Prrx1 (paired related homeobox 1) - Rat Genome Database

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Gene: Prrx1 (paired related homeobox 1) Mus musculus
Analyze
Symbol: Prrx1
Name: paired related homeobox 1
RGD ID: 1553420
MGI Page MGI
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II general transcription initiation factor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; neuronal stem cell population maintenance; and positive regulation of smoothened signaling pathway. Located in nucleus. Is expressed in several structures, including brain; cardiovascular system; embryo mesenchyme; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Orthologous to human PRRX1 (paired related homeobox 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A230024N07Rik; AA755424; AI385634; AI843499; homeobox protein K-2; homeobox protein mHox; K-2; mHo; mHox; MHox1; paired mesoderm homeobox 1; paired mesoderm homeobox protein 1; paired-related homeobox protein 1; Pmx; Pmx1; Pr; PRX-1; Prx1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,072,688 - 163,142,714 (-)NCBIGRCm39mm39
GRCm39 Ensembl1163,072,688 - 163,141,279 (-)Ensembl
GRCm381163,245,119 - 163,315,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1163,245,119 - 163,313,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv371165,175,250 - 165,243,781 (-)NCBIGRCm37mm9NCBIm37
MGSCv361165,081,794 - 165,150,325 (-)NCBImm8
Celera1165,686,221 - 165,753,419 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-fluorouracil  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
carbon nanotube  (EXP)
cefaloridine  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
decabromodiphenyl ether  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
ethyl methanesulfonate  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (ISO)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indometacin  (ISO)
kojic acid  (ISO)
L-methionine  (EXP)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
nitrofen  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD 0325901  (ISO)
phenylmercury acetate  (ISO)
progesterone  (ISO)
rofecoxib  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
tetrachloromethane  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IBA,IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal ameloblast differentiation  (IAGP)
abnormal ameloblast morphology  (IAGP)
abnormal aortic arch and aortic arch branch attachment  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal apical ectodermal ridge morphology  (IAGP)
abnormal artery morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal bone ossification  (IAGP)
abnormal carpal bone morphology  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cervical atlas morphology  (IAGP)
abnormal cervical axis morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal digit morphology  (IAGP)
abnormal ear position  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal fetal ductus arteriosus morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal forelimb zeugopod morphology  (IAGP)
abnormal hindlimb zeugopod morphology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal incisor morphology  (IAGP)
abnormal incudostapedial joint morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal limb morphology  (IAGP)
abnormal long bone hypertrophic chondrocyte zone  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lumbar vertebrae morphology  (IAGP)
abnormal lung vasculature morphology  (IAGP)
abnormal malleus manubrium morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal malleus processus brevis morphology  (IAGP)
abnormal mandible morphology  (IAGP)
abnormal maxilla morphology  (IAGP)
abnormal Meckel's cartilage morphology  (IAGP)
abnormal metacarpal bone morphology  (IAGP)
abnormal metatarsal bone morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal odontoblast differentiation  (IAGP)
abnormal oval window morphology  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal phalanx morphology  (IAGP)
abnormal pulmonary trunk morphology  (IAGP)
