Sumf1 (sulfatase modifying factor 1) - Rat Genome Database

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Gene: Sumf1 (sulfatase modifying factor 1) Mus musculus
Analyze
Symbol: Sumf1
Name: sulfatase modifying factor 1
RGD ID: 1553352
MGI Page MGI
Description: Exhibits identical protein binding activity. Predicted to be involved in post-translational protein modification and protein oxidation. Localizes to endoplasmic reticulum. Is expressed in femur. Used to study mucosulfatidosis. Human ortholog(s) of this gene implicated in mucosulfatidosis. Orthologous to human SUMF1 (sulfatase modifying factor 1).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA543204; AI463102; AI851573; C-alpha-formylglycine-generating enzyme 1; FGE; formylglycine-generating enzyme; MGC39076; sulfatase-modifying factor 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,083,982 - 108,162,552 (-)NCBIGRCm39mm39
GRCm39 Ensembl6108,083,989 - 108,162,543 (-)Ensembl
GRCm386108,107,021 - 108,185,591 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,107,028 - 108,185,582 (-)EnsemblGRCm38mm10GRCm38
MGSCv376108,057,022 - 108,135,576 (-)NCBIGRCm37mm9NCBIm37
MGSCv366108,072,805 - 108,151,333 (-)NCBImm8
Celera6109,910,767 - 109,990,697 (-)NCBICelera
Cytogenetic Map6E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
endoplasmic reticulum  (IBA,IDA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:15489334   PMID:15782199   PMID:15820682   PMID:15962010  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:17206939   PMID:17360554   PMID:17446859   PMID:17913701   PMID:18832069   PMID:19637231   PMID:20562862   PMID:20643830   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:22215441   PMID:22366163   PMID:22826245   PMID:24194600   PMID:25680957   PMID:26273529   PMID:30550785   PMID:32325033  


Genomics

Comparative Map Data
Sumf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396108,083,982 - 108,162,552 (-)NCBIGRCm39mm39
GRCm39 Ensembl6108,083,989 - 108,162,543 (-)Ensembl
GRCm386108,107,021 - 108,185,591 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6108,107,028 - 108,185,582 (-)EnsemblGRCm38mm10GRCm38
MGSCv376108,057,022 - 108,135,576 (-)NCBIGRCm37mm9NCBIm37
MGSCv366108,072,805 - 108,151,333 (-)NCBImm8
Celera6109,910,767 - 109,990,697 (-)NCBICelera
Cytogenetic Map6E1NCBI
SUMF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl33,700,814 - 4,467,273 (-)EnsemblGRCh38hg38GRCh38
GRCh3833,700,814 - 3,800,875 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3733,742,498 - 3,842,559 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3634,377,830 - 4,483,954 (-)NCBINCBI36hg18NCBI36
Build 3434,377,829 - 4,483,954NCBI
Celera34,340,773 - 4,447,046 (-)NCBI
Cytogenetic Map3p26.2NCBI
HuRef34,336,301 - 4,442,706 (-)NCBIHuRef
CHM1_133,474,731 - 3,819,228 (-)NCBICHM1_1
Sumf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24141,078,735 - 141,160,711 (-)NCBI
Rnor_6.0 Ensembl4140,139,003 - 140,220,487 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04140,139,017 - 140,220,482 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04204,606,895 - 204,688,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44143,596,618 - 143,678,517 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14143,841,457 - 143,923,349 (-)NCBI
Celera4129,731,612 - 129,812,899 (-)NCBICelera
Cytogenetic Map4q41NCBI
Sumf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554218,981,211 - 9,049,948 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554218,982,059 - 9,050,936 (+)NCBIChiLan1.0ChiLan1.0
SUMF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.134,415,726 - 4,523,850 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl34,415,726 - 4,523,850 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v034,314,790 - 4,422,503 (-)NCBIMhudiblu_PPA_v0panPan3
SUMF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12013,093,427 - 13,190,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2013,092,901 - 13,299,314 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2013,066,961 - 13,163,715 (+)NCBI
ROS_Cfam_1.02013,137,091 - 13,228,066 (+)NCBI
UMICH_Zoey_3.12012,841,772 - 12,932,488 (+)NCBI
UNSW_CanFamBas_1.02013,182,237 - 13,272,688 (+)NCBI
UU_Cfam_GSD_1.02013,169,249 - 13,260,076 (+)NCBI
Sumf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494210,836,722 - 10,910,566 (-)NCBI
SpeTri2.0NW_0049365773,792,108 - 3,865,967 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUMF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1360,946,003 - 61,037,295 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11360,946,718 - 61,037,298 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21367,255,357 - 67,345,941 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SUMF1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12240,443,134 - 40,547,480 (-)NCBI
ChlSab1.1 Ensembl2240,444,131 - 40,547,448 (-)Ensembl
Sumf1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477314,746,089 - 14,828,928 (-)NCBI

