Cyp4f15 (cytochrome P450, family 4, subfamily f, polypeptide 15) - Rat Genome Database

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Gene: Cyp4f15 (cytochrome P450, family 4, subfamily f, polypeptide 15) Mus musculus
Analyze
No known orthologs.
Symbol: Cyp4f15
Name: cytochrome P450, family 4, subfamily f, polypeptide 15
RGD ID: 1553283
MGI Page MGI
Description: Predicted to enable fatty acid binding activity; heme binding activity; and monooxygenase activity. Predicted to be involved in leukotriene B4 catabolic process; omega-hydroxylase P450 pathway; and prostaglandin catabolic process. Predicted to be located in apical plasma membrane; cytoplasm; and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including CYP4F11 (cytochrome P450 family 4 subfamily F member 11) and CYP4F2 (cytochrome P450 family 4 subfamily F member 2).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AI787289; Cyp4f-15; cytochrome P450 CYP4F15; cytochrome P450, 4f15
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391732,904,605 - 32,922,329 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1732,904,601 - 32,922,326 (+)EnsemblGRCm39 Ensembl
GRCm381732,685,631 - 32,703,352 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,685,627 - 32,703,352 (+)EnsemblGRCm38mm10GRCm38
MGSCv371732,822,604 - 32,840,294 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361732,424,969 - 32,442,659 (+)NCBIMGSCv36mm8
Celera1733,598,901 - 33,616,587 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.76NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14681479   PMID:21267068   PMID:21677750   PMID:21873635  


Genomics

Variants

.
Variants in Cyp4f15
677 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:617
Count of miRNA genes:372
Interacting mature miRNAs:403
Transcripts:ENSMUST00000008801, ENSMUST00000163907, ENSMUST00000167789, ENSMUST00000168171
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
1302038Radpf1_mradiation pulmonary fibrosis 1 (mouse)Not determined171683545533819843Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173206165237644775Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
11038694Pas19_mpulmonary adenoma susceptibility 19 (mouse)172971116434754437Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173266042635520036Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse

Markers in Region
RH130839  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381732,689,138 - 32,689,292UniSTSGRCm38
GRCm3811120,292,063 - 120,292,219UniSTSGRCm38
MGSCv371732,826,083 - 32,826,237UniSTSGRCm37
MGSCv3711120,153,377 - 120,153,533UniSTSGRCm37
Celera1733,602,380 - 33,602,534UniSTS
Celera11132,027,925 - 132,028,081UniSTS
Cytogenetic Map11E2UniSTS
Cytogenetic Map17B1UniSTS
Cyp4f15  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17B1UniSTS
cM Map17 UniSTS
AI787289  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381732,703,108 - 32,703,199UniSTSGRCm38
MGSCv371732,840,053 - 32,840,144UniSTSGRCm37
Celera1733,616,346 - 33,616,437UniSTS
Cytogenetic Map17B1UniSTS
Whitehead/MRC_RH17386.12UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000008801   ⟹   ENSMUSP00000008801
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1732,904,653 - 32,922,326 (+)Ensembl
GRCm38.p6 Ensembl1732,685,679 - 32,703,352 (+)Ensembl
Ensembl Acc Id: ENSMUST00000163907
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1732,904,645 - 32,916,790 (+)Ensembl
GRCm38.p6 Ensembl1732,685,671 - 32,697,816 (+)Ensembl
Ensembl Acc Id: ENSMUST00000167789
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1732,904,642 - 32,909,876 (+)Ensembl
GRCm38.p6 Ensembl1732,685,668 - 32,690,902 (+)Ensembl
Ensembl Acc Id: ENSMUST00000168171   ⟹   ENSMUSP00000129264
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1732,904,601 - 32,922,326 (+)Ensembl
GRCm38.p6 Ensembl1732,685,627 - 32,703,352 (+)Ensembl
RefSeq Acc Id: NM_001346538   ⟹   NP_001333467
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391732,904,605 - 32,922,326 (+)NCBI
GRCm381732,685,631 - 32,703,352 (+)NCBI
Sequence:
RefSeq Acc Id: NM_134127   ⟹   NP_598888
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391732,904,633 - 32,922,323 (+)NCBI
GRCm381732,685,659 - 32,703,349 (+)NCBI
MGSCv371732,822,604 - 32,840,294 (+)RGD
Celera1733,598,901 - 33,616,587 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523412   ⟹   XP_006523475
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391732,911,571 - 32,922,329 (+)NCBI
GRCm381732,692,597 - 32,703,352 (+)NCBI
Sequence:
RefSeq Acc Id: NP_598888   ⟸   NM_134127
- Peptide Label: isoform 1
- UniProtKB: Q99N18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006523475   ⟸   XM_006523412
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001333467   ⟸   NM_001346538
- Peptide Label: isoform 2
- UniProtKB: Q8VCA4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000008801   ⟸   ENSMUST00000008801
Ensembl Acc Id: ENSMUSP00000129264   ⟸   ENSMUST00000168171

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99N18-F1-model_v2 AlphaFold Q99N18 1-534 view protein structure

Promoters
RGD ID:13675532
Promoter ID:EPDNEW_M21915
Type:multiple initiation site
Name:Cyp4f15_1
Description:Mus musculus cytochrome P450, family 4, subfamily f, polypeptide15 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381732,685,668 - 32,685,728EPDNEW
RGD ID:6827968
Promoter ID:MM_KWN:23061
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000008801,   UC008BXL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361732,822,381 - 32,822,881 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2146921 AgrOrtholog
Ensembl Genes ENSMUSG00000073424 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000008801 ENTREZGENE
  ENSMUST00000008801.7 UniProtKB/TrEMBL
  ENSMUST00000168171 ENTREZGENE
  ENSMUST00000168171.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_Monoox UniProtKB/TrEMBL
KEGG Report mmu:106648 UniProtKB/TrEMBL
MGD MGI:2146921 ENTREZGENE
NCBI Gene 106648 ENTREZGENE
PANTHER CYTOCHROME P450 4F2 UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 4 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp4f15 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt Q8VCA4 ENTREZGENE, UniProtKB/TrEMBL
  Q99N18 ENTREZGENE, UniProtKB/TrEMBL