abnormal respiration  (IAGP)
abnormal scapular spine morphology  (IAGP)
abnormal stapes crus morpholgy  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal stylohyoid ligament morphology  (IAGP)
abnormal thoracic vertebrae morphology  (IAGP)
abnormal tibia morphology  (IAGP)
abnormal tongue morphology  (IAGP)
abnormal tooth development  (IAGP)
abnormal trabecular bone morphology  (IAGP)
abnormal ulna morphology  (IAGP)
abnormal vertebrae morphology  (IAGP)
abnormal vertebral arch morphology  (IAGP)
absent alisphenoid bone  (IAGP)
absent eyelids  (IAGP)
absent gonial bone  (IAGP)
absent incisors  (IAGP)
absent lateral semicircular canal  (IAGP)
absent maxillary shelf  (IAGP)
absent maxillary zygomatic process  (IAGP)
absent Meckel's cartilage  (IAGP)
absent palatine bone horizontal plate  (IAGP)
absent pubic symphysis  (IAGP)
absent stapes obturator foramen  (IAGP)
absent supraoccipital bone  (IAGP)
absent temporal bone squamous part  (IAGP)
absent temporomandibular joint  (IAGP)
absent triquetrum  (IAGP)
absent tympanic ring  (IAGP)
absent vertebral arch  (IAGP)
absent zygomatic arch  (IAGP)
absent zygomatic bone  (IAGP)
alisphenoid bone hypoplasia  (IAGP)
anotia  (IAGP)
aphagia  (IAGP)
bowed radius  (IAGP)
bowed tibia  (IAGP)
bowed ulna  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
cyanosis  (IAGP)
decreased body size  (IAGP)
decreased width of hypertrophic chondrocyte zone  (IAGP)
delayed bone ossification  (IAGP)
distended abdomen  (IAGP)
ectopic cartilage  (IAGP)
ectopic digits  (IAGP)
eyelids open at birth  (IAGP)
fused tarsal bones  (IAGP)
growth retardation of incisors  (IAGP)
long limbs  (IAGP)
lowered ear position  (IAGP)
mandible hypoplasia  (IAGP)
maxillary shelf hypoplasia  (IAGP)
microcephaly  (IAGP)
micrognathia  (IAGP)
neonatal lethality  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
oligodactyly  (IAGP)
outer ear hypoplasia  (IAGP)
palatal shelf hypoplasia  (IAGP)
pointed snout  (IAGP)
polydactyly  (IAGP)
postaxial polydactyly  (IAGP)
preaxial polydactyly  (IAGP)
pterygoid bone hypoplasia  (IAGP)
pulmonary hypoplasia  (IAGP)
respiratory distress  (IAGP)
respiratory failure  (IAGP)
retroesophageal right subclavian artery  (IAGP)
short fibula  (IAGP)
short limbs  (IAGP)
short malleus manubrium  (IAGP)
short mandible  (IAGP)
short Meckel's cartilage  (IAGP)
short radius  (IAGP)
short tibia  (IAGP)
short ulna  (IAGP)
small ears  (IAGP)
small otic capsule  (IAGP)
spina bifida  (IAGP)
syndactyly  (IAGP)
xiphoid process foramen  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. Lu MF, etal., Nature 1999 Sep 16;401(6750):276-8.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. Mouse MP Annotation Import Pipeline RGD automated import pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Large-scale screen for genes involved in gonad development. Wertz K and Herrmann BG, Mech Dev 2000 Nov;98(1-2):51-70.
Additional References at PubMed
PMID:1360403   PMID:1383943   PMID:7554933   PMID:7577675   PMID:7592824   PMID:7758948   PMID:7910581   PMID:7964557   PMID:8075499   PMID:8889548   PMID:9053326   PMID:9205120  
PMID:9636074   PMID:9671575   PMID:9729491   PMID:9786416   PMID:9817598   PMID:9876178   PMID:9882503   PMID:10349636   PMID:10354604   PMID:10625532   PMID:10664157   PMID:10748458  
PMID:10804186   PMID:10976045   PMID:11042159   PMID:11063257   PMID:11076861   PMID:11520673   PMID:11532916   PMID:11685458   PMID:11747080   PMID:11748565   PMID:12112875   PMID:12114523  
PMID:12163022   PMID:12193642   PMID:12351180   PMID:12414734   PMID:12477932   PMID:14681479   PMID:14727108   PMID:15117820   PMID:15173589   PMID:15226823   PMID:15459107   PMID:15618518  
PMID:15936012   PMID:15944189   PMID:16141072   PMID:16141073   PMID:16169709   PMID:16297875   PMID:16492970   PMID:16582099   PMID:16893423   PMID:16971476   PMID:16998126   PMID:17586524  
PMID:17609113   PMID:17764670   PMID:17967808   PMID:18198333   PMID:18287559   PMID:18296734   PMID:18458156   PMID:18554416   PMID:19419974   PMID:19587446   PMID:19690384   PMID:19777594  
