Pwp1 (PWP1 homolog, endonuclein) - Rat Genome Database
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Gene: Pwp1 (PWP1 homolog, endonuclein) Mus musculus
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Symbol: Pwp1
Name: PWP1 homolog, endonuclein
RGD ID: 1553512
Description: Exhibits H4K20me3 modified histone binding activity. Involved in histone H4-K20 trimethylation; negative regulation of peptidyl-serine phosphorylation of STAT protein; and positive regulation of stem cell differentiation. Localizes to nucleus. Is expressed in several structures, including brain; neural retina; and trachea. Orthologous to human PWP1 (PWP1 homolog, endonuclein); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2310058A11Rik; 2610205J09Rik; AI098170; AL022879; AV083409; AW550690; periodic tryptophan protein 1 homolog; PWP1 homolog
Orthologs:
Homo sapiens (human) : PWP1 (PWP1 homolog, endonuclein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pwp1 (PWP1 homolog, endonuclein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pwp1 (PWP1 homolog, endonuclein)
Pan paniscus (bonobo/pygmy chimpanzee) : PWP1 (PWP1 homolog, endonuclein)
Canis lupus familiaris (dog) : PWP1 (PWP1 homolog, endonuclein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pwp1 (PWP1 homolog, endonuclein)
Sus scrofa (pig) : PWP1 (PWP1 homolog, endonuclein)
Chlorocebus sabaeus (African green monkey) : PWP1 (PWP1 homolog, endonuclein)
Heterocephalus glaber (naked mole-rat) : Pwp1 (PWP1 homolog, endonuclein)
more info ...
Related Pseudogenes: Gm3765   Gm6764  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391085,707,695 - 85,724,967 (+)NCBI
GRCm381085,871,831 - 85,889,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1085,829,494 - 85,889,096 (+)EnsemblGRCm38mm10GRCm38
MGSCv371085,334,576 - 85,351,848 (+)NCBIGRCm37mm9NCBIm37
MGSCv361085,301,664 - 85,318,895 (+)NCBImm8
Celera1087,846,400 - 87,863,672 (+)NCBICelera
Cytogenetic Map10C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
Golgi apparatus  (ISO)
nucleolus  (ISO)
nucleus  (IBA,IDA)

Molecular Function

References

Additional References at PubMed
PMID:7671812   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:12477932   PMID:12819125   PMID:15226823   PMID:15345747   PMID:15489334   PMID:15761153   PMID:15782199  
PMID:16141072   PMID:16141073   PMID:20059953   PMID:20211142   PMID:21267068   PMID:21677750   PMID:21873635   PMID:25335925   PMID:28378742   PMID:29078390   PMID:30196744   PMID:30713523  
PMID:32098917   PMID:32325033   PMID:32968282  


Genomics

Comparative Map Data
Pwp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391085,707,695 - 85,724,967 (+)NCBI
GRCm381085,871,831 - 85,889,103 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1085,829,494 - 85,889,096 (+)EnsemblGRCm38mm10GRCm38
MGSCv371085,334,576 - 85,351,848 (+)NCBIGRCm37mm9NCBIm37
MGSCv361085,301,664 - 85,318,895 (+)NCBImm8
Celera1087,846,400 - 87,863,672 (+)NCBICelera
Cytogenetic Map10C1NCBI
PWP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12107,685,799 - 107,713,162 (+)EnsemblGRCh38hg38GRCh38
GRCh3812107,685,799 - 107,713,162 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712108,079,590 - 108,106,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612106,603,720 - 106,630,387 (+)NCBINCBI36hg18NCBI36
Celera12107,745,148 - 107,771,815 (+)NCBI
Cytogenetic Map12q23.3NCBI
HuRef12105,139,992 - 105,166,399 (+)NCBIHuRef
CHM1_112108,045,481 - 108,072,890 (+)NCBICHM1_1
Pwp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0723,988,776 - 24,004,774 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl723,988,776 - 24,004,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0724,138,856 - 24,154,854 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4720,120,919 - 20,136,917 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1720,134,743 - 20,150,979 (-)NCBI
Celera715,214,789 - 15,230,786 (-)NCBICelera
Cytogenetic Map7q13NCBI
Pwp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540541,314,978 - 41,329,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540541,314,978 - 41,329,988 (+)NCBIChiLan1.0ChiLan1.0
PWP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112108,652,024 - 108,679,503 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12108,652,024 - 108,679,503 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012105,255,755 - 105,282,519 (+)NCBIMhudiblu_PPA_v0panPan3
PWP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1031,117,044 - 31,146,726 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11031,121,411 - 31,146,791 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pwp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364927,436,137 - 7,457,709 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PWP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl512,701,584 - 12,730,850 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1512,703,067 - 12,730,884 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2512,488,889 - 12,517,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PWP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl11102,917,606 - 102,942,481 (+)Ensembl
ChlSab1.111102,917,553 - 102,943,696 (+)NCBI
Pwp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247502,103,530 - 2,119,088 (-)NCBI