Position Markers
AI851573  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386108,107,330 - 108,107,444UniSTSGRCm38
MGSCv376108,057,324 - 108,057,438UniSTSGRCm37
Celera6109,911,069 - 109,911,183UniSTS
Cytogenetic Map6E1UniSTS
Whitehead/MRC_RH61108.74UniSTS
14.MMHAP17FE2.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386108,137,648 - 108,137,825UniSTSGRCm38
MGSCv376108,087,642 - 108,087,819UniSTSGRCm37
Celera6109,941,494 - 109,941,671UniSTS
Cytogenetic Map6E1UniSTS
Whitehead_YAC6 UniSTS
AI463102  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm386108,107,124 - 108,107,354UniSTSGRCm38
MGSCv376108,057,118 - 108,057,348UniSTSGRCm37
Celera6109,910,863 - 109,911,093UniSTS
Cytogenetic Map6E1UniSTS
Whitehead/MRC_RH61108.85UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301244Ichs_mimmediate cutaneous hypersensitivity QTL (mouse)Not determined690795610124795846Mouse
10043864T2dm4sa_mtype 2 diabetes mellitus 4 in SMXA RI mice (mouse)Not determined683713869147052561Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
4142416Egq11_mearly growth QTL 11 (mouse)Not determined96655951146633626Mouse
10412208Cypr4_mcytokine production 4 (mouse)Not determined675716503109716697Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
1301915Chab3_mcholesterol absorption 3 (mouse)Not determined698931748132940036Mouse
13506930Recrq9_mrecombination rate in male meiosis QTL 9 (mouse)673500000134700000Mouse
1357793Pnhdlc1_mplasma non-HDL cholesterol 1 (mouse)Not determined6105564822114368849Mouse
4141578Obrq1_mobesity resistance QTL 1 (mouse)Not determined92607306112004738Mouse
10043923Bhr7_mbronchial hyperresponsiveness 7 (mouse)Not determined698242853132242977Mouse
4141699Ibdq2_minflammatory bowel disease QTL 2 (mouse)Not determined106005405120917141Mouse
1301262Gasa3_mgastritis type A susceptibility locus 3 (mouse)Not determined689005405123005603Mouse
11353842Bmiq4_mbody mass index QTL 4 (mouse)692607306146429238Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
1301687Mnic2_mmacronutrient intake (mouse)Not determined686806805113544602Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
1357806Aaj3_manxiety in A/J 3 (mouse)Not determined6104503360136423692Mouse
1301744Hdlq11_mHDL QTL 11 (mouse)Not determined687503360121503555Mouse
1301509Sluc3_msusceptibility to lung cancer 3 (mouse)Not determined6104503360127042975Mouse
1301518Bbaa5_mB.burgdorferi-associated arthritis 5 (mouse)Not determined698506837145935444Mouse
12910776Hcga4b_mhome cage activity 4b (mouse)6104503360110960065Mouse
11040599Lmr4b_mleishmaniasis resistance 4b (mouse)696347325130347522Mouse
4141376Dbm1_mdiabetes modifier 1 (mouse)Not determined678629504121115387Mouse
1301923Lith6_mlithogenic gene 6 (mouse)Not determined698717516132717715Mouse
1302131Bmd8_mbone mineral density 8 (mouse)Not determined699155128133155267Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
10043901Pfat5_mpredicted fat percentage 5 (mouse)Not determined675607306109607450Mouse
1300887Pabr1_mplasma apolipoprotein B (human) regulator 1 (mouse)Not determined6103777444136423692Mouse
1300704Cia3_mcollagen induced arthritis QTL 3 (mouse)Not determined696347325130347522Mouse
11251720Ewc4_methanol withdrawal and consumption 4 (mouse)684122513118122513Mouse
4141940W6q5_mweight 6 weeks QTL 5 (mouse)Not determined96655951146633626Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
1357555Tesq2_mtestis weight QTL 2 (mouse)Not determined696655951146633626Mouse
1301292Cfbw2_mcystic fibrosis body weight 2 (mouse)Not determined695004651129004738Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1357875Pfat2_mpredicted fat percentage 2 (mouse)Not determined676463949110464093Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:962
Count of miRNA genes:512
Interacting mature miRNAs:605
Transcripts:ENSMUST00000032191, ENSMUST00000166197, ENSMUST00000167338, ENSMUST00000169446, ENSMUST00000171697, ENSMUST00000172188
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_145937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006506445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC108919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK160917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK194677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK198586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK207725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY331659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000032191   ⟹   ENSMUSP00000032191
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6108,107,028 - 108,185,582 (-)Ensembl
RefSeq Acc Id: ENSMUST00000166197
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6108,108,347 - 108,127,063 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167338   ⟹   ENSMUSP00000127537
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6108,108,476 - 108,185,556 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169446   ⟹   ENSMUSP00000130061
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6108,118,203 - 108,144,695 (-)Ensembl
RefSeq Acc Id: ENSMUST00000171697
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6108,144,313 - 108,152,286 (-)Ensembl
RefSeq Acc Id: ENSMUST00000172188   ⟹   ENSMUSP00000132321
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl6108,108,476 - 108,185,556 (-)Ensembl
RefSeq Acc Id: NM_145937   ⟹   NP_666049
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396108,083,982 - 108,162,544 (-)NCBI
GRCm386108,107,021 - 108,185,583 (-)NCBI
MGSCv376108,057,022 - 108,135,576 (-)RGD
Celera6109,910,760 - 109,990,698 (-)ENTREZGENE
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006506444   ⟹   XP_006506507
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396108,119,338 - 108,162,552 (-)NCBI
GRCm386108,142,377 - 108,185,591 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006506445   ⟹   XP_006506508
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm396108,119,338 - 108,162,552 (-)NCBI
GRCm386108,142,377 - 108,185,591 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_666049   ⟸   NM_145937
- Peptide Label: precursor
- UniProtKB: Q8R0F3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006506507   ⟸   XM_006506444
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006506508   ⟸   XM_006506445
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000032191   ⟸   ENSMUST00000032191
RefSeq Acc Id: ENSMUSP00000132321   ⟸   ENSMUST00000172188
RefSeq Acc Id: ENSMUSP00000130061   ⟸   ENSMUST00000169446
RefSeq Acc Id: ENSMUSP00000127537   ⟸   ENSMUST00000167338
Protein Domains
FGE-sulfatase

