl
GRCm38.p6 Ensembl1470,577,637 - 70,582,571 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228554   ⟹   ENSMUSP00000154027
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,815,287 - 70,820,128 (+)Ensembl
GRCm38.p6 Ensembl1470,577,847 - 70,582,688 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228768   ⟹   ENSMUSP00000154258
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,815,532 - 70,817,721 (+)Ensembl
GRCm38.p6 Ensembl1470,578,092 - 70,580,281 (+)Ensembl
RefSeq Acc Id: NM_001360474   ⟹   NP_001347403
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,815,539 - 70,820,128 (+)NCBI
GRCm381470,578,099 - 70,582,688 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001360475   ⟹   NP_001347404
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,815,264 - 70,820,128 (+)NCBI
GRCm381470,577,824 - 70,582,688 (+)NCBI
Sequence:
RefSeq Acc Id: NM_153136   ⟹   NP_694776
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,815,264 - 70,820,128 (+)NCBI
GRCm381470,577,824 - 70,582,688 (+)NCBI
MGSCv371470,977,654 - 70,982,378 (+)RGD
Celera1468,119,373 - 68,124,096 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_694776   ⟸   NM_153136
- Peptide Label: isoform 1
- UniProtKB: Q3U2V3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001347404   ⟸   NM_001360475
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001347403   ⟸   NM_001360474
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000086450   ⟸   ENSMUST00000089049
RefSeq Acc Id: ENSMUSP00000154027   ⟸   ENSMUST00000228554
RefSeq Acc Id: ENSMUSP00000154258   ⟸   ENSMUST00000228768
Protein Domains
Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q3U2V3-F1-model_v2 AlphaFold Q3U2V3 1-323 view protein structure

Promoters
RGD ID:8682960
Promoter ID:EPDNEW_M19496
Type:initiation region
Name:Nudt18_1
Description:Mus musculus nudix -type motif 18 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381470,577,826 - 70,577,886EPDNEW
RGD ID:6825230
Promoter ID:MM_KWN:17390
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_153136
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,976,921 - 70,978,022 (+)MPROMDB
RGD ID:6849033
Promoter ID:MM_XEF:2331
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_4Hour,   Lung,   MEF_B4
Transcripts:NM_001017843
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,978,251 - 70,978,992 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2385853 AgrOrtholog
Ensembl Genes ENSMUSG00000045211 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000086450 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000154027 UniProtKB/TrEMBL
  ENSMUSP00000154258 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000089049 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000228554 UniProtKB/TrEMBL
  ENSMUST00000228768 ENTREZGENE, UniProtKB/TrEMBL
InterPro Nudix_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_hydrolase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_hydrolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_hydrolase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDT18_NUDIX UniProtKB/Swiss-Prot
KEGG Report mmu:213484 UniProtKB/Swiss-Prot
MGD MGI:2385853 ENTREZGENE
NCBI Gene 213484 ENTREZGENE
Pfam NUDIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nudt18 PhenoGen
PRINTS NUDIXFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NUDIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55811 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BQ34_MOUSE UniProtKB/TrEMBL
  A0A2I3BQN8_MOUSE UniProtKB/TrEMBL
  NUD18_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8C223 UniProtKB/Swiss-Prot
  Q8K1Y7 UniProtKB/Swiss-Prot