PMID:20059953   PMID:20211142   PMID:20412781   PMID:20534727   PMID:20683885   PMID:20932939   PMID:21156168   PMID:21267068   PMID:21309073   PMID:21455939   PMID:21677750   PMID:21776009  
PMID:21779340   PMID:21826198   PMID:21873635   PMID:22174793   PMID:22438573   PMID:22510988   PMID:22988430   PMID:23250756   PMID:23355395   PMID:23447615   PMID:23473983   PMID:23475960  
PMID:24146773   PMID:24289074   PMID:24424161   PMID:24662046   PMID:24778262   PMID:24952961   PMID:25162226   PMID:26685160   PMID:26726832   PMID:26947973   PMID:26984772   PMID:27546376  
PMID:28366454   PMID:28455376   PMID:30002136   PMID:30071041   PMID:31171666   PMID:31712603   PMID:32005677   PMID:32188878   PMID:33105483   PMID:33176144   PMID:33561660   PMID:33587761  
PMID:34376651   PMID:34906895   PMID:34995520   PMID:35137272   PMID:35589735  


Genomics

Comparative Map Data
Prrx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391163,072,688 - 163,142,714 (-)NCBIGRCm39mm39
GRCm39 Ensembl1163,072,688 - 163,141,279 (-)Ensembl
GRCm381163,245,119 - 163,315,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1163,245,119 - 163,313,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv371165,175,250 - 165,243,781 (-)NCBIGRCm37mm9NCBIm37
MGSCv361165,081,794 - 165,150,325 (-)NCBImm8
Celera1165,686,221 - 165,753,419 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map170.53NCBI
PRRX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381170,662,768 - 170,739,421 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1170,662,728 - 170,739,421 (+)EnsemblGRCh38hg38GRCh38
GRCh371170,633,272 - 170,708,562 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361168,899,937 - 168,975,165 (+)NCBINCBI36hg18NCBI36
Celera1143,742,929 - 143,818,153 (+)NCBI
Cytogenetic Map1q24.2NCBI
HuRef1141,857,178 - 141,932,397 (+)NCBIHuRef
CHM1_11172,055,608 - 172,130,854 (+)NCBICHM1_1
T2T-CHM13v2.01170,020,416 - 170,095,719 (+)NCBI
Prrx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21375,600,777 - 75,671,896 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1375,601,706 - 75,670,866 (-)Ensembl
Rnor_6.01381,147,038 - 81,215,559 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1381,147,348 - 81,214,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01386,039,713 - 86,107,919 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,961,648 - 79,028,882 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11378,975,835 - 79,043,069 (-)NCBI
Celera1375,343,320 - 75,409,614 (-)NCBICelera
Cytogenetic Map13q22NCBI
Prrx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554626,919,899 - 6,991,733 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554626,919,905 - 6,991,733 (+)NCBIChiLan1.0ChiLan1.0
PRRX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11149,867,365 - 149,943,810 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1149,867,634 - 149,943,810 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01146,151,633 - 146,227,926 (+)NCBIMhudiblu_PPA_v0panPan3
PRRX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1728,065,570 - 28,138,734 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl728,068,711 - 28,138,787 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha727,598,170 - 27,671,127 (-)NCBI
ROS_Cfam_1.0727,867,506 - 27,940,906 (-)NCBI
ROS_Cfam_1.0 Ensembl727,867,529 - 27,939,818 (-)Ensembl
UMICH_Zoey_3.1727,717,090 - 27,790,221 (-)NCBI
UNSW_CanFamBas_1.0727,751,956 - 27,825,122 (-)NCBI
UU_Cfam_GSD_1.0727,988,098 - 28,061,291 (-)NCBI
Prrx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934498,358,502 - 98,426,095 (-)NCBI
SpeTri2.0NW_00493648116,208,243 - 16,272,836 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRRX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl480,427,685 - 80,501,646 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1480,427,682 - 80,502,689 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2487,973,831 - 88,044,655 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRRX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12558,347,686 - 58,423,454 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2558,347,704 - 58,421,980 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605559,994,168 - 60,070,286 (-)NCBIVero_WHO_p1.0
