Has3 (hyaluronan synthase 3) - Rat Genome Database

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Gene: Has3 (hyaluronan synthase 3) Mus musculus
Analyze
Symbol: Has3
Name: hyaluronan synthase 3
RGD ID: 1553481
MGI Page MGI
Description: Exhibits hyaluronan synthase activity. Involved in extracellular matrix assembly; extracellular polysaccharide biosynthetic process; and hyaluronan biosynthetic process. Localizes to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; metanephros; sensory organ; and skin. Orthologous to human HAS3 (hyaluronan synthase 3); INTERACTS WITH hyaluronic acid; tetrachloromethane; 1,4-phenylenediamine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HA synthase 3; hyaluronate synthase 3; hyaluronic acid synthase 3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,596,874 - 107,609,534 (+)NCBIGRCm39mm39
GRCm39 Ensembl8107,596,874 - 107,611,198 (+)Ensembl
GRCm388106,870,242 - 106,882,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,870,242 - 106,884,566 (+)EnsemblGRCm38mm10GRCm38
MGSCv378109,394,142 - 109,406,802 (+)NCBIGRCm37mm9NCBIm37
MGSCv368109,759,371 - 109,772,031 (+)NCBImm8
Celera8111,096,197 - 111,108,800 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:9060470   PMID:9083017   PMID:9169154   PMID:9206724   PMID:9442026   PMID:9457904   PMID:10093717   PMID:10349636   PMID:10455188   PMID:10617644   PMID:10878096   PMID:11006212  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11431361   PMID:12477932   PMID:14681479   PMID:14724275   PMID:15765504   PMID:15790861   PMID:15854028   PMID:16141072   PMID:16141073  
PMID:16595683   PMID:18574248   PMID:18799693   PMID:21267068   PMID:21677750   PMID:21850020   PMID:21873635   PMID:22654110   PMID:23382716   PMID:24057227   PMID:24194600   PMID:24790187  
PMID:25384213   PMID:26586662   PMID:27289075   PMID:28863216   PMID:28987865   PMID:29672913   PMID:29966020   PMID:30897620   PMID:32623025  


Genomics

Comparative Map Data
Has3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,596,874 - 107,609,534 (+)NCBIGRCm39mm39
GRCm39 Ensembl8107,596,874 - 107,611,198 (+)Ensembl
GRCm388106,870,242 - 106,882,902 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,870,242 - 106,884,566 (+)EnsemblGRCm38mm10GRCm38
MGSCv378109,394,142 - 109,406,802 (+)NCBIGRCm37mm9NCBIm37
MGSCv368109,759,371 - 109,772,031 (+)NCBImm8
Celera8111,096,197 - 111,108,800 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.28NCBI
HAS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1669,105,653 - 69,118,719 (+)EnsemblGRCh38hg38GRCh38
GRCh381669,105,653 - 69,118,719 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371669,139,556 - 69,152,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,697,661 - 67,710,123 (+)NCBINCBI36hg18NCBI36
Build 341667,697,660 - 67,710,118NCBI
Celera1653,649,484 - 53,661,945 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1655,012,157 - 55,025,357 (+)NCBIHuRef
CHM1_11670,547,541 - 70,560,696 (+)NCBICHM1_1
Has3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21934,768,421 - 34,782,170 (+)NCBI
Rnor_6.0 Ensembl1939,063,998 - 39,077,722 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01939,063,298 - 39,077,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01949,928,282 - 49,942,033 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,718,156 - 36,727,586 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11936,723,036 - 36,732,467 (+)NCBI
Celera1934,192,486 - 34,201,862 (+)NCBICelera
Cytogenetic Map19q12NCBI
Has3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,542,286 - 7,570,684 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554847,542,286 - 7,570,108 (-)NCBIChiLan1.0ChiLan1.0
HAS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11668,864,318 - 68,876,678 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1668,868,416 - 68,877,476 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01649,476,561 - 49,488,820 (+)NCBIMhudiblu_PPA_v0panPan3
HAS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1580,520,261 - 80,530,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl580,520,261 - 80,529,434 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha580,511,151 - 80,538,585 (-)NCBI
ROS_Cfam_1.0580,954,678 - 80,982,141 (-)NCBI
UMICH_Zoey_3.1580,781,897 - 80,809,330 (-)NCBI
UNSW_CanFamBas_1.0580,464,448 - 80,491,878 (-)NCBI
UU_Cfam_GSD_1.0581,104,369 - 81,131,818 (-)NCBI
Has3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934940,306,192 - 40,334,622 (-)NCBI
SpeTri2.0NW_00493647519,270,788 - 19,282,922 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,843,882 - 17,853,011 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,844,974 - 17,870,331 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HAS3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1558,289,672 - 58,306,843 (-)NCBI
ChlSab1.1 Ensembl558,292,044 - 58,298,524 (-)Ensembl
Vero_WHO_p1.0NW_02366604721,022,092 - 21,035,135 (-)NCBI
Has3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474617,218,792 - 17,235,499 (-)NCBI