Position Markers
RH125438  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381085,888,507 - 85,888,623UniSTSGRCm38
MGSCv371085,351,252 - 85,351,368UniSTSGRCm37
Celera1087,863,076 - 87,863,192UniSTS
Cytogenetic Map10C1UniSTS
AI098170  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381085,888,542 - 85,888,657UniSTSGRCm38
MGSCv371085,351,287 - 85,351,402UniSTSGRCm37
Celera1087,863,111 - 87,863,226UniSTS
Cytogenetic Map10C1UniSTS
Whitehead/MRC_RH10973.64UniSTS
Whitehead/MRC_RH10974.6UniSTS
AV083409  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381085,888,963 - 85,889,053UniSTSGRCm38
MGSCv371085,351,708 - 85,351,798UniSTSGRCm37
Celera1087,863,532 - 87,863,622UniSTS
Cytogenetic Map10C1UniSTS
Whitehead/MRC_RH10975.09UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1064100000116100000Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106565510499655287Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106565510499655287Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106565510499655287Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106701240892422811Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067500000111900000Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1068000000125000000Mouse
26884405Huml2_mhumerus length 2, 5 week (mouse)1069900000132500000Mouse
11039497Ltpr5a_mLeishmania tropica response 5a (mouse)1073671039107671185Mouse
11353832Pcholq4_mplasma cholesterol QTL 4 (mouse)1074151384125680038Mouse
11353843Gluq1_mblood glucose QTL 1 (mouse)1074151384125680038Mouse
1300975Fembrs3_mfemur breaking strength 3 (mouse)Not determined1075502706109502905Mouse
4142137Femwf3_mfemur work to failure 3 (mouse)Not determined75502706109502905Mouse
1357632Vtbt9_mvertebral trabecular bone trait 9 (mouse)Not determined1075502706109502905Mouse
11251717Siim1_mstress induced immobility 1 (mouse)1078545406112545406Mouse
14747004Mancz8_mmandible centroid size 8 (mouse)1082242550116242550Mouse
1301165Lith7_mlithogenic gene 7 (mouse)Not determined1082473556116473795Mouse
11059550Lmr32a_mleishmaniasis resistance 32a (mouse)1082473556116473795Mouse
11059551Lmr32b_mleishmaniasis resistance 32b (mouse)1082473556116473795Mouse
11059553Lmr32d_mleishmaniasis resistance 32d (mouse)1082473556116473795Mouse
11059554Lmr32e_mleishmaniasis resistance 32e (mouse)1082473556116473795Mouse
11059555Lmr32f_mleishmaniasis resistance 32f (mouse)1082473556116473795Mouse
10043881Adip24_madiposity 24 (mouse)Not determined1082556941116557090Mouse
4141382Ssrq4_mstress response QTL 4 (mouse)Not determined8265510491020240Mouse
12910789Pwgrq19_mpost-weaning growth rate QTL 19 (mouse)108299286692333194Mouse
4141054mwfh_mmodifier of white forlock hypopigmentation (mouse)Not determined83181141117181274Mouse
1357779Tesq3_mtestis weight QTL 3 (mouse)Not determined1084243786122205623Mouse
4141479W10q8_mweight 10 weeks QTL 8 (mouse)Not determined84243786122205623Mouse
4141387Lgaq5_mlate growth adjusted QTL 5 (mouse)Not determined84243786122205623Mouse
4142496W6q8_mweight 6 weeks QTL 8 (mouse)Not determined84243786122205623Mouse
4142365Egq9_mearly growth QTL 9 (mouse)Not determined84243786122205623Mouse
1357594Estoq3_membryo survival total QTL 3 (mouse)Not determined1084243786122205623Mouse
1357622Espq3_membryo survival preimplantation QTL 3 (mouse)Not determined1084243786122205623Mouse
14700795Mencq7_mmeniscus calcification QTL 7 (mouse)108547800086812000Mouse
1357638Cia29_mcollagen induced arthritis 29 (mouse)Not determined1085619118118661448Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:560
Count of miRNA genes:399
Interacting mature miRNAs:463
Transcripts:ENSMUST00000001836, ENSMUST00000164053, ENSMUST00000164562, ENSMUST00000168509
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000001836   ⟹   ENSMUSP00000001836
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1085,871,831 - 85,889,096 (+)Ensembl
RefSeq Acc Id: ENSMUST00000217667   ⟹   ENSMUSP00000152025
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1085,829,494 - 85,878,574 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219256   ⟹   ENSMUSP00000151813
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1085,871,906 - 85,882,099 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219626
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1085,876,254 - 85,884,487 (+)Ensembl
RefSeq Acc Id: ENSMUST00000219902
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1085,871,884 - 85,884,688 (+)Ensembl
RefSeq Acc Id: NM_133993   ⟹   NP_598754
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391085,707,695 - 85,724,967 (+)NCBI
GRCm381085,871,831 - 85,889,103 (+)ENTREZGENE
MGSCv371085,334,576 - 85,351,848 (+)RGD
Celera1087,846,400 - 87,863,672 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598754   ⟸   NM_133993
- UniProtKB: Q99LL5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000152025   ⟸   ENSMUST00000217667
RefSeq Acc Id: ENSMUSP00000151813   ⟸   ENSMUST00000219256
RefSeq Acc Id: ENSMUSP00000001836   ⟸   ENSMUST00000001836
Protein Domains
WD_REPEATS_REGION