Prrx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248268,361,033 - 8,435,656 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248268,361,039 - 8,435,488 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
AA755424  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,245,863 - 163,245,977UniSTSGRCm38
MGSCv371165,175,994 - 165,176,108UniSTSGRCm37
Celera1165,686,965 - 165,687,079UniSTS
Cytogenetic Map1H2.1UniSTS
Whitehead/MRC_RH12075.26UniSTS
AI843499  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,255,483 - 163,255,615UniSTSGRCm38
MGSCv371165,185,614 - 165,185,746UniSTSGRCm37
Celera1165,696,568 - 165,696,700UniSTS
Cytogenetic Map1H2.1UniSTS
Whitehead/MRC_RH12075.06UniSTS
Prrx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371165,176,953 - 165,177,458UniSTSGRCm37
Celera1165,687,928 - 165,688,433UniSTS
Cytogenetic Map1H2.1UniSTS
cM Map185.4UniSTS
D1Mit506  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,306,348 - 163,306,466UniSTSGRCm38
MGSCv371165,236,479 - 165,236,597UniSTSGRCm37
Celera1165,746,095 - 165,746,209UniSTS
Cytogenetic Map1H2.1UniSTS
cM Map186.6UniSTS
Whitehead Genetic184.2UniSTS
AI385634  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,312,799 - 163,312,900UniSTSGRCm38
MGSCv371165,242,930 - 165,243,031UniSTSGRCm37
Cytogenetic Map1H2.1UniSTS
Whitehead/MRC_RH12075.06UniSTS
Prrx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H2.1UniSTS
Prrx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381163,246,822 - 163,247,327UniSTSGRCm38
MGSCv371165,176,953 - 165,177,458UniSTSGRCm37
Celera1165,687,928 - 165,688,433UniSTS
Cytogenetic Map1H2.1UniSTS
cM Map185.4UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52457737182250592Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)175976637181327565Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194127725172027567Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112008822168186402Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112008822175468938Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117527730179827565Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121727729164827569Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122027729164827569Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128727737181327565Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129130858163130993Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131156308165139464Mouse
14746980Manh50_mmandible shape 50 (mouse)1134131564168131564Mouse
1301458Skts8_mskin tumor susceptibility 8 (mouse)Not determined1135794822169795012Mouse
1301408Lore8_mloss of righting induced by ethanol 8 (mouse)Not determined1135877901169878015Mouse
1357434Obsty1_mobesity 1 (mouse)Not determined1136209950170210094Mouse
4141160Cq1_mcholesterol QTL 1 (mouse)Not determined1139452188173452308Mouse
1301523Ccrs1_mcorpus callosum hemisphere surface size 1 (mouse)Not determined1139602037173602216Mouse
1300696Bpq2_mblood pressure QTL 2 (mouse)Not determined1139602037173602216Mouse
1357602Vtbt2_mvertebral trabecular bone trait 2 (mouse)Not determined1139602037173602216Mouse
1301710Bmd5_mbone mineral density 5 (mouse)Not determined1139602037173602216Mouse
11049576Lmr8a_mleishmaniasis resistance 8a (mouse)1139602037173602216Mouse
1301894Skull2_mskull morphology 2 (mouse)Not determined1139602037173602216Mouse
1302193Cpfd1_mcerebellum pattern fissures (mouse)Not determined1139602037173602216Mouse
1300740Tne1_mtotal number errors (mouse)Not determined1139602037173602216Mouse
4142014Wbcq5_mwhite blood cell quantitative locus 5 (mouse)Not determined1141095010175095156Mouse
1301467Pcir1_mperiosteal circumference 1 (mouse)Not determined1141233173175233272Mouse
1301191Stia1_mserum transfer induced arthritis 1 (mouse)Not determined1141233173175233272Mouse
11533913Rd6m1_mretinal degeneration 6 modifier 1 (mouse)1141233173175233272Mouse
4141233Femwf12_mfemur work to failure 12 (mouse)Not determined141233173175233272Mouse