Promoters
RGD ID:6840038
Promoter ID:MM_KWN:47098
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_145937
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv366108,135,346 - 108,135,846 (-)MPROMDB
RGD ID:6890580
Promoter ID:EPDNEW_M8741
Type:multiple initiation site
Name:Sumf1_1
Description:Mus musculus sulfatase modifying factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm386108,185,575 - 108,185,635EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1889844 AgrOrtholog
Ensembl Genes ENSMUSG00000030101 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000032191 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000127537 UniProtKB/TrEMBL
  ENSMUSP00000130061 UniProtKB/TrEMBL
  ENSMUSP00000132321 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000032191 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000167338 UniProtKB/TrEMBL
  ENSMUST00000169446 UniProtKB/TrEMBL
  ENSMUST00000172188 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1580.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUMF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUMF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:58911 UniProtKB/Swiss-Prot
MGD MGI:1889844 ENTREZGENE
NCBI Gene 58911 ENTREZGENE
Pfam FGE-sulfatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sumf1 PhenoGen
Superfamily-SCOP SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9Q0Z7_MOUSE UniProtKB/TrEMBL
  E9Q265_MOUSE UniProtKB/TrEMBL
  F6QZU1_MOUSE UniProtKB/TrEMBL
  Q8R0F3 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q3TTT6 UniProtKB/Swiss-Prot
  Q3TXM8 UniProtKB/Swiss-Prot
  Q3U9A5 UniProtKB/Swiss-Prot