Position Markers
UniSTS:235993  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388106,882,566 - 106,882,801UniSTSGRCm38
MGSCv378109,406,466 - 109,406,701UniSTSGRCm37
Celera8111,108,464 - 111,108,699UniSTS
Cytogenetic Map8D3UniSTS
cM Map853.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse
1302049Heal1_mwound healing/regeneration 1 (mouse)Not determined885716921119717069Mouse
1301253Skmw2_mskeletal muscle weight 2 (mouse)Not determined885716921119717069Mouse
10045619Heal14_mwound healing/regeneration 14 (mouse)Not determined885716921119717069Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1300560Tgl1_mtriglyceride level 1 (mouse)Not determined8101759576110923404Mouse
1300681Pgia22_mproteoglycan induced arthritis 22 (mouse)Not determined8101759576115298718Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8104307238129401213Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8104307238129401213Mouse
14746994Manh65_mmandible shape 65 (mouse)8105762890129401213Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2589
Count of miRNA genes:745
Interacting mature miRNAs:961
Transcripts:ENSMUST00000034385, ENSMUST00000175987, ENSMUST00000176144
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000034385   ⟹   ENSMUSP00000034385
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8106,870,242 - 106,882,902 (+)Ensembl
RefSeq Acc Id: ENSMUST00000175987   ⟹   ENSMUSP00000135596
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8106,870,891 - 106,884,566 (+)Ensembl
RefSeq Acc Id: ENSMUST00000176144   ⟹   ENSMUSP00000135303
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8106,870,836 - 106,881,197 (+)Ensembl
RefSeq Acc Id: NM_001331048   ⟹   NP_001317977
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398107,597,468 - 107,609,534 (+)NCBI
GRCm388106,870,836 - 106,882,902 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008217   ⟹   NP_032243
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398107,596,874 - 107,609,534 (+)NCBI
GRCm388106,870,242 - 106,882,902 (+)ENTREZGENE
MGSCv378109,394,142 - 109,406,802 (+)RGD
Celera8111,096,197 - 111,108,800 (+)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006530700   ⟹   XP_006530763
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398107,599,992 - 107,607,830 (+)NCBI
GRCm388106,873,360 - 106,881,198 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006530701   ⟹   XP_006530764
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398107,597,835 - 107,607,830 (+)NCBI
GRCm388106,870,437 - 106,881,198 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032243   ⟸   NM_008217
- UniProtKB: O08650 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530764   ⟸   XM_006530701
- Peptide Label: isoform X1
- UniProtKB: O08650 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006530763   ⟸   XM_006530700
- Peptide Label: isoform X1
- UniProtKB: O08650 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001317977   ⟸   NM_001331048
- UniProtKB: O08650 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000034385   ⟸   ENSMUST00000034385
RefSeq Acc Id: ENSMUSP00000135303   ⟸   ENSMUST00000176144
RefSeq Acc Id: ENSMUSP00000135596   ⟸   ENSMUST00000175987

Promoters
RGD ID:8668189
Promoter ID:EPDNEW_M12125
Type:initiation region
Name:Has3_1
Description:Mus musculus hyaluronan synthase 3 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388106,870,836 - 106,870,896EPDNEW
RGD ID:6843286
Promoter ID:MM_KWN:55625
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:NM_008217,   UC009NGM.1,   UC009NGN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368109,394,321 - 109,394,821 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:109599 AgrOrtholog
Ensembl Genes ENSMUSG00000031910 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034385 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000135303 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000135596 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034385 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000175987 UniProtKB/TrEMBL
  ENSMUST00000176144 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:15118 UniProtKB/Swiss-Prot
MGD MGI:109599 ENTREZGENE
NCBI Gene 15118 ENTREZGENE
PhenoGen Has3 PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RR08_MOUSE UniProtKB/TrEMBL
  H3BL01_MOUSE UniProtKB/TrEMBL
  HYAS3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8CEB9 UniProtKB/Swiss-Prot