1301151Hdlq14_mHDL QTL 14 (mouse)Not determined1142489543176489734Mouse
1558720Bpq8_mblood pressure QTL 8 (mouse)Not determined1143284665177284803Mouse
11537365Cnes4_mC. neoformans susceptibility locus 4 (mouse)1144449142178449142Mouse
1300571Opfa_mopen field activity (mouse)Not determined1144531347178531592Mouse
12790996Aath2_maortic arch atherosclerosis 2 (mouse)1145077630179077630Mouse
1300934Cfbw1_mcystic fibrosis body weight 1 (mouse)Not determined1145145207179145325Mouse
1301818Ap1q_malcohol preference 1 QTL (mouse)Not determined1146908199167586222Mouse
1357567Nidd3k_mNidd3 on KK-A<y> (mouse)Not determined7147125258169038913Mouse
12910522Scgq2_mspontaneous crescentic glomerulonephritis QTL 2 (mouse)1147125258171632257Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
12790984Pcho7_mplasma cholesterol 7 (mouse)1147219390181219390Mouse
12791001Aath6_maortic arch atherosclerosis 6 (mouse)1147219390181219390Mouse
1300777Chol10_mcholesterol 10 (mouse)Not determined9147875502181875616Mouse
10043899Hdlq99_mHDL QTL 99 (mouse)Not determined1147875502181875616Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
4142149Ctex_mCtla4 expression QTL (mouse)Not determined1153557406175468938Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
13452393Ity3b_mimmunity to S. typhimurium 3b (mouse)1156497439172097436Mouse
13452394Leusq1_mleucocytosis susceptibility QTL 1 (mouse)1156602037168186402Mouse
1301232Hcs7_mhepatocarcinogenesis susceptibility 7 (mouse)Not determined1156602037168186402Mouse
13452397Leusq4_mleucocytosis susceptibility QTL 4 (mouse)1156602037170803640Mouse
12910521Scgq1_mspontaneous crescentic glomerulonephritis QTL 1 (mouse)1156602037176262693Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:4593
Count of miRNA genes:908
Interacting mature miRNAs:1268
Transcripts:ENSMUST00000027878, ENSMUST00000075805, ENSMUST00000174098, ENSMUST00000174397, ENSMUST00000183691
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001025570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_175686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006496703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB221686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK008428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK019503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK031075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK032773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038524 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK038736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK048023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK165914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC092372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466520 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L06502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U03873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X59726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000027878   ⟹   ENSMUSP00000027878
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1163,072,688 - 163,141,279 (-)Ensembl
GRCm38.p6 Ensembl1163,245,119 - 163,313,710 (-)Ensembl
RefSeq Acc Id: ENSMUST00000075805   ⟹   ENSMUSP00000075203
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1163,072,688 - 163,141,241 (-)Ensembl
GRCm38.p6 Ensembl1163,245,119 - 163,313,672 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174098
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1163,110,388 - 163,141,240 (-)Ensembl
GRCm38.p6 Ensembl1163,282,819 - 163,313,671 (-)Ensembl
RefSeq Acc Id: ENSMUST00000174397   ⟹   ENSMUSP00000134338
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1163,080,435 - 163,141,237 (-)Ensembl
GRCm38.p6 Ensembl1163,252,866 - 163,313,668 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183691
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1163,075,146 - 163,116,793 (-)Ensembl
GRCm38.p6 Ensembl1163,247,577 - 163,289,224 (-)Ensembl
RefSeq Acc Id: NM_001025570   ⟹   NP_001020741