Promoters
RGD ID:6819780
Promoter ID:MM_KWN:5187
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_133993,   UC007GNC.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361085,334,339 - 85,334,839 (+)MPROMDB
RGD ID:8672918
Promoter ID:EPDNEW_M14490
Type:initiation region
Name:Pwp1_1
Description:Mus musculus PWP1 homolog, endonuclein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381085,871,865 - 85,871,925EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1914735 AgrOrtholog
Ensembl Genes ENSMUSG00000001785 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000001836 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000151813 UniProtKB/TrEMBL
  ENSMUSP00000152025 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000001836 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000217667 UniProtKB/TrEMBL
  ENSMUST00000219256 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:103136 UniProtKB/Swiss-Prot
MGD MGI:1914735 ENTREZGENE
NCBI Gene 103136 ENTREZGENE
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pwp1 PhenoGen
PRINTS GPROTEINBRPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.18834 ENTREZGENE
UniProt A0A1W2P7U7_MOUSE UniProtKB/TrEMBL
  A0A1W2P8G3_MOUSE UniProtKB/TrEMBL
  PWP1_MOUSE UniProtKB/Swiss-Prot
  Q8BW04_MOUSE UniProtKB/TrEMBL
  Q99LL5 ENTREZGENE
  Q9CSK2_MOUSE UniProtKB/TrEMBL
  Q9CTC0_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q9D6T6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 Pwp1  PWP1 homolog, endonuclein    PWP1 homolog (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED