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Gene: Whrn (whirlin) Mus musculus
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Symbol: Whrn
Name: whirlin
Description: Exhibits protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including detection of mechanical stimulus involved in sensory perception of sound; nervous system development; and paranodal junction maintenance. Localizes to several cellular components, including the USH2 complex; cytoskeleton; and periciliary membrane compartment. Predicted to colocalize with the neuronal cell body. Used to study Usher syndrome type 2D and autosomal recessive nonsyndromic deafness 31. Human ortholog(s) of this gene implicated in Usher syndrome type 2D; autosomal recessive nonsyndromic deafness 31; and sensorineural hearing loss. Is expressed in several structures, including central nervous system; cervical intervertebral disc; forelimb bud; sensory organ; and thymus. Orthologous to human WHRN (whirlin).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1110035G07Rik; AW122018; AW742671; bM340H1.8; C430046P22Rik; Dfnb31; MGC183668; mKIAA1526; Ush2d; whirler; whirlinNT1; whirlinNT2; wi
Orthologs:
Homo sapiens (human) : WHRN (whirlin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Whrn (whirlin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Whrn (whirlin)
Pan paniscus (bonobo/pygmy chimpanzee) : WHRN (whirlin)
Canis lupus familiaris (dog) : WHRN (whirlin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Whrn (whirlin)
Sus scrofa (pig) : WHRN (whirlin)
Chlorocebus sabaeus (African green monkey) : WHRN (whirlin)
Heterocephalus glaber (naked mole-rat) : Whrn (whirlin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl463,414,910 - 63,495,991 (-)Ensembl
GRCm38463,414,908 - 63,496,083 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37463,075,944 - 63,156,985 (-)NCBIGRCm37mm9NCBIm37
MGSCv36462,901,271 - 62,982,312 (-)NCBImm8
Celera462,074,390 - 62,155,782 (-)NCBICelera
Cytogenetic Map4 C1NCBI
cM Map433.97NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Whrn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553310
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.