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,082,846 - 163,141,219 (-)NCBI
GRCm381163,255,277 - 163,313,650 (-)NCBI
MGSCv371165,175,250 - 165,243,781 (-)RGD
Celera1165,686,221 - 165,753,419 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_011127   ⟹   NP_035257
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,072,688 - 163,141,219 (-)NCBI
GRCm381163,245,119 - 163,313,650 (-)NCBI
MGSCv371165,175,250 - 165,243,781 (-)RGD
Celera1165,686,221 - 165,753,419 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_175686   ⟹   NP_783617
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,072,688 - 163,141,219 (-)NCBI
GRCm381163,245,119 - 163,313,650 (-)NCBI
MGSCv371165,175,250 - 165,243,781 (-)RGD
Celera1165,686,221 - 165,753,419 (-)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006496703   ⟹   XP_006496766
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391163,077,254 - 163,142,714 (-)NCBI
GRCm381163,250,027 - 163,315,145 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035257   ⟸   NM_011127
- Peptide Label: isoform a
- UniProtKB: P63013 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_783617   ⟸   NM_175686
- Peptide Label: isoform b
- UniProtKB: P63013 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001020741   ⟸   NM_001025570
- Peptide Label: isoform c
- UniProtKB: G3UZ44 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006496766   ⟸   XM_006496703
- Peptide Label: isoform X1
- UniProtKB: P63013 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000027878   ⟸   ENSMUST00000027878
RefSeq Acc Id: ENSMUSP00000134338   ⟸   ENSMUST00000174397
RefSeq Acc Id: ENSMUSP00000075203   ⟸   ENSMUST00000075805
Protein Domains
Homeobox   OAR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63013-F1-model_v2 AlphaFold P63013 1-245 view protein structure

Promoters
RGD ID:6875488
Promoter ID:EPDNEW_M1194
Type:initiation region
Name:Prrx1_2
Description:Mus musculus paired related homeobox 1 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1195  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381163,313,478 - 163,313,538EPDNEW
RGD ID:6875490
Promoter ID:EPDNEW_M1195
Type:multiple initiation site
Name:Prrx1_1
Description:Mus musculus paired related homeobox 1 , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M1194  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381163,313,668 - 163,313,728EPDNEW
RGD ID:6817296
Promoter ID:MM_KWN:2663
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   MEF_B4,   MEF_B6
Transcripts:UC007DHJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361165,183,096 - 165,186,262 (-)MPROMDB
RGD ID:6818287
Promoter ID:MM_KWN:2664
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   MEF_B4,   MEF_B6
Transcripts:NM_001025570,   NM_011127,   NM_175686
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361165,242,576 - 165,244,612 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97712 AgrOrtholog
Ensembl Genes ENSMUSG00000026586 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000027878 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000075203 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000134338 ENTREZGENE
  ENSMUSP00000134338.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000027878 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000075805 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000174397 ENTREZGENE
  ENSMUST00000174397.3 UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRRX1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18933 UniProtKB/Swiss-Prot
MGD MGI:97712 ENTREZGENE
NCBI Gene 18933 ENTREZGENE
PANTHER PTHR46385 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prrx1 PhenoGen
PROSITE HOMEOBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3UZ44 ENTREZGENE, UniProtKB/TrEMBL
  P63013 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3TMI4_MOUSE UniProtKB/TrEMBL
  Q8BGB1_MOUSE UniProtKB/TrEMBL
  Q9D861_MOUSE UniProtKB/TrEMBL
  Q9D8E1_MOUSE UniProtKB/TrEMBL
UniProt Secondary P43271 UniProtKB/Swiss-Prot
  Q02810 UniProtKB/Swiss-Prot
  Q569N6 UniProtKB/Swiss-Prot